Project name: 4i77:H

Chain sequence(s)	H: QVTLREESGPALVKPTQTLTLTCTVSGFSLSAYSVNWIRQPPGKALEWLAMIWGDGKIVYNSALKSRLTISKDTSKNQVVLTMTNMDPVDTATYYCAGDGYYPYAMDNWGQGSLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESK
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -2.9106
• Maximal score value: 2.4044
• Average score: -0.5024
• Total score value: -110.0206

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	Q	H	-1.0926
2	V	H	-0.3059
3	T	H	-0.7738
4	L	H	0.0000
5	R	H	-2.2647
6	E	H	-1.4132
7	S	H	-0.8703
8	G	H	-0.4351
9	P	H	-0.2067
10	A	H	-0.3168
11	L	H	-0.2689
12	V	H	0.0000
13	K	H	-2.4842
14	P	H	-1.7899
15	T	H	-1.9836
16	Q	H	-2.3006
17	T	H	-1.4263
18	L	H	0.0000
19	T	H	-0.2192
20	L	H	0.0000
21	T	H	-0.4882
22	C	H	0.0000
23	T	H	-1.2902
24	V	H	0.0000
25	S	H	-0.8522
26	G	H	-0.5332
27	F	H	0.0749
28	S	H	-0.1630
29	L	H	0.0000
30	S	H	-0.8970
31	A	H	-0.4321
32	Y	H	0.0000
33	S	H	0.0000
34	V	H	0.0000
35	N	H	0.0000
36	W	H	0.0000
37	I	H	0.0000
38	R	H	0.0000
39	Q	H	-0.5865
40	P	H	-0.5620
41	P	H	-0.9644
42	G	H	-1.3447
43	K	H	-1.9043
44	A	H	-0.5552
45	L	H	0.3931
46	E	H	-0.1902
47	W	H	0.2822
48	L	H	0.0000
49	A	H	0.0000
50	M	H	0.0000
51	I	H	0.0000
52	W	H	-0.7878
53	G	H	-1.2293
54	D	H	-2.2419
55	G	H	-1.6478
56	K	H	-1.5493
57	I	H	0.4141
58	V	H	0.6016
59	Y	H	0.1191
60	N	H	-0.5438
61	S	H	-0.6461
62	A	H	-0.5678
63	L	H	-0.8930
64	K	H	-1.8015
65	S	H	-1.1823
66	R	H	-1.2278
67	L	H	0.0000
68	T	H	-0.1517
69	I	H	0.0000
70	S	H	-0.2896
71	K	H	-1.2972
72	D	H	-2.0818
73	T	H	-1.5869
74	S	H	-1.6319
75	K	H	-2.4205
76	N	H	-1.7265
77	Q	H	-1.5804
78	V	H	0.0000
79	V	H	0.0249
80	L	H	0.0000
81	T	H	-0.0376
82	M	H	0.0000
82A	T	H	-1.2472
82B	N	H	-2.2344
82C	M	H	0.0000
83	D	H	-1.3144
84	P	H	-0.1671
85	V	H	1.3071
86	D	H	0.0000
87	T	H	0.2525
88	A	H	0.0000
89	T	H	-0.0837
90	Y	H	0.0000
91	Y	H	-0.2688
92	C	H	0.0000
93	A	H	0.0000
94	G	H	0.0000
95	D	H	0.0000
96	G	H	0.5259
97	Y	H	1.9337
98	Y	H	2.1189
99	P	H	1.2867
100	Y	H	1.4784
100A	A	H	0.4470
100B	M	H	-0.1968
101	D	H	-1.4324
102	N	H	-0.9361
103	W	H	-0.5484
104	G	H	-1.1283
105	Q	H	-1.5272
106	G	H	-0.9555
107	S	H	-0.6502
108	L	H	-0.1255
109	V	H	0.0000
110	T	H	0.0000
111	V	H	0.0000
112	S	H	-0.9564
113	S	H	-0.8853
114	A	H	-0.5512
115	S	H	-0.6647
116	T	H	-0.7260
117	K	H	-1.1824
118	G	H	-1.4384
119	P	H	-0.5819
120	S	H	-0.0500
121	V	H	0.3476
122	F	H	1.1936
123	P	H	0.1343
124	L	H	0.6694
125	A	H	-0.4037
126	P	H	-0.3609
127	C	H	0.1553
128	S	H	-0.5495
129	R	H	-1.2860
130	S	H	-1.2551
131	T	H	-0.9612
132	S	H	-1.2526
133	E	H	-2.1213
134	S	H	-1.3174
135	T	H	-0.9358
136	A	H	0.0000
137	A	H	0.0118
138	L	H	0.0000
139	G	H	0.0000
140	C	H	0.0000
141	L	H	0.7207
142	V	H	0.0000
143	K	H	-0.1658
144	D	H	-0.5725
145	Y	H	0.0000
146	F	H	0.0000
147	P	H	0.0000
148	E	H	-0.3488
149	P	H	-0.6385
150	V	H	0.0000
151	T	H	-0.6251
152	V	H	-0.1793
153	S	H	-0.4613
154	W	H	0.0000
155	N	H	-0.9872
156	S	H	-0.7843
157	G	H	-0.5889
158	A	H	-0.2656
159	L	H	-0.1064
160	T	H	-0.3312
161	S	H	-0.3488
162	G	H	-0.4078
163	V	H	-0.1252
164	H	H	-0.5943
165	T	H	0.0622
166	F	H	0.9169
167	P	H	0.6718
168	A	H	1.2184
169	V	H	2.4044
170	L	H	1.9342
171	Q	H	0.6260
172	S	H	0.0552
173	S	H	-0.2418
174	G	H	0.1519
175	L	H	0.2895
176	Y	H	0.7735
177	S	H	0.7197
178	L	H	0.0000
179	S	H	0.6446
180	S	H	0.0000
181	V	H	0.3236
182	V	H	0.0000
183	T	H	-0.2181
184	V	H	0.0000
185	P	H	-0.6334
186	S	H	-0.8638
187	S	H	-0.7003
188	S	H	-0.6380
189	L	H	-0.7460
190	G	H	-1.0653
191	T	H	-0.8578
192	K	H	-1.4237
193	T	H	-1.4665
194	Y	H	0.0000
195	T	H	0.0000
196	C	H	0.0000
197	N	H	-1.6201
198	V	H	0.0000
199	D	H	-1.9282
200	H	H	0.0000
201	K	H	-2.7180
202	P	H	-1.5303
203	S	H	-1.7957
204	N	H	-2.5835
205	T	H	-2.0649
206	K	H	-2.6946
207	V	H	-1.5000
208	D	H	-2.6887
209	K	H	-2.0843
210	R	H	-2.9106
211	V	H	0.0000
212	E	H	-2.7082
213	S	H	-1.6844
214	K	H	-2.0748