| Chain sequence(s) |
A: QVQLQESGPGLVKPSVTLSLTCTVSGGSISSGYWNWIRQPPGKGLEWIGTISYSGDTYYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARYGSYVFDYWGQGTTVTVSSASTVGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVES B: DIVMTQTPLSLSVTPGQPASISCRSSQSLLHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCSQSTHVPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Q | A | -1.6580 | |
| 2 | V | A | 0.0000 | |
| 3 | Q | A | -2.1233 | |
| 4 | L | A | 0.0000 | |
| 5 | Q | A | -1.8529 | |
| 6 | E | A | 0.0000 | |
| 7 | S | A | -0.7746 | |
| 8 | G | A | -0.6220 | |
| 9 | P | A | -0.6344 | |
| 10 | G | A | -0.5353 | |
| 11 | L | A | -0.3205 | |
| 12 | V | A | 0.0000 | |
| 13 | K | A | -1.5832 | |
| 14 | P | A | -0.8769 | |
| 15 | S | A | -0.4500 | |
| 16 | V | A | 0.0300 | |
| 17 | T | A | -0.4704 | |
| 18 | L | A | 0.0000 | |
| 19 | S | A | -0.7981 | |
| 20 | L | A | 0.0000 | |
| 21 | T | A | -0.7033 | |
| 22 | C | A | 0.0000 | |
| 23 | T | A | -1.1457 | |
| 24 | V | A | 0.0000 | |
| 25 | S | A | -1.3047 | |
| 26 | G | A | -1.3492 | |
| 27 | G | A | -1.1562 | |
| 28 | S | A | -0.8557 | |
| 29 | I | A | 0.0000 | |
| 30 | S | A | -0.2074 | |
| 31 | S | A | 0.0149 | |
| 32 | G | A | 0.1264 | |
| 33 | Y | A | 0.1759 | |
| 34 | W | A | 0.0000 | |
| 35 | N | A | 0.0000 | |
| 36 | W | A | 0.0000 | |
| 37 | I | A | 0.0000 | |
| 38 | R | A | 0.0000 | |
| 39 | Q | A | -0.8424 | |
| 40 | P | A | -1.0265 | |
| 41 | P | A | -1.1358 | |
| 42 | G | A | -1.5004 | |
| 43 | K | A | -2.3634 | |
| 44 | G | A | -1.5179 | |
| 45 | L | A | 0.0000 | |
| 46 | E | A | -0.6540 | |
| 47 | W | A | 0.0000 | |
| 48 | I | A | 0.0000 | |
| 49 | G | A | 0.0000 | |
| 50 | T | A | 0.0000 | |
| 51 | I | A | 0.0000 | |
| 52 | S | A | 0.0425 | |
| 53 | Y | A | 0.5855 | |
| 54 | S | A | -0.4379 | |
| 55 | G | A | -0.9418 | |
| 56 | D | A | -1.5441 | |
| 57 | T | A | -0.3348 | |
| 58 | Y | A | 0.8014 | |
| 59 | Y | A | 0.5188 | |
| 60 | N | A | 0.0000 | |
| 61 | P | A | -0.8726 | |
| 62 | S | A | -1.1301 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.0180 | |
| 65 | S | A | -1.2795 | |
| 66 | R | A | -1.3926 | |
| 67 | V | A | 0.0000 | |
| 68 | T | A | -0.6197 | |
| 69 | I | A | 0.0000 | |
| 70 | S | A | -0.6379 | |
| 71 | V | A | -0.2949 | |
| 72 | D | A | -1.1925 | |
| 73 | T | A | -1.1503 | |
| 74 | S | A | -1.3418 | |
| 75 | K | A | -2.1433 | |
| 76 | N | A | -1.4606 | |
| 77 | Q | A | -1.2652 | |
| 78 | F | A | 0.0000 | |
| 79 | S | A | -0.5407 | |
| 80 | L | A | 0.0000 | |
| 81 | K | A | -1.7171 | |
| 82 | L | A | 0.0000 | |
| 83 | S | A | -0.6513 | |
| 84 | S | A | -0.4246 | |
| 85 | V | A | 0.0000 | |
| 86 | T | A | -0.3197 | |
| 87 | A | A | -0.2016 | |
| 88 | A | A | 0.0279 | |
| 89 | D | A | 0.0000 | |
| 90 | T | A | 0.0069 | |
| 91 | A | A | 0.0000 | |
| 92 | V | A | -0.0136 | |
| 93 | Y | A | 0.0000 | |
| 94 | Y | A | 0.0000 | |
| 95 | C | A | 0.0000 | |
| 96 | A | A | 0.0000 | |
| 97 | R | A | -0.6546 | |
| 98 | Y | A | -0.0526 | |
| 99 | G | A | -0.0701 | |
| 100 | S | A | -0.0662 | |
| 101 | Y | A | 0.2846 | |
| 102 | V | A | 0.0000 | |
| 103 | F | A | 0.0000 | |
| 104 | D | A | -0.4145 | |
| 105 | Y | A | -0.7763 | |
| 106 | W | A | 0.0000 | |
| 107 | G | A | 0.0000 | |
| 108 | Q | A | -1.8592 | |
| 109 | G | A | 0.0000 | |
| 110 | T | A | -0.5521 | |
| 111 | T | A | -0.2863 | |
| 112 | V | A | 0.0000 | |
| 113 | T | A | -0.3113 | |
| 114 | V | A | 0.0000 | |
| 115 | S | A | -0.6573 | |
| 116 | S | A | -0.8611 | |
| 117 | A | A | -0.3705 | |
| 118 | S | A | -0.3106 | |
| 119 | T | A | -0.1078 | |
| 120 | V | A | 0.0976 | |
| 121 | G | A | -0.7812 | |
| 122 | P | A | -0.3715 | |
| 123 | S | A | -0.3799 | |
| 124 | V | A | 0.0000 | |
| 125 | F | A | 0.0000 | |
| 126 | P | A | -1.3526 | |
| 127 | L | A | 0.0000 | |
| 128 | A | A | -0.8984 | |
| 129 | P | A | 0.0000 | |
| 130 | C | A | -0.4603 | |
| 131 | S | A | -0.5395 | |
| 132 | R | A | -0.8973 | |
| 133 | S | A | 0.0000 | |
| 134 | T | A | -0.9080 | |
| 135 | S | A | -1.3822 | |
| 136 | E | A | -2.0797 | |
| 137 | S | A | -1.3127 | |
| 138 | T | A | -0.9413 | |
| 139 | A | A | 0.0000 | |
| 140 | A | A | 0.0000 | |
| 141 | L | A | 0.0000 | |
| 142 | G | A | 0.0000 | |
| 143 | C | A | 0.0000 | |
| 144 | L | A | 0.0000 | |
| 145 | V | A | 0.0000 | |
| 146 | K | A | -0.3609 | |
| 147 | D | A | -0.2059 | |
| 148 | Y | A | 0.0000 | |
| 149 | F | A | 0.0000 | |
| 150 | P | A | 0.0000 | |
| 151 | E | A | -0.4584 | |
| 152 | P | A | -0.6965 | |
| 153 | V | A | -0.6329 | |
| 154 | T | A | -0.5273 | |
| 155 | V | A | -0.3162 | |
| 156 | S | A | -0.4472 | |
| 157 | W | A | 0.0000 | |
| 158 | N | A | -1.0153 | |
| 159 | S | A | -0.7608 | |
| 160 | G | A | -0.5911 | |
| 161 | A | A | -0.2820 | |
| 162 | L | A | -0.1349 | |
| 163 | T | A | -0.2458 | |
| 164 | S | A | -0.2735 | |
| 165 | G | A | -0.3915 | |
| 166 | V | A | 0.0732 | |
| 167 | H | A | -0.2485 | |
| 168 | T | A | 0.0055 | |
| 169 | F | A | 0.0000 | |
| 170 | P | A | -0.3569 | |
| 171 | A | A | 0.2090 | |
| 172 | V | A | 0.5172 | |
| 173 | L | A | 1.2900 | |
| 174 | Q | A | 0.2877 | |
| 175 | S | A | -0.0269 | |
| 176 | S | A | -0.1869 | |
| 177 | G | A | 0.0877 | |
| 178 | L | A | 0.3665 | |
| 179 | Y | A | 0.6004 | |
| 180 | S | A | 0.2412 | |
| 181 | L | A | 0.0000 | |
| 182 | S | A | 0.0000 | |
| 183 | S | A | 0.0000 | |
| 184 | V | A | 0.0000 | |
| 185 | V | A | 0.0000 | |
| 186 | T | A | -0.1883 | |
| 187 | V | A | 0.0000 | |
| 188 | P | A | -0.6407 | |
| 189 | S | A | -0.6909 | |
| 190 | S | A | -0.5637 | |
| 191 | S | A | -0.6956 | |
| 192 | L | A | -0.8528 | |
| 193 | G | A | -1.2069 | |
| 194 | T | A | -0.9546 | |
| 195 | K | A | -1.7444 | |
| 196 | T | A | -1.5446 | |
| 197 | Y | A | 0.0000 | |
| 198 | T | A | 0.0000 | |
| 199 | C | A | 0.0000 | |
| 200 | N | A | -1.7310 | |
| 201 | V | A | 0.0000 | |
| 202 | D | A | -1.8047 | |
| 203 | H | A | 0.0000 | |
| 204 | K | A | -2.7114 | |
| 205 | P | A | -1.4571 | |
| 206 | S | A | -1.5041 | |
| 207 | N | A | -2.3874 | |
| 208 | T | A | -1.9096 | |
| 209 | K | A | -2.6575 | |
| 210 | V | A | -2.0109 | |
| 211 | D | A | -2.9498 | |
| 212 | K | A | -2.7473 | |
| 213 | R | A | -3.1352 | |
| 214 | V | A | 0.0000 | |
| 215 | E | A | -2.6424 | |
| 216 | S | A | -1.1046 | |
| 217 | D | B | -1.2379 | |
| 218 | I | B | -0.1905 | |
| 219 | V | B | 0.7760 | |
| 220 | M | B | 0.0000 | |
| 221 | T | B | -0.4122 | |
| 222 | Q | B | 0.0000 | |
| 223 | T | B | -0.3554 | |
| 224 | P | B | -0.2756 | |
| 225 | L | B | -0.0027 | |
| 226 | S | B | -0.5853 | |
| 227 | L | B | 0.0000 | |
| 228 | S | B | -1.0224 | |
| 229 | V | B | 0.0000 | |
| 230 | T | B | -1.6636 | |
| 231 | P | B | -2.0319 | |
| 232 | G | B | -1.8974 | |
| 233 | Q | B | -2.3061 | |
| 234 | P | B | -2.1012 | |
| 235 | A | B | -1.2812 | |
| 236 | S | B | -0.7920 | |
| 237 | I | B | 0.0000 | |
| 238 | S | B | -0.8331 | |
| 239 | C | B | 0.0000 | |
| 240 | R | B | -1.9027 | |
| 241 | S | B | 0.0000 | |
| 242 | S | B | -0.8152 | |
| 243 | Q | B | -1.4477 | |
| 244 | S | B | -0.9282 | |
| 245 | L | B | 0.0000 | |
| 246 | L | B | -0.1861 | |
| 247 | H | B | -0.9886 | |
| 248 | S | B | -1.1228 | |
| 249 | N | B | -1.7985 | |
| 250 | G | B | -1.3894 | |
| 251 | N | B | -1.2994 | |
| 252 | T | B | -0.6104 | |
| 253 | Y | B | 0.0000 | |
| 254 | L | B | 0.0000 | |
| 255 | H | B | 0.0000 | |
| 256 | W | B | 0.0000 | |
| 257 | Y | B | 0.0000 | |
| 258 | L | B | 0.0000 | |
| 259 | Q | B | -1.1696 | |
| 260 | K | B | -1.8696 | |
| 261 | P | B | -1.4950 | |
| 262 | G | B | -1.6684 | |
| 263 | Q | B | -2.0530 | |
| 264 | S | B | 0.0000 | |
| 265 | P | B | 0.0000 | |
| 266 | Q | B | -1.2892 | |
| 267 | L | B | 0.0000 | |
| 268 | L | B | 0.0000 | |
| 269 | I | B | 0.0000 | |
| 270 | Y | B | -0.4977 | |
| 271 | K | B | -0.9096 | |
| 272 | V | B | 0.0000 | |
| 273 | S | B | -0.9495 | |
| 274 | N | B | -1.2658 | |
| 275 | R | B | -1.7506 | |
| 276 | F | B | -0.6671 | |
| 277 | S | B | -0.5850 | |
| 278 | G | B | -0.8117 | |
| 279 | V | B | -0.8977 | |
| 280 | P | B | -1.2743 | |
| 281 | D | B | -2.2276 | |
| 282 | R | B | -2.0430 | |
| 283 | F | B | 0.0000 | |
| 284 | S | B | -1.3165 | |
| 285 | G | B | 0.0000 | |
| 286 | S | B | -0.7718 | |
| 287 | G | B | -0.9397 | |
| 288 | S | B | -0.7361 | |
| 289 | G | B | -0.7904 | |
| 290 | T | B | -1.3899 | |
| 291 | D | B | -1.8821 | |
| 292 | F | B | 0.0000 | |
| 293 | T | B | -0.9505 | |
| 294 | L | B | 0.0000 | |
| 295 | K | B | -1.5637 | |
| 296 | I | B | 0.0000 | |
| 297 | S | B | -2.2763 | |
| 298 | R | B | -3.0372 | |
| 299 | V | B | 0.0000 | |
| 300 | E | B | -2.6448 | |
| 301 | A | B | -2.3752 | |
| 302 | E | B | -2.6014 | |
| 303 | D | B | 0.0000 | |
| 304 | V | B | 0.0000 | |
| 305 | G | B | 0.0000 | |
| 306 | V | B | -0.7806 | |
| 307 | Y | B | 0.0000 | |
| 308 | Y | B | 0.0000 | |
| 309 | C | B | 0.0000 | |
| 310 | S | B | 0.0000 | |
| 311 | Q | B | 0.0000 | |
| 312 | S | B | 0.0000 | |
| 313 | T | B | 0.0000 | |
| 314 | H | B | -0.1586 | |
| 315 | V | B | 0.8624 | |
| 316 | P | B | 0.3358 | |
| 317 | W | B | 0.0000 | |
| 318 | T | B | 0.1232 | |
| 319 | F | B | 0.1398 | |
| 320 | G | B | 0.0000 | |
| 321 | Q | B | -1.2112 | |
| 322 | G | B | 0.0000 | |
| 323 | T | B | 0.0000 | |
| 324 | K | B | -1.7881 | |
| 325 | V | B | 0.0000 | |
| 326 | E | B | -1.7045 | |
| 327 | I | B | 0.0000 | |
| 328 | K | B | -1.5122 | |
| 329 | R | B | -1.0266 | |
| 330 | T | B | -0.0606 | |
| 331 | V | B | 0.3040 | |
| 332 | A | B | -0.0920 | |
| 333 | A | B | -0.1786 | |
| 334 | P | B | 0.0000 | |
| 335 | S | B | -0.2208 | |
| 336 | V | B | 0.0000 | |
| 337 | F | B | 0.0000 | |
| 338 | I | B | 0.0000 | |
| 339 | F | B | 0.0000 | |
| 340 | P | B | -0.6839 | |
| 341 | P | B | 0.0000 | |
| 342 | S | B | -1.5296 | |
| 343 | D | B | -2.9858 | |
| 344 | E | B | -2.8305 | |
| 345 | Q | B | 0.0000 | |
| 346 | L | B | -2.1141 | |
| 347 | K | B | -2.6999 | |
| 348 | S | B | -1.7169 | |
| 349 | G | B | -1.0373 | |
| 350 | T | B | -1.0528 | |
| 351 | A | B | 0.0000 | |
| 352 | S | B | 0.0000 | |
| 353 | V | B | 0.0000 | |
| 354 | V | B | 0.0000 | |
| 355 | C | B | 0.0000 | |
| 356 | L | B | 0.0000 | |
| 357 | L | B | 0.0000 | |
| 358 | N | B | 0.0000 | |
| 359 | N | B | -1.1241 | |
| 360 | F | B | 0.0000 | |
| 361 | Y | B | 0.0000 | |
| 362 | P | B | -1.7893 | |
| 363 | R | B | -3.1741 | |
| 364 | E | B | -3.2847 | |
| 365 | A | B | -2.4037 | |
| 366 | K | B | -2.5395 | |
| 367 | V | B | -1.2440 | |
| 368 | Q | B | -0.8000 | |
| 369 | W | B | 0.0000 | |
| 370 | K | B | -0.8709 | |
| 371 | V | B | 0.0000 | |
| 372 | D | B | -2.1542 | |
| 373 | N | B | -1.6806 | |
| 374 | A | B | -0.3964 | |
| 375 | L | B | 0.6691 | |
| 376 | Q | B | -0.2205 | |
| 377 | S | B | -0.5004 | |
| 378 | G | B | -0.9183 | |
| 379 | N | B | -0.8480 | |
| 380 | S | B | -1.2284 | |
| 381 | Q | B | -1.5644 | |
| 382 | E | B | -2.0436 | |
| 383 | S | B | -0.9335 | |
| 384 | V | B | -0.8521 | |
| 385 | T | B | -1.2857 | |
| 386 | E | B | -2.3783 | |
| 387 | Q | B | 0.0000 | |
| 388 | D | B | -2.3527 | |
| 389 | S | B | -2.4956 | |
| 390 | K | B | -2.7881 | |
| 391 | D | B | -2.0490 | |
| 392 | S | B | 0.0000 | |
| 393 | T | B | 0.0000 | |
| 394 | Y | B | 0.0000 | |
| 395 | S | B | 0.0000 | |
| 396 | L | B | 0.0000 | |
| 397 | S | B | 0.0000 | |
| 398 | S | B | 0.0000 | |
| 399 | T | B | -0.7100 | |
| 400 | L | B | 0.0000 | |
| 401 | T | B | -0.4640 | |
| 402 | L | B | -0.7937 | |
| 403 | S | B | -1.3512 | |
| 404 | K | B | -2.0928 | |
| 405 | A | B | -2.1105 | |
| 406 | D | B | -2.9901 | |
| 407 | Y | B | 0.0000 | |
| 408 | E | B | -3.6779 | |
| 409 | K | B | -3.8099 | |
| 410 | H | B | -3.2946 | |
| 411 | K | B | -3.4025 | |
| 412 | V | B | -2.1651 | |
| 413 | Y | B | 0.0000 | |
| 414 | A | B | -0.9049 | |
| 415 | C | B | 0.0000 | |
| 416 | E | B | -1.0291 | |
| 417 | V | B | 0.0000 | |
| 418 | T | B | -1.2668 | |
| 419 | H | B | 0.0000 | |
| 420 | Q | B | -1.7840 | |
| 421 | G | B | -0.4982 | |
| 422 | L | B | -0.2833 | |
| 423 | S | B | -0.4384 | |
| 424 | S | B | -0.4244 | |
| 425 | P | B | -0.5656 | |
| 426 | V | B | 0.0903 | |
| 427 | T | B | -0.4606 | |
| 428 | K | B | -0.7449 | |
| 429 | S | B | -0.9929 | |
| 430 | F | B | 0.0000 | |
| 431 | N | B | -2.5051 | |
| 432 | R | B | -2.8548 | |
| 433 | G | B | -2.2578 | |
| 434 | E | B | -2.2176 | |
| 435 | C | B | -0.7068 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine