| Chain sequence(s) |
A: FRDCADVYQAGFNKSGIYTIYINNMPEPKKVFCNMDVNGGGWTVIQHREDGSLDFQRGWKEYKMGFGNPSGEYWLGNEFIFAITSQRQYMLRIELMDWEGNRAYSQYDRFHIGNEKQNYRLYLKGHTGTAGKQSSLILHGADFSTKDADNDNCMCKCALMLTGGWWFDACGPSNLNGMFYTAGQNHGKLNGIKWHYFKGPSYSLRSTTMMIRPLD B: FRDCADVYQAGFNKSGIYTIYINNMPEPKKVFCNMDVNGGGWTVIQHREDGSLDFQRGWKEYKMGFGNPSGEYWLGNEFIFAITSQRQYMLRIELMDWEGNRAYSQYDRFHIGNEKQNYRLYLKGHTGTAGKQSSLILHGADFSTKDADNDNCMCKCALMLTGGWWFDACGPSNLNGMFYTAGQNHGKLNGIKWHYFKGPSYSLRSTTMMIRPLD |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 283 | F | A | 1.7446 | |
| 284 | R | A | 0.3165 | |
| 285 | D | A | 0.0000 | |
| 286 | C | A | 0.0000 | |
| 287 | A | A | -0.1467 | |
| 288 | D | A | 0.0000 | |
| 289 | V | A | 0.0000 | |
| 290 | Y | A | -0.1824 | |
| 291 | Q | A | -0.7631 | |
| 292 | A | A | -0.1101 | |
| 293 | G | A | -0.5268 | |
| 294 | F | A | 0.1462 | |
| 295 | N | A | -1.8078 | |
| 296 | K | A | -2.1490 | |
| 297 | S | A | -1.1404 | |
| 298 | G | A | -0.1101 | |
| 299 | I | A | 0.0090 | |
| 300 | Y | A | 0.1784 | |
| 301 | T | A | -0.1282 | |
| 302 | I | A | 0.0000 | |
| 303 | Y | A | 0.4731 | |
| 304 | I | A | 0.0000 | |
| 305 | N | A | -1.7094 | |
| 306 | N | A | -1.9473 | |
| 307 | M | A | -1.3924 | |
| 308 | P | A | -1.4636 | |
| 309 | E | A | -2.2523 | |
| 310 | P | A | -1.2817 | |
| 311 | K | A | -1.3446 | |
| 312 | K | A | -1.7781 | |
| 313 | V | A | 0.0000 | |
| 314 | F | A | 0.0634 | |
| 315 | C | A | 0.0000 | |
| 316 | N | A | -1.1169 | |
| 317 | M | A | 0.0000 | |
| 318 | D | A | -2.6930 | |
| 319 | V | A | -1.4944 | |
| 320 | N | A | -1.8792 | |
| 321 | G | A | -1.5977 | |
| 322 | G | A | 0.0000 | |
| 323 | G | A | 0.0000 | |
| 324 | W | A | 0.0000 | |
| 325 | T | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | I | A | 0.0000 | |
| 328 | Q | A | 0.0000 | |
| 329 | H | A | -0.9886 | |
| 330 | R | A | 0.0000 | |
| 331 | E | A | -2.8911 | |
| 332 | D | A | -2.8565 | |
| 333 | G | A | -1.6894 | |
| 334 | S | A | -1.3647 | |
| 335 | L | A | -1.3549 | |
| 336 | D | A | -1.5048 | |
| 337 | F | A | 0.0000 | |
| 338 | Q | A | -1.4058 | |
| 339 | R | A | -1.9766 | |
| 340 | G | A | -1.9739 | |
| 341 | W | A | -1.9135 | |
| 342 | K | A | -2.3260 | |
| 343 | E | A | -1.7355 | |
| 344 | Y | A | 0.0000 | |
| 345 | K | A | -1.1114 | |
| 346 | M | A | -0.5367 | |
| 347 | G | A | -0.7156 | |
| 348 | F | A | -0.7962 | |
| 349 | G | A | -1.2054 | |
| 350 | N | A | -1.6519 | |
| 351 | P | A | -0.9548 | |
| 352 | S | A | -0.7501 | |
| 353 | G | A | -1.3154 | |
| 354 | E | A | 0.0000 | |
| 355 | Y | A | 0.0000 | |
| 356 | W | A | 0.0000 | |
| 357 | L | A | 0.0000 | |
| 358 | G | A | 0.0000 | |
| 359 | N | A | 0.0000 | |
| 360 | E | A | -0.4975 | |
| 361 | F | A | 0.0000 | |
| 362 | I | A | 0.0000 | |
| 363 | F | A | 0.1743 | |
| 364 | A | A | 0.0000 | |
| 365 | I | A | 0.0000 | |
| 366 | T | A | 0.0000 | |
| 367 | S | A | -0.8387 | |
| 368 | Q | A | 0.0000 | |
| 369 | R | A | -1.3219 | |
| 370 | Q | A | -1.1111 | |
| 371 | Y | A | 0.0000 | |
| 372 | M | A | -0.8414 | |
| 373 | L | A | 0.0000 | |
| 374 | R | A | 0.0000 | |
| 375 | I | A | 0.0000 | |
| 376 | E | A | 0.0000 | |
| 377 | L | A | 0.0000 | |
| 378 | M | A | -1.5357 | |
| 379 | D | A | 0.0000 | |
| 380 | W | A | -1.5763 | |
| 381 | E | A | -2.6035 | |
| 382 | G | A | -2.2652 | |
| 383 | N | A | -2.6917 | |
| 384 | R | A | -2.5062 | |
| 385 | A | A | 0.0000 | |
| 386 | Y | A | -0.0204 | |
| 387 | S | A | 0.0000 | |
| 388 | Q | A | -0.7603 | |
| 389 | Y | A | 0.0000 | |
| 390 | D | A | -2.0086 | |
| 391 | R | A | 0.0000 | |
| 392 | F | A | 0.0000 | |
| 393 | H | A | 0.0000 | |
| 394 | I | A | 0.0000 | |
| 395 | G | A | 0.0000 | |
| 396 | N | A | -1.0694 | |
| 397 | E | A | -1.6879 | |
| 398 | K | A | -2.2977 | |
| 399 | Q | A | 0.0000 | |
| 400 | N | A | -1.2101 | |
| 401 | Y | A | 0.0000 | |
| 402 | R | A | 0.0000 | |
| 403 | L | A | 0.0000 | |
| 404 | Y | A | 0.0000 | |
| 405 | L | A | 0.0000 | |
| 406 | K | A | -1.2810 | |
| 407 | G | A | -1.3722 | |
| 408 | H | A | -1.4797 | |
| 409 | T | A | -1.2508 | |
| 410 | G | A | -0.8004 | |
| 411 | T | A | -0.7262 | |
| 412 | A | A | 0.0000 | |
| 413 | G | A | -1.1488 | |
| 414 | K | A | -2.2766 | |
| 415 | Q | A | -1.9788 | |
| 416 | S | A | 0.0000 | |
| 417 | S | A | 0.0000 | |
| 418 | L | A | 0.0000 | |
| 419 | I | A | -0.0674 | |
| 420 | L | A | -0.1267 | |
| 421 | H | A | -0.6788 | |
| 422 | G | A | 0.0000 | |
| 423 | A | A | 0.0000 | |
| 424 | D | A | 0.0000 | |
| 425 | F | A | 0.0000 | |
| 426 | S | A | 0.0000 | |
| 427 | T | A | 0.0000 | |
| 428 | K | A | -2.2687 | |
| 429 | D | A | -2.9791 | |
| 430 | A | A | -2.4918 | |
| 431 | D | A | -2.7486 | |
| 432 | N | A | -1.9709 | |
| 433 | D | A | -1.3772 | |
| 434 | N | A | -1.0608 | |
| 435 | C | A | -0.3682 | |
| 436 | M | A | 0.5249 | |
| 437 | C | A | 0.0142 | |
| 438 | K | A | -1.3499 | |
| 439 | C | A | 0.0000 | |
| 440 | A | A | 0.0000 | |
| 441 | L | A | 0.3328 | |
| 442 | M | A | 1.1081 | |
| 443 | L | A | 0.0000 | |
| 444 | T | A | 0.0231 | |
| 445 | G | A | 0.0000 | |
| 446 | G | A | 0.0000 | |
| 447 | W | A | 0.0000 | |
| 448 | W | A | 0.0000 | |
| 449 | F | A | 0.0000 | |
| 450 | D | A | -0.7863 | |
| 451 | A | A | -0.3648 | |
| 452 | C | A | -0.2319 | |
| 453 | G | A | -0.3588 | |
| 454 | P | A | -0.2306 | |
| 455 | S | A | 0.0000 | |
| 456 | N | A | 0.0000 | |
| 457 | L | A | 0.0000 | |
| 458 | N | A | 0.0000 | |
| 459 | G | A | 0.0000 | |
| 460 | M | A | 0.0587 | |
| 461 | F | A | -0.5456 | |
| 462 | Y | A | -0.4362 | |
| 463 | T | A | -0.4217 | |
| 464 | A | A | -0.8532 | |
| 465 | G | A | 0.0000 | |
| 466 | Q | A | -1.9629 | |
| 467 | N | A | -2.2071 | |
| 468 | H | A | -2.1012 | |
| 469 | G | A | -1.7570 | |
| 470 | K | A | -1.5467 | |
| 471 | L | A | 0.4752 | |
| 472 | N | A | 0.3637 | |
| 473 | G | A | 0.0000 | |
| 474 | I | A | 0.0000 | |
| 475 | K | A | 0.0000 | |
| 476 | W | A | 0.0000 | |
| 477 | H | A | -0.3575 | |
| 478 | Y | A | -0.3701 | |
| 479 | F | A | -0.1891 | |
| 480 | K | A | -0.4879 | |
| 481 | G | A | -0.2089 | |
| 482 | P | A | -0.2882 | |
| 483 | S | A | -0.8537 | |
| 484 | Y | A | -0.9201 | |
| 485 | S | A | 0.0000 | |
| 486 | L | A | 0.0000 | |
| 487 | R | A | -1.7581 | |
| 488 | S | A | -1.4810 | |
| 489 | T | A | 0.0000 | |
| 490 | T | A | -0.2758 | |
| 491 | M | A | 0.0000 | |
| 492 | M | A | 0.0000 | |
| 493 | I | A | 0.0000 | |
| 494 | R | A | -0.4423 | |
| 495 | P | A | 0.0000 | |
| 496 | L | A | -0.7306 | |
| 497 | D | A | -1.5895 | |
| 283 | F | B | 1.7779 | |
| 284 | R | B | 0.3853 | |
| 285 | D | B | 0.0000 | |
| 286 | C | B | 0.0000 | |
| 287 | A | B | -0.1427 | |
| 288 | D | B | 0.0000 | |
| 289 | V | B | 0.0000 | |
| 290 | Y | B | -0.2195 | |
| 291 | Q | B | -0.7864 | |
| 292 | A | B | -0.1403 | |
| 293 | G | B | -0.5804 | |
| 294 | F | B | 0.0390 | |
| 295 | N | B | -1.8762 | |
| 296 | K | B | -2.1709 | |
| 297 | S | B | -1.1234 | |
| 298 | G | B | -0.0533 | |
| 299 | I | B | 0.1632 | |
| 300 | Y | B | 0.2553 | |
| 301 | T | B | -0.0689 | |
| 302 | I | B | 0.0000 | |
| 303 | Y | B | 0.4986 | |
| 304 | I | B | 0.0000 | |
| 305 | N | B | -1.6925 | |
| 306 | N | B | -1.9473 | |
| 307 | M | B | -1.4041 | |
| 308 | P | B | -1.4677 | |
| 309 | E | B | -2.2522 | |
| 310 | P | B | -1.2711 | |
| 311 | K | B | -1.3350 | |
| 312 | K | B | -1.6933 | |
| 313 | V | B | 0.0000 | |
| 314 | F | B | 0.1611 | |
| 315 | C | B | 0.0000 | |
| 316 | N | B | -1.0782 | |
| 317 | M | B | 0.0000 | |
| 318 | D | B | -2.6758 | |
| 319 | V | B | -1.4578 | |
| 320 | N | B | -1.8608 | |
| 321 | G | B | -1.5868 | |
| 322 | G | B | 0.0000 | |
| 323 | G | B | 0.0000 | |
| 324 | W | B | 0.0000 | |
| 325 | T | B | 0.0000 | |
| 326 | V | B | 0.0000 | |
| 327 | I | B | 0.0000 | |
| 328 | Q | B | 0.0000 | |
| 329 | H | B | -0.8552 | |
| 330 | R | B | 0.0000 | |
| 331 | E | B | -2.5810 | |
| 332 | D | B | -2.7012 | |
| 333 | G | B | -1.7151 | |
| 334 | S | B | -1.4095 | |
| 335 | L | B | -1.5967 | |
| 336 | D | B | -2.0396 | |
| 337 | F | B | 0.0000 | |
| 338 | Q | B | -1.7640 | |
| 339 | R | B | -2.2718 | |
| 340 | G | B | 0.0000 | |
| 341 | W | B | -2.0369 | |
| 342 | K | B | -2.4293 | |
| 343 | E | B | -2.0195 | |
| 344 | Y | B | 0.0000 | |
| 345 | K | B | -1.1640 | |
| 346 | M | B | -0.6052 | |
| 347 | G | B | -0.8699 | |
| 348 | F | B | 0.0000 | |
| 349 | G | B | -1.4071 | |
| 350 | N | B | -1.6624 | |
| 351 | P | B | -0.9080 | |
| 352 | S | B | -0.6796 | |
| 353 | G | B | -1.1776 | |
| 354 | E | B | 0.0000 | |
| 355 | Y | B | 0.0000 | |
| 356 | W | B | 0.0000 | |
| 357 | L | B | 0.0000 | |
| 358 | G | B | 0.0000 | |
| 359 | N | B | 0.0000 | |
| 360 | E | B | -0.5084 | |
| 361 | F | B | 0.0000 | |
| 362 | I | B | 0.0000 | |
| 363 | F | B | 0.1521 | |
| 364 | A | B | 0.0000 | |
| 365 | I | B | 0.0000 | |
| 366 | T | B | 0.0000 | |
| 367 | S | B | -0.8505 | |
| 368 | Q | B | 0.0000 | |
| 369 | R | B | -1.3680 | |
| 370 | Q | B | -1.2019 | |
| 371 | Y | B | 0.0000 | |
| 372 | M | B | 0.0000 | |
| 373 | L | B | 0.0000 | |
| 374 | R | B | 0.0000 | |
| 375 | I | B | 0.0000 | |
| 376 | E | B | 0.0000 | |
| 377 | L | B | 0.0000 | |
| 378 | M | B | -1.5724 | |
| 379 | D | B | 0.0000 | |
| 380 | W | B | -1.5394 | |
| 381 | E | B | -2.5523 | |
| 382 | G | B | -2.1941 | |
| 383 | N | B | -2.5469 | |
| 384 | R | B | -2.5134 | |
| 385 | A | B | 0.0000 | |
| 386 | Y | B | -0.0537 | |
| 387 | S | B | 0.0000 | |
| 388 | Q | B | -0.8716 | |
| 389 | Y | B | 0.0000 | |
| 390 | D | B | -2.1640 | |
| 391 | R | B | -1.3257 | |
| 392 | F | B | 0.0000 | |
| 393 | H | B | 0.0000 | |
| 394 | I | B | 0.0000 | |
| 395 | G | B | 0.0000 | |
| 396 | N | B | -1.0603 | |
| 397 | E | B | -1.6403 | |
| 398 | K | B | -2.2599 | |
| 399 | Q | B | 0.0000 | |
| 400 | N | B | -1.1753 | |
| 401 | Y | B | 0.0000 | |
| 402 | R | B | 0.0000 | |
| 403 | L | B | 0.0000 | |
| 404 | Y | B | 0.0000 | |
| 405 | L | B | 0.0000 | |
| 406 | K | B | -1.3861 | |
| 407 | G | B | -1.4565 | |
| 408 | H | B | -1.7548 | |
| 409 | T | B | -1.3368 | |
| 410 | G | B | -0.8042 | |
| 411 | T | B | -0.6789 | |
| 412 | A | B | 0.0000 | |
| 413 | G | B | -1.1182 | |
| 414 | K | B | -2.2176 | |
| 415 | Q | B | -1.8515 | |
| 416 | S | B | -0.9643 | |
| 417 | S | B | 0.0000 | |
| 418 | L | B | 0.0000 | |
| 419 | I | B | -0.1104 | |
| 420 | L | B | -0.2623 | |
| 421 | H | B | -0.7558 | |
| 422 | G | B | 0.0000 | |
| 423 | A | B | 0.0000 | |
| 424 | D | B | 0.0000 | |
| 425 | F | B | 0.0000 | |
| 426 | S | B | 0.0000 | |
| 427 | T | B | 0.0000 | |
| 428 | K | B | -2.7471 | |
| 429 | D | B | -3.1859 | |
| 430 | A | B | -2.6241 | |
| 431 | D | B | -2.7909 | |
| 432 | N | B | -1.9943 | |
| 433 | D | B | -1.3198 | |
| 434 | N | B | -1.0089 | |
| 435 | C | B | -0.2863 | |
| 436 | M | B | 0.5781 | |
| 437 | C | B | 0.1402 | |
| 438 | K | B | -1.1462 | |
| 439 | C | B | 0.0000 | |
| 440 | A | B | 0.0000 | |
| 441 | L | B | 0.4224 | |
| 442 | M | B | 1.2148 | |
| 443 | L | B | 0.0000 | |
| 444 | T | B | -0.0406 | |
| 445 | G | B | 0.0000 | |
| 446 | G | B | 0.0000 | |
| 447 | W | B | 0.0000 | |
| 448 | W | B | 0.0000 | |
| 449 | F | B | 0.0000 | |
| 450 | D | B | -0.7672 | |
| 451 | A | B | -0.3137 | |
| 452 | C | B | -0.1809 | |
| 453 | G | B | -0.3433 | |
| 454 | P | B | -0.1581 | |
| 455 | S | B | 0.0000 | |
| 456 | N | B | 0.0000 | |
| 457 | L | B | 0.0000 | |
| 458 | N | B | 0.0000 | |
| 459 | G | B | 0.0000 | |
| 460 | M | B | -0.0285 | |
| 461 | F | B | -0.5904 | |
| 462 | Y | B | -0.4240 | |
| 463 | T | B | -0.5890 | |
| 464 | A | B | -0.8494 | |
| 465 | G | B | 0.0000 | |
| 466 | Q | B | -1.9956 | |
| 467 | N | B | -2.2108 | |
| 468 | H | B | -2.1028 | |
| 469 | G | B | -1.7955 | |
| 470 | K | B | -1.5496 | |
| 471 | L | B | 0.4756 | |
| 472 | N | B | 0.3971 | |
| 473 | G | B | 0.0000 | |
| 474 | I | B | 0.0000 | |
| 475 | K | B | 0.0000 | |
| 476 | W | B | 0.0000 | |
| 477 | H | B | -0.2723 | |
| 478 | Y | B | -0.1610 | |
| 479 | F | B | -0.1605 | |
| 480 | K | B | -0.6306 | |
| 481 | G | B | -0.2181 | |
| 482 | P | B | -0.2770 | |
| 483 | S | B | -0.8991 | |
| 484 | Y | B | -0.9708 | |
| 485 | S | B | 0.0000 | |
| 486 | L | B | 0.0000 | |
| 487 | R | B | -1.7773 | |
| 488 | S | B | -1.4402 | |
| 489 | T | B | 0.0000 | |
| 490 | T | B | -0.2240 | |
| 491 | M | B | 0.0000 | |
| 492 | M | B | 0.0000 | |
| 493 | I | B | 0.0000 | |
| 494 | R | B | -0.4961 | |
| 495 | P | B | 0.0000 | |
| 496 | L | B | -0.7864 | |
| 497 | D | B | -1.6003 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine