| Chain sequence(s) |
A: MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQARMVSKSKDGTGSDDKKAKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL B: VSEIRHTADRWRVSLDVNHFAPDELTVKTKDGVVEITGKHEERQDEHGYISRCFTRKYTLPPGVDPTQVSSSLSPEGTLTVEAPMP |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | M | A | -0.0452 | |
| 2 | A | A | -1.3062 | |
| 3 | E | A | -2.3676 | |
| 4 | P | A | -2.2662 | |
| 5 | R | A | -3.0068 | |
| 6 | Q | A | -2.4326 | |
| 7 | E | A | -1.6061 | |
| 8 | F | A | 0.0000 | |
| 9 | E | A | 0.0000 | |
| 10 | V | A | 0.0000 | |
| 11 | M | A | -1.4114 | |
| 12 | E | A | -2.5523 | |
| 13 | D | A | -2.7508 | |
| 14 | H | A | -1.9522 | |
| 15 | A | A | -1.9100 | |
| 16 | G | A | -1.8194 | |
| 17 | T | A | -1.4937 | |
| 18 | Y | A | -1.8235 | |
| 19 | G | A | 0.0000 | |
| 20 | L | A | -1.3130 | |
| 21 | G | A | -1.9964 | |
| 22 | D | A | -3.1666 | |
| 23 | R | A | -3.1810 | |
| 24 | K | A | -2.8878 | |
| 25 | D | A | -2.2527 | |
| 26 | Q | A | 0.0000 | |
| 27 | G | A | 0.0000 | |
| 28 | G | A | -0.0808 | |
| 29 | Y | A | 0.8249 | |
| 30 | T | A | 0.7255 | |
| 31 | M | A | 0.5669 | |
| 32 | H | A | -0.9742 | |
| 33 | Q | A | -2.5005 | |
| 34 | D | A | -3.6168 | |
| 35 | Q | A | 0.0000 | |
| 36 | E | A | -2.7794 | |
| 37 | G | A | -2.9621 | |
| 38 | D | A | -3.2816 | |
| 39 | T | A | -2.4436 | |
| 40 | D | A | -2.5914 | |
| 41 | A | A | -1.8617 | |
| 42 | G | A | -1.1750 | |
| 43 | L | A | -0.3584 | |
| 44 | K | A | -2.3651 | |
| 45 | E | A | -2.8530 | |
| 46 | S | A | -1.3384 | |
| 47 | P | A | -0.1559 | |
| 48 | L | A | 0.5494 | |
| 49 | Q | A | -0.3172 | |
| 50 | T | A | 0.0000 | |
| 51 | P | A | 0.0000 | |
| 52 | T | A | -2.9544 | |
| 53 | E | A | -3.5344 | |
| 54 | D | A | -2.3219 | |
| 55 | G | A | -1.8291 | |
| 56 | S | A | -1.5695 | |
| 57 | E | A | -2.7379 | |
| 58 | E | A | -2.3530 | |
| 59 | P | A | -1.7091 | |
| 60 | G | A | -1.5055 | |
| 61 | S | A | -1.9096 | |
| 62 | E | A | -2.4367 | |
| 63 | T | A | -2.1822 | |
| 64 | S | A | -1.8941 | |
| 65 | D | A | -2.1618 | |
| 66 | A | A | -1.5544 | |
| 67 | K | A | -2.4220 | |
| 68 | S | A | -1.2005 | |
| 69 | T | A | -1.0153 | |
| 70 | P | A | -1.3027 | |
| 71 | T | A | 0.0000 | |
| 72 | A | A | 0.0000 | |
| 73 | E | A | -1.9819 | |
| 74 | D | A | -1.3359 | |
| 75 | V | A | -0.1466 | |
| 76 | T | A | -0.3224 | |
| 77 | A | A | 0.4200 | |
| 78 | P | A | 0.6260 | |
| 79 | L | A | 1.2533 | |
| 80 | V | A | 0.1898 | |
| 81 | D | A | -1.9668 | |
| 82 | E | A | -2.4783 | |
| 83 | G | A | -1.8806 | |
| 84 | A | A | -1.4605 | |
| 85 | P | A | -1.4287 | |
| 86 | G | A | -1.8105 | |
| 87 | K | A | -2.7855 | |
| 88 | Q | A | -2.1562 | |
| 89 | A | A | -1.4646 | |
| 90 | A | A | -1.3317 | |
| 91 | A | A | -1.2760 | |
| 92 | Q | A | -1.6248 | |
| 93 | P | A | -1.8066 | |
| 94 | H | A | -2.2379 | |
| 95 | T | A | -2.0583 | |
| 96 | E | A | -2.7904 | |
| 97 | I | A | -1.4673 | |
| 98 | P | A | -1.9727 | |
| 99 | E | A | -2.7449 | |
| 100 | G | A | -2.1203 | |
| 101 | T | A | -1.8750 | |
| 102 | T | A | -1.6724 | |
| 103 | A | A | -2.2474 | |
| 104 | E | A | -2.9805 | |
| 105 | E | A | -2.6622 | |
| 106 | A | A | -2.0782 | |
| 107 | G | A | -2.0078 | |
| 108 | I | A | -1.1442 | |
| 109 | G | A | -2.0660 | |
| 110 | D | A | -2.6491 | |
| 111 | T | A | -1.9153 | |
| 112 | P | A | -1.3552 | |
| 113 | S | A | -1.3936 | |
| 114 | L | A | -1.6910 | |
| 115 | E | A | -2.7635 | |
| 116 | D | A | -2.5752 | |
| 117 | E | A | 0.0000 | |
| 118 | A | A | 0.0000 | |
| 119 | A | A | -0.3079 | |
| 120 | G | A | -0.8852 | |
| 121 | H | A | -1.0033 | |
| 122 | V | A | 0.9066 | |
| 123 | T | A | -0.3684 | |
| 124 | Q | A | -0.5285 | |
| 125 | A | A | -0.8474 | |
| 126 | R | A | 0.0000 | |
| 127 | M | A | 0.3617 | |
| 128 | V | A | 0.0871 | |
| 129 | S | A | -1.0275 | |
| 130 | K | A | -2.1099 | |
| 131 | S | A | -2.0197 | |
| 132 | K | A | -2.8289 | |
| 133 | D | A | -3.6525 | |
| 134 | G | A | -2.0886 | |
| 135 | T | A | -1.5279 | |
| 136 | G | A | -1.7622 | |
| 137 | S | A | -2.6124 | |
| 138 | D | A | -3.2620 | |
| 139 | D | A | -3.7147 | |
| 140 | K | A | -3.0759 | |
| 141 | K | A | -1.8620 | |
| 142 | A | A | -1.1928 | |
| 143 | K | A | -0.9166 | |
| 144 | G | A | -1.4666 | |
| 145 | A | A | -1.8033 | |
| 146 | D | A | -3.0957 | |
| 147 | G | A | -2.6440 | |
| 148 | K | A | -2.6302 | |
| 149 | T | A | -1.9666 | |
| 150 | K | A | -1.4809 | |
| 151 | I | A | 0.7346 | |
| 152 | A | A | 0.1545 | |
| 153 | T | A | -0.2984 | |
| 154 | P | A | -1.2735 | |
| 155 | R | A | -2.5738 | |
| 156 | G | A | -1.8974 | |
| 157 | A | A | -1.1221 | |
| 158 | A | A | -1.0610 | |
| 159 | P | A | -1.0266 | |
| 160 | P | A | -1.4469 | |
| 161 | G | A | -2.1463 | |
| 162 | Q | A | -2.9616 | |
| 163 | K | A | -2.9417 | |
| 164 | G | A | -2.5347 | |
| 165 | Q | A | -2.7442 | |
| 166 | A | A | -2.2750 | |
| 167 | N | A | -2.5470 | |
| 168 | A | A | -1.2690 | |
| 169 | T | A | -1.1032 | |
| 170 | R | A | -1.4509 | |
| 171 | I | A | 0.3867 | |
