Project name: Full TAU and sHSP27

Status: done

submitted: 2019-02-19 21:04:00, status changed: 2019-02-19 21:20:16
Settings
Chain sequence(s) A: MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQARMVSKSKDGTGSDDKKAKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
B: VSEIRHTADRWRVSLDVNHFAPDELTVKTKDGVVEITGKHEERQDEHGYISRCFTRKYTLPPGVDPTQVSSSLSPEGTLTVEAPMP
Distance of aggregation 10 Å
Dynamic mode No
Show buried residues

Minimal score value
-3.7147
Maximal score value
1.8558
Average score
-1.1157
Total score value
-587.9477

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index residue name chain Aggrescan3D score mutation
residue index residue name chain Aggrescan3D score
mutation
1 M A -0.0452
2 A A -1.3062
3 E A -2.3676
4 P A -2.2662
5 R A -3.0068
6 Q A -2.4326
7 E A -1.6061
8 F A 0.0000
9 E A 0.0000
10 V A 0.0000
11 M A -1.4114
12 E A -2.5523
13 D A -2.7508
14 H A -1.9522
15 A A -1.9100
16 G A -1.8194
17 T A -1.4937
18 Y A -1.8235
19 G A 0.0000
20 L A -1.3130
21 G A -1.9964
22 D A -3.1666
23 R A -3.1810
24 K A -2.8878
25 D A -2.2527
26 Q A 0.0000
27 G A 0.0000
28 G A -0.0808
29 Y A 0.8249
30 T A 0.7255
31 M A 0.5669
32 H A -0.9742
33 Q A -2.5005
34 D A -3.6168
35 Q A 0.0000
36 E A -2.7794
37 G A -2.9621
38 D A -3.2816
39 T A -2.4436
40 D A -2.5914
41 A A -1.8617
42 G A -1.1750
43 L A -0.3584
44 K A -2.3651
45 E A -2.8530
46 S A -1.3384
47 P A -0.1559
48 L A 0.5494
49 Q A -0.3172
50 T A 0.0000
51 P A 0.0000
52 T A -2.9544
53 E A -3.5344
54 D A -2.3219
55 G A -1.8291
56 S A -1.5695
57 E A -2.7379
58 E A -2.3530
59 P A -1.7091
60 G A -1.5055
61 S A -1.9096
62 E A -2.4367
63 T A -2.1822
64 S A -1.8941
65 D A -2.1618
66 A A -1.5544
67 K A -2.4220
68 S A -1.2005
69 T A -1.0153
70 P A -1.3027
71 T A 0.0000
72 A A 0.0000
73 E A -1.9819
74 D A -1.3359
75 V A -0.1466
76 T A -0.3224
77 A A 0.4200
78 P A 0.6260
79 L A 1.2533
80 V A 0.1898
81 D A -1.9668
82 E A -2.4783
83 G A -1.8806
84 A A -1.4605
85 P A -1.4287
86 G A -1.8105
87 K A -2.7855
88 Q A -2.1562
89 A A -1.4646
90 A A -1.3317
91 A A -1.2760
92 Q A -1.6248
93 P A -1.8066
94 H A -2.2379
95 T A -2.0583
96 E A -2.7904
97 I A -1.4673
98 P A -1.9727
99 E A -2.7449
100 G A -2.1203
101 T A -1.8750
102 T A -1.6724
103 A A -2.2474
104 E A -2.9805
105 E A -2.6622
106 A A -2.0782
107 G A -2.0078
108 I A -1.1442
109 G A -2.0660
110 D A -2.6491
111 T A -1.9153
112 P A -1.3552
113 S A -1.3936
114 L A -1.6910
115 E A -2.7635
116 D A -2.5752
117 E A 0.0000
118 A A 0.0000
119 A A -0.3079
120 G A -0.8852
121 H A -1.0033
122 V A 0.9066
123 T A -0.3684
124 Q A -0.5285
125 A A -0.8474
126 R A 0.0000
127 M A 0.3617
128 V A 0.0871
129 S A -1.0275
130 K A -2.1099
131 S A -2.0197
132 K A -2.8289
133 D A -3.6525
134 G A -2.0886
135 T A -1.5279
136 G A -1.7622
137 S A -2.6124
138 D A -3.2620
139 D A -3.7147
140 K A -3.0759
141 K A -1.8620
142 A A -1.1928
143 K A -0.9166
144 G A -1.4666
145 A A -1.8033
146 D A -3.0957
147 G A -2.6440
148 K A -2.6302
149 T A -1.9666
150 K A -1.4809
151 I A 0.7346
152 A A 0.1545
153 T A -0.2984
154 P A -1.2735
155 R A -2.5738
156 G A -1.8974
157 A A -1.1221
158 A A -1.0610
159 P A -1.0266
160 P A -1.4469
161 G A -2.1463
162 Q A -2.9616
163 K A -2.9417
164 G A -2.5347
165 Q A -2.7442
166 A A -2.2750
167 N A -2.5470
168 A A -1.2690
169 T A -1.1032
170 R A -1.4509
171 I A 0.3867
172 P A -0.0960
173 A A -0.9279
174 K A -1.9664
175 T A -1.0397
176 P A -1.0704
177 P A -0.9097
178 A A -0.7358
179 P A -1.4536
180 K A -1.9546
181 T A -1.1296
182 P A -1.1188
183 P A -1.4030
184 S A 0.0000
185 S A -0.5700
186 G A -1.1480
187 E A -1.8579
188 P A -2.0411
189 P A -1.8450
190 K A -2.8111
191 S A -2.3577
192 G A -2.0831
193 D A -3.3778
194 R A -3.4482
195 S A 0.0000
196 G A -1.3062
197 Y A 0.0000
198 S A -0.6195
199 S A 0.0000
200 P A -0.7344
201 G A -0.9454
202 S A -0.4840
203 P A -0.5389
204 G A -1.1776
205 T A -0.9336
206 P A -0.9774
207 G A -0.5702
208 S A 0.0000
209 R A -1.0412
210 S A -1.1021
211 R A -2.0524
212 T A -1.2794
213 P A -1.2784
214 S A -1.1868
215 L A -1.3351
216 P A 0.0000
217 T A -2.2425
218 P A -2.2102
219 P A -1.2077
220 T A -1.4501
221 R A -3.2127
222 E A -3.2225
223 P A 0.0000
224 K A -3.4018
225 K A -2.4290
226 V A -0.6688
227 A A 0.3230
228 V A 1.8558
229 V A 1.7499
230 R A -0.9606
231 T A -1.2688
232 P A -1.2342
233 P A -1.4580
234 K A -2.0693
235 S A 0.0000
236 P A 0.0000
237 S A -0.7458
238 S A 0.0000
239 A A -0.9406
240 K A -1.2146
241 S A -1.8246
242 R A -2.3434
243 L A -0.8332
244 Q A -1.1836
245 T A -0.5503
246 A A -0.1339
247 P A -0.2578
248 V A -0.0126
249 P A 0.0000
250 M A -0.6300
251 P A -0.9903
252 D A -1.4349
253 L A 0.2068
254 K A -1.1147
255 N A -1.7032
256 V A -0.8296
257 K A -1.9556
258 S A -1.3134
259 K A -1.1790
260 I A 0.5048
261 G A 0.0000
262 S A -0.7980
263 T A -0.5775
264 E A -1.0732
265 N A -1.6859
266 L A -0.5875
267 K A -2.0831
268 H A -1.7889
269 Q A -1.0780
270 P A -1.0826
271 G A -1.5160
272 G A -1.0468
273 G A -0.4004
274 K A 0.0000
275 V A 0.0024
276 Q A -1.4910
277 I A -0.8779
278 I A 0.0000
279 N A -2.5801
280 K A -2.9446
281 K A -2.2992
282 L A -1.1688
283 D A 0.0000
284 L A -1.4710
285 S A -1.4420
286 N A -1.9137
287 V A -1.0901
288 Q A -1.8120
289 S A -1.6627
290 K A -1.7845
291 C A -1.6858
292 G A 0.0000
293 S A -1.8432
294 K A -2.7659
295 D A -2.5422
296 N A -1.7455
297 I A -1.2675
298 K A -1.9748
299 H A 0.0000
300 V A 0.0000
301 P A 0.1133
302 G A -0.7979
303 G A -0.8653
304 G A -0.3049
305 S A 0.1675
306 V A 1.5414
307 Q A 0.3366
308 I A 0.0000
309 V A 0.8076
310 Y A 0.6649
311 K A -1.1212
312 P A 0.0295
313 V A 1.1392
314 D A -0.6512
315 L A 0.3996
316 S A -0.5359
317 K A -1.6720
318 V A -0.2993
319 T A -0.2703
320 S A -0.8616
321 K A -1.6109
322 C A -0.8463
323 G A -0.3354
324 S A 0.0000
325 L A -0.2044
326 G A -0.8100
327 N A -1.0983
328 I A 0.4780
329 H A -0.9133
330 H A -1.3311
331 K A -1.0096
332 P A -1.0617
333 G A -1.4447
334 G A -1.3538
335 G A -1.6578
336 Q A -2.4022
337 V A -1.7338
338 E A -1.2303
339 V A -0.6550
340 K A -2.0425
341 S A -1.7961
342 E A -2.6279
343 K A -1.3150
344 L A -0.1686
345 D A -0.7363
346 F A -0.3586
347 K A -1.0346
348 D A -2.0090
349 R A -1.7828
350 V A -0.2684
351 Q A -1.6097
352 S A -1.0779
353 K A -1.1672
354 I A 0.6115
355 G A -0.1297
356 S A -0.0210
357 L A 0.0689
358 D A -1.4637
359 N A -0.7524
360 I A 1.0116
361 T A 0.2261
362 H A 0.1428
363 V A 1.4174
364 P A 0.1938
365 G A -0.8656
366 G A -1.4925
367 G A -1.8275
368 N A -2.3493
369 K A -2.4776
370 K A -2.0956
371 I A -0.4733
372 E A -2.0018
373 T A -1.5483
374 H A -1.7389
375 K A -1.4267
376 L A 0.7267
377 T A 0.5434
378 F A 0.5763
379 R A -1.8940
380 E A -3.0240
381 N A -2.6791
382 A A -2.1303
383 K A -2.7835
384 A A -1.7938
385 K A -2.6634
386 T A -1.8436
387 D A -2.0679
388 H A -2.0370
389 G A -0.9529
390 A A -0.4636
391 E A -0.8468
392 I A 0.1484
393 V A 0.2550
394 Y A -0.6375
395 K A -1.5073
396 S A -0.1347
397 P A 0.5728
398 V A 1.3898
399 V A 1.7000
400 S A 0.2754
401 G A -0.1417
402 D A -0.5230
403 T A -0.6223
404 S A -0.5131
405 P A -0.6783
406 R A -1.5750
407 H A -1.0696
408 L A 0.2181
409 S A -0.4983
410 N A -1.2314
411 V A -0.6379
412 S A -0.7061
413 S A -0.5080
414 T A 0.1612
415 G A 0.0000
416 S A 0.5969
417 I A 1.5976
418 D A -0.2687
419 M A 0.7872
420 V A 0.2179
421 D A -1.0577
422 S A -0.6548
423 P A -0.2473
424 Q A -0.8678
425 L A 0.0000
426 A A 0.5226
427 T A 0.1383
428 L A 0.4750
429 A A -0.4676
430 D A -1.9402
431 E A -1.7531
432 V A 0.2434
433 S A -0.3681
434 A A -0.1775
435 S A -0.2210
436 L A -0.5077
437 A A -0.8096
438 K A -1.8798
439 Q A -0.9772
440 G A -0.4381
441 L A 0.9019
85 V B 1.0639
86 S B 0.6257
87 E B 0.3034
88 I B 1.1241
89 R B -0.1493
90 H B -0.9485
91 T B -0.8874
92 A B -1.1239
93 D B -2.0171
94 R B -1.4216
95 W B -0.5135
96 R B 0.0000
97 V B 0.0000
98 S B 0.0000
99 L B 0.0000
100 D B -0.8504
101 V B 0.0000
102 N B -2.0102
103 H B -2.0806
104 F B -1.4969
105 A B -1.1793
106 P B -1.1804
107 D B -2.1268
108 E B -1.9152
109 L B -0.6326
110 T B -0.7900
111 V B -0.6334
112 K B -1.9932
113 T B 0.0000
114 K B -2.6293
115 D B -2.6748
116 G B -1.4334
117 V B -1.2148
118 V B 0.0000
119 E B -1.6599
120 I B 0.0000
121 T B -0.2636
122 G B 0.0000
123 K B -1.8969
124 H B 0.0000
125 E B -3.5199
126 E B -3.6947
127 R B -3.3190
128 Q B -3.0707
129 D B -3.1665
130 E B -2.9647
131 H B -2.1812
132 G B -1.6313
133 Y B -1.0374
134 I B -1.3817
135 S B -2.3564
136 R B -1.9566
137 C B 0.0718
138 F B 1.2908
139 T B 0.0892
140 R B -0.9729
141 K B -2.0669
142 Y B -0.7859
143 T B -0.6584
144 L B 0.0000
145 P B -0.4964
146 P B -0.8944
147 G B -0.9389
148 V B 0.0000
149 D B -1.8247
150 P B 0.0000
151 T B 0.0000
152 Q B -1.0159
153 V B -0.8023
154 S B -1.0484
155 S B -0.5715
156 S B -0.6076
157 L B -0.0889
158 S B -0.3896
159 P B -0.9830
160 E B -1.6456
161 G B -1.3763
162 T B 0.0000
163 L B 0.0000
164 T B -0.0249
165 V B 0.0000
166 E B 0.0000
167 A B 0.0000
168 P B -0.8969
169 M B -0.8659
170 P B -0.7612

 

Laboratory of Theory of Biopolymers 2015