Project name: 4cni:H

Chain sequence(s)	H: EVQLVESGGGLVQPGGSLRLSCAASGFNFNDYFMNWVRQAPGKGLEWVAQMRNKNYQYGTYYAESLEGRFTISRDDSKNSLYLQMNSLKTEDTAVYYCARESYYGFTSYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVE
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -2.9278
• Maximal score value: 2.4222
• Average score: -0.5482
• Total score value: -120.0479

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-2.1357
2	V	H	-1.2922
3	Q	H	-1.4785
4	L	H	0.0000
5	V	H	0.0242
6	E	H	0.0000
7	S	H	-0.5450
8	G	H	-1.0055
9	G	H	-0.5793
10	G	H	-0.0380
11	L	H	0.0859
12	V	H	0.0000
13	Q	H	-1.6315
14	P	H	-1.7201
15	G	H	-1.4120
16	G	H	-1.0917
17	S	H	-1.2790
18	L	H	-1.2235
19	R	H	-2.1089
20	L	H	0.0000
21	S	H	-0.5901
22	C	H	0.0000
23	A	H	-0.5104
24	A	H	0.0000
25	S	H	-1.3777
26	G	H	-1.4981
27	F	H	-1.2464
28	N	H	-1.7170
29	F	H	0.0000
30	N	H	-2.0803
31	D	H	-1.8445
32	Y	H	-0.7936
33	F	H	0.0090
34	M	H	0.0000
35	N	H	0.0000
36	W	H	0.0000
37	V	H	0.0000
38	R	H	0.0000
39	Q	H	-0.4586
40	A	H	-1.0986
41	P	H	-1.0848
42	G	H	-1.4417
43	K	H	-2.0682
44	G	H	-0.8895
45	L	H	0.5902
46	E	H	-0.1275
47	W	H	0.4106
48	V	H	0.0000
49	A	H	0.0000
50	Q	H	0.0000
51	M	H	0.0000
52	R	H	-0.7842
53	N	H	0.0000
54	K	H	-2.0519
55	N	H	-1.8146
56	Y	H	-0.2854
57	Q	H	-1.2953
58	Y	H	-0.4508
59	G	H	-0.1751
60	T	H	0.4309
61	Y	H	0.6951
62	Y	H	-0.1102
63	A	H	-0.9739
64	E	H	-2.3789
65	S	H	-1.7698
66	L	H	0.0000
67	E	H	-2.7049
68	G	H	-1.7738
69	R	H	-1.4489
70	F	H	0.0000
71	T	H	-0.4013
72	I	H	0.0000
73	S	H	-0.3394
74	R	H	-0.9203
75	D	H	-1.5589
76	D	H	-1.9588
77	S	H	-1.5480
78	K	H	-2.3815
79	N	H	-1.9213
80	S	H	0.0000
81	L	H	0.0000
82	Y	H	-0.5525
83	L	H	0.0000
84	Q	H	-1.1186
85	M	H	0.0000
86	N	H	-1.3088
87	S	H	-1.1518
88	L	H	0.0000
89	K	H	-2.3520
90	T	H	-1.8491
91	E	H	-2.2914
92	D	H	0.0000
93	T	H	-0.7525
94	A	H	0.0000
95	V	H	0.3340
96	Y	H	0.0000
97	Y	H	0.4535
98	C	H	0.0000
99	A	H	0.0000
100	R	H	0.5466
101	E	H	0.0000
102	S	H	1.7320
103	Y	H	2.1169
104	Y	H	2.3427
105	G	H	1.7083
106	F	H	2.4222
107	T	H	1.4132
108	S	H	1.0686
109	Y	H	1.0512
110	W	H	0.5260
111	G	H	-0.2092
112	Q	H	-1.0596
113	G	H	-0.2797
114	T	H	-0.0406
115	L	H	0.4150
116	V	H	0.0000
117	T	H	0.0000
118	V	H	0.0000
119	S	H	-1.0046
120	S	H	-0.7454
121	A	H	-0.4830
122	S	H	-0.5576
123	T	H	-0.5445
124	K	H	-1.1086
125	G	H	-1.4806
126	P	H	0.0000
127	S	H	-0.1326
128	V	H	0.0000
129	F	H	0.7141
130	P	H	-0.2037
131	L	H	0.4643
132	A	H	-0.3569
133	P	H	-0.5035
134	C	H	0.1960
135	S	H	-1.0396
136	R	H	-2.1381
137	S	H	-1.7057
138	T	H	-1.2965
139	S	H	-1.4635
140	E	H	-2.4042
141	S	H	-1.3318
142	T	H	-0.8917
143	A	H	-0.8425
144	A	H	0.1235
145	L	H	0.0000
146	G	H	0.0000
147	C	H	0.0000
148	L	H	0.6102
149	V	H	0.0000
150	K	H	-0.2693
151	D	H	-0.6125
152	Y	H	0.0000
153	F	H	0.0000
154	P	H	0.0000
155	E	H	-0.5755
156	P	H	-0.8814
157	V	H	-0.9287
158	T	H	-0.8297
159	V	H	-0.2955
160	S	H	-0.6393
161	W	H	0.0000
162	N	H	-1.0169
163	S	H	-0.7706
164	G	H	-0.5933
165	A	H	-0.2744
166	L	H	-0.1255
167	T	H	-0.3154
168	S	H	-0.3665
169	G	H	-0.4533
170	V	H	0.0421
171	H	H	-0.3517
172	T	H	0.2418
173	F	H	0.9916
174	P	H	0.6259
175	A	H	1.1990
176	V	H	2.4200
177	L	H	1.9617
178	Q	H	0.6327
179	S	H	0.0690
180	S	H	-0.2198
181	G	H	0.1469
182	L	H	0.1931
183	Y	H	0.0000
184	S	H	0.0000
185	L	H	0.8944
186	S	H	0.6739
187	S	H	0.0000
188	V	H	0.4226
189	V	H	0.0000
190	T	H	-0.1987
191	V	H	0.0000
192	P	H	-0.6190
193	S	H	-1.0688
194	S	H	-0.5823
195	S	H	-0.6500
196	L	H	-1.0150
197	G	H	-1.1801
198	T	H	-1.0970
199	K	H	-1.8455
200	T	H	-1.6766
201	Y	H	0.0000
202	T	H	-1.9811
203	C	H	0.0000
204	N	H	-1.8369
205	V	H	0.0000
206	D	H	-2.5977
207	H	H	0.0000
208	K	H	-2.9278
209	P	H	-1.6746
210	S	H	-1.8865
211	N	H	-2.7151
212	T	H	-2.2590
213	K	H	-2.9225
214	V	H	-1.9279
215	D	H	-2.8837
216	K	H	-2.1925
217	R	H	-2.8512
218	V	H	0.0000
219	E	H	-2.3225