| 172 | P | A | -0.0960 | |
| 173 | A | A | -0.9279 | |
| 174 | K | A | -1.9664 | |
| 175 | T | A | -1.0397 | |
| 176 | P | A | -1.0704 | |
| 177 | P | A | -0.9097 | |
| 178 | A | A | -0.7358 | |
| 179 | P | A | -1.4536 | |
| 180 | K | A | -1.9546 | |
| 181 | T | A | -1.1296 | |
| 182 | P | A | -1.1188 | |
| 183 | P | A | -1.4030 | |
| 184 | S | A | 0.0000 | |
| 185 | S | A | -0.5700 | |
| 186 | G | A | -1.1480 | |
| 187 | E | A | -1.8579 | |
| 188 | P | A | -2.0411 | |
| 189 | P | A | -1.8450 | |
| 190 | K | A | -2.8111 | |
| 191 | S | A | -2.3577 | |
| 192 | G | A | -2.0831 | |
| 193 | D | A | -3.3778 | |
| 194 | R | A | -3.4482 | |
| 195 | S | A | 0.0000 | |
| 196 | G | A | -1.3062 | |
| 197 | Y | A | 0.0000 | |
| 198 | S | A | -0.6195 | |
| 199 | S | A | 0.0000 | |
| 200 | P | A | -0.7344 | |
| 201 | G | A | -0.9454 | |
| 202 | S | A | -0.4840 | |
| 203 | P | A | -0.5389 | |
| 204 | G | A | -1.1776 | |
| 205 | T | A | -0.9336 | |
| 206 | P | A | -0.9774 | |
| 207 | G | A | -0.5702 | |
| 208 | S | A | 0.0000 | |
| 209 | R | A | -1.0412 | |
| 210 | S | A | -1.1021 | |
| 211 | R | A | -2.0524 | |
| 212 | T | A | -1.2794 | |
| 213 | P | A | -1.2784 | |
| 214 | S | A | -1.1868 | |
| 215 | L | A | -1.3351 | |
| 216 | P | A | 0.0000 | |
| 217 | T | A | -2.2425 | |
| 218 | P | A | -2.2102 | |
| 219 | P | A | -1.2077 | |
| 220 | T | A | -1.4501 | |
| 221 | R | A | -3.2127 | |
| 222 | E | A | -3.2225 | |
| 223 | P | A | 0.0000 | |
| 224 | K | A | -3.4018 | |
| 225 | K | A | -2.4290 | |
| 226 | V | A | -0.6688 | |
| 227 | A | A | 0.3230 | |
| 228 | V | A | 1.8558 | |
| 229 | V | A | 1.7499 | |
| 230 | R | A | -0.9606 | |
| 231 | T | A | -1.2688 | |
| 232 | P | A | -1.2342 | |
| 233 | P | A | -1.4580 | |
| 234 | K | A | -2.0693 | |
| 235 | S | A | 0.0000 | |
| 236 | P | A | 0.0000 | |
| 237 | S | A | -0.7458 | |
| 238 | S | A | 0.0000 | |
| 239 | A | A | -0.9406 | |
| 240 | K | A | -1.2146 | |
| 241 | S | A | -1.8246 | |
| 242 | R | A | -2.3434 | |
| 243 | L | A | -0.8332 | |
| 244 | Q | A | -1.1836 | |
| 245 | T | A | -0.5503 | |
| 246 | A | A | -0.1339 | |
| 247 | P | A | -0.2578 | |
| 248 | V | A | -0.0126 | |
| 249 | P | A | 0.0000 | |
| 250 | M | A | -0.6300 | |
| 251 | P | A | -0.9903 | |
| 252 | D | A | -1.4349 | |
| 253 | L | A | 0.2068 | |
| 254 | K | A | -1.1147 | |
| 255 | N | A | -1.7032 | |
| 256 | V | A | -0.8296 | |
| 257 | K | A | -1.9556 | |
| 258 | S | A | -1.3134 | |
| 259 | K | A | -1.1790 | |
