Project name: 1ihg

Chain sequence(s)	A: SHPSPQAKPSNPSNPRVFFDVDIGGERVGRIVLELFADIVPKTAENFRALCTGEKGIGPTTGKPLHFKGCPFHRIIKKFMIQGGDFSNQNGTGGESIYGEKFEDENFHYKHDKEGLLSMANAGSNTNGSQFFITTVPTPHLDGKHVVFGQVIKGMGVAKILENVEVKGEKPAKLCVIAECGELKEGDDWGIFPKDGSGDSHPDFPEDADVDLKDVDKILLISEDLKNIGNTFFKSQNWEMAIKKYTKVLRYVEGSRAAAEDADGAKLQPVALSCVLNIGACKLKMSDWQGAVDSCLEALEIDPSNTKALYRRAQGWQGLKEYDQALADLKKAQEIAPEDKAIQAELLKVKQKIKAQKDKEKAAY
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.5486
• Maximal score value: 1.3565
• Average score: -1.072
• Total score value: -390.202

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
2	S	A	-0.9803
3	H	A	-1.2146
4	P	A	-1.1500
5	S	A	0.0000
6	P	A	-1.2652
7	Q	A	-1.6655
8	A	A	-1.4541
9	K	A	-2.1492
10	P	A	-1.5631
11	S	A	-1.3123
12	N	A	-1.1123
13	P	A	-1.0217
14	S	A	-0.9602
15	N	A	0.0000
16	P	A	-1.2083
17	R	A	-0.9333
18	V	A	0.0000
19	F	A	-0.0625
20	F	A	0.0000
21	D	A	0.0000
22	V	A	0.0000
23	D	A	-1.2847
24	I	A	-0.6716
25	G	A	-1.1279
26	G	A	-1.5730
27	E	A	-2.3978
28	R	A	-2.1967
29	V	A	-0.8690
30	G	A	-0.4763
31	R	A	-0.3133
32	I	A	0.0000
33	V	A	0.0000
34	L	A	0.0000
35	E	A	0.0000
36	L	A	0.0000
37	F	A	0.0000
38	A	A	-1.0780
39	D	A	-1.4305
40	I	A	-0.4522
41	V	A	0.0000
42	P	A	-1.2331
43	K	A	-1.6677
44	T	A	0.0000
45	A	A	0.0000
46	E	A	-1.2847
47	N	A	0.0000
48	F	A	0.0000
49	R	A	-0.9686
50	A	A	0.0000
51	L	A	0.0000
52	C	A	0.0000
53	T	A	-1.3956
54	G	A	-1.6353
55	E	A	-2.5819
56	K	A	-2.2995
57	G	A	-0.9430
58	I	A	0.6986
59	G	A	0.0000
60	P	A	-0.4292
61	T	A	-0.7166
62	T	A	-0.8023
63	G	A	-0.4874
64	K	A	-0.7323
65	P	A	-0.6555
66	L	A	0.0000
67	H	A	-1.2335
68	F	A	0.0000
69	K	A	-1.8699
70	G	A	-1.2212
71	C	A	0.0000
72	P	A	0.0000
73	F	A	0.0000
74	H	A	0.0000
75	R	A	-1.7020
76	I	A	0.0000
77	I	A	-1.2269
78	K	A	-2.5731
79	K	A	-2.5256
80	F	A	-0.8894
81	M	A	0.0000
82	I	A	0.0000
83	Q	A	0.0000
84	G	A	0.0000
85	G	A	0.0000
86	D	A	0.0000
87	F	A	0.0000
88	S	A	-1.4616
89	N	A	-2.2052
90	Q	A	-2.1246
91	N	A	-2.3781
92	G	A	-1.4863
93	T	A	-1.0614
94	G	A	-1.2984
95	G	A	-1.3917
96	E	A	0.0000
97	S	A	0.0000
98	I	A	0.0000
99	Y	A	-0.2894
100	G	A	-1.1266
101	E	A	-2.4130
102	K	A	-2.6746
103	F	A	0.0000
104	E	A	-2.9671
105	D	A	-2.4132
106	E	A	-1.6619
107	N	A	-0.9919
108	F	A	-0.6147
109	H	A	-0.6645
110	Y	A	-0.7975
111	K	A	-1.5119
112	H	A	0.0000
113	D	A	-1.5625
114	K	A	-1.4036
115	E	A	-1.4593
116	G	A	0.0000
117	L	A	0.0000
118	L	A	0.0000
119	S	A	0.0000
120	M	A	0.0000
121	A	A	-0.3545
122	N	A	-0.9153
123	A	A	-0.4977
124	G	A	-0.8492
125	S	A	-1.5472
126	N	A	-2.6205
127	T	A	-1.8923
128	N	A	0.0000
129	G	A	0.0000
130	S	A	0.0000
131	Q	A	-0.3168
132	F	A	0.0000
133	F	A	0.0000
134	I	A	0.0000
135	T	A	0.0000
136	T	A	0.0000
137	V	A	-1.0200
138	P	A	-1.1612
139	T	A	0.0000
140	P	A	-1.5139
141	H	A	-1.7521
142	L	A	0.0000
143	D	A	-1.9194
144	G	A	-1.7194
145	K	A	-2.1916
146	H	A	0.0000
147	V	A	0.0000
148	V	A	0.0000
149	F	A	0.0000
150	G	A	0.0000
151	Q	A	0.0000
152	V	A	0.0000
153	I	A	0.0000
154	K	A	-0.6619
155	G	A	0.0000
156	M	A	-0.3759
157	G	A	-0.3035
158	V	A	0.0000
159	A	A	0.0000
160	K	A	-0.9630
161	I	A	0.0531
162	L	A	0.0000
163	E	A	0.0000
164	N	A	-1.8911
165	V	A	-1.2251
166	E	A	-2.1878
167	V	A	-1.9088
168	K	A	-2.6116
169	G	A	-2.0102
170	E	A	-2.4516
171	K	A	-2.5017
172	P	A	-1.4804
173	A	A	-1.1025
174	K	A	-0.8797
175	L	A	0.5282
176	C	A	0.0000
177	V	A	-0.3686
178	I	A	0.0000
179	A	A	-1.2540
180	E	A	-1.2058
181	C	A	0.0000
182	G	A	-0.9432
183	E	A	-1.2027
184	L	A	0.0000
185	K	A	-3.5794
186	E	A	-3.7221
187	G	A	-2.9629
188	D	A	-3.7485
189	D	A	-2.9411
190	W	A	-1.1362
191	G	A	-0.4527
192	I	A	0.2130
193	F	A	0.5204
194	P	A	-0.6550
195	K	A	-1.5297
196	D	A	-1.5389
197	G	A	-1.2796
198	S	A	-0.8536
199	G	A	-0.8064
200	D	A	0.0000
201	S	A	-0.3390
202	H	A	-0.3313
203	P	A	-0.3399
204	D	A	-0.5856
205	F	A	-0.5752
206	P	A	0.0000
207	E	A	-2.4728
208	D	A	-1.4147
209	A	A	-1.7002
210	D	A	-2.4490
211	V	A	-2.5658
212	D	A	-3.4425
213	L	A	-3.3057
214	K	A	-4.0494
215	D	A	-3.8757
216	V	A	0.0000
217	D	A	-2.8896
218	K	A	-2.2335
219	I	A	0.0000
220	L	A	-0.9826
221	L	A	0.1305
222	I	A	0.0000
223	S	A	0.0000
224	E	A	-1.6693
225	D	A	-1.7229
226	L	A	0.0000
227	K	A	-1.5451
228	N	A	-2.0799
229	I	A	-1.1880
230	G	A	0.0000
231	N	A	-1.2493
232	T	A	-1.0853
233	F	A	-1.2955
