Project name: 4f0318522378a57

Status: done

submitted: 2018-12-12 11:24:52, status changed: 2018-12-12 11:37:39
Settings
Chain sequence(s) A: RWKHTSSLKVANEPVLAFTQGSPERDALQKALKDLKGRMEAIPCVVGDEEVWTSDVQYQVSPFNHGHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGGPHYILRWTSPQVIKETHKPLGDWSYAYMQ
Distance of aggregation 10 Å
Dynamic mode No
Show buried residues
Minimal score value
-4.2555
Maximal score value
2.0223
Average score
-0.7203
Total score value
-389.6573

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index residue name chain Aggrescan3D score mutation
residue index residue name chain Aggrescan3D score
mutation
23 R A -1.6594
24 W A -0.7863
25 K A -2.0973
26 H A -1.6278
27 T A -1.6216
28 S A -0.9272
29 S A -0.9098
30 L A -0.7763
31 K A -1.5205
32 V A -0.6519
33 A A -0.4245
34 N A -0.3878
35 E A 0.0000
36 P A 0.3621
37 V A 1.3610
38 L A 0.9918
39 A A 0.3925
40 F A 0.0000
41 T A -1.0802
42 Q A -1.8797
43 G A -1.6790
44 S A -1.3439
45 P A -1.3612
46 E A -1.5630
47 R A -2.1848
48 D A -3.0575
49 A A -1.9522
50 L A 0.0000
51 Q A -3.0633
52 K A -3.5878
53 A A -2.7956
54 L A 0.0000
55 K A -4.2555
56 D A -3.9660
57 L A -3.2297
58 K A -3.4057
59 G A -2.6770
60 R A -3.2175
61 M A -1.4937
62 E A -1.5877
63 A A -0.7488
64 I A 0.0000
65 P A 0.0000
66 C A 0.0000
67 V A 0.0000
68 V A 0.0000
69 G A 0.0000
70 D A -3.2142
71 E A -3.4795
72 E A -2.8864
73 V A -1.0256
74 W A 0.0365
75 T A -0.2625
76 S A -0.7329
77 D A -1.4281
78 V A -0.1214
79 Q A -0.2394
80 Y A 0.1313
81 Q A 0.0000
82 V A -0.2452
83 S A 0.0000
84 P A 0.0000
85 F A 0.0000
86 N A -0.7034
87 H A -0.7156
88 G A -0.7318
89 H A -1.4440
90 K A -1.3421
91 V A 0.0000
92 A A 0.0000
93 K A -0.5132
94 F A 0.0000
95 C A 0.0000
96 Y A -0.9052
97 A A 0.0000
98 D A -2.6972
99 K A -2.8422
100 S A -1.9878
101 L A 0.0000
102 L A 0.0000
103 N A -2.3945
104 K A -2.4930
105 A A 0.0000
106 I A 0.0000
107 E A -2.2984
108 A A -1.2349
109 A A 0.0000
110 L A -0.9030
111 A A -0.9031
112 A A -1.2250
113 R A -1.6393
114 K A -2.6427
115 E A -2.4062
116 W A 0.0000
117 D A -1.2676
118 L A -0.1698
119 K A -1.1800
120 P A -0.8029
121 I A 0.0000
122 A A -1.3406
123 D A -2.1202
124 R A 0.0000
125 A A 0.0000
126 Q A -1.9192
127 I A 0.0000
128 F A 0.0000
129 L A -1.1446
130 K A -2.0129
131 A A 0.0000
132 A A 0.0000
133 D A -2.2480
134 M A -1.4331
135 L A 0.0000
136 S A -1.1531
137 G A -1.1373
138 P A -0.9352
139 R A -0.9162
140 R A 0.0000
141 A A -1.1230
142 E A -1.0920
143 I A 0.0000
144 L A 0.0000
145 A A 0.0000
146 K A -0.3070
147 T A 0.0000
148 M A 0.0000
149 V A 0.0000
150 G A 0.0000
151 Q A 0.0000
152 G A 0.0000
153 K A 0.0000
154 T A 0.0000
155 V A 0.0000
156 I A 1.3823
157 Q A 0.0000
158 A A 0.0000
159 E A 0.0000
160 I A 0.9628
161 D A 0.0000
162 A A 0.0000
163 A A 0.0000
164 A A 0.0000
165 E A 0.0262
166 L A 0.0000
167 I A 0.0000
168 D A 0.0000
169 F A 0.0000
170 F A 0.0000
171 R A -0.8405
172 F A 0.0000
173 N A 0.0000
174 A A 0.0000
175 K A -0.5565
176 Y A -0.5244
177 A A 0.0000
178 V A -0.8167
179 E A -1.4378
180 L A -1.5553
181 E A -2.2114
182 G A -2.3678
183 Q A -1.8217
184 Q A -0.9882
185 P A 0.6150
186 I A 2.0223
187 S A 0.8206
188 V A 1.9642
189 P A 0.0776
190 P A -0.7696
191 S A -1.0737
192 T A -0.8825
193 N A -0.1652
194 S A -0.1363
195 T A 0.1524
196 V A 0.6963
197 Y A 0.1000
198 R A -0.6369
199 G A 0.0000
200 L A 0.0000
201 E A -2.1731
202 G A -1.4613
203 F A 0.0000
204 V A 0.0000
205 A A 0.0000
206 A A 0.0000
207 I A 0.0885
208 S A 0.0000
209 P A 0.0617
210 F A 0.2239
211 N A 0.0000
212 F A 0.3987
213 T A 0.0000
214 A A 0.0000
215 I A 0.2934
216 G A 0.0000
217 G A 0.0000
218 N A 0.0000
219 L A 0.0000
220 A A 0.0000
221 G A 0.0000
222 A A 0.0000
223 P A 0.0000
224 A A 0.0000
225 L A 0.0000
226 M A 0.0000
227 G A 0.0000
228 N A 0.0000
229 V A 0.0000
230 V A 0.0000
231 L A 0.0000
232 W A 0.0000
233 K A -0.3210
234 P A 0.0000
235 S A -0.3027
236 D A -0.4752
237 T A -0.0418
238 A A 0.0000
239 M A 0.0000
240 L A 0.0000
241 A A 0.0000
242 S A 0.0000
243 Y A 0.0000
244 A A 0.0000
245 V A 0.0000
246 Y A 0.0000
247 R A -1.4480
248 I A 0.0000
249 L A 0.0000
250 R A -1.5993
251 E A -1.8827
252 A A 0.0000
253 G A -1.3728
254 L A 0.0000
255 P A -0.7203
256 P A -1.1079
257 N A -0.9824
258 I A 0.0000
259 I A 0.0000
260 Q A 0.0000
261 F A 0.0000
262 V A 0.0000
263 P A 0.0000
264 A A 0.0000
265 D A -1.4492
266 G A -0.9685
267 P A -0.9636
268 L A -1.1802
269 F A 0.0000
270 G A 0.0000
271 D A -1.4867
272 T A 0.0000
273 V A 0.0000
274 T A 0.0000
275 S A -1.1566
276 S A -1.2957
277 E A -2.0768
278 H A -1.5491
279 L A 0.0000
280 C A 0.0000
281 G A 0.0000
282 I A 0.0000
283 N A 0.0000
284 F A 0.0000
285 T A 0.0000
286 G A -0.2127
287 S A -0.4084
288 V A -0.5445
289 P A -0.8813
290 T A -1.0789
291 F A 0.0000
292 K A -2.1053
293 H A -2.1539
294 L A 0.0000
295 W A -1.2236
296 K A -2.4627
297 Q A -1.9716
298 V A 0.0000
299 A A -1.0054
300 Q A -2.0181
301 N A -1.8961
302 L A -1.1487
303 D A -2.4941
304 R A -2.8050
305 F A 0.0000
306 H A -1.7677
307 T A -0.5071
308 F A 1.1294
309 P A 0.0000
310 R A -0.0997
311 L A 0.0000
312 A A 0.0000
313 G A 0.0000
314 E A -0.4650
315 C A 0.0000
316 G A 0.0000
317 G A 0.0000
318 K A 0.0000
319 N A 0.0000
320 F A 0.0000
321 H A 0.0000
322 F A 0.0000
323 V A 0.0000
324 H A -1.6004
325 R A -2.5051
326 S A -2.0368
327 A A 0.0000
328 D A -2.3493
329 V A -1.7619
330 E A -2.3771
331 S A -1.8532
332 V A 0.0000
333 V A 0.0000
334 S A -1.3109
335 G A -1.4209
336 T A 0.0000
337 L A 0.0000
338 R A -1.1647
339 S A 0.0000
340 A A 0.0000
341 F A 0.0000
342 E A -0.3338
343 Y A 0.0000
344 G A 0.0000
345 G A 0.0000
346 Q A 0.0000
347 K A 0.0000
348 C A -0.0106
349 S A 0.0000
350 A A 0.0000
351 C A 0.0000
352 S A -0.3359
353 R A 0.0000
354 L A 0.0000
355 Y A 0.0000
356 V A 0.0000
357 P A 0.0000
358 H A -1.6300
359 S A -1.2039
360 L A -1.1298
361 W A -1.1072
362 P A -1.2918
363 Q A -1.8940
364 I A 0.0000
365 K A -1.6128
366 G A -1.8694
367 R A -2.4484
368 L A 0.0000
369 L A -1.6110
370 E A -2.9751
371 E A -2.6178
372 H A -2.0907
373 S A -2.1446
374 R A -2.8215
375 I A -1.8949
376 K A -2.0448
377 V A -0.8510
378 G A -0.8746
379 D A -1.4074
380 P A 0.0000
381 A A -1.6711
382 E A -2.4800
383 D A -1.6994
384 F A -0.6801
385 G A -0.9519
386 T A 0.0000
387 F A -0.3388
388 F A 0.0000
389 S A 0.0000
390 A A 0.0000
391 V A 0.0000
392 I A 0.0000
393 D A -0.7854
394 A A -1.2311
395 K A -1.9234
396 S A 0.0000
397 F A 0.0000
398 A A -1.8453
399 R A -2.0354
400 I A 0.0000
401 K A -2.9145
402 K A -3.1368
403 W A 0.0000
404 L A 0.0000
405 E A -3.6378
406 H A -2.4715
407 A A 0.0000
408 R A -2.6022
409 S A -1.7713
410 S A -1.1598
411 P A -1.0175
412 S A -1.2779
413 L A 0.0000
414 T A -0.7251
415 I A -0.0427
416 L A 0.3131
417 A A 0.0000
418 G A -0.8856
419 G A 0.0000
420 K A -2.5671
421 C A -2.0835
422 D A -2.1904
423 D A -1.6285
424 S A -0.5512
425 V A 0.6733
426 G A 0.0000
427 Y A -0.6514
428 F A -0.7465
429 V A 0.0000
430 E A -1.7425
431 P A 0.0000
432 C A 0.0000
433 I A 0.0000
434 V A 0.0000
435 E A -0.7246
436 S A 0.0000
437 K A -2.2209
438 D A -1.8469
439 P A -1.0908
440 Q A -1.1285
441 E A 0.0000
442 P A -1.1751
443 I A 0.0000
444 M A 0.0000
445 K A -1.6781
446 E A -2.3088
447 E A -1.4401
448 I A 0.0000
449 F A -0.1438
450 G A 0.0000
451 P A 0.0000
452 V A 0.0000
453 L A 0.0000
454 S A 0.0000
455 V A 0.0000
456 Y A -0.5901
457 V A -0.5266
458 Y A 0.0000
459 P A -1.7122
460 D A -2.5248
461 D A -3.2232
462 K A -3.3769
463 Y A -2.8233
464 K A -3.3623
465 E A -3.3956
466 T A 0.0000
467 L A 0.0000
468 Q A -1.6518
469 L A -0.8718
470 V A 0.0000
471 D A -1.0068
472 S A -0.5216
473 T A 0.0000
474 T A -0.8493
475 S A -0.7010
476 Y A -0.7122
477 G A 0.0000
478 L A 0.0000
479 T A 0.0000
480 G A 0.0000
481 A A 0.0000
482 V A 0.0000
483 F A 0.0000
484 S A 0.0000
485 Q A -2.9065
486 D A -3.1883
487 K A -3.6342
488 D A -3.5067
489 V A 0.0000
490 V A 0.0000
491 Q A -2.7784
492 E A -2.4762
493 A A 0.0000
494 T A -1.9318
495 K A -2.7453
496 V A -1.9590
497 L A 0.0000
498 R A -2.9421
499 N A -2.4028
500 A A 0.0000
501 A A 0.0000
502 G A -0.8697
503 N A 0.0000
504 F A -0.1563
505 Y A 0.0000
506 I A -0.3424
507 N A -1.7250
508 D A -2.1290
509 K A -1.5341
510 S A 0.0000
511 T A 0.0000
512 G A -0.6147
513 S A -0.3758
514 I A -0.2251
515 V A 0.0000
516 G A -0.9108
517 Q A -1.4185
518 Q A -0.9954
519 P A -0.8614
520 F A -0.4436
521 G A 0.0000
522 G A 0.0000
523 A A -0.8809
524 R A -1.0419
525 A A -0.3985
526 S A 0.0000
527 G A -0.6737
528 T A -0.6504
529 N A -1.0384
530 D A -1.0141
531 K A -1.0083
532 P A -0.6266
533 G A 0.0000
534 G A 0.0000
535 P A -0.8156
536 H A -1.1476
537 Y A 0.0000
538 I A 0.0000
539 L A -0.1083
540 R A -0.5686
541 W A 0.0000
542 T A 0.0000
543 S A -0.5385
544 P A 0.2584
545 Q A 0.3835
546 V A 1.5190
547 I A 0.3300
548 K A -2.0799
549 E A -3.0101
550 T A -1.9662
551 H A -2.4170
552 K A -2.2719
553 P A -0.8693
554 L A 0.4364
555 G A -0.4461
556 D A -0.8868
557 W A 0.7326
558 S A 0.6749
559 Y A 1.5829
560 A A 1.0802
561 Y A 1.7135
562 M A 1.1967
563 Q A -0.1465

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Laboratory of Theory of Biopolymers 2015