| 260 | I | A | 0.5048 | |
| 261 | G | A | 0.0000 | |
| 262 | S | A | -0.7980 | |
| 263 | T | A | -0.5775 | |
| 264 | E | A | -1.0732 | |
| 265 | N | A | -1.6859 | |
| 266 | L | A | -0.5875 | |
| 267 | K | A | -2.0831 | |
| 268 | H | A | -1.7889 | |
| 269 | Q | A | -1.0780 | |
| 270 | P | A | -1.0826 | |
| 271 | G | A | -1.5160 | |
| 272 | G | A | -1.0468 | |
| 273 | G | A | -0.4004 | |
| 274 | K | A | 0.0000 | |
| 275 | V | A | 0.0024 | |
| 276 | Q | A | -1.4910 | |
| 277 | I | A | -0.8779 | |
| 278 | I | A | 0.0000 | |
| 279 | N | A | -2.5801 | |
| 280 | K | A | -2.9446 | |
| 281 | K | A | -2.2992 | |
| 282 | L | A | -1.1688 | |
| 283 | D | A | 0.0000 | |
| 284 | L | A | -1.4710 | |
| 285 | S | A | -1.4420 | |
| 286 | N | A | -1.9137 | |
| 287 | V | A | -1.0901 | |
| 288 | Q | A | -1.8120 | |
| 289 | S | A | -1.6627 | |
| 290 | K | A | -1.7845 | |
| 291 | C | A | -1.6858 | |
| 292 | G | A | 0.0000 | |
| 293 | S | A | -1.8432 | |
| 294 | K | A | -2.7659 | |
| 295 | D | A | -2.5422 | |
| 296 | N | A | -1.7455 | |
| 297 | I | A | -1.2675 | |
| 298 | K | A | -1.9748 | |
| 299 | H | A | 0.0000 | |
| 300 | V | A | 0.0000 | |
| 301 | P | A | 0.1133 | |
| 302 | G | A | -0.7979 | |
| 303 | G | A | -0.8653 | |
| 304 | G | A | -0.3049 | |
| 305 | S | A | 0.1675 | |
| 306 | V | A | 1.5414 | |
| 307 | Q | A | 0.3366 | |
| 308 | I | A | 0.0000 | |
| 309 | V | A | 0.8076 | |
| 310 | Y | A | 0.6649 | |
| 311 | K | A | -1.1212 | |
| 312 | P | A | 0.0295 | |
| 313 | V | A | 1.1392 | |
| 314 | D | A | -0.6512 | |
| 315 | L | A | 0.3996 | |
| 316 | S | A | -0.5359 | |
| 317 | K | A | -1.6720 | |
| 318 | V | A | -0.2993 | |
| 319 | T | A | -0.2703 | |
| 320 | S | A | -0.8616 | |
| 321 | K | A | -1.6109 | |
| 322 | C | A | -0.8463 | |
| 323 | G | A | -0.3354 | |
| 324 | S | A | 0.0000 | |
| 325 | L | A | -0.2044 | |
| 326 | G | A | -0.8100 | |
| 327 | N | A | -1.0983 | |
| 328 | I | A | 0.4780 | |
| 329 | H | A | -0.9133 | |
| 330 | H | A | -1.3311 | |
| 331 | K | A | -1.0096 | |
| 332 | P | A | -1.0617 | |
| 333 | G | A | -1.4447 | |
| 334 | G | A | -1.3538 | |
| 335 | G | A | -1.6578 | |
| 336 | Q | A | -2.4022 | |
| 337 | V | A | -1.7338 | |
| 338 | E | A | -1.2303 | |
| 339 | V | A | -0.6550 | |
| 340 | K | A | -2.0425 | |
| 341 | S | A | -1.7961 | |
| 342 | E | A | -2.6279 | |
| 343 | K | A | -1.3150 | |
| 344 | L | A | -0.1686 | |
| 345 | D | A | -0.7363 | |
| 346 | F | A | -0.3586 | |
| 347 | K | A | -1.0346 | |
| 348 | D | A | -2.0090 | |
