Project name: 4ioi:B

Chain sequence(s)	B: EVQLVESGGGLVQPGGSLRLSCAASGFNIKDTYIHWVRQSPGKGLEWVARIYPTNGYTRRYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAIYYCCSRWGGDGFYAMDYWGQGTLVTVSSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSSLSSVVTTVPSSSLGTQTYICNVNNHKPSNTKVDKKKVEP
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -2.8855
• Maximal score value: 2.4722
• Average score: -0.5648
• Total score value: -124.2555

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	B	-2.1165
2	V	B	-1.3206
3	Q	B	-1.4011
4	L	B	0.0000
5	V	B	0.0872
6	E	B	0.0000
7	S	B	-0.5987
8	G	B	-0.8745
9	G	B	-0.4743
10	G	B	-0.4826
11	L	B	-0.1310
12	V	B	0.0000
13	Q	B	-1.6653
14	P	B	-1.7494
15	G	B	-1.4470
16	G	B	-1.1430
17	S	B	-1.1066
18	L	B	-1.0339
19	R	B	-1.7832
20	L	B	0.0000
21	S	B	-0.4413
22	C	B	0.0000
23	A	B	-0.3852
24	A	B	0.0000
25	S	B	-1.2693
26	G	B	-1.4437
27	F	B	-1.5717
28	N	B	-2.0909
29	I	B	0.0000
30	K	B	-2.6982
31	D	B	-2.8508
32	T	B	0.0000
33	Y	B	-0.0747
34	I	B	0.0000
35	H	B	0.0000
36	W	B	0.0000
37	V	B	0.0000
38	R	B	0.0000
39	Q	B	-0.3557
40	S	B	-1.0302
41	P	B	-1.1265
42	G	B	-1.7677
43	K	B	-2.1618
44	G	B	-0.7089
45	L	B	0.6440
46	E	B	-0.0923
47	W	B	0.3256
48	V	B	0.0000
49	A	B	0.0000
50	R	B	-1.1339
51	I	B	0.0000
52	Y	B	-0.5056
53	P	B	-1.1324
54	T	B	-1.2132
55	N	B	-0.9808
56	G	B	-0.4545
57	Y	B	0.3763
58	T	B	-0.6892
59	R	B	-2.2045
60	Y	B	-1.9584
61	A	B	-1.8064
62	D	B	-2.6758
63	S	B	-1.8209
64	V	B	0.0000
65	K	B	-2.8855
66	G	B	-1.8037
67	R	B	-1.4430
68	F	B	0.0000
69	T	B	-1.1264
70	I	B	0.0000
71	S	B	-0.1934
72	A	B	-0.7511
73	D	B	-1.3298
74	T	B	-1.5341
75	S	B	-1.5341
76	K	B	-2.1792
77	N	B	-1.7339
78	T	B	-0.9022
79	A	B	0.0000
80	Y	B	-0.3791
81	L	B	0.0000
82	Q	B	-1.0166
83	M	B	0.0000
84	N	B	-1.4125
85	S	B	-1.2932
86	L	B	0.0000
87	R	B	-2.4273
88	A	B	-1.7935
89	E	B	-2.6307
90	D	B	0.0000
91	T	B	-0.8447
92	A	B	0.0000
93	I	B	0.5012
94	Y	B	0.0000
95	Y	B	0.1830
96	C	B	0.0000
97	S	B	0.0000
98	R	B	0.0000
99	W	B	0.6500
100	G	B	0.3704
101	G	B	0.0000
102	D	B	-1.5255
103	G	B	-0.2291
104	F	B	1.7677
105	Y	B	1.9101
106	A	B	1.2953
107	M	B	1.0136
108	D	B	0.4747
109	Y	B	0.3973
110	W	B	0.3925
111	G	B	-0.2719
112	Q	B	-0.9296
113	G	B	-0.2692
114	T	B	-0.0461
115	L	B	0.1395
116	V	B	0.0000
117	T	B	-0.4542
118	V	B	0.0000
119	S	B	-0.8173
120	S	B	-0.7109
121	A	B	-0.4435
122	S	B	-0.5531
123	T	B	-0.5769
124	K	B	-1.1207
125	G	B	-1.4211
126	P	B	-0.5519
127	S	B	-0.0625
128	V	B	0.0000
129	F	B	1.0272
130	P	B	0.0762
131	L	B	0.4814
132	A	B	-0.6776
133	P	B	0.0000
134	S	B	-0.9883
135	S	B	-1.1655
136	K	B	-1.8885
137	S	B	-0.9931
138	T	B	-0.9938
139	S	B	-0.9533
140	G	B	-0.8570
141	G	B	-0.9193
142	T	B	-0.6363
143	A	B	0.0000
144	A	B	-0.2194
145	L	B	0.0000
146	G	B	0.0000
147	C	B	0.0000
148	L	B	0.7551
149	V	B	0.0000
150	K	B	-0.2097
151	D	B	-0.5668
152	Y	B	0.0000
153	F	B	0.0000
154	P	B	0.0000
155	E	B	-0.4825
156	P	B	-0.6698
157	V	B	-0.6238
158	T	B	-0.5037
159	V	B	-0.2019
160	S	B	-0.3612
161	W	B	0.0000
162	N	B	-0.7388
163	S	B	-0.6404
164	G	B	-0.5702
165	A	B	-0.2492
166	L	B	-0.0444
167	T	B	-0.3280
168	S	B	-0.3593
169	G	B	-0.4335
170	V	B	-0.1388
171	H	B	-0.5533
172	T	B	0.1646
173	F	B	1.0073
174	P	B	0.7488
175	A	B	1.2683
176	V	B	2.4722
177	L	B	2.0234
178	Q	B	0.6520
179	S	B	0.0706
180	S	B	-0.2240
181	G	B	0.2001
182	L	B	0.2963
183	Y	B	0.8223
184	S	B	0.7288
185	L	B	0.0000
186	S	B	0.6816
187	S	B	0.0000
188	V	B	0.3649
189	V	B	0.0000
190	T	B	-0.2396
191	V	B	0.0000
192	P	B	-0.6261
193	S	B	-0.5731
194	S	B	-0.5375
195	S	B	-0.5290
196	L	B	-0.7228
197	G	B	-1.0720
198	T	B	-0.7001
199	Q	B	-1.2301
200	T	B	-1.1246
201	Y	B	0.0000
202	I	B	-1.2789
203	C	B	0.0000
204	N	B	-1.3751
205	V	B	0.0000
206	N	B	-1.8276
207	H	B	0.0000
208	K	B	-2.7578
209	P	B	-1.6162
210	S	B	-1.8213
211	N	B	-2.5548
212	T	B	-2.0664
213	K	B	-2.6520
214	V	B	-1.6217
215	D	B	-2.3036
216	K	B	-1.9713
217	K	B	-2.4318
218	V	B	0.0000
219	E	B	-2.4628
220	P	B	-1.1677