| Chain sequence(s) |
A: GPHSLRYFVTAVSRPGLGEPRYMEVGYVDDTEFVRFDSDAENPRYEPRARWMEQEGPEYWERETQKAKGNEQSFRVDLRTLLGYYNQSKGGSHTIQVISGCEVGSDGRLLRGYQQYAYDGCDYIALNEDLKTWTAADMAALITKHKWEQAGEAERLRAYLEGTCVEWLRRYLKNGNATLLRTDSPKAHVTHHSRPEDKVTLRCWALGFYPADITLTWQLNGEELIQDMELVETRPAGDGTFQKWASVVVPLGKEQYYTCHVYHQGLPEPLTLRW P: GNYSFYAL B: IQKTPQIQVYSRHPPENGKPNILNCYVTQFHPPHIEIQMLKNGKKIPKVEMSDMSFSKDWSFYILAHTEFTPTETDTYACRVKHDSMAEPKTVYWDRDM |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | -0.7962 | |
| 2 | P | A | -1.1323 | |
| 3 | H | A | -0.6789 | |
| 4 | S | A | -0.7604 | |
| 5 | L | A | 0.0000 | |
| 6 | R | A | -0.5249 | |
| 7 | Y | A | 0.0000 | |
| 8 | F | A | 0.0000 | |
| 9 | V | A | 0.0000 | |
| 10 | T | A | 0.0000 | |
| 11 | A | A | 0.0000 | |
| 12 | V | A | 0.0000 | |
| 13 | S | A | -1.4695 | |
| 14 | R | A | -1.0323 | |
| 15 | P | A | -1.0101 | |
| 16 | G | A | -0.5175 | |
| 17 | L | A | 0.5593 | |
| 18 | G | A | -0.9128 | |
| 19 | E | A | -2.3680 | |
| 20 | P | A | -1.8557 | |
| 21 | R | A | -1.7988 | |
| 22 | Y | A | 0.0000 | |
| 23 | M | A | -0.4794 | |
| 24 | E | A | 0.0000 | |
| 25 | V | A | 0.0000 | |
| 26 | G | A | 0.0000 | |
| 27 | Y | A | 0.0000 | |
| 28 | V | A | 0.0000 | |
| 29 | D | A | -0.5085 | |
| 30 | D | A | -1.0082 | |
| 31 | T | A | -0.5208 | |
| 32 | E | A | 0.0000 | |
| 33 | F | A | 0.0000 | |
| 34 | V | A | 0.0000 | |
| 35 | R | A | -1.0880 | |
| 36 | F | A | 0.0000 | |
| 37 | D | A | -1.7834 | |
| 38 | S | A | -2.2326 | |
| 39 | D | A | -2.5031 | |
| 40 | A | A | -2.3142 | |
| 41 | E | A | -3.0287 | |
| 42 | N | A | -2.8253 | |
| 43 | P | A | -2.6921 | |
| 44 | R | A | -3.2090 | |
| 45 | Y | A | 0.0000 | |
| 46 | E | A | -2.1906 | |
| 47 | P | A | -1.8708 | |
| 48 | R | A | -1.5061 | |
| 49 | A | A | -1.6366 | |
| 50 | R | A | -2.6002 | |
| 51 | W | A | 0.0000 | |
| 52 | M | A | 0.0000 | |
| 53 | E | A | -3.0485 | |
| 54 | Q | A | -2.1253 | |
| 55 | E | A | 0.0000 | |
| 56 | G | A | -1.6918 | |
| 57 | P | A | -2.2334 | |
| 58 | E | A | -3.1270 | |
| 59 | Y | A | 0.0000 | |
| 60 | W | A | -2.8041 | |
| 61 | E | A | -3.9989 | |
| 62 | R | A | -3.8456 | |
| 63 | E | A | 0.0000 | |
| 64 | T | A | -3.1719 | |
| 65 | Q | A | -3.2166 | |
| 66 | K | A | -2.3280 | |
| 67 | A | A | 0.0000 | |
| 68 | K | A | -2.7006 | |
| 69 | G | A | -1.6727 | |
| 70 | N | A | 0.0000 | |
| 71 | E | A | -1.9780 | |
| 72 | Q | A | -1.8800 | |
| 73 | S | A | -0.7190 | |
| 74 | F | A | 0.0000 | |
| 75 | R | A | -2.1679 | |
| 76 | V | A | -0.6543 | |
| 77 | D | A | 0.0000 | |
| 78 | L | A | 0.0000 | |
| 79 | R | A | -2.2152 | |
| 80 | T | A | 0.0000 | |
| 81 | L | A | 0.0000 | |
| 82 | L | A | -1.4400 | |
| 83 | G | A | -1.3110 | |
| 84 | Y | A | -0.1546 | |
| 85 | Y | A | -0.2078 | |
