Project name: 59a647e3cb75552

Chain sequence(s)	A: SSSQGLLGYYFSDLNFQAPMVVTSSTTGDLSIPSSELENIPSENQYFQSAIWSGFIKVKKSDEYTFATSADNHVTMWVDDQEVINSNKIRLEKGRLYQIKIQYQRENPTEKGLDFKLYWTDSQNKKEVISSDNLQLPELKQKSSVPDRDNDGIPDSLEVEGYTVDVKNKRTFLSPWISNIHEKKGLTKYKSSPEKWSTASDPYSDFEKVTGRIDKNVSPEARHPLVAAYPIVHVDMENIILSKNETISKNTSTSRTHTSEVVSAGFSNSNSSTVAIDHSLSLAGGLNTADTARLNANIRYVNTGTAPIYNVLPTTSLVLGKNQTLATIKAKENQLSQILAPNNYYPSKNLAPIALNAQDDFSSTPITMNYNQFLELEKTKQLRLDTDQVYGNIATYNFENGRVRVDTGSNWSEVLPQIQETTARIIFNGKDLNLVERRIAAVNPSTTKPDMTLKEALKIAFGFNEPNGNLQYQGKDITEFDFNFDQQTSQNIKNQLAELNATNIYTVLDKIKLNAKMNILIRDKRFHYDRNNIAVGADESVVKEAHREVINSSTEGLLLNIDKDIRKILSGYIVEIEDTEGLKEVINDRYDMLNISSLRQDGKTFIDFKKYNDKLPLYISNPNYKVNVYAVTKENTIINPSENGDTSTNGIKKILIFSKKGYEIG
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.5269
• Maximal score value: 1.5407
• Average score: -0.9608
• Total score value: -638.965

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
14	S	A	-1.1933
15	S	A	-1.0272
16	S	A	-0.9961
17	Q	A	-1.0418
18	G	A	0.0000
19	L	A	0.0000
20	L	A	0.0000
21	G	A	0.0000
22	Y	A	0.0000
23	Y	A	0.0000
24	F	A	0.0000
25	S	A	0.0000
26	D	A	-1.1501
27	L	A	-1.4560
28	N	A	-1.7684
29	F	A	-0.6758
30	Q	A	-1.2284
31	A	A	-0.7900
32	P	A	0.0000
33	M	A	0.0000
34	V	A	0.0000
35	V	A	0.0000
36	T	A	0.0000
37	S	A	-0.1261
38	S	A	0.0000
39	T	A	-0.8311
40	T	A	-0.7948
41	G	A	0.0000
42	D	A	-1.6460
43	L	A	0.0000
44	S	A	-1.3081
45	I	A	0.0000
46	P	A	-0.8869
47	S	A	-1.3825
48	S	A	-1.0050
49	E	A	-1.2256
50	L	A	0.0000
51	E	A	-2.0116
52	N	A	0.0000
53	I	A	0.0000
54	P	A	-1.1303
55	S	A	-1.5891
56	E	A	-2.1303
57	N	A	-1.3799
58	Q	A	0.0000
59	Y	A	-1.5783
60	F	A	0.0000
61	Q	A	-1.6474
62	S	A	0.0000
63	A	A	0.0000
64	I	A	0.0000
65	W	A	0.0000
66	S	A	-0.6135
67	G	A	0.0000
68	F	A	-1.2329
69	I	A	0.0000
70	K	A	-2.4490
71	V	A	0.0000
72	K	A	-4.0106
73	K	A	-3.9746
74	S	A	-3.4879
75	D	A	-2.8554
76	E	A	-2.6994
77	Y	A	-1.9864
78	T	A	-1.3045
79	F	A	0.0000
80	A	A	-0.6854
81	T	A	0.0000
82	S	A	-1.1294
83	A	A	-1.2254
84	D	A	-1.7920
85	N	A	-2.2083
86	H	A	-1.9277
87	V	A	0.0000
88	T	A	-1.5310
89	M	A	0.0000
90	W	A	-2.6121
91	V	A	0.0000
92	D	A	-2.8471
93	D	A	-3.6061
94	Q	A	-3.3558
95	E	A	-3.3899
96	V	A	-2.0077
97	I	A	0.0000
98	N	A	-2.1408
103	S	A	-1.5001
104	N	A	-1.8444
105	K	A	-1.8094
106	I	A	-1.7579
107	R	A	-2.8347
108	L	A	0.0000
109	E	A	-3.7439
110	K	A	-4.5269
111	G	A	-3.1144
112	R	A	-3.2532
113	L	A	-1.6346
114	Y	A	-1.3929
115	Q	A	-2.2006
116	I	A	0.0000
117	K	A	-2.0518
118	I	A	0.0000
119	Q	A	-0.7561
120	Y	A	0.0000
121	Q	A	-1.8256
122	R	A	-2.6627
123	E	A	-3.0673
124	N	A	-2.6888
125	P	A	-2.1245
126	T	A	-1.6460
127	E	A	-2.5822
128	K	A	-2.2636
129	G	A	0.0000
130	L	A	0.0000
131	D	A	-2.5073
132	F	A	0.0000
133	K	A	-1.6356
134	L	A	0.0000
135	Y	A	-0.9055
136	W	A	-1.3609
137	T	A	0.0000
138	D	A	-2.7359
139	S	A	-2.3560
140	Q	A	-2.8843
141	N	A	-3.4245
142	K	A	-4.0125
143	K	A	-3.8063
144	E	A	-3.0231
145	V	A	-1.2329
146	I	A	0.0000
147	S	A	-1.0406
148	S	A	-1.0790
149	D	A	-1.9874
150	N	A	-1.3500
151	L	A	0.0000
152	Q	A	0.0000
153	L	A	0.0000
154	P	A	-1.4372
155	E	A	-2.7008
156	L	A	0.0000
157	K	A	-2.1161
158	Q	A	-2.6616
159	K	A	-2.9844
160	S	A	-1.4582
161	S	A	-0.8682
175	V	A	1.2281
176	P	A	-0.1647
177	D	A	-1.2072
178	R	A	-2.6608
179	D	A	0.0000
180	N	A	-2.0669
181	D	A	0.0000
182	G	A	0.0000
183	I	A	0.0000
184	P	A	0.0000
185	D	A	0.0000
186	S	A	-0.3621
187	L	A	0.0000
188	E	A	0.0000
189	V	A	0.3414
190	E	A	-1.2731
191	G	A	0.0000
192	Y	A	0.0000
193	T	A	0.0000
194	V	A	0.3885
195	D	A	0.4238
196	V	A	0.8711
197	K	A	-0.8299
198	N	A	-1.9086
199	K	A	-2.1642
200	R	A	-1.0414
201	T	A	0.0200
202	F	A	0.0000
203	L	A	0.0000
204	S	A	0.0000
205	P	A	-0.3284
206	W	A	-0.6695
207	I	A	-0.3574
208	S	A	-1.6371
209	N	A	-2.0628
210	I	A	-1.6252
211	H	A	0.0000
212	E	A	-3.6179
213	K	A	-3.6090
214	K	A	-3.1676
215	G	A	-2.3545
216	L	A	-1.5080
217	T	A	-1.1956
218	K	A	-1.7625
219	Y	A	-0.7359
220	K	A	-0.9312
221	S	A	0.0000
222	S	A	0.0000
223	P	A	0.0000
224	E	A	-2.4537
225	K	A	-1.7273
226	W	A	0.0000
227	S	A	-0.6035
228	T	A	0.0000
229	A	A	0.0000
230	S	A	-0.5754
231	D	A	0.0000
232	P	A	-0.4383
233	Y	A	0.0000
234	S	A	0.0000
235	D	A	0.0000
236	F	A	0.0000
237	E	A	0.0000
238	K	A	0.0000
239	V	A	0.0000
240	T	A	-0.1069
241	G	A	-0.6985
242	R	A	-0.9394
243	I	A	0.0000
244	D	A	0.0000
245	K	A	-1.8344
246	N	A	-1.1478
247	V	A	0.0000
248	S	A	-0.9156
249	P	A	-0.8375
250	E	A	-0.7626
251	A	A	0.0000
252	R	A	-0.7742
253	H	A	-0.6048
254	P	A	0.0000
255	L	A	0.0000
256	V	A	0.0000
257	A	A	0.0000
258	A	A	0.0000
259	Y	A	0.0000
260	P	A	0.0000
261	I	A	0.0000
262	V	A	0.0000
263	H	A	0.0000
264	V	A	0.0000
265	D	A	-0.6579
266	M	A	0.0000
267	E	A	-1.6210
268	N	A	-1.5345
269	I	A	0.0000
270	I	A	0.4386
271	L	A	0.0000
272	S	A	-1.1597
273	K	A	-2.7155
274	N	A	-2.8793
275	E	A	-2.7305
288	T	A	0.0616
289	I	A	1.1488
290	S	A	0.3248
291	K	A	-0.7873
292	N	A	-1.9041
293	T	A	-1.4822
294	S	A	-0.9201
295	T	A	-0.5503
296	S	A	-0.3096
297	R	A	0.0000
298	T	A	-0.4139
299	H	A	0.0000
300	T	A	-0.6244
301	S	A	-0.5803
302	E	A	-0.8334
303	V	A	1.0830
320	V	A	1.2861
321	S	A	0.0000
322	A	A	0.0000
323	G	A	0.3383
324	F	A	0.8400
325	S	A	0.2481
326	N	A	-0.4906
327	S	A	-0.6705
328	N	A	0.0000
329	S	A	-0.6593
330	S	A	0.0000
331	T	A	-0.4871
332	V	A	0.0000
333	A	A	-0.6966
334	I	A	-0.9865
335	D	A	-1.0753
336	H	A	-0.5288
337	S	A	0.0000
338	L	A	0.2439
339	S	A	0.3706
340	L	A	1.5407
341	A	A	0.5995
342	G	A	-0.1100
351	G	A	-0.9594
352	L	A	-1.1131
353	N	A	-1.7476
354	T	A	-1.2264
355	A	A	-1.0796
356	D	A	-2.3290
357	T	A	-2.2934
358	A	A	0.0000
359	R	A	-1.8522
360	L	A	0.0000
361	N	A	-0.3790
362	A	A	0.0000
363	N	A	-0.7133
364	I	A	0.0000
365	R	A	0.0000
366	Y	A	0.0000
367	V	A	0.0000
368	N	A	0.0000
369	T	A	-0.6278
370	G	A	0.0000
371	T	A	0.0000
372	A	A	0.0000
373	P	A	0.0000
374	I	A	0.0000
375	Y	A	-0.1528
376	N	A	-1.3742
377	V	A	-1.0988
378	L	A	0.0000
379	P	A	0.0000
380	T	A	-0.6154
381	T	A	0.0000
382	S	A	-0.8128
383	L	A	0.0000
384	V	A	0.0000
385	L	A	0.0000
386	G	A	-1.8797
387	K	A	-2.5858
388	N	A	-2.4219
389	Q	A	-1.5670
390	T	A	-0.9261
391	L	A	-0.1748
392	A	A	-0.1855
393	T	A	-0.4560
394	I	A	-0.6849
395	K	A	-2.2028
396	A	A	-2.3535
397	K	A	-3.6203
398	E	A	-3.7608
399	N	A	-3.1063
400	Q	A	-2.9212
401	L	A	-1.5196
402	S	A	-0.5974
403	Q	A	-0.1837
404	I	A	0.3813
405	L	A	0.0000
406	A	A	-0.5865
407	P	A	-0.8174
408	N	A	-1.5593
409	N	A	-1.3767
410	Y	A	-0.7979
411	Y	A	0.0000
412	P	A	-0.3219
413	S	A	-1.0024
414	K	A	-2.0618
415	N	A	-1.5994
416	L	A	-0.0914
417	A	A	-0.0373
418	P	A	-0.2510
419	I	A	0.4518
420	A	A	-0.3214
421	L	A	-0.4360
422	N	A	-0.8306
423	A	A	-1.4923
424	Q	A	-2.2194
425	D	A	-2.8042
426	D	A	-2.1560
427	F	A	0.2651
428	S	A	-0.1769
429	S	A	-0.5426
430	T	A	-0.1410
431	P	A	-0.2647
432	I	A	0.0000
433	T	A	-0.9216
434	M	A	0.0000
435	N	A	-1.8507
436	Y	A	-1.4527
437	N	A	-1.9363
438	Q	A	-1.5473
439	F	A	0.0000
440	L	A	-1.2859
441	E	A	-1.8259
442	L	A	0.0000
443	E	A	-2.1922
444	K	A	-2.4939
445	T	A	-1.6119
446	K	A	-1.4772
447	Q	A	-1.4241
448	L	A	0.0000
449	R	A	-1.2518
450	L	A	0.0000
451	D	A	-0.9473
452	T	A	0.0000
453	D	A	-0.7529
454	Q	A	-0.1228
455	V	A	0.9744
456	Y	A	0.0000
457	G	A	0.0000
458	N	A	-0.7109
459	I	A	0.0000
460	A	A	0.0000
461	T	A	0.0000
462	Y	A	0.0000
463	N	A	-2.2774
464	F	A	0.0000
465	E	A	-2.9480
466	N	A	-2.4677
467	G	A	-2.2715
468	R	A	-2.7822
469	V	A	-1.6239
470	R	A	-2.0135
471	V	A	-0.7719
472	D	A	-1.2092
473	T	A	-0.8606
474	G	A	-0.8115
475	S	A	-1.0065
476	N	A	-1.0900
477	W	A	0.0000
478	S	A	-1.0285
479	E	A	-2.1820
480	V	A	-1.2259
481	L	A	0.0000
482	P	A	-1.5726
483	Q	A	-1.8825
484	I	A	0.0000
485	Q	A	-1.4892
486	E	A	-2.5430
487	T	A	-1.5823
488	T	A	0.0000
489	A	A	0.0000
490	R	A	0.0000
491	I	A	0.0000
492	I	A	0.0000
493	F	A	0.0000
494	N	A	0.0000
495	G	A	0.0000
496	K	A	-2.2227
497	D	A	-2.2240
498	L	A	0.0000
499	N	A	-1.1766
500	L	A	0.0000
501	V	A	-0.4300
502	E	A	0.0000
503	R	A	0.0000
504	R	A	0.0000
505	I	A	0.0000
506	A	A	0.0000
507	A	A	0.0000
508	V	A	-1.1446
509	N	A	-1.7204
510	P	A	-0.9065
511	S	A	-0.7338
516	T	A	-0.4894
517	T	A	-0.4896
518	K	A	-0.8760
519	P	A	0.0000
520	D	A	-2.1855
521	M	A	0.0000
522	T	A	-2.2936
523	L	A	0.0000
524	K	A	-1.9941
525	E	A	-2.4272
526	A	A	0.0000
527	L	A	0.0000
528	K	A	-1.5180
529	I	A	-0.7385
530	A	A	0.0000
531	F	A	0.0000
532	G	A	-1.2863
533	F	A	0.0000
534	N	A	-2.7992
535	E	A	-2.6795
536	P	A	-1.9556
537	N	A	-2.3503
538	G	A	-2.1462
539	N	A	-2.3646
540	L	A	0.0000
541	Q	A	-2.3424
542	Y	A	0.0000
543	Q	A	-2.2113
544	G	A	-1.6442
545	K	A	-1.5597
546	D	A	-1.8313
547	I	A	0.0000
548	T	A	-1.1258
549	E	A	-2.2323
550	F	A	0.0000
551	D	A	-1.3694
552	F	A	-0.3036
553	N	A	-0.0135
554	F	A	-0.1706
555	D	A	0.0000
556	Q	A	-1.9835
557	Q	A	-2.5720
558	T	A	0.0000
559	S	A	-2.2020
560	Q	A	-3.0791
561	N	A	-2.6231
562	I	A	0.0000
563	K	A	-3.3006
564	N	A	-3.0854
565	Q	A	-2.4680
566	L	A	-2.0588
567	A	A	-1.9886
568	E	A	-2.4743
569	L	A	-1.3541
570	N	A	-1.8219
571	A	A	-1.0763
572	T	A	-0.7671
573	N	A	-0.9068
574	I	A	-0.5359
575	Y	A	-0.2588
576	T	A	-0.4716
577	V	A	-0.8322
578	L	A	0.0000
579	D	A	-2.8514
580	K	A	-2.5667
581	I	A	0.0000
582	K	A	-2.3064
583	L	A	0.0000
584	N	A	-1.3296
585	A	A	-1.3910
586	K	A	-1.6669
587	M	A	0.0000
588	N	A	0.0000
589	I	A	0.0000
590	L	A	0.0000
591	I	A	0.0000
592	R	A	-1.0777
593	D	A	0.0000
594	K	A	-2.3227
595	R	A	-1.7840
596	F	A	0.0000
597	H	A	-1.2441
598	Y	A	-1.0987
599	D	A	-1.8195
600	R	A	-2.0045
601	N	A	-1.4114
602	N	A	0.0000
603	I	A	-0.5164
604	A	A	0.0000
605	V	A	0.0000
606	G	A	0.0000
607	A	A	0.0000
608	D	A	-2.3249
609	E	A	-2.6638
610	S	A	-1.9396
611	V	A	-1.5955
612	V	A	0.0000
613	K	A	-2.5924
614	E	A	-3.3542
615	A	A	-2.4504
616	H	A	0.0000
617	R	A	-3.2259
618	E	A	-2.6486
619	V	A	-0.7407
620	I	A	-0.0863
621	N	A	-0.7237
622	S	A	-0.8040
623	S	A	-1.0393
624	T	A	-0.3767
625	E	A	-1.4827
626	G	A	0.0000
627	L	A	0.0000
628	L	A	-0.2255
629	L	A	0.0000
630	N	A	-1.6042
631	I	A	0.0000
632	D	A	-2.1102
633	K	A	-2.6979
634	D	A	-2.1417
635	I	A	0.0000
636	R	A	-1.4435
637	K	A	-1.8470
638	I	A	0.0000
639	L	A	-0.7880
640	S	A	-0.8423
641	G	A	0.0000
642	Y	A	0.0000
643	I	A	0.0000
644	V	A	0.0000
645	E	A	0.0000
646	I	A	0.0000
647	E	A	-2.0057
648	D	A	-1.9282
649	T	A	-1.6785
650	E	A	-1.8992
651	G	A	-1.1457
652	L	A	-0.5798
653	K	A	-2.3099
654	E	A	-2.2772
655	V	A	-1.2051
656	I	A	-0.8190
657	N	A	0.0000
658	D	A	-1.0942
659	R	A	-0.9592
660	Y	A	-0.5120
661	D	A	0.0000
662	M	A	-0.4340
663	L	A	0.0000
664	N	A	-0.9443
665	I	A	0.0000
666	S	A	-0.3650
667	S	A	-0.2684
668	L	A	-0.5403
669	R	A	-2.0172
670	Q	A	-2.5300
671	D	A	-2.6668
672	G	A	-2.1393
673	K	A	-1.4332
674	T	A	0.0000
675	F	A	0.1343
676	I	A	0.0000
677	D	A	-1.2556
678	F	A	0.0000
679	K	A	-2.4084
680	K	A	-2.5774
681	Y	A	-1.6311
682	N	A	-1.7781
683	D	A	-2.7581
684	K	A	-2.9796
685	L	A	-1.0179
686	P	A	-0.7953
687	L	A	0.0000
688	Y	A	1.3406
689	I	A	0.4923
690	S	A	-0.1123
691	N	A	-0.7924
692	P	A	-1.1500
693	N	A	-1.7641
694	Y	A	-1.5120
695	K	A	-1.9203
696	V	A	0.0000
697	N	A	0.0000
698	V	A	0.0000
699	Y	A	0.0000
700	A	A	0.0000
701	V	A	0.0000
702	T	A	0.0000
703	K	A	-1.5999
704	E	A	-2.1176
705	N	A	-1.5185
706	T	A	-0.7804
707	I	A	0.0249
708	I	A	-0.1069
709	N	A	-1.1854
710	P	A	-1.5775
711	S	A	-1.9732
712	E	A	-2.9711
713	N	A	-2.7340
714	G	A	-2.2430
715	D	A	-2.2707
716	T	A	-1.4022
717	S	A	-1.2349
718	T	A	0.0000
719	N	A	-2.0428
720	G	A	-1.6329
721	I	A	0.0000
722	K	A	-2.4041
723	K	A	-1.6493
724	I	A	0.0000
725	L	A	0.1428
726	I	A	-0.7470
727	F	A	0.0000
728	S	A	-0.8727
729	K	A	-1.9783
730	K	A	-2.0086
731	G	A	-0.9508
732	Y	A	-0.3548
733	E	A	-1.8227
734	I	A	-1.1373
735	G	A	-0.6431