Project name: 2r56

Chain sequence(s)	A: DIVMTQSPSSLSASVGDRVTITCRASQGISSRLAWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTEFTLTISSLQPEDFATYYCQQYHSYPWTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRQVSLRESGGGLVQPGRSLRLSCTASGFTFRHHGMTWVRQAPGKGLEWVASLSGSGTKTHFADSVKGRFTISRDNSNNTLYLQMDNVRDEDTAIYYCAKAKRVGATGYFDLWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKAEP
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.5797
• Maximal score value: 1.296
• Average score: -0.7639
• Total score value: -328.4742

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	D	A	-1.6766
2	I	A	0.0000
3	V	A	0.7719
4	M	A	0.0000
5	T	A	-0.7826
6	Q	A	0.0000
7	S	A	-0.8183
8	P	A	-0.5545
9	S	A	-0.6886
10	S	A	-0.4817
11	L	A	-0.1601
12	S	A	-0.6068
13	A	A	-1.1334
14	S	A	-1.4430
15	V	A	-1.0524
16	G	A	-1.5622
17	D	A	-2.8041
18	R	A	-2.7689
19	V	A	-1.1779
20	T	A	-0.4001
21	I	A	0.0000
22	T	A	-0.9583
23	C	A	0.0000
24	R	A	-2.7027
25	A	A	0.0000
26	S	A	-1.0780
27	Q	A	-1.7139
28	G	A	-1.8351
29	I	A	0.0000
30	S	A	-1.2170
31	S	A	-1.1085
32	R	A	-1.1723
33	L	A	0.0000
34	A	A	0.0000
35	W	A	0.0000
36	Y	A	0.0000
37	Q	A	0.0000
38	Q	A	-1.1461
39	K	A	-1.6952
40	P	A	-1.4667
41	G	A	-1.7013
42	K	A	-2.6574
43	A	A	-1.8260
44	P	A	0.0000
45	K	A	-1.3662
46	L	A	0.0000
47	L	A	0.0000
48	I	A	0.0000
49	Y	A	0.2477
50	A	A	-0.1820
51	A	A	0.0000
52	S	A	-0.1576
53	S	A	0.1772
54	L	A	0.4080
55	Q	A	0.0000
56	S	A	-0.3206
57	G	A	-0.4525
58	V	A	-0.2632
59	P	A	-0.3076
60	S	A	-0.4270
61	R	A	-0.7808
62	F	A	0.0000
63	S	A	-0.3241
64	G	A	-0.2614
65	S	A	-0.8321
66	G	A	-1.5523
67	S	A	-1.6507
68	G	A	-1.7360
69	T	A	-2.2729
70	E	A	-2.9414
71	F	A	0.0000
72	T	A	-0.9393
73	L	A	0.0000
74	T	A	-0.6027
75	I	A	0.0000
76	S	A	-1.6584
77	S	A	-1.7270
78	L	A	0.0000
79	Q	A	-1.4193
80	P	A	-1.9888
81	E	A	-2.3523
82	D	A	0.0000
83	F	A	0.0000
84	A	A	0.0000
85	T	A	-0.4736
86	Y	A	0.0000
87	Y	A	-0.2968
88	C	A	0.0000
89	Q	A	0.0000
90	Q	A	0.0000
91	Y	A	-0.4852
92	H	A	-1.3360
93	S	A	-0.8656
94	Y	A	0.0000
95	P	A	-0.8653
96	W	A	0.0000
97	T	A	-0.0383
98	F	A	0.1600
99	G	A	0.0000
100	Q	A	-1.2551
101	G	A	0.0000
102	T	A	0.0000
103	K	A	-0.6527
104	L	A	0.0000
105	E	A	-0.9661
106	I	A	0.0000
107	K	A	-1.8298
108	R	A	-1.0945
109	T	A	0.0915
110	V	A	1.1209
111	A	A	0.4268
112	A	A	0.0513
113	P	A	0.0000
114	S	A	-0.2718
115	V	A	-0.0622
116	F	A	0.0000
117	I	A	0.0000
118	F	A	0.0000
119	P	A	-0.3718
120	P	A	-0.5029
121	S	A	-1.3192
122	D	A	-2.3946
123	E	A	-1.7239
124	Q	A	0.0000
125	L	A	-1.5566
126	K	A	-2.3684
127	S	A	-1.3878
128	G	A	-1.2176
129	T	A	-0.9168
130	A	A	0.0000
131	S	A	0.0000
132	V	A	0.0000
133	V	A	0.0000
134	C	A	0.0000
135	L	A	0.0000
136	L	A	0.0000
137	N	A	-0.5657
138	N	A	-0.9514
139	F	A	0.0000
140	Y	A	-0.6582
141	P	A	-1.1301
142	R	A	-1.7315
143	E	A	-2.8770
144	A	A	0.0000
145	K	A	-2.6088
146	V	A	-1.3551
147	Q	A	-0.9585
148	W	A	0.0000
149	K	A	-0.6786
150	V	A	0.0000
151	D	A	-2.4430
152	N	A	-1.6110
153	A	A	-0.3423
154	L	A	0.6400
155	Q	A	-0.3191
156	S	A	-0.3295
157	G	A	-0.8881
158	N	A	-1.0299
159	S	A	-1.1084
160	Q	A	-1.0813
161	E	A	-1.6151
162	S	A	-0.4170
163	V	A	0.1363
164	T	A	-0.3469
165	E	A	-1.0700
166	Q	A	0.0000
167	D	A	-3.0283
168	S	A	-2.6439
169	K	A	-2.7130
170	D	A	-1.9447
171	S	A	0.0000
172	T	A	-1.2421
173	Y	A	0.0000
174	S	A	0.0000
175	L	A	0.0000
176	S	A	0.0000
177	S	A	0.0000
178	T	A	0.0000
179	L	A	0.0000
180	T	A	-0.4277
181	L	A	-0.6464
182	S	A	-0.8966
183	K	A	-1.9236
184	A	A	-1.5374
185	D	A	-2.2213
186	Y	A	-2.3547
187	E	A	-3.4615
188	K	A	-3.5797
189	H	A	-3.2678
190	K	A	-2.9876
191	V	A	-1.9708
192	Y	A	0.0000
193	A	A	0.0000
194	C	A	0.0000
195	E	A	-0.7779
196	V	A	0.0000
197	T	A	-1.0495
198	H	A	0.0000
199	Q	A	-1.7502
200	G	A	-0.4548
201	L	A	0.0859
202	S	A	-0.3010
203	S	A	-0.1365
204	P	A	-0.0256
205	V	A	0.4645
206	T	A	-0.1174
207	K	A	-0.4095
208	S	A	-0.5134
209	F	A	-0.5409
210	N	A	-1.5118
1	Q	A	-0.7940
2	V	A	0.4058
3	S	A	-0.4939
4	L	A	0.0000
5	R	A	-2.5352
6	E	A	-1.7410
7	S	A	-1.2629
8	G	A	-0.8595
9	G	A	-0.3865
10	G	A	-0.3539
11	L	A	-0.0371
12	V	A	-0.9569
13	Q	A	-2.2328
14	P	A	-2.4544
15	G	A	-2.7381
16	R	A	-3.1564
17	S	A	-2.3855
18	L	A	-1.5332
19	R	A	-1.4654
20	L	A	0.0000
21	S	A	-0.9431
22	C	A	0.0000
23	T	A	-1.2371
24	A	A	0.0000
25	S	A	-0.4949
26	G	A	-0.3010
27	F	A	-0.4016
28	T	A	-0.9253
29	F	A	0.0000
30	R	A	-2.6424
31	H	A	-2.1629
32	H	A	-1.6116
33	G	A	0.0000
34	M	A	0.0000
35	T	A	0.0000
36	W	A	0.0000
37	V	A	0.0000
38	R	A	0.0000
39	Q	A	-0.5923
40	A	A	-1.2479
41	P	A	-0.9530
42	G	A	-1.4701
43	K	A	-2.3521
44	G	A	-1.5252
45	L	A	0.0000
46	E	A	-0.7037
47	W	A	0.0000
48	V	A	0.0000
49	A	A	0.0000
50	S	A	0.0000
51	L	A	0.0000
52	S	A	-1.2333
53	G	A	0.0000
54	S	A	-1.3854
55	G	A	-1.4374
56	T	A	-1.0927
57	K	A	-1.9560
58	T	A	-1.0447
59	H	A	-0.9722
60	F	A	-0.9205
61	A	A	0.0000
62	D	A	-2.4546
63	S	A	-1.7602
64	V	A	0.0000
65	K	A	-2.6429
66	G	A	-1.8225
67	R	A	-1.7612
68	F	A	0.0000
69	T	A	-0.8335
70	I	A	-0.3447
71	S	A	-0.8680
72	R	A	-2.2607
73	D	A	-2.3262
74	N	A	-2.6924
75	S	A	-1.7190
76	N	A	-2.2698
77	N	A	-2.0469
78	T	A	-1.6646
79	L	A	0.0000
80	Y	A	-0.6990
81	L	A	0.0000
82	Q	A	-1.1786
83	M	A	0.0000
84	D	A	-2.5924
85	N	A	-2.9822
86	V	A	0.0000
87	R	A	-3.5496
88	D	A	-3.3967
89	E	A	-3.0785
90	D	A	0.0000
91	T	A	-1.2826
92	A	A	0.0000
93	I	A	0.3730
94	Y	A	0.0000
95	Y	A	0.0000
96	C	A	0.0000
97	A	A	0.0000
98	K	A	0.0000
99	A	A	0.0000
100	K	A	-1.6627
101	R	A	-2.0835
102	V	A	-0.9946
103	G	A	-0.7900
104	A	A	-0.5288
105	T	A	-0.4187
106	G	A	0.0000
107	Y	A	0.0358
108	F	A	0.0000
109	D	A	-0.7495
110	L	A	-0.0362
111	W	A	0.0000
112	G	A	0.0000
113	R	A	-2.7831
114	G	A	-1.4694
115	T	A	-0.5974
116	L	A	0.3237
117	V	A	0.0000
118	T	A	-0.7453
119	V	A	0.0000
120	S	A	-1.0226
121	S	A	-0.6092
122	A	A	-0.5171
123	S	A	-0.6968
124	T	A	-0.8154
125	K	A	-1.5856
126	G	A	-1.6288
127	P	A	0.0000
128	S	A	-0.6997
129	V	A	0.0000
130	F	A	-0.5681
131	P	A	-1.0215
132	L	A	0.0000
133	A	A	-0.7566
134	P	A	-0.6315
135	S	A	-0.7950
136	S	A	-1.0523
137	K	A	-1.9398
138	S	A	-1.2221
139	T	A	-1.0046
140	S	A	-1.1114
141	G	A	-1.0856
142	G	A	-0.9053
143	T	A	-0.6230
144	A	A	0.0000
145	A	A	0.0000
146	L	A	0.0000
147	G	A	0.0000
148	C	A	0.0000
149	L	A	0.0000
150	V	A	0.0000
151	K	A	0.0000
152	D	A	-0.5751
153	Y	A	0.0000
154	F	A	-0.3389
155	P	A	0.0000
156	E	A	-0.3435
157	P	A	-0.6021
158	V	A	-0.6222
159	T	A	-0.6870
160	V	A	-0.1324
161	S	A	-0.4156
162	W	A	0.0000
163	N	A	-0.7884
164	S	A	-0.6423
165	G	A	-0.5954
166	A	A	-0.2436
167	L	A	-0.0230
168	T	A	-0.1501
169	S	A	-0.2167
170	G	A	-0.2786
171	V	A	0.0658
172	H	A	-0.2857
173	T	A	-0.0309
174	F	A	0.0000
175	P	A	-0.0119
176	A	A	0.3025
177	V	A	0.6269
178	L	A	1.2960
179	Q	A	0.3616
180	S	A	-0.0224
181	S	A	-0.1820
182	G	A	0.1592
183	L	A	0.1288
184	Y	A	0.4356
185	S	A	0.0000
186	L	A	0.0000
187	S	A	0.0000
188	S	A	0.0000
189	V	A	0.0000
190	V	A	0.0000
191	T	A	-0.1920
192	V	A	0.0000
193	P	A	-0.5465
194	S	A	-0.5608
195	S	A	-0.6229
196	S	A	-0.5633
197	L	A	-0.7372
198	G	A	-1.1158
199	T	A	-0.8327
200	Q	A	-1.5653
201	T	A	-1.2359
202	Y	A	0.0000
203	I	A	-1.0770
204	C	A	0.0000
205	N	A	-1.2482
206	V	A	0.0000
207	N	A	-2.0260
208	H	A	0.0000
209	K	A	-2.7359
210	P	A	-1.6673
211	S	A	-1.9185
212	N	A	-2.5288
213	T	A	-2.1027
214	K	A	-2.4613
215	V	A	-1.0153
216	D	A	-1.7938
217	K	A	-1.6071
218	K	A	-2.0176
219	A	A	0.0000
220	E	A	-2.3295