Project name: Michael

Chain sequence(s)	A: MAGVRAACCVFVLAVWALCLPDTGGAARPSRRRQQESPIDKIAVQEDFNLDQMSGKWFLIGVASECESLRQSNAVLEGTTITLKVPPKSPQTSAKSLLSVSTLRKLDLQCWDIRQEYHLTPTKGRFLLKGPGTSNNIDIVVAKTDYRGYAILYYQKRGKITIKLYGRSTEIPEDILNMYEDLAQDQKISIDSVYYFPKYGFCESADEFHILPEAPTA
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.2998
• Maximal score value: 2.8323
• Average score: -0.8002
• Total score value: -173.6524

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	M	A	1.4981
2	A	A	0.9476
3	G	A	1.2478
4	V	A	1.7070
5	R	A	1.2461
6	A	A	1.0345
7	A	A	0.0000
8	C	A	0.8388
9	C	A	1.1680
10	V	A	2.1682
11	F	A	2.8323
12	V	A	2.0413
13	L	A	1.4831
14	A	A	0.0000
15	V	A	1.3949
16	W	A	1.0308
17	A	A	0.0000
18	L	A	0.0000
19	C	A	-0.2716
20	L	A	0.0068
21	P	A	0.0000
22	D	A	-1.9983
23	T	A	-0.9882
24	G	A	0.0000
25	G	A	-2.1586
26	A	A	-1.3243
27	A	A	-1.7350
28	R	A	-2.8767
29	P	A	-3.0104
30	S	A	-2.3939
31	R	A	-3.4495
32	R	A	-4.2998
33	R	A	-3.6069
34	Q	A	-3.6143
35	Q	A	-3.7377
36	E	A	-3.9550
37	S	A	-3.2661
38	P	A	-2.0693
39	I	A	0.0000
40	D	A	-2.9268
41	K	A	-2.6120
42	I	A	-1.0150
43	A	A	-0.8357
44	V	A	-1.2608
45	Q	A	-1.9134
46	E	A	-3.0599
47	D	A	-3.1086
48	F	A	0.0000
49	N	A	-2.3561
50	L	A	0.0000
51	D	A	-2.6611
52	Q	A	-2.6793
53	M	A	0.0000
54	S	A	-1.5374
55	G	A	-1.3298
56	K	A	-0.9721
57	W	A	0.0000
58	F	A	-0.0681
59	L	A	0.0000
60	I	A	0.0000
61	G	A	0.0000
62	V	A	0.0000
63	A	A	0.0000
64	S	A	0.0000
65	E	A	-1.5414
66	C	A	0.0000
67	E	A	-2.3851
68	S	A	-0.8284
69	L	A	-0.6117
70	R	A	-2.0481
71	Q	A	-1.7282
72	S	A	-0.3598
73	N	A	-0.2460
74	A	A	0.5439
75	V	A	1.2407
76	L	A	0.3699
77	E	A	-1.1031
78	G	A	0.0000
79	T	A	0.0000
80	T	A	0.0000
81	I	A	0.0000
82	T	A	-0.7505
83	L	A	0.0000
84	K	A	-1.4332
85	V	A	-1.6155
86	P	A	-1.8805
87	P	A	-2.3546
88	K	A	-2.5807
89	S	A	-2.0702
90	P	A	-1.5710
91	Q	A	-2.0599
92	T	A	0.0000
93	S	A	-1.2809
94	A	A	-1.5244
95	K	A	-2.4068
96	S	A	-1.6043
97	L	A	0.0000
98	L	A	0.0000
99	S	A	-0.8109
100	V	A	0.0000
101	S	A	-0.5396
102	T	A	-0.4585
103	L	A	0.0000
104	R	A	-1.2725
105	K	A	-1.1321
106	L	A	-0.8558
107	D	A	-1.3341
108	L	A	0.1968
109	Q	A	-0.5410
110	C	A	-0.7830
111	W	A	-0.5606
112	D	A	0.0000
113	I	A	-0.1362
114	R	A	-0.7898
115	Q	A	-0.7952
116	E	A	-0.9143
117	Y	A	0.0000
118	H	A	-0.5559
119	L	A	-0.5708
120	T	A	-0.3973
121	P	A	-0.6363
122	T	A	-0.8732
123	K	A	-2.3084
124	G	A	0.0000
125	R	A	-0.8471
126	F	A	0.0000
127	L	A	-0.2879
128	L	A	0.0000
129	K	A	-1.1931
130	G	A	-1.1330
131	P	A	-0.7908
132	G	A	-0.6450
133	T	A	-0.3553
134	S	A	0.0000
135	N	A	-1.5733
136	N	A	-1.6411
137	I	A	0.0000
138	D	A	-1.0404
139	I	A	0.0000
140	V	A	0.0000
141	V	A	0.0000
142	A	A	0.0000
143	K	A	-0.7807
144	T	A	0.0000
145	D	A	-1.5450
146	Y	A	-1.8867
147	R	A	-2.3965
148	G	A	-1.5435
149	Y	A	-0.6498
150	A	A	0.0000
151	I	A	0.0000
152	L	A	0.0000
153	Y	A	0.0000
154	Y	A	0.0000
155	Q	A	0.0000
156	K	A	0.0000
157	R	A	-3.3947
158	G	A	-2.6528
159	K	A	-1.4751
160	I	A	0.0000
161	T	A	0.0000
162	I	A	0.0000
163	K	A	-0.0423
164	L	A	0.0000
165	Y	A	0.0000
166	G	A	0.0000
167	R	A	-1.2919
168	S	A	-1.2082
169	T	A	-1.0295
170	E	A	-2.2149
171	I	A	-1.4362
172	P	A	-1.9684
173	E	A	-3.0050
174	D	A	-2.8457
175	I	A	-1.5445
176	L	A	-1.2848
177	N	A	-2.5336
178	M	A	-1.6683
179	Y	A	0.0000
180	E	A	-1.5264
181	D	A	-2.6114
182	L	A	-1.9192
183	A	A	0.0000
184	Q	A	-2.4009
185	D	A	-3.1408
186	Q	A	0.0000
187	K	A	-2.5931
188	I	A	0.0000
189	S	A	-0.6418
190	I	A	0.5625
191	D	A	-0.9201
192	S	A	0.0000
193	V	A	0.0000
194	Y	A	0.7236
195	Y	A	1.2100
196	F	A	0.0000
197	P	A	0.2331
198	K	A	-0.3790
199	Y	A	0.5276
200	G	A	-0.2587
201	F	A	-0.4511
202	C	A	0.0000
203	E	A	-2.0085
204	S	A	-1.7008
205	A	A	-1.4950
206	D	A	-2.0928
207	E	A	-1.6963
208	F	A	0.5665
209	H	A	-0.1535
210	I	A	-0.1601
211	L	A	0.1084
212	P	A	-0.5099
213	E	A	-0.6801
214	A	A	-0.8221
215	P	A	-0.6723
216	T	A	-0.3980
217	A	A	-0.1022