Project name: 588539caac7b6fe

Chain sequence(s)	A: MERRRITSAARREYVSSGEMMVGGLAPGRRLGPGTRLSLARMPPPLPTRVDFSLAGALNAGFKETRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTKLADVYQAELRELRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEATLARLDLERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKPDLTAALKEIRTQYEAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGTNESLERQMREQEERHVREAAEYQEALARLEEEGQELKDEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEENRITIPVQTFSNLQIRETSLDTKSVSEGHLKRNIVVKTVEMRDGEVIKESKQEHKDVM
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.191
• Maximal score value: 2.2058
• Average score: -1.0303
• Total score value: -445.1001

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	M	A	-0.4000
2	E	A	-2.5440
3	R	A	-2.7895
4	R	A	-2.4303
5	R	A	-1.4736
6	I	A	0.2303
7	T	A	-0.4148
8	S	A	-0.4551
9	A	A	-1.0644
10	A	A	-1.2491
11	R	A	-1.6536
12	R	A	-1.6319
13	E	A	-1.0077
14	Y	A	-0.6534
15	V	A	-0.0148
16	S	A	-0.5181
17	S	A	-0.3668
18	G	A	-1.2004
19	E	A	-1.6955
20	M	A	-0.0203
21	M	A	0.2855
22	V	A	1.5688
23	G	A	0.6832
24	G	A	0.0000
25	L	A	0.5618
26	A	A	0.0000
27	P	A	-0.2543
28	G	A	0.0000
29	R	A	-0.4691
30	R	A	-1.1128
31	L	A	0.0000
32	G	A	0.0000
33	P	A	-0.1817
34	G	A	0.0000
35	T	A	0.0000
36	R	A	0.0000
37	L	A	0.0000
38	S	A	0.0000
39	L	A	0.0000
40	A	A	0.0000
41	R	A	-0.4658
42	M	A	-0.0698
43	P	A	0.0000
44	P	A	0.0000
45	P	A	-0.6789
46	L	A	-0.3059
47	P	A	0.0805
48	T	A	0.1119
49	R	A	-0.4238
50	V	A	0.2377
51	D	A	-1.0728
52	F	A	0.2801
53	S	A	0.0000
54	L	A	1.3511
55	A	A	0.5366
56	G	A	-0.2858
57	A	A	-0.2640
58	L	A	0.0000
59	N	A	-0.9605
60	A	A	-1.1966
61	G	A	0.0000
62	F	A	-1.7401
63	K	A	-3.2367
64	E	A	-3.3111
65	T	A	-2.6767
66	R	A	-3.3418
67	A	A	-2.2456
68	S	A	-2.7302
69	E	A	-3.3202
70	R	A	-2.9216
71	A	A	-2.1941
72	E	A	-2.6475
73	M	A	-1.9078
74	M	A	-1.4822
75	E	A	-2.1987
76	L	A	0.0000
77	N	A	0.0000
78	D	A	-1.9650
79	R	A	-1.6616
80	F	A	0.0000
81	A	A	-1.0603
82	S	A	-1.1177
83	Y	A	-1.3100
84	I	A	-1.0872
85	E	A	-2.3777
86	K	A	-2.3821
87	V	A	0.0000
88	R	A	-1.4580
89	F	A	0.2127
90	L	A	-0.6953
91	E	A	0.0000
92	Q	A	-1.4105
93	Q	A	-1.2750
94	N	A	-0.9837
95	K	A	-1.7487
96	A	A	-1.1146
97	L	A	-1.2217
98	A	A	0.0000
99	A	A	-1.5794
100	E	A	-1.5898
101	L	A	0.0000
102	N	A	-2.2718
103	Q	A	-2.1015
104	L	A	-1.6169
105	R	A	-2.1906
106	A	A	-1.8255
107	K	A	-2.6100
108	E	A	-2.2071
109	P	A	-1.1036
110	T	A	-0.8266
111	K	A	-0.8975
112	L	A	0.9301
113	A	A	0.2757
114	D	A	-0.6887
115	V	A	0.8210
116	Y	A	-0.4087
117	Q	A	-1.6641
118	A	A	-1.6055
119	E	A	-2.0356
120	L	A	0.0000
121	R	A	-3.3921
122	E	A	-2.7028
123	L	A	0.0000
124	R	A	-3.2387
125	L	A	-1.6000
126	R	A	-1.8246
127	L	A	0.0000
128	D	A	-2.6173
129	Q	A	-1.9911
130	L	A	0.0000
131	T	A	-1.3977
132	A	A	-1.4819
133	N	A	0.0000
134	S	A	-1.1294
135	A	A	-1.2170
136	R	A	-1.9245
137	L	A	0.0000
138	E	A	-2.5217
139	V	A	-1.0972
140	E	A	-2.3006
141	R	A	-2.4614
142	D	A	-2.9297
143	N	A	-2.6353
144	L	A	-1.7699
145	A	A	-1.8415
146	Q	A	-2.1881
147	D	A	-1.1362
148	L	A	0.0000
149	A	A	-1.7547
150	T	A	-1.3596
151	V	A	-1.7120
152	R	A	-2.9289
153	Q	A	-2.8050
154	K	A	-2.9542
155	L	A	-2.5397
156	Q	A	-3.2860
157	D	A	-3.4076
158	E	A	-3.2619
159	T	A	-2.4027
160	N	A	-2.3581
161	L	A	-0.9967
162	R	A	-0.9113
163	L	A	-1.0709
164	E	A	-1.9286
165	A	A	-0.6900
166	E	A	0.0000
167	N	A	-0.6874
168	N	A	-0.8124
169	L	A	0.0000
170	A	A	0.0000
171	A	A	-0.5364
172	Y	A	0.1181
173	R	A	-1.6910
174	Q	A	-2.4737
175	E	A	-3.2883
176	A	A	-2.8060
177	D	A	-3.1622
178	E	A	-2.4500
179	A	A	0.0000
180	T	A	-0.0917
181	L	A	0.9405
182	A	A	-0.1278
183	R	A	0.0000
184	L	A	-0.2527
185	D	A	-1.9403
186	L	A	0.0000
187	E	A	-2.3143
188	R	A	-3.4131
189	K	A	-2.3113
190	I	A	-1.8231
191	E	A	-3.1521
192	S	A	-1.7367
193	L	A	0.0000
194	E	A	-1.3817
195	E	A	-1.7130
196	E	A	-1.2852
197	I	A	0.0000
198	R	A	-1.0826
199	F	A	-0.5710
200	L	A	0.0000
201	R	A	0.0000
202	K	A	0.0000
203	I	A	-0.2385
204	H	A	-1.4001
205	E	A	-1.6145
206	E	A	-1.0328
207	E	A	-0.6330
208	V	A	0.0000
209	R	A	0.0000
210	E	A	-0.1358
211	L	A	-0.2471
212	Q	A	-0.7646
213	E	A	-1.5128
214	Q	A	-0.2628
215	L	A	0.6104
216	A	A	-0.3980
217	R	A	-1.3774
218	Q	A	-1.4205
219	Q	A	0.0000
220	V	A	0.5934
221	H	A	-0.6024
222	V	A	-0.8110
223	E	A	-1.3396
224	L	A	0.0000
225	D	A	-1.4787
226	V	A	-0.3926
227	A	A	-0.5148
228	K	A	0.0000
229	P	A	0.0000
230	D	A	-0.3976
231	L	A	0.0000
232	T	A	-0.4456
233	A	A	-0.4769
234	A	A	-0.5805
235	L	A	-1.2977
236	K	A	-1.9785
237	E	A	-2.1251
238	I	A	-0.6235
239	R	A	-1.2722
240	T	A	-0.7292
241	Q	A	0.0296
242	Y	A	0.9358
243	E	A	0.0371
244	A	A	-0.2484
245	M	A	-0.6115
246	A	A	0.0000
247	S	A	-0.4686
248	S	A	-1.1071
249	N	A	-1.5839
250	M	A	0.0000
251	H	A	-2.8511
252	E	A	-2.9139
253	A	A	0.0000
254	E	A	-2.3928
255	E	A	-2.6792
256	W	A	-1.2332
257	Y	A	-0.8534
258	R	A	-1.0430
259	S	A	-0.7268
260	K	A	0.0000
261	F	A	0.0000
262	A	A	-0.5405
263	D	A	-0.9104
264	L	A	0.0000
265	T	A	0.0000
266	D	A	-1.2882
267	A	A	0.0000
268	A	A	0.0000
269	A	A	-1.2436
270	R	A	-2.6417
271	N	A	-1.9625
272	A	A	-1.2582
273	E	A	-1.7129
274	L	A	-0.5573
275	L	A	-0.0308
276	R	A	-2.2058
277	Q	A	-2.0210
278	A	A	-1.3849
279	K	A	-1.6506
280	H	A	-2.1341
281	E	A	-2.4043
282	A	A	0.0000
283	N	A	0.0000
284	D	A	-1.2637
285	Y	A	-0.2187
286	R	A	0.0000
287	R	A	-0.3789
288	Q	A	0.0000
289	L	A	0.0000
290	Q	A	0.0000
291	S	A	0.0000
292	L	A	0.0758
293	T	A	0.0000
294	C	A	0.0000
295	D	A	0.0000
296	L	A	-0.6479
297	E	A	-1.9746
298	S	A	-1.7581
299	L	A	0.0000
300	R	A	-2.5108
301	G	A	-2.0900
302	T	A	-1.6973
303	N	A	0.0000
304	E	A	-2.3234
305	S	A	-1.8224
306	L	A	0.0000
307	E	A	-2.3390
308	R	A	-3.0474
309	Q	A	-2.2328
310	M	A	-2.1739
311	R	A	-3.1134
312	E	A	-2.6906
313	Q	A	-2.2487
314	E	A	-2.9359
315	E	A	-3.2449
316	R	A	-2.8765
317	H	A	-1.5812
318	V	A	-0.5792
319	R	A	-1.9051
320	E	A	-1.3713
321	A	A	-0.9413
322	A	A	-1.1016
323	E	A	-1.2916
324	Y	A	0.0000
325	Q	A	-2.0934
326	E	A	-1.4352
327	A	A	0.0000
328	L	A	-1.7341
329	A	A	-1.7669
330	R	A	-2.7571
331	L	A	-3.2229
332	E	A	-3.6995
333	E	A	-4.1910
334	E	A	-4.0445
335	G	A	-2.9958
336	Q	A	-3.6905
337	E	A	-3.5224
338	L	A	0.0000
339	K	A	-2.0532
340	D	A	-2.1765
341	E	A	-2.6103
342	M	A	0.0000
343	A	A	-2.5751
344	R	A	-3.2410
345	H	A	-2.4158
346	L	A	0.0000
347	Q	A	-3.3139
348	E	A	-3.3619
349	Y	A	0.0000
350	Q	A	-2.7432
351	D	A	-2.5856
352	L	A	-1.3353
353	L	A	0.0000
354	N	A	-1.3954
355	V	A	0.2285
356	K	A	-0.1755
357	L	A	-0.3776
358	A	A	0.0396
359	L	A	0.0689
360	D	A	-0.6441
361	I	A	0.2497
362	E	A	-0.4857
363	I	A	0.0000
364	A	A	-0.2031
365	T	A	-0.1278
366	Y	A	0.0000
367	R	A	-0.5406
368	K	A	0.0000
369	L	A	0.0000
370	L	A	0.0000
371	E	A	-0.3296
372	G	A	-0.5085
373	E	A	0.0000
374	E	A	-0.6377
375	N	A	-0.5482
376	R	A	-0.8188
377	I	A	0.0000
378	T	A	0.0000
379	I	A	1.1722
380	P	A	0.4425
381	V	A	0.9856
382	Q	A	0.2474
383	T	A	0.9608
384	F	A	2.1343
385	S	A	0.0000
386	N	A	0.8459
387	L	A	1.1458
388	Q	A	-0.1637
389	I	A	-0.5147
390	R	A	-0.7935
391	E	A	-1.4120
392	T	A	-0.4907
393	S	A	-0.0111
394	L	A	0.4456
395	D	A	-0.5862
396	T	A	-0.9470
397	K	A	-1.7128
398	S	A	-0.9310
399	V	A	0.8460
400	S	A	-0.1670
401	E	A	0.0000
402	G	A	-0.0435
403	H	A	-0.6535
404	L	A	-0.9501
405	K	A	-2.3529
406	R	A	-2.7085
407	N	A	-1.4017
408	I	A	1.5113
409	V	A	1.7547
410	V	A	2.2058
411	K	A	0.6139
412	T	A	-0.1542
413	V	A	-0.8836
414	E	A	-1.3281
415	M	A	0.0000
416	R	A	-1.3622
417	D	A	-1.8281
418	G	A	-1.8615
419	E	A	-2.4913
420	V	A	-2.0569
421	I	A	-2.1571
422	K	A	-3.2472
423	E	A	-2.9842
424	S	A	-2.1106
425	K	A	-2.0836
426	Q	A	-1.9387
427	E	A	-2.2878
428	H	A	-0.7701
429	K	A	-0.5990
430	D	A	0.4544
431	V	A	1.4271
432	M	A	1.3197