| Chain sequence(s) |
H: QVQLVQSGAEVKKPGASVKVSCKASGYTFTDYSVHWVRQAPGQGLEWMGVINTYGGNTDYAQKFQGRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARGYGSWLAYWGQGTTLTVSS L: DIQMTQSPSSLSASVGDRVTITCIVSSSISSSGLHWYQQKPEKAPKSLIFATSNLLSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQHWSSYPLTFGAGTKLEIKRTV |
| Distance of aggregation | 5 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | D | L | -1.7503 | |
| 2 | I | L | -0.3313 | |
| 3 | Q | L | -1.1592 | |
| 4 | M | L | 0.0000 | |
| 5 | T | L | -0.0659 | |
| 6 | Q | L | 0.0000 | |
| 7 | S | L | -0.2164 | |
| 8 | P | L | -0.1921 | |
| 9 | S | L | -0.2689 | |
| 10 | S | L | -0.3832 | |
| 11 | L | L | 0.1302 | |
| 12 | S | L | -0.1736 | |
| 13 | A | L | -0.0394 | |
| 14 | S | L | -0.0065 | |
| 15 | V | L | 1.2462 | |
| 16 | G | L | -0.2146 | |
| 17 | D | L | -1.2548 | |
| 18 | R | L | -2.0140 | |
| 19 | V | L | 0.0000 | |
| 20 | T | L | -0.0726 | |
| 21 | I | L | 0.0000 | |
| 22 | T | L | -0.0215 | |
| 23 | C | L | 0.0000 | |
| 24 | I | L | 0.7887 | |
| 25 | V | L | 0.0000 | |
| 26 | S | L | -0.2521 | |
| 27 | S | L | -0.2914 | |
| 28 | S | L | -0.2244 | |
| 29 | I | L | 0.1356 | |
| 30 | S | L | -0.2089 | |
| 31 | S | L | -0.1662 | |
| 32 | S | L | -0.2282 | |
| 33 | G | L | -0.0985 | |
| 34 | L | L | 0.0000 | |
| 35 | H | L | 0.0000 | |
| 36 | W | L | 0.0000 | |
| 37 | Y | L | 0.0000 | |
| 38 | Q | L | -0.1458 | |
| 39 | Q | L | -0.2525 | |
| 40 | K | L | -0.5478 | |
| 41 | P | L | -0.6110 | |
| 42 | E | L | -2.1580 | |
| 43 | K | L | -1.9803 | |
| 44 | A | L | -0.2872 | |
| 45 | P | L | 0.0000 | |
| 46 | K | L | -1.1089 | |
| 47 | S | L | 0.0000 | |
| 48 | L | L | 0.0000 | |
| 49 | I | L | 0.0000 | |
| 50 | F | L | 0.4132 | |
| 51 | A | L | 0.0535 | |
| 52 | T | L | 0.0000 | |
| 53 | S | L | -0.3701 | |
| 54 | N | L | -1.1781 | |
| 55 | L | L | 0.4572 | |
| 56 | L | L | 0.3694 | |
| 57 | S | L | -0.2446 | |
| 58 | G | L | -0.5051 | |
| 59 | V | L | 0.0000 | |
| 60 | P | L | -0.1446 | |
| 61 | S | L | -0.2966 | |
| 62 | R | L | -0.3907 | |
| 63 | F | L | 0.0000 | |
| 64 | S | L | -0.1341 | |
| 65 | G | L | -0.1464 | |
| 66 | S | L | -0.2535 | |
| 67 | G | L | -0.2933 | |
| 68 | S | L | -0.2748 | |
| 69 | G | L | -0.1442 | |
| 70 | T | L | -0.3646 | |
| 71 | D | L | -1.5650 | |
| 72 | F | L | 0.0000 | |
| 73 | T | L | -0.0135 | |
| 74 | L | L | 0.0000 | |
| 75 | T | L | -0.0229 | |
| 76 | I | L | 0.0000 | |
| 77 | S | L | -0.3523 | |
| 78 | S | L | -0.2587 | |
| 79 | L | L | 0.0000 | |
| 80 | Q | L | -0.4508 | |
| 81 | P | L | -0.6302 | |
| 82 | E | L | -1.5704 | |
| 83 | D | L | 0.0000 | |
| 84 | F | L | 0.7520 | |
| 85 | A | L | 0.0000 | |
| 86 | T | L | -0.2067 | |
| 87 | Y | L | 0.0000 | |
| 88 | Y | L | 0.0000 | |
| 89 | C | L | 0.0000 | |
| 90 | Q | L | 0.0000 | |
| 91 | H | L | 0.0000 | |
| 92 | W | L | 0.0992 | |
| 93 | S | L | -0.1368 | |
| 94 | S | L | 0.0030 | |
| 95 | Y | L | 1.2547 | |
| 96 | P | L | 0.2775 | |
| 97 | L | L | 0.0000 | |
| 98 | T | L | 0.0222 | |
| 99 | F | L | 0.1977 | |
| 100 | G | L | 0.0000 | |
| 101 | A | L | 0.0585 | |
| 102 | G | L | 0.0000 | |
| 103 | T | L | 0.0000 | |
| 104 | K | L | -1.3323 | |
| 105 | L | L | 0.0000 | |
| 106 | E | L | -0.9433 | |
| 107 | I | L | -0.2204 | |
| 108 | K | L | -1.9926 | |
| 109 | R | L | -2.1691 | |
| 110 | T | L | -0.0808 | |
| 111 | V | L | 1.7596 | |
| 112 | Q | H | -1.0556 | |
| 113 | V | H | 0.2708 | |
| 114 | Q | H | -1.0567 | |
| 115 | L | H | 0.0000 | |
| 116 | V | H | 0.6029 | |
| 117 | Q | H | 0.0000 | |
| 118 | S | H | -0.2623 | |
| 119 | G | H | -0.4880 | |
| 120 | A | H | -0.3571 | |
| 121 | E | H | -1.3966 | |
| 122 | V | H | 1.3237 | |
| 123 | K | H | -0.6655 | |
| 124 | K | H | -1.8680 | |
| 125 | P | H | -0.6298 | |
| 126 | G | H | -0.5344 | |
| 127 | A | H | -0.0920 | |
| 128 | S | H | -0.1597 | |
| 129 | V | H | 0.0000 | |
| 130 | K | H | -1.7140 | |
| 131 | V | H | 0.0000 | |
| 133 | C | H | 0.0000 | |
| 134 | K | H | -0.7581 | |
| 135 | A | H | 0.0000 | |
| 136 | S | H | -0.1382 | |
| 137 | G | H | -0.3113 | |
| 138 | Y | H | 0.1070 | |
| 139 | T | H | -0.0333 | |
| 140 | F | H | 0.0000 | |
| 141 | T | H | -0.3877 | |
| 142 | D | H | -1.7591 | |
| 143 | Y | H | -0.1052 | |
| 144 | S | H | -0.0882 | |
| 145 | V | H | 0.0000 | |
| 146 | H | H | 0.0000 | |
| 147 | W | H | 0.0000 | |
| 148 | V | H | 0.0000 | |
| 149 | R | H | 0.0000 | |
| 150 | Q | H | -0.1295 | |
| 151 | A | H | -0.0584 | |
| 152 | P | H | -0.3380 | |
| 153 | G | H | -0.7318 | |
| 154 | Q | H | -1.2835 | |
| 155 | G | H | 0.0000 | |
| 156 | L | H | 0.0000 | |
| 157 | E | H | -0.2775 | |
| 158 | W | H | 0.0000 | |
| 159 | M | H | 0.0000 | |
| 160 | G | H | 0.0000 | |
| 161 | V | H | 0.1782 | |
| 162 | I | H | 0.0000 | |
| 163 | N | H | -0.8069 | |
| 164 | T | H | 0.0850 | |
| 165 | Y | H | 1.2279 | |
| 166 | G | H | -0.2515 | |
| 167 | G | H | -0.4630 | |
| 168 | N | H | -1.3041 | |
| 169 | T | H | -0.5940 | |
| 170 | D | H | -1.7558 | |
| 171 | Y | H | -0.1182 | |
| 172 | A | H | -0.1753 | |
| 173 | Q | H | -1.5066 | |
| 174 | K | H | -1.9180 | |
| 175 | F | H | 0.0000 | |
| 176 | Q | H | -1.2832 | |
| 177 | G | H | -0.7485 | |
| 178 | R | H | -0.4369 | |
| 179 | V | H | 0.0000 | |
| 180 | T | H | -0.0462 | |
| 181 | M | H | 0.0000 | |
| 182 | T | H | -0.1127 | |
| 183 | R | H | -0.5823 | |
| 184 | D | H | -0.8348 | |
| 185 | T | H | -0.2458 | |
| 186 | S | H | -0.2387 | |
| 187 | T | H | -0.1195 | |
| 188 | S | H | -0.0664 | |
| 189 | T | H | 0.0000 | |
| 190 | V | H | 0.0000 | |
| 191 | Y | H | 0.2828 | |
| 192 | M | H | 0.0000 | |
| 193 | E | H | -1.0235 | |
| 194 | L | H | 0.0000 | |
| 195 | S | H | -0.1474 | |
| 196 | S | H | -0.2917 | |
| 197 | L | H | 0.0000 | |
| 198 | R | H | -1.7986 | |
| 199 | S | H | -0.8677 | |
| 200 | E | H | -1.8588 | |
| 201 | D | H | 0.0000 | |
| 202 | T | H | -0.0204 | |
| 203 | A | H | 0.0000 | |
| 204 | V | H | 0.3019 | |
| 205 | Y | H | 0.0000 | |
| 206 | Y | H | 0.0000 | |
| 207 | C | H | 0.0000 | |
| 208 | A | H | 0.0000 | |
| 209 | R | H | 0.0000 | |
| 210 | G | H | 0.0000 | |
| 211 | Y | H | 0.9825 | |
| 212 | G | H | -0.0782 | |
| 213 | S | H | -0.2093 | |
| 214 | W | H | 0.2128 | |
| 215 | L | H | 0.0000 | |
| 216 | A | H | 0.1614 | |
| 217 | Y | H | 0.8505 | |
| 218 | W | H | 0.0000 | |
| 219 | G | H | -0.2910 | |
| 220 | Q | H | -1.2184 | |
| 221 | G | H | -0.2755 | |
| 222 | T | H | 0.0000 | |
| 223 | T | H | -0.0062 | |
| 224 | L | H | 0.0000 | |
| 225 | T | H | 0.1717 | |
| 226 | V | H | 0.0000 | |
| 227 | S | H | -0.1488 | |
| 228 | S | H | -0.2330 |