| Chain sequence(s) |
A: QVQLQESGPGLVKPSLTLSLTCTVSGGSISSGYWNWIRQPPGKGLEWIGTISYSGDTYYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARYGSYVFDYWGQGTTVTVSSASTFGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVES B: DIVMTQTPLSLSVTPGQPASISCRSSQSLLHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCSQSTHVPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Q | A | -1.6580 | |
| 2 | V | A | 0.0000 | |
| 3 | Q | A | -2.1233 | |
| 4 | L | A | 0.0000 | |
| 5 | Q | A | -1.8529 | |
| 6 | E | A | 0.0000 | |
| 7 | S | A | -0.7721 | |
| 8 | G | A | -0.6290 | |
| 9 | P | A | -0.6627 | |
| 10 | G | A | -0.5602 | |
| 11 | L | A | -0.3866 | |
| 12 | V | A | 0.0000 | |
| 13 | K | A | -1.5669 | |
| 14 | P | A | -0.8738 | |
| 15 | S | A | -0.3986 | |
| 16 | L | A | 0.1428 | |
| 17 | T | A | -0.3928 | |
| 18 | L | A | 0.0000 | |
| 19 | S | A | -0.7574 | |
| 20 | L | A | 0.0000 | |
| 21 | T | A | -0.6940 | |
| 22 | C | A | 0.0000 | |
| 23 | T | A | -1.1457 | |
| 24 | V | A | 0.0000 | |
| 25 | S | A | -1.3047 | |
| 26 | G | A | -1.3492 | |
| 27 | G | A | -1.1562 | |
| 28 | S | A | -0.8557 | |
| 29 | I | A | 0.0000 | |
| 30 | S | A | -0.2074 | |
| 31 | S | A | 0.0149 | |
| 32 | G | A | 0.1264 | |
| 33 | Y | A | 0.1765 | |
| 34 | W | A | 0.0000 | |
| 35 | N | A | 0.0000 | |
| 36 | W | A | 0.0000 | |
| 37 | I | A | 0.0000 | |
| 38 | R | A | 0.0000 | |
| 39 | Q | A | -0.8041 | |
| 40 | P | A | -0.9959 | |
| 41 | P | A | -1.1134 | |
| 42 | G | A | -1.5012 | |
| 43 | K | A | -2.3720 | |
| 44 | G | A | -1.5296 | |
| 45 | L | A | 0.0000 | |
| 46 | E | A | -0.6553 | |
| 47 | W | A | 0.0000 | |
| 48 | I | A | 0.0000 | |
| 49 | G | A | 0.0000 | |
| 50 | T | A | 0.0000 | |
| 51 | I | A | 0.0000 | |
| 52 | S | A | 0.0430 | |
| 53 | Y | A | 0.5855 | |
| 54 | S | A | -0.4379 | |
| 55 | G | A | -0.9420 | |
| 56 | D | A | -1.5434 | |
| 57 | T | A | -0.3328 | |
| 58 | Y | A | 0.8088 | |
| 59 | Y | A | 0.5245 | |
| 60 | N | A | 0.0000 | |
| 61 | P | A | -0.8688 | |
| 62 | S | A | -1.1291 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.0154 | |
| 65 | S | A | -1.2754 | |
| 66 | R | A | -1.3715 | |
| 67 | V | A | 0.0000 | |
| 68 | T | A | -0.5960 | |
| 69 | I | A | 0.0000 | |
| 70 | S | A | -0.6296 | |
| 71 | V | A | -0.2954 | |
| 72 | D | A | -1.1927 | |
| 73 | T | A | -1.1504 | |
| 74 | S | A | -1.3418 | |
| 75 | K | A | -2.1433 | |
| 76 | N | A | -1.4606 | |
| 77 | Q | A | -1.2653 | |
| 78 | F | A | 0.0000 | |
| 79 | S | A | -0.5260 | |
| 80 | L | A | 0.0000 | |
| 81 | K | A | -1.6529 | |
| 82 | L | A | 0.0000 | |
| 83 | S | A | -0.5998 | |
| 84 | S | A | -0.3818 | |
| 85 | V | A | 0.0000 | |
| 86 | T | A | -0.3111 | |
| 87 | A | A | -0.2089 | |
| 88 | A | A | 0.0277 | |
| 89 | D | A | 0.0000 | |
| 90 | T | A | 0.0225 | |
| 91 | A | A | 0.0000 | |
| 92 | V | A | 0.1129 | |
| 93 | Y | A | 0.0000 | |
| 94 | Y | A | 0.0000 | |
| 95 | C | A | 0.0000 | |
| 96 | A | A | 0.0000 | |
| 97 | R | A | -0.6540 | |
| 98 | Y | A | -0.0548 | |
| 99 | G | A | -0.0746 | |
| 100 | S | A | -0.0608 | |
| 101 | Y | A | 0.2843 | |
| 102 | V | A | 0.0000 | |
| 103 | F | A | 0.0000 | |
| 104 | D | A | -0.4199 | |
| 105 | Y | A | -0.7841 | |
| 106 | W | A | 0.0000 | |
| 107 | G | A | 0.0000 | |
| 108 | Q | A | -1.8502 | |
| 109 | G | A | 0.0000 | |
| 110 | T | A | -0.5058 | |
| 111 | T | A | -0.2321 | |
| 112 | V | A | 0.0000 | |
| 113 | T | A | -0.3245 | |
| 114 | V | A | 0.0000 | |
| 115 | S | A | -0.6653 | |
| 116 | S | A | -0.8715 | |
| 117 | A | A | -0.2867 | |
| 118 | S | A | -0.1048 | |
| 119 | T | A | 0.2160 | |
| 120 | F | A | 0.7372 | |
| 121 | G | A | -0.5240 | |
| 122 | P | A | -0.2474 | |
| 123 | S | A | -0.3554 | |
| 124 | V | A | 0.0000 | |
| 125 | F | A | 0.0000 | |
| 126 | P | A | -1.4126 | |
| 127 | L | A | 0.0000 | |
| 128 | A | A | -0.8995 | |
| 129 | P | A | 0.0000 | |
| 130 | C | A | -0.4624 | |
| 131 | S | A | -0.5444 | |
| 132 | R | A | -0.9039 | |
| 133 | S | A | 0.0000 | |
| 134 | T | A | -0.8889 | |
| 135 | S | A | -1.3587 | |
| 136 | E | A | -2.0792 | |
| 137 | S | A | -1.3117 | |
| 138 | T | A | -0.9402 | |
| 139 | A | A | 0.0000 | |
| 140 | A | A | 0.0000 | |
| 141 | L | A | 0.0000 | |
| 142 | G | A | 0.0000 | |
| 143 | C | A | 0.0000 | |
| 144 | L | A | 0.0000 | |
| 145 | V | A | 0.0000 | |
| 146 | K | A | -0.3754 | |
| 147 | D | A | -0.1290 | |
| 148 | Y | A | 0.0000 | |
| 149 | F | A | 0.0000 | |
| 150 | P | A | 0.0000 | |
| 151 | E | A | -0.3952 | |
| 152 | P | A | -0.6936 | |
| 153 | V | A | -0.6405 | |
| 154 | T | A | -0.5288 | |
| 155 | V | A | -0.3175 | |
| 156 | S | A | -0.4491 | |
| 157 | W | A | 0.0000 | |
| 158 | N | A | -1.0212 | |
| 159 | S | A | -0.7620 | |
| 160 | G | A | -0.5918 | |
| 161 | A | A | -0.2828 | |
| 162 | L | A | -0.1360 | |
| 163 | T | A | -0.2467 | |
| 164 | S | A | -0.2741 | |
| 165 | G | A | -0.3925 | |
| 166 | V | A | 0.0711 | |
| 167 | H | A | -0.2448 | |
| 168 | T | A | -0.0014 | |
| 169 | F | A | 0.0000 | |
| 170 | P | A | -0.3811 | |
| 171 | A | A | 0.1969 | |
| 172 | V | A | 0.5109 | |
| 173 | L | A | 1.2230 | |
| 174 | Q | A | 0.2277 | |
| 175 | S | A | -0.0751 | |
| 176 | S | A | -0.2453 | |
| 177 | G | A | -0.0068 | |
| 178 | L | A | 0.3908 | |
| 179 | Y | A | 0.6254 | |
| 180 | S | A | 0.0000 | |
| 181 | L | A | 0.0000 | |
| 182 | S | A | 0.0000 | |
| 183 | S | A | 0.0000 | |
| 184 | V | A | 0.0000 | |
| 185 | V | A | 0.0000 | |
| 186 | T | A | -0.1883 | |
| 187 | V | A | 0.0000 | |
| 188 | P | A | -0.6366 | |
| 189 | S | A | -0.6838 | |
| 190 | S | A | -0.5608 | |
| 191 | S | A | -0.6948 | |
| 192 | L | A | -0.8455 | |
| 193 | G | A | -1.2071 | |
| 194 | T | A | -0.9608 | |
| 195 | K | A | -1.7626 | |
| 196 | T | A | -1.5535 | |
| 197 | Y | A | 0.0000 | |
| 198 | T | A | 0.0000 | |
| 199 | C | A | 0.0000 | |
| 200 | N | A | -1.7379 | |
| 201 | V | A | 0.0000 | |
| 202 | D | A | -1.8167 | |
| 203 | H | A | 0.0000 | |
| 204 | K | A | -2.7203 | |
| 205 | P | A | -1.3773 | |
| 206 | S | A | -1.3426 | |
| 207 | N | A | -2.3261 | |
| 208 | T | A | -1.8442 | |
| 209 | K | A | -2.6631 | |
| 210 | V | A | -2.0108 | |
| 211 | D | A | -2.9621 | |
| 212 | K | A | -2.7771 | |
| 213 | R | A | -3.1504 | |
| 214 | V | A | 0.0000 | |
| 215 | E | A | -2.6462 | |
| 216 | S | A | -1.1023 | |
| 217 | D | B | -1.2320 | |
| 218 | I | B | -0.2016 | |
| 219 | V | B | 0.7467 | |
| 220 | M | B | 0.0000 | |
| 221 | T | B | -0.4997 | |
| 222 | Q | B | 0.0000 | |
| 223 | T | B | -0.3839 | |
| 224 | P | B | -0.2642 | |
| 225 | L | B | 0.0231 | |
| 226 | S | B | -0.5638 | |
| 227 | L | B | 0.0000 | |
| 228 | S | B | -1.0288 | |
| 229 | V | B | 0.0000 | |
| 230 | T | B | -1.6733 | |
| 231 | P | B | -2.0314 | |
| 232 | G | B | -1.9026 | |
| 233 | Q | B | -2.3090 | |
| 234 | P | B | -2.1031 | |
| 235 | A | B | -1.2828 | |
| 236 | S | B | -0.7920 | |
| 237 | I | B | 0.0000 | |
| 238 | S | B | -0.8916 | |
| 239 | C | B | 0.0000 | |
| 240 | R | B | -2.1320 | |
| 241 | S | B | 0.0000 | |
| 242 | S | B | -0.8547 | |
| 243 | Q | B | -1.3784 | |
| 244 | S | B | -0.7177 | |
| 245 | L | B | 0.0000 | |
| 246 | L | B | 0.5215 | |
| 247 | H | B | -0.6175 | |
| 248 | S | B | -0.9414 | |
| 249 | N | B | -1.6514 | |
| 250 | G | B | -1.1450 | |
| 251 | N | B | -0.9741 | |
| 252 | T | B | -0.2637 | |
| 253 | Y | B | 0.0000 | |
| 254 | L | B | 0.0000 | |
| 255 | H | B | 0.0000 | |
| 256 | W | B | 0.0000 | |
| 257 | Y | B | 0.0000 | |
| 258 | L | B | 0.0000 | |
| 259 | Q | B | -1.1436 | |
| 260 | K | B | -1.7941 | |
| 261 | P | B | -1.4399 | |
| 262 | G | B | -1.6525 | |
| 263 | Q | B | -2.0473 | |
| 264 | S | B | -1.4106 | |
| 265 | P | B | 0.0000 | |
| 266 | Q | B | -1.3159 | |
| 267 | L | B | 0.0000 | |
| 268 | L | B | 0.0000 | |
| 269 | I | B | 0.0000 | |
| 270 | Y | B | -0.4756 | |
| 271 | K | B | -0.8646 | |
| 272 | V | B | 0.0000 | |
| 273 | S | B | -0.9306 | |
| 274 | N | B | -1.2388 | |
| 275 | R | B | -1.7360 | |
| 276 | F | B | -0.6622 | |
| 277 | S | B | -0.5829 | |
| 278 | G | B | -0.8114 | |
| 279 | V | B | -0.8954 | |
| 280 | P | B | -1.2732 | |
| 281 | D | B | -2.2270 | |
| 282 | R | B | -2.0440 | |
| 283 | F | B | 0.0000 | |
| 284 | S | B | -1.3123 | |
| 285 | G | B | 0.0000 | |
| 286 | S | B | -0.7742 | |
| 287 | G | B | -0.9731 | |
| 288 | S | B | -0.6454 | |
| 289 | G | B | -0.6141 | |
| 290 | T | B | -1.3644 | |
| 291 | D | B | -1.9946 | |
| 292 | F | B | 0.0000 | |
| 293 | T | B | -0.9920 | |
| 294 | L | B | 0.0000 | |
| 295 | K | B | -1.5639 | |
| 296 | I | B | 0.0000 | |
| 297 | S | B | -2.2778 | |
| 298 | R | B | -3.0411 | |
| 299 | V | B | 0.0000 | |
| 300 | E | B | -2.6244 | |
| 301 | A | B | -2.3118 | |
| 302 | E | B | -2.4788 | |
| 303 | D | B | 0.0000 | |
| 304 | V | B | 0.0000 | |
| 305 | G | B | 0.0000 | |
| 306 | V | B | -0.7309 | |
| 307 | Y | B | 0.0000 | |
| 308 | Y | B | 0.0000 | |
| 309 | C | B | 0.0000 | |
| 310 | S | B | 0.0000 | |
| 311 | Q | B | 0.0000 | |
| 312 | S | B | 0.0000 | |
| 313 | T | B | 0.0000 | |
| 314 | H | B | -0.0839 | |
| 315 | V | B | 0.8785 | |
| 316 | P | B | 0.3464 | |
| 317 | W | B | 0.0000 | |
| 318 | T | B | 0.1224 | |
| 319 | F | B | 0.1304 | |
| 320 | G | B | 0.0000 | |
| 321 | Q | B | -1.2464 | |
| 322 | G | B | 0.0000 | |
| 323 | T | B | 0.0000 | |
| 324 | K | B | -1.7531 | |
| 325 | V | B | 0.0000 | |
| 326 | E | B | -1.6980 | |
| 327 | I | B | 0.0000 | |
| 328 | K | B | -1.5281 | |
| 329 | R | B | -1.0262 | |
| 330 | T | B | -0.0662 | |
| 331 | V | B | 0.2966 | |
| 332 | A | B | -0.0948 | |
| 333 | A | B | -0.1567 | |
| 334 | P | B | 0.0000 | |
| 335 | S | B | -0.1319 | |
| 336 | V | B | -0.1549 | |
| 337 | F | B | 0.0000 | |
| 338 | I | B | 0.0000 | |
| 339 | F | B | 0.0000 | |
| 340 | P | B | -0.6836 | |
| 341 | P | B | 0.0000 | |
| 342 | S | B | -1.6584 | |
| 343 | D | B | -3.1582 | |
| 344 | E | B | -3.1710 | |
| 345 | Q | B | 0.0000 | |
| 346 | L | B | -2.2471 | |
| 347 | K | B | -2.8150 | |
| 348 | S | B | -1.7921 | |
| 349 | G | B | -1.0473 | |
| 350 | T | B | -1.0962 | |
| 351 | A | B | 0.0000 | |
| 352 | S | B | 0.0000 | |
| 353 | V | B | 0.0000 | |
| 354 | V | B | 0.0000 | |
| 355 | C | B | 0.0000 | |
| 356 | L | B | 0.0000 | |
| 357 | L | B | 0.0000 | |
| 358 | N | B | 0.0000 | |
| 359 | N | B | -1.0833 | |
| 360 | F | B | 0.0000 | |
| 361 | Y | B | 0.0000 | |
| 362 | P | B | -1.7933 | |
| 363 | R | B | -3.1704 | |
| 364 | E | B | -3.2746 | |
| 365 | A | B | -2.3798 | |
| 366 | K | B | -2.4783 | |
| 367 | V | B | -1.1989 | |
| 368 | Q | B | -0.8193 | |
| 369 | W | B | 0.0000 | |
| 370 | K | B | -0.9030 | |
| 371 | V | B | 0.0000 | |
| 372 | D | B | -2.1529 | |
| 373 | N | B | -1.6930 | |
| 374 | A | B | -0.4176 | |
| 375 | L | B | 0.6186 | |
| 376 | Q | B | -0.2837 | |
| 377 | S | B | -0.5273 | |
| 378 | G | B | -0.9144 | |
| 379 | N | B | -0.8402 | |
| 380 | S | B | -1.2103 | |
| 381 | Q | B | -1.4990 | |
| 382 | E | B | -2.0064 | |
| 383 | S | B | -0.9223 | |
| 384 | V | B | -0.8555 | |
| 385 | T | B | -1.2775 | |
| 386 | E | B | -2.3556 | |
| 387 | Q | B | 0.0000 | |
| 388 | D | B | -2.2453 | |
| 389 | S | B | -2.4129 | |
| 390 | K | B | -2.7161 | |
| 391 | D | B | -1.9522 | |
| 392 | S | B | 0.0000 | |
| 393 | T | B | 0.0000 | |
| 394 | Y | B | 0.0000 | |
| 395 | S | B | 0.0000 | |
| 396 | L | B | 0.0000 | |
| 397 | S | B | 0.0000 | |
| 398 | S | B | 0.0000 | |
| 399 | T | B | -0.6824 | |
| 400 | L | B | 0.0000 | |
| 401 | T | B | -0.4502 | |
| 402 | L | B | -0.7949 | |
| 403 | S | B | -1.3604 | |
| 404 | K | B | -2.1186 | |
| 405 | A | B | -2.1251 | |
| 406 | D | B | -2.9896 | |
| 407 | Y | B | 0.0000 | |
| 408 | E | B | -3.7150 | |
| 409 | K | B | -3.8188 | |
| 410 | H | B | -3.2889 | |
| 411 | K | B | -3.3866 | |
| 412 | V | B | -2.1239 | |
| 413 | Y | B | 0.0000 | |
| 414 | A | B | -0.9006 | |
| 415 | C | B | 0.0000 | |
| 416 | E | B | -0.8628 | |
| 417 | V | B | 0.0000 | |
| 418 | T | B | -1.2112 | |
| 419 | H | B | 0.0000 | |
| 420 | Q | B | -1.7792 | |
| 421 | G | B | -0.4989 | |
| 422 | L | B | -0.2830 | |
| 423 | S | B | -0.4381 | |
| 424 | S | B | -0.4244 | |
| 425 | P | B | -0.5127 | |
| 426 | V | B | 0.1528 | |
| 427 | T | B | -0.4127 | |
| 428 | K | B | -0.7639 | |
| 429 | S | B | -1.0007 | |
| 430 | F | B | 0.0000 | |
| 431 | N | B | -2.4853 | |
| 432 | R | B | -2.8502 | |
| 433 | G | B | -2.2587 | |
| 434 | E | B | -2.2184 | |
| 435 | C | B | -0.7073 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine