| Chain sequence(s) |
A: QVQLQESGPGLVKPSETLSLTCTVSGGSISSGYWNWIRQPPGKGLEWIGTISYSGDTYYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARYGSYVFQYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVES B: DIVMTQTPLSLSVTPGQPASISCRSSQSLLHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCSQSTHVPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Q | A | -1.5434 | |
| 2 | V | A | -1.2607 | |
| 3 | Q | A | -1.9583 | |
| 4 | L | A | 0.0000 | |
| 5 | Q | A | -1.8529 | |
| 6 | E | A | 0.0000 | |
| 7 | S | A | -0.7712 | |
| 8 | G | A | -0.6200 | |
| 9 | P | A | -0.6446 | |
| 10 | G | A | -0.5231 | |
| 11 | L | A | -0.4961 | |
| 12 | V | A | 0.0000 | |
| 13 | K | A | -2.1552 | |
| 14 | P | A | -1.4478 | |
| 15 | S | A | -1.2316 | |
| 16 | E | A | -1.5760 | |
| 17 | T | A | -1.2457 | |
| 18 | L | A | 0.0000 | |
| 19 | S | A | -0.9556 | |
| 20 | L | A | 0.0000 | |
| 21 | T | A | -0.6963 | |
| 22 | C | A | 0.0000 | |
| 23 | T | A | -1.1449 | |
| 24 | V | A | 0.0000 | |
| 25 | S | A | -1.2348 | |
| 26 | G | A | -1.2554 | |
| 27 | G | A | -1.0441 | |
| 28 | S | A | -0.8256 | |
| 29 | I | A | 0.0000 | |
| 30 | S | A | -0.2060 | |
| 31 | S | A | 0.0172 | |
| 32 | G | A | 0.2101 | |
| 33 | Y | A | 0.2887 | |
| 34 | W | A | 0.0000 | |
| 35 | N | A | 0.0000 | |
| 36 | W | A | 0.0000 | |
| 37 | I | A | 0.0000 | |
| 38 | R | A | 0.0000 | |
| 39 | Q | A | -0.8016 | |
| 40 | P | A | -0.9910 | |
| 41 | P | A | -1.1109 | |
| 42 | G | A | -1.4999 | |
| 43 | K | A | -2.3779 | |
| 44 | G | A | -1.5438 | |
| 45 | L | A | 0.0000 | |
| 46 | E | A | -0.6569 | |
| 47 | W | A | 0.0000 | |
| 48 | I | A | 0.0000 | |
| 49 | G | A | 0.0000 | |
| 50 | T | A | 0.0000 | |
| 51 | I | A | 0.0000 | |
| 52 | S | A | 0.0439 | |
| 53 | Y | A | 0.5867 | |
| 54 | S | A | -0.4375 | |
| 55 | G | A | -0.9417 | |
| 56 | D | A | -1.5434 | |
| 57 | T | A | -0.3323 | |
| 58 | Y | A | 0.8098 | |
| 59 | Y | A | 0.5245 | |
| 60 | N | A | 0.0000 | |
| 61 | P | A | -0.8680 | |
| 62 | S | A | -1.1323 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.0185 | |
| 65 | S | A | -1.2795 | |
| 66 | R | A | -1.3889 | |
| 67 | V | A | 0.0000 | |
| 68 | T | A | -0.6046 | |
| 69 | I | A | 0.0000 | |
| 70 | S | A | -0.6305 | |
| 71 | V | A | -0.2924 | |
| 72 | D | A | -1.1888 | |
| 73 | T | A | -1.1487 | |
| 74 | S | A | -1.3409 | |
| 75 | K | A | -2.1423 | |
| 76 | N | A | -1.4597 | |
| 77 | Q | A | -1.2633 | |
| 78 | F | A | 0.0000 | |
| 79 | S | A | -0.5284 | |
| 80 | L | A | 0.0000 | |
| 81 | K | A | -1.6854 | |
| 82 | L | A | 0.0000 | |
| 83 | S | A | -1.0237 | |
| 84 | S | A | -0.9014 | |
| 85 | V | A | 0.0000 | |
| 86 | T | A | -0.5506 | |
| 87 | A | A | -0.2069 | |
| 88 | A | A | 0.0288 | |
| 89 | D | A | 0.0000 | |
| 90 | T | A | 0.0316 | |
| 91 | A | A | 0.0000 | |
| 92 | V | A | 0.1147 | |
| 93 | Y | A | 0.0000 | |
| 94 | Y | A | 0.0000 | |
| 95 | C | A | 0.0000 | |
| 96 | A | A | 0.0000 | |
| 97 | R | A | -0.1776 | |
| 98 | Y | A | 0.1876 | |
| 99 | G | A | 0.0816 | |
| 100 | S | A | -0.0225 | |
| 101 | Y | A | 0.3628 | |
| 102 | V | A | 0.0000 | |
| 103 | F | A | 0.0000 | |
| 104 | Q | A | -0.2180 | |
| 105 | Y | A | -0.5811 | |
| 106 | W | A | 0.0000 | |
| 107 | G | A | 0.0000 | |
| 108 | Q | A | -1.8505 | |
| 109 | G | A | 0.0000 | |
| 110 | T | A | -0.5088 | |
| 111 | T | A | -0.2134 | |
| 112 | V | A | 0.0000 | |
| 113 | T | A | -0.2908 | |
| 114 | V | A | 0.0000 | |
| 115 | S | A | -0.8333 | |
| 116 | S | A | -0.9407 | |
| 117 | A | A | -0.5494 | |
| 118 | S | A | -0.6645 | |
| 119 | T | A | -0.7517 | |
| 120 | K | A | -1.1954 | |
| 121 | G | A | -1.3211 | |
| 122 | P | A | -0.6128 | |
| 123 | S | A | -0.4879 | |
| 124 | V | A | 0.0000 | |
| 125 | F | A | 0.0000 | |
| 126 | P | A | -1.3712 | |
| 127 | L | A | 0.0000 | |
| 128 | A | A | -0.8875 | |
| 129 | P | A | 0.0000 | |
| 130 | C | A | -0.4142 | |
| 131 | S | A | -0.5118 | |
| 132 | R | A | -0.8711 | |
| 133 | S | A | 0.0000 | |
| 134 | T | A | -0.8719 | |
| 135 | S | A | -1.3520 | |
| 136 | E | A | -2.0794 | |
| 137 | S | A | -1.3122 | |
| 138 | T | A | -0.9408 | |
| 139 | A | A | 0.0000 | |
| 140 | A | A | 0.0000 | |
| 141 | L | A | 0.0000 | |
| 142 | G | A | 0.0000 | |
| 143 | C | A | 0.0000 | |
| 144 | L | A | 0.0000 | |
| 145 | V | A | 0.0000 | |
| 146 | K | A | -0.2797 | |
| 147 | D | A | -0.3681 | |
| 148 | Y | A | 0.0000 | |
| 149 | F | A | 0.0000 | |
| 150 | P | A | 0.0000 | |
| 151 | E | A | -0.5190 | |
| 152 | P | A | -0.6726 | |
| 153 | V | A | -0.6089 | |
| 154 | T | A | -0.5265 | |
| 155 | V | A | -0.3248 | |
| 156 | S | A | -0.4570 | |
| 157 | W | A | 0.0000 | |
| 158 | N | A | -1.0250 | |
| 159 | S | A | -0.7695 | |
| 160 | G | A | -0.5961 | |
| 161 | A | A | -0.2860 | |
| 162 | L | A | -0.1406 | |
| 163 | T | A | -0.2500 | |
| 164 | S | A | -0.2763 | |
| 165 | G | A | -0.3956 | |
| 166 | V | A | 0.0649 | |
| 167 | H | A | -0.2477 | |
| 168 | T | A | 0.0018 | |
| 169 | F | A | 0.0000 | |
| 170 | P | A | -0.2902 | |
| 171 | A | A | 0.3223 | |
| 172 | V | A | 0.7188 | |
| 173 | L | A | 1.4076 | |
| 174 | Q | A | 0.3856 | |
| 175 | S | A | 0.0079 | |
| 176 | S | A | -0.1556 | |
| 177 | G | A | 0.1312 | |
| 178 | L | A | 0.2372 | |
| 179 | Y | A | 0.5255 | |
| 180 | S | A | 0.0000 | |
| 181 | L | A | 0.0000 | |
| 182 | S | A | 0.0000 | |
| 183 | S | A | 0.0000 | |
| 184 | V | A | 0.0000 | |
| 185 | V | A | 0.0000 | |
| 186 | T | A | -0.1898 | |
| 187 | V | A | 0.0000 | |
| 188 | P | A | -0.6409 | |
| 189 | S | A | -0.6854 | |
| 190 | S | A | -0.5495 | |
| 191 | S | A | -0.6600 | |
| 192 | L | A | -0.8161 | |
| 193 | G | A | -1.1693 | |
| 194 | T | A | -0.8943 | |
| 195 | K | A | -1.6203 | |
| 196 | T | A | -1.4834 | |
| 197 | Y | A | 0.0000 | |
| 198 | T | A | 0.0000 | |
| 199 | C | A | 0.0000 | |
| 200 | N | A | -1.7354 | |
| 201 | V | A | 0.0000 | |
| 202 | D | A | -1.8044 | |
| 203 | H | A | 0.0000 | |
| 204 | K | A | -2.6927 | |
| 205 | P | A | -1.6490 | |
| 206 | S | A | -1.8334 | |
| 207 | N | A | -2.5174 | |
| 208 | T | A | -2.0466 | |
| 209 | K | A | -2.6445 | |
| 210 | V | A | -1.9956 | |
| 211 | D | A | -2.9334 | |
| 212 | K | A | -2.7101 | |
| 213 | R | A | -3.1176 | |
| 214 | V | A | 0.0000 | |
| 215 | E | A | -2.6198 | |
| 216 | S | A | -1.0942 | |
| 217 | D | B | -1.2308 | |
| 218 | I | B | -0.1775 | |
| 219 | V | B | 0.7789 | |
| 220 | M | B | 0.0000 | |
| 221 | T | B | -0.4090 | |
| 222 | Q | B | 0.0000 | |
| 223 | T | B | -0.3262 | |
| 224 | P | B | -0.2304 | |
| 225 | L | B | 0.0511 | |
| 226 | S | B | -0.5006 | |
| 227 | L | B | -0.6329 | |
| 228 | S | B | -0.9751 | |
| 229 | V | B | 0.0000 | |
| 230 | T | B | -1.6506 | |
| 231 | P | B | -2.0811 | |
| 232 | G | B | -1.9292 | |
| 233 | Q | B | -2.3060 | |
| 234 | P | B | -2.1256 | |
| 235 | A | B | -1.2580 | |
| 236 | S | B | -0.7689 | |
| 237 | I | B | 0.0000 | |
| 238 | S | B | -0.8108 | |
| 239 | C | B | 0.0000 | |
| 240 | R | B | -1.8434 | |
| 241 | S | B | 0.0000 | |
| 242 | S | B | -0.7894 | |
| 243 | Q | B | -1.3342 | |
| 244 | S | B | -0.6761 | |
| 245 | L | B | 0.0000 | |
| 246 | L | B | 0.5209 | |
| 247 | H | B | -0.6044 | |
| 248 | S | B | -0.9348 | |
| 249 | N | B | -1.6460 | |
| 250 | G | B | -1.1394 | |
| 251 | N | B | -0.9742 | |
| 252 | T | B | -0.2719 | |
| 253 | Y | B | 0.0000 | |
| 254 | L | B | 0.0000 | |
| 255 | H | B | 0.0000 | |
| 256 | W | B | 0.0000 | |
| 257 | Y | B | 0.0000 | |
| 258 | L | B | 0.0000 | |
| 259 | Q | B | -1.1473 | |
| 260 | K | B | -1.8400 | |
| 261 | P | B | -1.4278 | |
| 262 | G | B | -1.6427 | |
| 263 | Q | B | -2.0399 | |
| 264 | S | B | -1.4108 | |
| 265 | P | B | 0.0000 | |
| 266 | Q | B | -1.3279 | |
| 267 | L | B | 0.0000 | |
| 268 | L | B | 0.0000 | |
| 269 | I | B | 0.0000 | |
| 270 | Y | B | -0.3394 | |
| 271 | K | B | -0.8302 | |
| 272 | V | B | 0.0000 | |
| 273 | S | B | -0.7875 | |
| 274 | N | B | -0.9677 | |
| 275 | R | B | -1.2122 | |
| 276 | F | B | -0.3665 | |
| 277 | S | B | -0.4375 | |
| 278 | G | B | -0.7190 | |
| 279 | V | B | -0.7698 | |
| 280 | P | B | -1.2532 | |
| 281 | D | B | -2.2507 | |
| 282 | R | B | -2.2636 | |
| 283 | F | B | 0.0000 | |
| 284 | S | B | -1.2765 | |
| 285 | G | B | -0.8143 | |
| 286 | S | B | -0.7719 | |
| 287 | G | B | -0.9118 | |
| 288 | S | B | -0.5793 | |
| 289 | G | B | -0.5472 | |
| 290 | T | B | -1.2233 | |
| 291 | D | B | -1.7653 | |
| 292 | F | B | 0.0000 | |
| 293 | T | B | -0.9379 | |
| 294 | L | B | 0.0000 | |
| 295 | K | B | -1.6109 | |
| 296 | I | B | 0.0000 | |
| 297 | S | B | -2.3557 | |
| 298 | R | B | -3.1031 | |
| 299 | V | B | 0.0000 | |
| 300 | E | B | -2.8012 | |
| 301 | A | B | -2.5171 | |
| 302 | E | B | -2.9317 | |
| 303 | D | B | 0.0000 | |
| 304 | V | B | 0.0000 | |
| 305 | G | B | 0.0000 | |
| 306 | V | B | -0.7371 | |
| 307 | Y | B | 0.0000 | |
| 308 | Y | B | 0.0000 | |
| 309 | C | B | 0.0000 | |
| 310 | S | B | 0.0000 | |
| 311 | Q | B | 0.0000 | |
| 312 | S | B | 0.0000 | |
| 313 | T | B | 0.0000 | |
| 314 | H | B | -0.0742 | |
| 315 | V | B | 0.8834 | |
| 316 | P | B | 0.3492 | |
| 317 | W | B | 0.0000 | |
| 318 | T | B | 0.1183 | |
| 319 | F | B | 0.1184 | |
| 320 | G | B | 0.0000 | |
| 321 | Q | B | -1.2994 | |
| 322 | G | B | 0.0000 | |
| 323 | T | B | 0.0000 | |
| 324 | K | B | -1.7681 | |
| 325 | V | B | 0.0000 | |
| 326 | E | B | -1.6245 | |
| 327 | I | B | 0.0000 | |
| 328 | K | B | -1.5308 | |
| 329 | R | B | -1.0821 | |
| 330 | T | B | -0.1903 | |
| 331 | V | B | 0.0578 | |
| 332 | A | B | -0.2148 | |
| 333 | A | B | -0.2129 | |
| 334 | P | B | 0.0000 | |
| 335 | S | B | -0.1437 | |
| 336 | V | B | -0.1747 | |
| 337 | F | B | 0.0000 | |
| 338 | I | B | 0.0000 | |
| 339 | F | B | 0.0000 | |
| 340 | P | B | -0.6979 | |
| 341 | P | B | 0.0000 | |
| 342 | S | B | -1.6038 | |
| 343 | D | B | -3.0849 | |
| 344 | E | B | -3.0094 | |
| 345 | Q | B | 0.0000 | |
| 346 | L | B | -2.2617 | |
| 347 | K | B | -2.7992 | |
| 348 | S | B | -1.8029 | |
| 349 | G | B | -1.1000 | |
| 350 | T | B | -1.1407 | |
| 351 | A | B | 0.0000 | |
| 352 | S | B | 0.0000 | |
| 353 | V | B | 0.0000 | |
| 354 | V | B | 0.0000 | |
| 355 | C | B | 0.0000 | |
| 356 | L | B | 0.0000 | |
| 357 | L | B | 0.0000 | |
| 358 | N | B | 0.0000 | |
| 359 | N | B | -1.0706 | |
| 360 | F | B | 0.0000 | |
| 361 | Y | B | 0.0000 | |
| 362 | P | B | -1.8589 | |
| 363 | R | B | -3.1955 | |
| 364 | E | B | -3.2813 | |
| 365 | A | B | -2.4359 | |
| 366 | K | B | -2.5584 | |
| 367 | V | B | 0.0000 | |
| 368 | Q | B | -0.7579 | |
| 369 | W | B | 0.0000 | |
| 370 | K | B | -0.8225 | |
| 371 | V | B | 0.0000 | |
| 372 | D | B | -2.1507 | |
| 373 | N | B | -1.6795 | |
| 374 | A | B | -0.4000 | |
| 375 | L | B | 0.6691 | |
| 376 | Q | B | -0.2264 | |
| 377 | S | B | -0.4847 | |
| 378 | G | B | -0.8919 | |
| 379 | N | B | -0.7939 | |
| 380 | S | B | -1.0425 | |
| 381 | Q | B | -1.1703 | |
| 382 | E | B | -1.4162 | |
| 383 | S | B | -0.5964 | |
| 384 | V | B | -0.6856 | |
| 385 | T | B | -1.2635 | |
| 386 | E | B | -2.3410 | |
| 387 | Q | B | 0.0000 | |
| 388 | D | B | -2.2890 | |
| 389 | S | B | -2.5722 | |
| 390 | K | B | -2.8105 | |
| 391 | D | B | -1.9326 | |
| 392 | S | B | 0.0000 | |
| 393 | T | B | 0.0000 | |
| 394 | Y | B | 0.0000 | |
| 395 | S | B | 0.0000 | |
| 396 | L | B | 0.0000 | |
| 397 | S | B | 0.0000 | |
| 398 | S | B | 0.0000 | |
| 399 | T | B | -0.5218 | |
| 400 | L | B | 0.0000 | |
| 401 | T | B | -0.4533 | |
| 402 | L | B | -0.8196 | |
| 403 | S | B | -1.4312 | |
| 404 | K | B | -2.2598 | |
| 405 | A | B | -2.2071 | |
| 406 | D | B | -3.0433 | |
| 407 | Y | B | 0.0000 | |
| 408 | E | B | -3.8409 | |
| 409 | K | B | -3.8839 | |
| 410 | H | B | -3.3339 | |
| 411 | K | B | -3.4524 | |
| 412 | V | B | -2.1891 | |
| 413 | Y | B | 0.0000 | |
| 414 | A | B | -0.8836 | |
| 415 | C | B | 0.0000 | |
| 416 | E | B | -0.8842 | |
| 417 | V | B | 0.0000 | |
| 418 | T | B | -1.2596 | |
| 419 | H | B | 0.0000 | |
| 420 | Q | B | -1.8258 | |
| 421 | G | B | -0.5655 | |
| 422 | L | B | -0.3203 | |
| 423 | S | B | -0.4470 | |
| 424 | S | B | -0.4412 | |
| 425 | P | B | -0.5643 | |
| 426 | V | B | 0.0708 | |
| 427 | T | B | -0.4533 | |
| 428 | K | B | -0.7942 | |
| 429 | S | B | -1.0326 | |
| 430 | F | B | 0.0000 | |
| 431 | N | B | -2.5518 | |
| 432 | R | B | -2.9672 | |
| 433 | G | B | -2.3178 | |
| 434 | E | B | -2.2377 | |
| 435 | C | B | -0.7202 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine