Project name: Full TAU and FKBP12

Status: done

submitted: 2019-02-24 21:40:58, status changed: 2019-02-24 22:00:42
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Chain sequence(s) A: MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQARMVSKSKDGTGSDDKKAKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
B: GVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE
Distance of aggregation 10 Å
Dynamic mode No
Show buried residues

Minimal score value
-4.1428
Maximal score value
1.8824
Average score
-1.1874
Total score value
-650.686

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index residue name chain Aggrescan3D score mutation
residue index residue name chain Aggrescan3D score
mutation
1 M A -0.0438
2 A A -1.2953
3 E A -2.3676
4 P A -2.2530
5 R A -2.9957
6 Q A -2.4228
7 E A -1.5804
8 F A 0.0000
9 E A -1.9466
10 V A 0.0000
11 M A -1.4590
12 E A -2.5769
13 D A -2.7785
14 H A -1.9908
15 A A -1.9126
16 G A -1.8273
17 T A -1.5068
18 Y A -1.8588
19 G A 0.0000
20 L A -1.3534
21 G A -2.0158
22 D A -3.1763
23 R A -3.1892
24 K A -2.8867
25 D A -2.2557
26 Q A 0.0000
27 G A 0.0000
28 G A -0.0842
29 Y A 0.8242
30 T A 0.7260
31 M A 0.5674
32 H A -0.9753
33 Q A -2.5030
34 D A -3.6209
35 Q A 0.0000
36 E A -2.8186
37 G A -2.9867
38 D A -3.2950
39 T A -2.4534
40 D A -2.6112
41 A A -1.8651
42 G A -1.1777
43 L A -0.3599
44 K A -2.3669
45 E A -2.8545
46 S A -1.3405
47 P A -0.1554
48 L A 0.5508
49 Q A -0.3171
50 T A 0.0000
51 P A 0.0000
52 T A -2.9835
53 E A -3.5553
54 D A -2.3382
55 G A -1.8465
56 S A -1.5722
57 E A -2.7494
58 E A -2.3748
59 P A -1.7326
60 G A -1.5280
61 S A -1.9245
62 E A -2.4461
63 T A -2.1967
64 S A -1.9065
65 D A -2.1749
66 A A -1.5606
67 K A -2.4285
68 S A -1.2009
69 T A -1.0159
70 P A -1.3266
71 T A 0.0000
72 A A 0.0000
73 E A -1.9647
74 D A -1.2953
75 V A -0.0710
76 T A -0.2809
77 A A 0.4855
78 P A 0.7119
79 L A 1.4146
80 V A 0.5247
81 D A -1.8042
82 E A -2.3912
83 G A -1.8393
84 A A -1.4605
85 P A -1.4287
86 G A -1.8105
87 K A -2.7855
88 Q A -2.1562
89 A A -1.4786
90 A A -1.3552
91 A A -1.3110
92 Q A -1.6438
93 P A -1.9466
94 H A -2.3672
95 T A -2.1506
96 E A -2.8257
97 I A -1.5214
98 P A -2.0686
99 E A -2.7918
100 G A -2.1554
101 T A -1.8761
102 T A -1.6815
103 A A -2.2548
104 E A -2.9538
105 E A -2.6194
106 A A -2.0369
107 G A -1.9268
108 I A -1.0758
109 G A -2.0379
110 D A -2.6269
111 T A -1.8948
112 P A -1.3472
113 S A -1.4189
114 L A -1.7293
115 E A -2.8327
116 D A -2.7817
117 E A -1.7080
118 A A 0.0000
119 A A -0.3983
120 G A -0.9733
121 H A -1.0957
122 V A 0.8691
123 T A -0.3949
124 Q A -0.5932
125 A A -0.8422
126 R A 0.0000
127 M A 0.2647
128 V A 0.0508
129 S A -1.0150
130 K A -2.0959
131 S A -1.9260
132 K A -2.6632
133 D A -3.5576
134 G A -2.0361
135 T A -1.4860
136 G A -1.7413
137 S A -2.5740
138 D A -3.2379
139 D A -3.7146
140 K A -3.1016
141 K A 0.0000
142 A A -1.1819
143 K A -0.9700
144 G A -1.5005
145 A A -1.8257
146 D A -3.1097
147 G A -2.6386
148 K A -2.6041
149 T A -1.9199
150 K A -1.4404
151 I A 0.8276
152 A A 0.1712
153 T A -0.2758
154 P A -1.2609
155 R A -2.5915
156 G A -1.9263
157 A A -1.1539
158 A A -1.0855
159 P A -1.0109
160 P A -1.4633
161 G A -2.2391
162 Q A -2.9308
163 K A -3.3745
164 G A -2.7287
165 Q A -2.8323
166 A A -2.2895
167 N A -2.5928
168 A A -1.2920
169 T A -1.2466
170 R A -1.7565
171 I A -0.2230
172 P A -0.4060
173 A A -0.9777
174 K A -2.0314
175 T A -1.2386
176 P A -1.2516
177 P A -1.0235
178 A A -0.7526
179 P A -1.6598
180 K A -1.9465
181 T A -1.3219
182 P A -1.2351
183 P A -1.1131
184 S A 0.0000
185 S A -0.5778
186 G A -1.1801
187 E A -2.0348
188 P A -2.2170
189 P A -1.9370
190 K A -2.8546
191 S A -2.4579
192 G A -2.1181
193 D A -3.3834
194 R A -3.4941
195 S A 0.0000
196 G A -1.2849
197 Y A 0.0000
198 S A -0.4954
199 S A 0.0000
200 P A -0.2446
201 G A -0.7759
202 S A -0.5777
203 P A -0.1452
204 G A -1.0171
205 T A -0.8667
206 P A 0.0000
207 G A 0.0000
208 S A 0.0000
209 R A -0.7918
210 S A -0.8724
211 R A -1.5303
212 T A -0.8755
213 P A -1.0869
214 S A -1.0793
215 L A -1.2515
216 P A 0.0000
217 T A -2.1035
218 P A -2.1242
219 P A -1.1900
220 T A -1.4160
221 R A -3.0989
222 E A -3.1232
223 P A 0.0000
224 K A -3.0714
225 K A -2.2705
226 V A -0.5705
227 A A 0.3816
228 V A 1.8824
229 V A 1.7539
230 R A -0.9041
231 T A -1.2014
232 P A -1.1717
233 P A -1.4631
234 K A -2.0269
235 S A 0.0000
236 P A 0.0000
237 S A -0.6315
238 S A 0.0000
239 A A -0.8873
240 K A -1.1032
241 S A -1.7695
242 R A -2.3151
243 L A -0.7925
244 Q A -1.1508
245 T A -0.5774
246 A A -0.3097
247 P A -0.5577
248 V A 0.0000
249 P A 0.0000
250 M A 0.0000
251 P A -0.9367
252 D A -1.4651
253 L A 0.0000
254 K A -1.5664
255 N A -1.9682
256 V A -1.6787
257 K A -2.4171
258 S A -2.1362
259 K A -2.1605
260 I A -1.8385
261 G A -2.2285
262 S A -1.7924
263 T A -1.4594
264 E A -2.3728
265 N A -2.2923
266 L A -1.0680
267 K A -2.3971
268 H A -2.2580
269 Q A -2.0608
270 P A -1.6774
271 G A -1.8549
272 G A -0.9641
273 G A -0.4209
274 K A -0.4768
275 V A -0.0452
276 Q A -1.6552
277 I A -1.1011
278 I A 0.0000
279 N A -2.7453
280 K A -3.1709
281 K A -2.7772
282 L A -1.3897
283 D A 0.0000
284 L A -1.7600
285 S A -1.6390
286 N A -2.0485
287 V A -1.2215
288 Q A -1.9238
289 S A -1.9004
290 K A -2.4398
291 C A 0.0000
292 G A -2.3030
293 S A -2.3041
294 K A -3.0583
295 D A -2.7437
296 N A -1.9056
297 I A -1.2916
298 K A -2.0006
299 H A 0.0000
300 V A 0.0000
301 P A 0.0502
302 G A -0.8208
303 G A -0.8915
304 G A -0.3504
305 S A 0.0884
306 V A 1.3857
307 Q A 0.2553
308 I A 0.0000
309 V A 0.7542
310 Y A 0.6437
311 K A -1.1077
312 P A 0.0317
313 V A 1.1407
314 D A -0.6453
315 L A 0.4003
316 S A -0.5353
317 K A -1.6740
318 V A -0.3312
319 T A -0.2945
320 S A -0.8653
321 K A -1.6180
322 C A -0.8609
323 G A -0.3402
324 S A 0.0000
325 L A -0.2030
326 G A -0.7737
327 N A -1.1043
328 I A 0.5139
329 H A -0.8957
330 H A -1.3124
331 K A -0.9805
332 P A 0.0000
333 G A -1.5100
334 G A -1.4763
335 G A -2.0726
336 Q A -2.9840
337 V A -2.1587
338 E A -2.3688
339 V A -0.5738
340 K A -2.1355
341 S A -2.0213
342 E A -2.7121
343 K A -1.5601
344 L A -0.2826
345 D A -1.1820
346 F A 0.0727
347 K A -0.9725
348 D A -1.5191
349 R A -1.6772
350 V A -0.0326
351 Q A -1.4887
352 S A -0.9932
353 K A -1.1119
354 I A 0.6044
355 G A -0.1444
356 S A -0.0281
357 L A 0.0920
358 D A -1.4513
359 N A -0.7569
360 I A 1.0095
361 T A 0.2246
362 H A 0.1428
363 V A 1.4174
364 P A 0.1938
365 G A -0.8656
366 G A -1.4756
367 G A -1.7916
368 N A -2.2808
369 K A -2.3357
370 K A -2.0275
371 I A -0.4305
372 E A -1.9825
373 T A -1.5483
374 H A -1.7385
375 K A -1.4257
376 L A 0.7282
377 T A 0.5467
378 F A 0.5779
379 R A -1.8933
380 E A -3.0240
381 N A -2.6791
382 A A -2.1303
383 K A -2.8076
384 A A -1.8077
385 K A -2.7187
386 T A -1.9329
387 D A -2.1487
388 H A -2.1510
389 G A -1.0487
390 A A -0.5105
391 E A -0.8883
392 I A 0.0878
393 V A 0.1426
394 Y A -0.8326
395 K A -1.6343
396 S A -0.1484
397 P A 0.6284
398 V A 1.3869
399 V A 1.7444
400 S A 0.2754
401 G A -0.0119
402 D A -0.3661
403 T A -0.5742
404 S A -0.6014
405 P A -0.9541
406 R A -2.2237
407 H A -1.4107
408 L A -0.0217
409 S A -0.6396
410 N A -1.3703
411 V A -0.7281
412 S A -0.7359
413 S A -0.5781
414 T A 0.0795
415 G A 0.0000
416 S A 0.5713
417 I A 1.5727
418 D A -0.3052
419 M A 0.7350
420 V A 0.1215
421 D A -1.0652
422 S A -0.6216
423 P A -0.2515
424 Q A -0.7874
425 L A 0.0000
426 A A 0.6240
427 T A 0.3487
428 L A 0.9027
429 A A -0.2594
430 D A -1.8287
431 E A -1.7037
432 V A 0.2937
433 S A -0.3263
434 A A -0.0402
435 S A -0.0898
436 L A -0.2283
437 A A -0.6641
438 K A -1.8106
439 Q A -0.8592
440 G A -0.3627
441 L A 1.0869
1 G B -1.2466
2 V B 0.0000
3 Q B -1.3390
4 V B 0.0000
5 E B -1.3905
6 T B -0.7709
7 I B -0.0434
8 S B -0.4766
9 P B -0.8626
10 G B -1.1947
11 D B -1.6071
12 G B -1.7485
13 R B -2.2512
14 T B -1.3885
15 F B -1.0680
16 P B 0.0000
17 K B -2.7692
18 R B -3.3018
19 G B -2.4957
20 Q B -2.2494
21 T B -1.9517
22 C B 0.0000
23 V B 0.0000
24 V B 0.0000
25 H B -1.3622
26 Y B 0.0000
27 T B 0.0000
28 G B 0.0000
29 M B -2.0554
30 L B -2.0598
31 E B -3.1355
32 D B -3.4956
33 G B -2.9556
34 K B -3.5361
35 K B -3.1255
36 F B -1.0759
37 D B -2.0705
38 S B -2.3618
39 S B 0.0000
40 R B -2.9592
41 D B -3.8294
42 R B -4.1428
43 N B -3.7374
44 K B -3.4133
45 P B -1.6710
46 F B -1.0237
47 K B -1.6143
48 F B 0.0000
49 M B -2.0856
50 L B 0.0000
51 G B -2.7959
52 K B -3.2577
53 Q B -3.0669
54 E B -2.9269
55 V B -1.6418
56 I B -0.9000
57 R B -1.6415
58 G B 0.0000
59 W B 0.0000
60 E B -1.3951
61 E B 0.0000
62 G B 0.0000
63 V B 0.0000
64 A B 0.0000
65 Q B 0.0000
66 M B 0.0000
67 S B 0.0000
68 V B -0.7854
69 G B -0.9919
70 Q B 0.0000
71 R B -1.0061
72 A B 0.0000
73 K B -1.0866
74 L B 0.0000
75 T B -0.7995
76 I B 0.0000
77 S B -1.0627
78 P B 0.0000
79 D B -1.9991
80 Y B -1.0094
81 A B -0.5381
82 Y B -0.3886
83 G B -0.9454
84 A B -0.8077
85 T B -0.5961
86 G B -0.6048
87 H B -0.7290
88 P B -0.5668
89 G B -0.0802
90 I B 0.9638
91 I B 0.0000
92 P B -0.4766
93 P B -0.8209
94 H B -1.4058
95 A B 0.0000
96 T B -1.1225
97 L B 0.0000
98 V B -0.9784
99 F B 0.0000
100 D B 0.0000
101 V B 0.0000
102 E B -0.9360
103 L B 0.0000
104 L B -0.4133
105 K B -1.4475
106 L B -1.4593
107 E B -2.2746

 

Laboratory of Theory of Biopolymers 2015