| 86 | N | A | -1.5337 | |
| 87 | Q | A | -1.6712 | |
| 88 | S | A | -1.8914 | |
| 89 | K | A | -2.7606 | |
| 90 | G | A | -1.7329 | |
| 91 | G | A | -1.2853 | |
| 92 | S | A | -1.0234 | |
| 93 | H | A | -0.8989 | |
| 94 | T | A | 0.0000 | |
| 95 | I | A | 0.0000 | |
| 96 | Q | A | 0.0000 | |
| 97 | V | A | 0.0000 | |
| 98 | I | A | -0.1775 | |
| 99 | S | A | 0.0000 | |
| 100 | G | A | 0.0000 | |
| 101 | C | A | 0.0000 | |
| 102 | E | A | -1.3212 | |
| 103 | V | A | 0.0000 | |
| 104 | G | A | -1.6559 | |
| 105 | S | A | -1.7063 | |
| 106 | D | A | -2.7000 | |
| 107 | G | A | -2.3912 | |
| 108 | R | A | -3.0369 | |
| 109 | L | A | -1.9618 | |
| 110 | L | A | -0.9495 | |
| 111 | R | A | -2.5765 | |
| 112 | G | A | -1.9013 | |
| 113 | Y | A | -1.1289 | |
| 114 | Q | A | 0.0000 | |
| 115 | Q | A | -0.7306 | |
| 116 | Y | A | 0.0000 | |
| 117 | A | A | 0.0000 | |
| 118 | Y | A | 0.0000 | |
| 119 | D | A | -0.2540 | |
| 120 | G | A | 0.0000 | |
| 121 | C | A | -0.4110 | |
| 122 | D | A | -2.1407 | |
| 123 | Y | A | 0.0000 | |
| 124 | I | A | 0.0000 | |
| 125 | A | A | -0.8017 | |
| 126 | L | A | 0.0000 | |
| 127 | N | A | -2.2222 | |
| 128 | E | A | -3.4758 | |
| 129 | D | A | -3.6283 | |
| 130 | L | A | 0.0000 | |
| 131 | K | A | -3.2891 | |
| 132 | T | A | -2.0990 | |
| 133 | W | A | 0.0000 | |
| 134 | T | A | -0.2504 | |
| 135 | A | A | -0.2126 | |
| 136 | A | A | -0.4251 | |
| 137 | D | A | -0.2402 | |
| 138 | M | A | 1.0929 | |
| 139 | A | A | 0.0000 | |
| 140 | A | A | 0.0000 | |
| 141 | L | A | 0.4459 | |
| 142 | I | A | 0.2289 | |
| 143 | T | A | 0.0000 | |
| 144 | K | A | -1.1331 | |
| 145 | H | A | -2.0663 | |
| 146 | K | A | -2.2726 | |
| 147 | W | A | 0.0000 | |
| 148 | E | A | -3.0021 | |
| 149 | Q | A | -2.4873 | |
| 150 | A | A | -1.7576 | |
| 151 | G | A | -1.7389 | |
| 152 | E | A | 0.0000 | |
| 153 | A | A | 0.0000 | |
| 154 | E | A | -2.9073 | |
| 155 | R | A | -1.8701 | |
| 156 | L | A | 0.0000 | |
| 157 | R | A | -2.4593 | |
| 158 | A | A | -1.5964 | |
| 159 | Y | A | 0.0000 | |
| 160 | L | A | 0.0000 | |
| 161 | E | A | -2.7134 | |
| 162 | G | A | -1.6176 | |
| 163 | T | A | -1.2952 | |
| 164 | C | A | 0.0000 | |
| 165 | V | A | 0.0000 | |
| 166 | E | A | -2.8132 | |
| 167 | W | A | -1.5496 | |
| 168 | L | A | 0.0000 | |
| 169 | R | A | -2.7964 | |
| 170 | R | A | -2.4848 | |
| 171 | Y | A | 0.0000 | |
| 172 | L | A | -1.4157 | |
| 173 | K | A | -2.4107 | |
| 174 | N | A | -2.0183 | |
| 175 | G | A | 0.0000 | |
| 176 | N | A | -1.2428 | |
| 177 | A | A | -0.3778 | |
| 178 | T | A | -0.2952 | |
| 179 | L | A | 0.0000 | |
| 180 | L | A | 0.7253 | |
| 181 | R | A | 0.0045 | |
| 182 | T | A | -0.4604 | |
| 183 | D | A | -1.1514 | |
| 184 | S | A | -1.1177 | |
| 185 | P | A | 0.0000 | |
| 186 | K | A | -1.8028 | |
| 187 | A | A | -0.8832 | |
| 188 | H | A | -0.6543 | |
| 189 | V | A | -0.0678 | |
| 190 | T | A | -0.4570 | |
| 191 | H | A | -0.4995 | |
| 192 | H | A | -1.0587 | |
| 193 | S | A | -1.4567 | |
| 194 | R | A | -2.2023 | |
| 195 | P | A | -2.2614 | |
| 196 | E | A | -3.2272 | |
| 197 | D | A | -3.1215 | |
| 198 | K | A | -2.4035 | |
| 199 | V | A | 0.0000 | |
| 200 | T | A | 0.0000 | |
| 201 | L | A | 0.0000 | |
| 202 | R | A | -0.2621 | |
| 203 | C | A | 0.0000 | |
| 204 | W | A | 0.0000 | |
| 205 | A | A | 0.0000 | |
| 206 | L | A | 0.0000 | |
| 207 | G | A | -1.0531 | |
| 208 | F | A | 0.0000 | |
| 209 | Y | A | 0.0000 | |
| 210 | P | A | -0.9669 | |
| 211 | A | A | -1.2565 | |
| 212 | D | A | -1.8811 | |
| 213 | I | A | -0.7451 | |
| 214 | T | A | -0.1485 | |
| 215 | L | A | 0.0000 | |
| 216 | T | A | 0.0000 | |
| 217 | W | A | 0.0000 | |
| 218 | Q | A | -1.3155 | |
| 219 | L | A | -1.2173 | |
| 220 | N | A | -1.9240 | |
| 221 | G | A | -2.1659 | |
| 222 | E | A | -2.9885 | |
| 223 | E | A | -2.7040 | |
| 224 | L | A | -1.2455 | |
| 225 | I | A | 0.1584 | |
| 226 | Q | A | -1.4963 | |
| 227 | D | A | -2.1151 | |
| 228 | M | A | -1.0257 | |
| 229 | E | A | -1.1422 | |
| 230 | L | A | 0.3388 | |
| 231 | V | A | 0.0000 | |
| 232 | E | A | -0.9157 | |
| 233 | T | A | -0.7535 | |
| 234 | R | A | 0.0000 | |
| 235 | P | A | 0.0000 | |
| 236 | A | A | 0.0000 | |
| 237 | G | A | -1.2218 | |
| 238 | D | A | -1.6055 | |
| 239 | G | A | -1.2225 | |
| 240 | T | A | 0.0000 | |
| 241 | F | A | 0.0000 | |
| 242 | Q | A | 0.0000 | |
| 243 | K | A | -0.2076 | |
| 244 | W | A | 0.0000 | |
| 245 | A | A | 0.0000 | |
| 246 | S | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | V | A | -0.3252 | |
| 249 | V | A | 0.0000 | |
| 250 | P | A | -1.1372 | |
| 251 | L | A | -1.0350 | |
| 252 | G | A | -0.9242 | |
| 253 | K | A | -1.0884 | |
| 254 | E | A | -0.7400 | |
| 255 | Q | A | -0.8700 | |
| 256 | Y | A | 0.0544 | |
| 257 | Y | A | 0.0000 | |
| 258 | T | A | -0.8581 | |
| 259 | C | A | 0.0000 | |
| 260 | H | A | -0.2917 | |
| 261 | V | A | 0.0000 | |
| 262 | Y | A | -0.1320 | |
| 263 | H | A | -0.9981 | |
| 264 | Q | A | -1.7364 | |
| 265 | G | A | -1.0878 | |
| 266 | L | A | -1.0983 | |
| 267 | P | A | -1.2483 | |
| 268 | E | A | -1.8739 | |
| 269 | P | A | -0.7211 | |
| 270 | L | A | -0.1355 | |
| 271 | T | A | -0.3772 | |
| 272 | L | A | -0.4050 | |
| 273 | R | A | -1.2617 | |
| 274 | W | A | 0.1474 | |
| 1 | I | B | 0.9245 | |
| 2 | Q | B | -0.8877 | |
| 3 | K | B | -1.1620 | |
| 4 | T | B | -1.0114 | |
| 5 | P | B | 0.0000 | |
| 6 | Q | B | -0.9483 | |
| 7 | I | B | -0.3474 | |
| 8 | Q | B | -0.0739 | |
| 9 | V | B | 0.1250 | |
| 10 | Y | B | 0.0000 | |
| 11 | S | B | -0.7687 | |
| 12 | R | B | -0.9555 | |
| 13 | H | B | -1.2973 | |
| 14 | P | B | -1.5675 | |
| 15 | P | B | -2.4267 | |
| 16 | E | B | -3.4908 | |
| 17 | N | B | -3.3602 | |
| 18 | G | B | -2.5604 | |
| 19 | K | B | -2.8586 | |
| 20 | P | B | -1.9701 | |
| 21 | N | B | 0.0000 | |
| 22 | I | B | -1.0342 | |
| 23 | L | B | 0.0000 | |
| 24 | N | B | 0.0000 | |
| 25 | C | B | 0.0000 | |
| 26 | Y | B | 0.0000 | |
| 27 | V | B | 0.0000 | |
| 28 | T | B | 0.0000 | |
| 29 | Q | B | -0.9868 | |
| 30 | F | B | 0.0000 | |
| 31 | H | B | 0.0000 | |
| 32 | P | B | -0.6492 | |
| 33 | P | B | -0.7220 | |
| 34 | H | B | -1.0410 | |
| 35 | I | B | -0.9181 | |
| 36 | E | B | -1.7343 | |
| 37 | I | B | 0.0000 | |
| 38 | Q | B | -1.5170 | |
| 39 | M | B | 0.0000 | |
| 40 | L | B | 0.0000 | |
| 41 | K | B | -2.4205 | |
| 42 | N | B | -2.3985 | |
| 43 | G | B | -2.5267 | |
| 44 | K | B | -3.2915 | |
| 45 | K | B | -3.2034 | |
| 46 | I | B | -1.9960 | |
| 47 | P | B | -1.6487 | |
| 48 | K | B | -2.1016 | |
| 49 | V | B | -1.2112 | |
| 50 | E | B | -1.0772 | |
| 51 | M | B | -0.2152 | |
| 52 | S | B | 0.0000 | |
| 53 | D | B | -0.4023 | |
| 54 | M | B | 0.0000 | |
| 55 | S | B | -0.0311 | |
| 56 | F | B | 0.0000 | |
| 57 | S | B | -1.3469 | |
| 58 | K | B | -2.4293 | |
| 59 | D | B | -2.0001 | |
| 60 | W | B | 0.0000 | |
| 61 | S | B | 0.0000 | |
| 62 | F | B | 0.0000 | |
| 63 | Y | B | 0.0000 | |
| 64 | I | B | 0.1468 | |
| 65 | L | B | 0.0000 | |
| 66 | A | B | 0.0000 | |
| 67 | H | B | -0.8928 | |
| 68 | T | B | 0.0000 | |
| 69 | E | B | -2.0003 | |
| 70 | F | B | 0.0000 | |
| 71 | T | B | -1.6617 | |
| 72 | P | B | 0.0000 | |
| 73 | T | B | -2.2326 | |
| 74 | E | B | -2.6741 | |
| 75 | T | B | -1.4421 | |
| 76 | D | B | -1.5613 | |
| 77 | T | B | -1.1645 | |
| 78 | Y | B | 0.0000 | |
| 79 | A | B | 0.0000 | |
| 80 | C | B | 0.0000 | |
| 81 | R | B | -1.8391 | |
| 82 | V | B | 0.0000 | |
| 83 | K | B | -2.8442 | |
| 84 | H | B | 0.0000 | |
| 85 | D | B | -2.6736 | |
| 86 | S | B | -1.4973 | |
| 87 | M | B | -1.5437 | |
| 88 | A | B | -1.4824 | |
| 89 | E | B | -2.6003 | |
| 90 | P | B | -2.5732 | |
| 91 | K | B | -2.0388 | |
| 92 | T | B | -0.8623 | |
| 93 | V | B | 0.2365 | |
| 94 | Y | B | 0.8748 | |
| 95 | W | B | -0.3773 | |
| 96 | D | B | -2.1031 | |
| 97 | R | B | -2.4607 | |
| 98 | D | B | -2.5968 | |
| 99 | M | B | -1.4158 | |
| 1 | G | P | 0.0000 | |
| 2 | N | P | 0.0000 | |
| 3 | Y | P | 0.0000 | |
| 4 | S | P | -0.3800 | |
| 5 | F | P | 0.0000 | |
| 6 | Y | P | 1.1746 | |
| 7 | A | P | 0.3721 | |
| 8 | L | P | 0.0000 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine