Project name: Cerrena_lac

Chain sequence(s)	A: AVGPVTDIHIVNKDIAPDGFSRPSVLAGGTFPGPLITGQKGDNFKLNVVDDLTDASMLKSTSIHWHGFFQKGTNWADGPAFVNQCPISTGNSFLYNFQVPDQAGTYWYHSHLSTQYCDGLRGAFVVYDPTDPHKALYDVDDESTVITLADWYHTLARQIVGVAIADTTLINGLGRNTNGPADAALAVINVEAGKRYRLRLVSISCDPNYVFSIDNHDFNIIEVDGVNSKPLNVDSIQIFAGQRYSAVLNANQPVGNYWVRANPNLGTTGFTGGINSAILRYKGAPVAEPTTTQTTSTKPLQEPNLRPLVSMPVPGSATPGGVDVVHNLILGFSAGKFTINGAAFTPPSVPVLLQILSGTTNAQDLLPSGSVITLPIGKTIELTLAAGVLGGPHPFHLHGHNFHVVRSAGQTTPNYVDPIVRDVVNTGGTGDNVTIRFTTDNPGPWFLHCHIDWHLEAGFAVVFAEGVNQTNAANPTPADWNNLCNIYNALADGDK
Distance of aggregation	5 Å
Dynamic mode	No

• Minimal score value: -2.039
• Maximal score value: 1.912
• Average score: -0.1591
• Total score value: -78.7351

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	A	A	0.1531
2	V	A	0.4935
3	G	A	0.1196
4	P	A	0.1998
5	V	A	1.6529
6	T	A	-0.0176
7	D	A	-1.8305
8	I	A	0.0000
9	H	A	-0.5353
10	I	A	0.0000
11	V	A	0.2841
12	N	A	-0.4994
13	K	A	-1.5525
14	D	A	-1.9643
15	I	A	-0.0456
16	A	A	0.0620
17	P	A	-0.0251
18	D	A	0.0000
19	G	A	-0.3540
20	F	A	0.4749
21	S	A	-0.0986
22	R	A	0.0000
23	P	A	-0.3428
24	S	A	0.0000
25	V	A	0.0000
26	L	A	0.0000
27	A	A	0.0000
28	G	A	-0.4706
29	G	A	-0.1445
30	T	A	-0.0248
31	F	A	0.1981
32	P	A	0.0222
33	G	A	-0.0644
34	P	A	-0.0627
35	L	A	0.0000
36	I	A	0.0000
37	T	A	-0.0195
38	G	A	-0.2128
39	Q	A	-0.9497
40	K	A	-0.9424
41	G	A	-0.6778
42	D	A	-0.7029
43	N	A	-1.2540
44	F	A	0.0000
45	K	A	-0.5377
46	L	A	0.0000
47	N	A	-0.4690
48	V	A	0.0000
49	V	A	0.1598
50	D	A	0.0000
51	D	A	-0.9233
52	L	A	0.0000
53	T	A	-0.1686
54	D	A	-0.5429
55	A	A	-0.0515
56	S	A	-0.0646
57	M	A	0.0000
58	L	A	0.1421
59	K	A	-0.1648
60	S	A	0.0000
61	T	A	0.0000
62	S	A	0.0000
63	I	A	0.0000
64	H	A	0.0000
65	W	A	0.0000
66	H	A	0.0000
67	G	A	-0.0507
68	F	A	0.0000
69	F	A	0.2990
70	Q	A	0.0000
71	K	A	-1.4983
72	G	A	-0.4311
73	T	A	-0.0390
74	N	A	0.0000
75	W	A	0.0000
76	A	A	0.0000
77	D	A	0.0000
78	G	A	0.0000
79	P	A	0.0000
80	A	A	0.0000
81	F	A	0.2222
82	V	A	0.0000
83	N	A	0.0000
84	Q	A	0.0000
85	C	A	0.0000
86	P	A	0.0000
87	I	A	0.0000
88	S	A	0.0000
89	T	A	-0.1014
90	G	A	-0.5449
91	N	A	-0.5264
92	S	A	-0.1910
93	F	A	0.0000
94	L	A	0.4077
95	Y	A	0.0000
96	N	A	-0.4504
97	F	A	0.0000
98	Q	A	-1.3338
99	V	A	0.0000
100	P	A	-0.6516
101	D	A	-1.8582
102	Q	A	-0.4473
103	A	A	-0.0150
104	G	A	0.0000
105	T	A	0.0000
106	Y	A	0.0000
107	W	A	0.0000
108	Y	A	0.0000
109	H	A	0.0000
110	S	A	0.0000
111	H	A	0.0000
112	L	A	0.0000
113	S	A	-0.0656
114	T	A	0.0000
115	Q	A	0.0000
116	Y	A	0.0000
117	C	A	0.0000
118	D	A	0.0000
119	G	A	0.0000
120	L	A	0.0000
121	R	A	0.0000
122	G	A	0.0000
123	A	A	0.0000
124	F	A	0.0000
125	V	A	0.0000
126	V	A	0.0000
127	Y	A	0.1722
128	D	A	-0.2346
129	P	A	-0.2643
130	T	A	-0.1080
131	D	A	0.0000
132	P	A	-0.2549
133	H	A	0.0000
134	K	A	-1.6894
135	A	A	-0.1459
136	L	A	0.6104
137	Y	A	-0.0621
138	D	A	-1.2722
139	V	A	-0.0614
140	D	A	-0.4959
141	D	A	-1.3806
142	E	A	-2.0390
143	S	A	-0.5430
144	T	A	0.0000
145	V	A	0.0000
146	I	A	0.0000
147	T	A	0.0000
148	L	A	0.0000
149	A	A	0.0000
150	D	A	0.0000
151	W	A	0.0000
152	Y	A	0.0000
153	H	A	-0.2527
154	T	A	-0.0799
155	L	A	0.0000
156	A	A	0.0000
157	R	A	-1.8032
158	Q	A	-1.4106
159	I	A	0.5248
160	V	A	1.7638
161	G	A	0.1859
162	V	A	1.6868
163	A	A	0.0000
164	I	A	1.5280
165	A	A	0.1455
166	D	A	-0.7683
167	T	A	0.0000
168	T	A	0.0000
169	L	A	0.0000
170	I	A	0.0000
171	N	A	-0.4330
172	G	A	0.0000
173	L	A	0.6028
174	G	A	0.0000
175	R	A	-0.1796
176	N	A	0.0000
177	T	A	-0.2975
178	N	A	-1.3072
179	G	A	-0.3808
180	P	A	-0.1626
181	A	A	-0.2987
182	D	A	-1.7775
183	A	A	-0.3096
184	A	A	0.0879
185	L	A	0.1647
186	A	A	0.0000
187	V	A	0.6029
188	I	A	0.0000
189	N	A	-1.2730
190	V	A	0.0000
191	E	A	-0.5470
192	A	A	-0.1299
193	G	A	-0.6035
194	K	A	-0.9772
195	R	A	-0.6989
196	Y	A	0.0000
197	R	A	0.0000
198	L	A	0.0000
199	R	A	0.0000
200	L	A	0.0000
201	V	A	0.0000
202	S	A	0.0000
203	I	A	0.0000
204	S	A	0.0000
205	C	A	0.0000
206	D	A	-0.1817
207	P	A	0.0000
208	N	A	0.0000
209	Y	A	0.0000
210	V	A	0.6340
211	F	A	0.0000
212	S	A	-0.0239
213	I	A	0.0000
214	D	A	0.0000
215	N	A	-1.2730
216	H	A	0.0000
217	D	A	-1.0881
218	F	A	0.0000
219	N	A	-0.5029
220	I	A	0.0000
221	I	A	0.0000
222	E	A	0.0000
223	V	A	0.0000
224	D	A	0.0000
225	G	A	-0.0178
226	V	A	0.1211
227	N	A	-0.2803
228	S	A	0.0000
229	K	A	-0.8972
230	P	A	-0.3088
231	L	A	0.0412
232	N	A	-0.4784
233	V	A	0.0000
234	D	A	-0.4116
235	S	A	0.0000
236	I	A	0.0000
237	Q	A	-0.5312
238	I	A	0.0000
239	F	A	0.0000
240	A	A	0.0000
241	G	A	0.0000
242	Q	A	0.0000
243	R	A	0.0000
244	Y	A	0.0000
245	S	A	0.0000
246	A	A	0.0000
247	V	A	0.0000
248	L	A	0.0000
249	N	A	-0.8468
250	A	A	0.0000
251	N	A	-1.3143
252	Q	A	-0.5058
253	P	A	-0.0098
254	V	A	1.5063
255	G	A	0.2036
256	N	A	-0.1607
257	Y	A	0.0000
258	W	A	0.1231
259	V	A	0.0000
260	R	A	0.0000
261	A	A	0.0000
262	N	A	-0.2569
263	P	A	0.0000
264	N	A	-0.8194
265	L	A	0.0705
266	G	A	-0.2083
267	T	A	-0.0922
268	T	A	-0.0855
269	G	A	-0.0716
270	F	A	0.2960
271	T	A	-0.0954
272	G	A	-0.4793
273	G	A	0.0000
274	I	A	0.0000
275	N	A	0.0000
276	S	A	0.0000
277	A	A	0.0000
278	I	A	0.0000
279	L	A	0.0000
280	R	A	-0.2177
281	Y	A	0.0000
282	K	A	-1.7857
283	G	A	-0.7776
284	A	A	-0.1329
285	P	A	0.0728
286	V	A	1.7318
287	A	A	0.1260
288	E	A	-1.2512
289	P	A	0.0000
290	T	A	-0.0739
291	T	A	-0.0422
292	T	A	-0.2474
293	Q	A	-0.9593
294	T	A	-0.2548
295	T	A	-0.1023
296	S	A	-0.1255
297	T	A	-0.3486
298	K	A	-1.4602
299	P	A	-0.4270
300	L	A	0.0000
301	Q	A	-1.2424
302	E	A	-0.4910
303	P	A	-0.4291
304	N	A	-1.2085
305	L	A	0.0000
306	R	A	-0.8224
307	P	A	0.0000
308	L	A	0.5021
309	V	A	1.7879
310	S	A	0.1586
311	M	A	0.1562
312	P	A	-0.1759
313	V	A	0.1328
314	P	A	-0.0832
315	G	A	-0.4833
316	S	A	-0.2977
317	A	A	0.0085
318	T	A	-0.0937
319	P	A	-0.3110
320	G	A	-0.3100
321	G	A	-0.1078
322	V	A	-0.1588
323	D	A	-1.6985
324	V	A	0.0613
325	V	A	0.7284
326	H	A	-0.2903
327	N	A	-1.3085
328	L	A	0.0000
329	I	A	1.9120
330	L	A	0.0000
331	G	A	0.0896
332	F	A	0.8907
333	S	A	-0.0283
334	A	A	-0.0656
335	G	A	-0.6474
336	K	A	-1.1325
337	F	A	0.0000
338	T	A	-0.0129
339	I	A	0.0000
340	N	A	-0.7934
341	G	A	-0.6347
342	A	A	-0.0735
343	A	A	0.0208
344	F	A	0.0000
345	T	A	-0.1123
346	P	A	-0.2439
347	P	A	-0.1063
348	S	A	-0.0374
349	V	A	0.9450
350	P	A	0.0000
351	V	A	0.0000
352	L	A	0.0000
353	L	A	0.4372
354	Q	A	0.0000
355	I	A	0.0000
356	L	A	0.2680
357	S	A	-0.2494
358	G	A	-0.5082
359	T	A	-0.1104
360	T	A	-0.2787
361	N	A	-1.2709
362	A	A	-0.3964
363	Q	A	-1.3493
364	D	A	-1.1036
365	L	A	0.0000
366	L	A	0.9019
367	P	A	0.1989
368	S	A	-0.1999
369	G	A	-0.5054
370	S	A	0.0000
371	V	A	0.2864
372	I	A	0.3636
373	T	A	0.0353
374	L	A	0.0000
375	P	A	-0.0408
376	I	A	0.4938
377	G	A	-0.4935
378	K	A	-0.8380
379	T	A	-0.1524
380	I	A	0.0000
381	E	A	0.0000
382	L	A	0.0000
383	T	A	-0.1532
384	L	A	0.0000
385	A	A	-0.0614
386	A	A	-0.0925
387	G	A	-0.4514
388	V	A	0.4327
389	L	A	1.5059
390	G	A	-0.2418
391	G	A	-0.4745
392	P	A	-0.1749
393	H	A	0.0000
394	P	A	0.0000
395	F	A	0.0000
396	H	A	0.0000
397	L	A	0.0000
398	H	A	0.0000
399	G	A	0.0000
400	H	A	0.0000
401	N	A	-0.4805
402	F	A	0.0000
403	H	A	0.0000
404	V	A	0.0000
405	V	A	0.0000
406	R	A	-0.3462
407	S	A	0.0000
408	A	A	-0.0799
409	G	A	-0.4936
410	Q	A	-0.2588
411	T	A	-0.1133
412	T	A	-0.0952
413	P	A	-0.1697
414	N	A	-0.2801
415	Y	A	0.4669
416	V	A	1.6032
417	D	A	-0.7934
418	P	A	0.0000
419	I	A	0.0000
420	V	A	0.0000
421	R	A	0.0000
422	D	A	0.0000
423	V	A	0.0000
424	V	A	0.0000
425	N	A	-0.1833
426	T	A	0.0000
427	G	A	-0.1003
428	G	A	-0.2541
429	T	A	-0.2612
430	G	A	-0.5245
431	D	A	-0.4287
432	N	A	-0.5649
433	V	A	0.0000
434	T	A	0.0000
435	I	A	0.0000
436	R	A	0.0000
437	F	A	0.0000
438	T	A	-0.0252
439	T	A	0.0000
440	D	A	-1.7894
441	N	A	0.0000
442	P	A	-0.0324
443	G	A	0.0000
444	P	A	0.0000
445	W	A	0.0000
446	F	A	0.0000
447	L	A	0.0000
448	H	A	0.0000
449	C	A	0.0000
450	H	A	0.0000
451	I	A	0.0000
452	D	A	0.0000
453	W	A	0.1154
454	H	A	-0.0475
455	L	A	-0.1781
456	E	A	-1.7591
457	A	A	-0.3277
458	G	A	0.0000
459	F	A	0.0000
460	A	A	0.0000
461	V	A	0.0000
462	V	A	0.0000
463	F	A	0.0000
464	A	A	0.0000
465	E	A	0.0000
466	G	A	0.0000
467	V	A	0.0000
468	N	A	-1.3820
469	Q	A	-0.8290
470	T	A	0.0000
471	N	A	-0.7899
472	A	A	-0.0863
473	A	A	0.0220
474	N	A	0.0000
475	P	A	-0.2583
476	T	A	-0.0791
477	P	A	-0.0671
478	A	A	-0.2134
479	D	A	-0.6718
480	W	A	0.0000
481	N	A	-1.4207
482	N	A	-1.0757
483	L	A	0.0000
484	C	A	-0.1095
485	N	A	-1.1265
486	I	A	0.4444
487	Y	A	0.0000
488	N	A	-1.2624
489	A	A	-0.1205
490	L	A	0.3091
491	A	A	-0.2142
492	D	A	-1.8565
493	G	A	-0.8924
494	D	A	-1.0049
495	K	A	-1.0045