Project name: 58f25a5ebcc2e8e

Chain sequence(s)	A: MERRRITSAARREYVSSGEMMVGGLAPGRRLGPGTRLSLARMPPPLPTRVDFSLAGALNAGFKETRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTKLADVYQAELRELRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEATLARLDLERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKPDLTAALKEIRTQYEAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGTNESLERQMREQEERHVREAAEYQEALARLEEEGQELKDEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEENRITIPVQTFSNLQIRETSLDTKSVSEGHLKRNIVVKTVEMRDGEVIKESKQEHKDVM
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.1411
• Maximal score value: 1.3253
• Average score: -0.7464
• Total score value: -322.4614

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	M	A	-0.8886
2	E	A	-1.8195
3	R	A	-1.9090
4	R	A	-3.2639
5	R	A	-3.1527
6	I	A	-2.0300
7	T	A	-3.0032
8	S	A	-2.6923
9	A	A	-1.9825
10	A	A	-2.1738
11	R	A	-3.0544
12	R	A	-2.7595
13	E	A	-0.9583
14	Y	A	0.5178
15	V	A	0.9636
16	S	A	0.2920
17	S	A	0.0433
18	G	A	-0.7131
19	E	A	-1.7324
20	M	A	-0.4172
21	M	A	0.1990
22	V	A	0.0000
23	G	A	0.0000
24	G	A	0.2687
25	L	A	0.4836
26	A	A	0.0000
27	P	A	0.0000
28	G	A	0.0000
29	R	A	0.0000
30	R	A	0.0000
31	L	A	0.0000
32	G	A	0.0000
33	P	A	0.0000
34	G	A	0.0000
35	T	A	0.0000
36	R	A	0.0000
37	L	A	0.0000
38	S	A	0.0000
39	L	A	0.0000
40	A	A	0.0000
41	R	A	0.0000
42	M	A	0.0000
43	P	A	0.0000
44	P	A	0.0000
45	P	A	-0.6590
46	L	A	0.3464
47	P	A	0.0000
48	T	A	-0.7743
49	R	A	-2.3264
50	V	A	-1.4553
51	D	A	-1.3651
52	F	A	-0.3424
53	S	A	0.1001
54	L	A	1.1412
55	A	A	0.3321
56	G	A	-0.3124
57	A	A	-0.0159
58	L	A	0.0000
59	N	A	-1.6368
60	A	A	-1.6449
61	G	A	0.0000
62	F	A	0.0000
63	K	A	-3.3384
64	E	A	-3.2762
65	T	A	0.0000
66	R	A	-2.7886
67	A	A	-2.0006
68	S	A	0.0000
69	E	A	0.0000
70	R	A	-1.3239
71	A	A	-0.4581
72	E	A	0.0000
73	M	A	0.0476
74	M	A	0.0319
75	E	A	-0.8498
76	L	A	0.0000
77	N	A	0.0000
78	D	A	-1.2725
79	R	A	-1.6918
80	F	A	0.0000
81	A	A	-0.8498
82	S	A	-1.1901
83	Y	A	0.0000
84	I	A	0.0000
85	E	A	-0.7501
86	K	A	-1.6393
87	V	A	0.0000
88	R	A	-0.5891
89	F	A	-0.3288
90	L	A	0.0000
91	E	A	0.0000
92	Q	A	-1.6667
93	Q	A	-1.3984
94	N	A	0.0000
95	K	A	-1.0965
96	A	A	-0.9601
97	L	A	-1.0275
98	A	A	-1.0598
99	A	A	-1.1184
100	E	A	-2.0699
101	L	A	0.0000
102	N	A	-1.7208
103	Q	A	-1.8249
104	L	A	-1.7134
105	R	A	-1.7893
106	A	A	-1.3126
107	K	A	-1.0713
108	E	A	0.0000
109	P	A	-0.8444
110	T	A	-0.4414
111	K	A	-0.5950
112	L	A	0.7465
113	A	A	-0.1760
114	D	A	-1.2675
115	V	A	-0.2941
116	Y	A	-0.7678
117	Q	A	-1.4121
118	A	A	-1.4277
119	E	A	-1.7964
120	L	A	-2.0506
121	R	A	-2.5987
122	E	A	-2.3366
123	L	A	0.0000
124	R	A	-1.9306
125	L	A	-0.9124
126	R	A	-2.1128
127	L	A	0.0000
128	D	A	-1.9115
129	Q	A	-1.9130
130	L	A	0.0000
131	T	A	0.0000
132	A	A	-1.5370
133	N	A	-1.2918
134	S	A	0.0000
135	A	A	-0.7525
136	R	A	-1.9473
137	L	A	0.0000
138	E	A	-0.8961
139	V	A	-0.3440
140	E	A	-1.9508
141	R	A	0.0000
142	D	A	-2.5625
143	N	A	-2.4251
144	L	A	0.0000
145	A	A	0.0000
146	Q	A	-2.3493
147	D	A	-1.8617
148	L	A	0.0000
149	A	A	-1.2276
150	T	A	-0.9303
151	V	A	-0.9552
152	R	A	-1.4417
153	Q	A	-1.5819
154	K	A	-1.8069
155	L	A	0.0000
156	Q	A	-1.8058
157	D	A	-2.0573
158	E	A	-1.6726
159	T	A	0.0000
160	N	A	-1.4388
161	L	A	0.0611
162	R	A	0.0000
163	L	A	-0.9685
164	E	A	-1.8216
165	A	A	-0.9946
166	E	A	0.0000
167	N	A	-1.3065
168	N	A	-1.0109
169	L	A	0.0625
170	A	A	0.0000
171	A	A	-0.4177
172	Y	A	0.9082
173	R	A	0.0000
174	Q	A	-1.5964
175	E	A	-2.2232
176	A	A	-2.2340
177	D	A	-2.5316
178	E	A	-2.1028
179	A	A	0.0000
180	T	A	-0.5859
181	L	A	0.6027
182	A	A	-0.4044
183	R	A	0.0000
184	L	A	0.0971
185	D	A	-0.9747
186	L	A	0.0000
187	E	A	-1.4785
188	R	A	-2.6985
189	K	A	-1.6919
190	I	A	-1.4210
191	E	A	-2.8456
192	S	A	-1.6642
193	L	A	0.0000
194	E	A	0.0000
195	E	A	-1.0889
196	E	A	-0.9678
197	I	A	0.0000
198	R	A	-0.4526
199	F	A	-0.2246
200	L	A	0.0000
201	R	A	0.0000
202	K	A	-0.2476
203	I	A	-0.4268
204	H	A	-1.4993
205	E	A	0.0000
206	E	A	-2.6092
207	E	A	-2.1350
208	V	A	0.0000
209	R	A	-0.7687
210	E	A	0.0000
211	L	A	0.0000
212	Q	A	0.0000
213	E	A	0.0000
214	Q	A	0.0000
215	L	A	0.8489
216	A	A	0.1499
217	R	A	-0.3621
218	Q	A	-1.0141
219	Q	A	0.0000
220	V	A	0.6377
221	H	A	-0.2492
222	V	A	0.0000
223	E	A	-1.6851
224	L	A	-0.8646
225	D	A	-1.2095
226	V	A	0.0000
227	A	A	-0.6033
228	K	A	0.0000
229	P	A	0.0000
230	D	A	0.0000
231	L	A	0.4044
232	T	A	0.2397
233	A	A	0.0571
234	A	A	0.0000
235	L	A	-0.7582
236	K	A	-1.3092
237	E	A	-0.9614
238	I	A	0.0000
239	R	A	-0.9675
240	T	A	-0.5384
241	Q	A	-0.0852
242	Y	A	0.8260
243	E	A	-0.1214
244	A	A	0.2701
245	M	A	0.5997
246	A	A	0.0000
247	S	A	-0.3993
248	S	A	-0.6119
249	N	A	-0.8580
250	M	A	0.0000
251	H	A	-1.6046
252	E	A	-1.8042
253	A	A	0.0000
254	E	A	-2.1629
255	E	A	-2.6412
256	W	A	-1.0287
257	Y	A	-0.9087
258	R	A	-1.8588
259	S	A	-0.7875
260	K	A	0.0000
261	F	A	0.8761
262	A	A	0.1650
263	D	A	-0.2376
264	L	A	0.0000
265	T	A	-0.0773
266	D	A	-1.2097
267	A	A	0.0000
268	A	A	0.0000
269	A	A	-0.7271
270	R	A	-1.3183
271	N	A	0.0000
272	A	A	-0.7065
273	E	A	-1.3104
274	L	A	0.4748
275	L	A	0.0687
276	R	A	-2.0364
277	Q	A	-1.9004
278	A	A	-0.8613
279	K	A	0.0000
280	H	A	-1.4635
281	E	A	-0.7440
282	A	A	0.0000
283	N	A	0.0000
284	D	A	-0.4454
285	Y	A	0.0000
286	R	A	0.0000
287	R	A	0.0000
288	Q	A	0.0000
289	L	A	0.0000
290	Q	A	0.0000
291	S	A	0.0000
292	L	A	0.0000
293	T	A	0.0000
294	C	A	0.0000
295	D	A	-0.6368
296	L	A	0.0000
297	E	A	-1.2505
298	S	A	-0.9320
299	L	A	0.0000
300	R	A	-1.1588
301	G	A	-0.6028
302	T	A	0.0000
303	N	A	0.0000
304	E	A	-1.1482
305	S	A	-1.0462
306	L	A	0.0000
307	E	A	0.0000
308	R	A	-2.5401
309	Q	A	0.0000
310	M	A	0.0000
311	R	A	-3.0968
312	E	A	-2.2944
313	Q	A	0.0000
314	E	A	-2.1189
315	E	A	-2.8404
316	R	A	-1.9678
317	H	A	0.0000
318	V	A	-0.7912
319	R	A	-2.3380
320	E	A	0.0000
321	A	A	0.0000
322	A	A	-1.2702
323	E	A	-2.0830
324	Y	A	0.0000
325	Q	A	-1.6739
326	E	A	-2.1652
327	A	A	0.0000
328	L	A	-1.7773
329	A	A	-2.5109
330	R	A	-3.0895
331	L	A	0.0000
332	E	A	-3.9431
333	E	A	-4.1411
334	E	A	-3.9564
335	G	A	-2.7513
336	Q	A	-2.4223
337	E	A	-2.3285
338	L	A	-0.6373
339	K	A	0.0000
340	D	A	-2.5773
341	E	A	-2.4293
342	M	A	0.0000
343	A	A	-2.1667
344	R	A	-2.7525
345	H	A	-2.2242
346	L	A	0.0000
347	Q	A	-1.8274
348	E	A	-2.0476
349	Y	A	0.0000
350	Q	A	0.0000
351	D	A	-1.2365
352	L	A	0.0000
353	L	A	0.0000
354	N	A	-0.8903
355	V	A	0.1628
356	K	A	0.0000
357	L	A	-0.0219
358	A	A	0.2415
359	L	A	0.0000
360	D	A	0.0000
361	I	A	0.4213
362	E	A	-0.3483
363	I	A	0.0000
364	A	A	0.0000
365	T	A	0.0000
366	Y	A	0.0000
367	R	A	0.0000
368	K	A	0.0000
369	L	A	0.0000
370	L	A	0.0000
371	E	A	0.0000
372	G	A	0.0000
373	E	A	0.0000
374	E	A	0.0000
375	N	A	0.0000
376	R	A	0.1017
377	I	A	0.0000
378	T	A	0.0000
379	I	A	0.1698
380	P	A	0.0621
381	V	A	0.7823
382	Q	A	0.2778
383	T	A	0.7774
384	F	A	1.3253
385	S	A	0.1783
386	N	A	0.0000
387	L	A	0.5512
388	Q	A	-0.4484
389	I	A	0.0000
390	R	A	-2.0136
391	E	A	-1.1668
392	T	A	-0.6977
393	S	A	-1.3924
394	L	A	-1.1118
395	D	A	0.0000
396	T	A	-1.1104
397	K	A	-1.7326
398	S	A	-1.1554
399	V	A	-0.9659
400	S	A	0.0000
401	E	A	-1.5983
402	G	A	0.0000
403	H	A	-1.0529
404	L	A	-0.2121
405	K	A	-1.9409
406	R	A	-1.3435
407	N	A	-1.5822
408	I	A	-0.6499
409	V	A	-0.7888
410	V	A	0.0000
411	K	A	0.0000
412	T	A	-0.9520
413	V	A	-0.8170
414	E	A	-1.0920
415	M	A	0.0000
416	R	A	0.0000
417	D	A	0.0000
418	G	A	0.0000
419	E	A	0.0000
420	V	A	-1.1338
421	I	A	0.0000
422	K	A	-1.9008
423	E	A	-2.8016
424	S	A	-1.9363
425	K	A	-2.5136
426	Q	A	-2.3693
427	E	A	0.0000
428	H	A	0.0000
429	K	A	-1.9851
430	D	A	-0.7546
431	V	A	0.0000
432	M	A	-0.4115