Project name: igg4 Fc 2

Chain sequence(s)	A: LGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTFPPSQEEMTKNQVSLRCLVKGFYPSDIAVEWESNGQPENNYKTTKPVLDSDGSFRLESRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLS
Distance of aggregation	5 Å
Dynamic mode	No

• Minimal score value: -2.2643
• Maximal score value: 2.0533
• Average score: -0.4021
• Total score value: -84.4462

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
235	L	A	1.4641
236	G	A	-0.2626
237	G	A	-0.4950
238	P	A	0.0000
239	S	A	-0.0505
240	V	A	0.0000
241	F	A	1.0662
242	L	A	0.0000
243	F	A	1.1101
244	P	A	0.0117
245	P	A	0.0000
246	K	A	-1.7079
247	P	A	-0.4342
248	K	A	-0.5041
249	D	A	-0.2943
250	T	A	0.0000
251	L	A	0.3157
252	M	A	0.8445
253	I	A	2.0533
254	S	A	-0.1262
255	R	A	-1.5885
256	T	A	-0.3576
257	P	A	0.0000
258	E	A	-0.8351
259	V	A	0.0000
260	T	A	0.0176
261	C	A	0.0000
262	V	A	0.0000
263	V	A	0.0000
264	V	A	-0.2329
265	D	A	-1.7554
266	V	A	0.0000
267	S	A	-0.2913
268	Q	A	-1.5364
269	E	A	-2.0881
270	D	A	-0.6110
271	P	A	-0.4424
272	E	A	-1.7864
273	V	A	-0.3081
274	Q	A	-1.1121
275	F	A	-0.0135
276	N	A	-0.1532
277	W	A	0.0000
278	Y	A	0.0628
279	V	A	-0.0116
280	D	A	-1.5749
281	G	A	-0.4136
282	V	A	1.3662
283	E	A	-1.3891
284	V	A	-0.0943
285	H	A	-1.1559
286	N	A	-1.4573
287	A	A	-0.5362
288	K	A	-1.7070
289	T	A	-0.6096
290	K	A	-1.3339
291	P	A	-0.7520
292	R	A	-1.8154
293	E	A	-2.2643
294	E	A	-2.1527
295	Q	A	-0.2407
296	F	A	1.6621
297	N	A	-0.9628
298	S	A	-0.4401
299	T	A	-0.0185
300	Y	A	-0.2266
301	R	A	-0.7617
302	V	A	0.0000
303	V	A	0.2008
304	S	A	0.0000
305	V	A	0.2157
306	L	A	0.0000
307	T	A	-0.1686
308	V	A	0.0000
309	L	A	1.1502
310	H	A	-0.1125
311	Q	A	-1.0123
312	D	A	-0.5427
313	W	A	0.0000
314	L	A	0.0512
315	N	A	-1.2335
316	G	A	-0.4129
317	K	A	-0.9521
318	E	A	-1.7458
319	Y	A	0.0000
320	K	A	-0.5419
321	C	A	0.0000
322	K	A	-0.6166
323	V	A	0.0000
324	S	A	-0.1777
325	N	A	0.0000
326	K	A	-1.7573
327	G	A	-0.5958
328	L	A	0.0466
329	P	A	-0.2661
330	S	A	-0.2809
331	S	A	-0.0550
332	I	A	0.2748
333	E	A	-1.6024
334	K	A	-1.1100
335	T	A	-0.2158
336	I	A	0.3317
337	S	A	-0.2088
338	K	A	-0.1986
339	A	A	-0.3131
340	K	A	-1.7782
341	G	A	-0.9874
342	Q	A	-1.2972
343	P	A	-0.4300
344	R	A	-1.0452
345	E	A	-1.9512
346	P	A	0.0000
347	Q	A	-0.9037
348	V	A	0.8951
349	Y	A	0.9918
350	T	A	0.2218
351	F	A	0.6723
352	P	A	-0.1248
353	P	A	-0.0927
354	S	A	-0.3701
355	Q	A	-1.5474
356	E	A	-2.1126
357	E	A	-0.7128
358	M	A	0.1470
359	T	A	-0.3354
360	K	A	-1.9505
361	N	A	-1.7166
362	Q	A	-1.1408
363	V	A	0.0000
364	S	A	-0.0305
365	L	A	0.0000
366	R	A	-0.6314
367	C	A	0.0000
368	L	A	0.0886
369	V	A	0.0000
370	K	A	-0.7904
371	G	A	-0.2569
372	F	A	0.0000
373	Y	A	0.1040
374	P	A	0.0000
375	S	A	-0.2964
376	D	A	-1.2828
377	I	A	-0.0504
378	A	A	0.0000
379	V	A	0.0000
380	E	A	-0.5784
381	W	A	0.0000
382	E	A	-1.0417
383	S	A	0.0000
384	N	A	-1.3597
385	G	A	-0.9304
386	Q	A	-1.3328
387	P	A	-0.6530
388	E	A	-0.6185
389	N	A	-1.5462
390	N	A	-1.4396
391	Y	A	-0.1782
392	K	A	-1.6377
393	T	A	-0.3538
394	T	A	-0.3816
395	K	A	-1.7228
396	P	A	-0.2372
397	V	A	1.0310
398	L	A	1.6560
399	D	A	-0.0882
400	S	A	-0.5902
401	D	A	-1.8655
402	G	A	-0.5369
403	S	A	0.0000
404	F	A	0.3368
405	R	A	-0.7048
406	L	A	0.0000
407	E	A	-1.7794
408	S	A	0.0000
409	R	A	-1.8932
410	L	A	0.0000
411	T	A	-0.0227
412	V	A	0.0000
413	D	A	-1.4093
414	K	A	-0.7924
415	S	A	-0.5450
416	R	A	-0.6483
417	W	A	-0.0761
418	Q	A	-1.5091
419	E	A	-2.1248
420	G	A	-0.8776
421	N	A	-0.1845
422	V	A	1.7345
423	F	A	0.5129
424	S	A	-0.1094
425	C	A	0.0481
426	S	A	-0.0330
427	V	A	0.2223
428	M	A	0.1634
429	H	A	0.0000
430	E	A	-0.2153
431	A	A	-0.0950
432	L	A	0.5128
433	H	A	-1.1065
434	N	A	-1.6509
435	H	A	-0.9905
436	Y	A	1.1235
437	T	A	-0.0517
438	Q	A	-1.5236
439	K	A	-1.9605
440	S	A	-0.2511
441	L	A	1.4696
442	S	A	0.3489
443	L	A	1.4713
444	S	A	0.0647