| 349 | R | A | -1.7828 | |
| 350 | V | A | -0.2684 | |
| 351 | Q | A | -1.6097 | |
| 352 | S | A | -1.0779 | |
| 353 | K | A | -1.1672 | |
| 354 | I | A | 0.6115 | |
| 355 | G | A | -0.1297 | |
| 356 | S | A | -0.0210 | |
| 357 | L | A | 0.0689 | |
| 358 | D | A | -1.4637 | |
| 359 | N | A | -0.7524 | |
| 360 | I | A | 1.0116 | |
| 361 | T | A | 0.2261 | |
| 362 | H | A | 0.1428 | |
| 363 | V | A | 1.4174 | |
| 364 | P | A | 0.1938 | |
| 365 | G | A | -0.8656 | |
| 366 | G | A | -1.4925 | |
| 367 | G | A | -1.8275 | |
| 368 | N | A | -2.3493 | |
| 369 | K | A | -2.4776 | |
| 370 | K | A | -2.0956 | |
| 371 | I | A | -0.4733 | |
| 372 | E | A | -2.0018 | |
| 373 | T | A | -1.5483 | |
| 374 | H | A | -1.7389 | |
| 375 | K | A | -1.4267 | |
| 376 | L | A | 0.7267 | |
| 377 | T | A | 0.5434 | |
| 378 | F | A | 0.5763 | |
| 379 | R | A | -1.8940 | |
| 380 | E | A | -3.0240 | |
| 381 | N | A | -2.6791 | |
| 382 | A | A | -2.1303 | |
| 383 | K | A | -2.7835 | |
| 384 | A | A | -1.7938 | |
| 385 | K | A | -2.6634 | |
| 386 | T | A | -1.8436 | |
| 387 | D | A | -2.0679 | |
| 388 | H | A | -2.0370 | |
| 389 | G | A | -0.9529 | |
| 390 | A | A | -0.4636 | |
| 391 | E | A | -0.8468 | |
| 392 | I | A | 0.1484 | |
| 393 | V | A | 0.2550 | |
| 394 | Y | A | -0.6375 | |
| 395 | K | A | -1.5073 | |
| 396 | S | A | -0.1347 | |
| 397 | P | A | 0.5728 | |
| 398 | V | A | 1.3898 | |
| 399 | V | A | 1.7000 | |
| 400 | S | A | 0.2754 | |
| 401 | G | A | -0.1417 | |
| 402 | D | A | -0.5230 | |
| 403 | T | A | -0.6223 | |
| 404 | S | A | -0.5131 | |
| 405 | P | A | -0.6783 | |
| 406 | R | A | -1.5750 | |
| 407 | H | A | -1.0696 | |
| 408 | L | A | 0.2181 | |
| 409 | S | A | -0.4983 | |
| 410 | N | A | -1.2314 | |
| 411 | V | A | -0.6379 | |
| 412 | S | A | -0.7061 | |
| 413 | S | A | -0.5080 | |
| 414 | T | A | 0.1612 | |
| 415 | G | A | 0.0000 | |
| 416 | S | A | 0.5969 | |
| 417 | I | A | 1.5976 | |
| 418 | D | A | -0.2687 | |
| 419 | M | A | 0.7872 | |
| 420 | V | A | 0.2179 | |
| 421 | D | A | -1.0577 | |
| 422 | S | A | -0.6548 | |
| 423 | P | A | -0.2473 | |
| 424 | Q | A | -0.8678 | |
| 425 | L | A | 0.0000 | |
| 426 | A | A | 0.5226 | |
| 427 | T | A | 0.1383 | |
| 428 | L | A | 0.4750 | |
| 429 | A | A | -0.4676 | |
| 430 | D | A | -1.9402 | |
| 431 | E | A | -1.7531 | |
| 432 | V | A | 0.2434 | |
| 433 | S | A | -0.3681 | |
| 434 | A | A | -0.1775 | |
| 435 | S | A | -0.2210 | |
| 436 | L | A | -0.5077 | |
| 437 | A | A | -0.8096 | |
| 438 | K | A | -1.8798 | |
| 439 | Q | A | -0.9772 | |
| 440 | G | A | -0.4381 | |
| 441 | L | A | 0.9019 | |
| 85 | V | B | 1.0639 | |
| 86 | S | B | 0.6257 | |
| 87 | E | B | 0.3034 | |
| 88 | I | B | 1.1241 | |
| 89 | R | B | -0.1493 | |
| 90 | H | B | -0.9485 | |
| 91 | T | B | -0.8874 | |
| 92 | A | B | -1.1239 | |
| 93 | D | B | -2.0171 | |
| 94 | R | B | -1.4216 | |
| 95 | W | B | -0.5135 | |
| 96 | R | B | 0.0000 | |
| 97 | V | B | 0.0000 | |
| 98 | S | B | 0.0000 | |
| 99 | L | B | 0.0000 | |
| 100 | D | B | -0.8504 | |
| 101 | V | B | 0.0000 | |
| 102 | N | B | -2.0102 | |
| 103 | H | B | -2.0806 | |
| 104 | F | B | -1.4969 | |
| 105 | A | B | -1.1793 | |
| 106 | P | B | -1.1804 | |
| 107 | D | B | -2.1268 | |
| 108 | E | B | -1.9152 | |
| 109 | L | B | -0.6326 | |
| 110 | T | B | -0.7900 | |
| 111 | V | B | -0.6334 | |
| 112 | K | B | -1.9932 | |
| 113 | T | B | 0.0000 | |
| 114 | K | B | -2.6293 | |
| 115 | D | B | -2.6748 | |
| 116 | G | B | -1.4334 | |
| 117 | V | B | -1.2148 | |
| 118 | V | B | 0.0000 | |
| 119 | E | B | -1.6599 | |
| 120 | I | B | 0.0000 | |
| 121 | T | B | -0.2636 | |
| 122 | G | B | 0.0000 | |
| 123 | K | B | -1.8969 | |
| 124 | H | B | 0.0000 | |
| 125 | E | B | -3.5199 | |
| 126 | E | B | -3.6947 | |
| 127 | R | B | -3.3190 | |
| 128 | Q | B | -3.0707 | |
| 129 | D | B | -3.1665 | |
| 130 | E | B | -2.9647 | |
| 131 | H | B | -2.1812 | |
| 132 | G | B | -1.6313 | |
| 133 | Y | B | -1.0374 | |
| 134 | I | B | -1.3817 | |
| 135 | S | B | -2.3564 | |
| 136 | R | B | -1.9566 | |
| 137 | C | B | 0.0718 | |
| 138 | F | B | 1.2908 | |
| 139 | T | B | 0.0892 | |
| 140 | R | B | -0.9729 | |
| 141 | K | B | -2.0669 | |
| 142 | Y | B | -0.7859 | |
| 143 | T | B | -0.6584 | |
| 144 | L | B | 0.0000 | |
| 145 | P | B | -0.4964 | |
| 146 | P | B | -0.8944 | |
| 147 | G | B | -0.9389 | |
| 148 | V | B | 0.0000 | |
| 149 | D | B | -1.8247 | |
| 150 | P | B | 0.0000 | |
| 151 | T | B | 0.0000 | |
| 152 | Q | B | -1.0159 | |
| 153 | V | B | -0.8023 | |
| 154 | S | B | -1.0484 | |
| 155 | S | B | -0.5715 | |
| 156 | S | B | -0.6076 | |
| 157 | L | B | -0.0889 | |
| 158 | S | B | -0.3896 | |
| 159 | P | B | -0.9830 | |
| 160 | E | B | -1.6456 | |
| 161 | G | B | -1.3763 | |
| 162 | T | B | 0.0000 | |
| 163 | L | B | 0.0000 | |
| 164 | T | B | -0.0249 | |
| 165 | V | B | 0.0000 | |
| 166 | E | B | 0.0000 | |
| 167 | A | B | 0.0000 | |
| 168 | P | B | -0.8969 | |
| 169 | M | B | -0.8659 | |
| 170 | P | B | -0.7612 |