234	F	A	-1.4203
235	K	A	-2.0989
236	S	A	-1.6022
237	Q	A	-2.3447
238	N	A	-1.8957
239	W	A	-1.9178
240	E	A	-2.4018
241	M	A	-1.5135
242	A	A	0.0000
243	I	A	-1.1980
244	K	A	-1.9200
245	K	A	0.0000
246	Y	A	0.0000
247	T	A	-0.6805
248	K	A	0.0000
249	V	A	0.0000
250	L	A	-0.7927
251	R	A	-1.5080
252	Y	A	0.0000
253	V	A	0.0000
254	E	A	-2.5737
255	G	A	-2.2665
256	S	A	0.0000
257	R	A	-4.0769
258	A	A	-2.1225
259	A	A	-2.4564
260	A	A	-3.3427
261	E	A	-3.7776
262	D	A	-3.5913
263	A	A	-2.5475
264	D	A	-3.9637
265	G	A	0.0000
266	A	A	-2.2874
267	K	A	-2.6034
268	L	A	0.0000
269	Q	A	-1.1765
270	P	A	-0.6839
271	V	A	0.0000
272	A	A	0.0000
273	L	A	-0.4204
274	S	A	-0.2091
275	C	A	0.0000
276	V	A	0.0000
277	L	A	0.0000
278	N	A	-0.2183
279	I	A	0.0000
280	G	A	0.0000
281	A	A	-0.6003
282	C	A	0.0000
283	K	A	-1.3784
284	L	A	-1.1368
285	K	A	-2.0475
286	M	A	-1.0594
287	S	A	-0.9767
288	D	A	-1.2301
289	W	A	-1.0771
290	Q	A	-1.2976
291	G	A	-1.0862
292	A	A	0.0000
293	V	A	0.0000
294	D	A	-1.6429
295	S	A	0.0000
296	C	A	0.0000
297	L	A	-0.9188
298	E	A	-1.8883
299	A	A	0.0000
300	L	A	0.0000
301	E	A	-1.9682
302	I	A	-0.7832
303	D	A	-1.0104
304	P	A	-0.9935
305	S	A	-0.8821
306	N	A	-0.7389
307	T	A	-1.0632
308	K	A	-1.3573
309	A	A	0.0000
310	L	A	0.0000
311	Y	A	-0.8556
312	R	A	-0.8601
313	R	A	-0.8759
314	A	A	0.0000
315	Q	A	-0.7065
316	G	A	0.0000
317	W	A	-1.0860
318	Q	A	0.0000
319	G	A	-0.7228
320	L	A	-0.7682
321	K	A	-2.1553
322	E	A	-2.0351
323	Y	A	-2.0090
324	D	A	-2.4695
325	Q	A	-1.9181
326	A	A	0.0000
327	L	A	-1.3012
328	A	A	-1.1975
329	D	A	0.0000
330	L	A	0.0000
331	K	A	-2.2194
332	K	A	-1.9529
333	A	A	0.0000
334	Q	A	-2.3241
335	E	A	-2.4057
336	I	A	-0.6794
337	A	A	-1.5367
338	P	A	-2.2699
339	E	A	-2.8736
340	D	A	-2.5883
341	K	A	-2.7141
342	A	A	-1.3747
343	I	A	0.0000
344	Q	A	-1.6737
345	A	A	-0.6420
346	E	A	0.0000
347	L	A	0.0000
348	L	A	-0.2705
349	K	A	-1.8439
350	V	A	0.0000
351	K	A	-2.6780
352	Q	A	-2.8998
353	K	A	-2.9085
354	I	A	-3.1301
355	K	A	-3.7526
356	A	A	-3.0950
357	Q	A	-3.6639
358	K	A	-4.3518
359	D	A	-4.0021
360	K	A	-4.2646
361	E	A	-4.5486
362	K	A	-3.7744
363	A	A	-1.9513
364	A	A	-0.2521
365	Y	A	1.3565