Project name: 59d02888d5f18ac

Chain sequence(s)	A: QFPRQCATVEALRSGMCCPDLSPVSGPGTDRCGSSSGRGRCEAVTADSRPHSPQYPHDGRDDREVWPLRFFNRTCHCNGNFSGHNCGTCRPGWRGAACDQRVLIVRRNLLDLSKEEKNHFVRALDMAKRTTHPLFVIATRRSEEILGPDGNTPQFENISIYNYFVWTHYYSVKKTFLGVGQESFGEVDFSHEGPAFLTWHRYHLLRLEKDMQEMLQEPSFSLPYWNFATGKNVCDICTDDLMGSRSNFDSTLISPNSVFSQWRVVCDSLEDYDTLGTLCNSTEDGPIRRNPAGNVARPMVQRLPEPQDVAQCLEVGLFDTPPFYSNSTNSFRNTVEGYSDPTGKYDPAVRSLHNLAHLFLNGTGGQTHLSPNDPIFVLLHTFTDAVFDEWLRRYNADISTFPLENAPIGHNRQYNMVPFWPPVTNTEMFVTAPDNLGYTYEIQWPS
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.4026
• Maximal score value: 1.4687
• Average score: -0.7335
• Total score value: -327.1628

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
25	Q	A	0.0000
26	F	A	0.0000
27	P	A	0.0000
28	R	A	-1.2016
29	Q	A	-1.2408
30	C	A	0.0000
31	A	A	-0.6556
32	T	A	-1.1509
33	V	A	-1.5410
34	E	A	-2.5109
35	A	A	-1.4539
36	L	A	-1.3397
37	R	A	-2.3364
38	S	A	-1.6598
39	G	A	-1.4504
40	M	A	-0.9905
41	C	A	0.0000
42	C	A	0.0000
43	P	A	0.0000
44	D	A	-1.1051
45	L	A	-0.2108
46	S	A	-0.0882
47	P	A	0.1940
48	V	A	1.4687
49	S	A	0.4163
50	G	A	-0.0015
51	P	A	-0.4324
52	G	A	-0.6272
53	T	A	-0.4317
54	D	A	0.0000
55	R	A	-1.8630
56	C	A	0.0000
57	G	A	0.0000
58	S	A	-1.7566
59	S	A	-0.7892
60	S	A	-0.8736
61	G	A	-1.2855
62	R	A	-1.7230
63	G	A	-2.3485
64	R	A	-3.0190
65	C	A	-1.7524
66	E	A	-1.5155
67	A	A	-1.0111
68	V	A	-0.5975
69	T	A	-0.2933
70	A	A	-0.1484
71	D	A	-0.5612
72	S	A	-0.7639
73	R	A	-1.4452
74	P	A	-1.4666
75	H	A	-1.6862
76	S	A	0.0000
77	P	A	-0.8261
78	Q	A	-1.1789
79	Y	A	0.0000
80	P	A	-1.4234
81	H	A	-1.7370
82	D	A	-2.6424
83	G	A	-2.3944
84	R	A	-2.6045
85	D	A	0.0000
86	D	A	-1.3478
87	R	A	0.0000
88	E	A	0.0000
89	V	A	0.1470
90	W	A	0.0000
91	P	A	0.0000
92	L	A	-0.3703
93	R	A	-1.3816
94	F	A	0.0000
95	F	A	0.0000
96	N	A	-1.4556
97	R	A	-1.5424
98	T	A	0.0000
99	C	A	0.0000
100	H	A	-2.1309
101	C	A	-1.9822
102	N	A	-2.3044
103	G	A	-1.8170
104	N	A	-1.8069
105	F	A	-1.4821
106	S	A	-0.9924
107	G	A	-0.5253
108	H	A	-0.4314
109	N	A	-0.9490
110	C	A	0.0000
111	G	A	-0.2969
112	T	A	-0.6105
113	C	A	-1.2929
114	R	A	-1.5822
115	P	A	-0.9670
116	G	A	-1.4591
117	W	A	-2.1635
118	R	A	-2.7055
119	G	A	-1.7583
120	A	A	-0.7198
121	A	A	-1.1626
122	C	A	0.0000
123	D	A	-3.3091
124	Q	A	-3.2845
125	R	A	-2.6418
126	V	A	-0.5543
127	L	A	0.9240
128	I	A	0.0000
129	V	A	0.4244
130	R	A	0.0000
131	R	A	-1.1359
132	N	A	-1.1208
133	L	A	0.0000
134	L	A	-0.7814
135	D	A	-1.9457
136	L	A	-1.8325
137	S	A	-2.2694
138	K	A	-3.3897
139	E	A	-3.4026
140	E	A	-3.0919
141	K	A	0.0000
142	N	A	-2.6578
143	H	A	-2.3004
144	F	A	0.0000
145	V	A	-1.1845
146	R	A	-1.8696
147	A	A	0.0000
148	L	A	0.0000
149	D	A	0.0000
150	M	A	-0.6704
151	A	A	0.0000
152	K	A	0.0000
153	R	A	-1.7391
154	T	A	-0.8516
155	T	A	-0.7965
156	H	A	0.0000
157	P	A	-0.6331
158	L	A	-0.4113
159	F	A	0.0000
160	V	A	0.0000
161	I	A	0.0000
162	A	A	0.0000
163	T	A	-0.8656
164	R	A	-1.4814
165	R	A	-1.6124
166	S	A	-1.9046
167	E	A	-2.7705
168	E	A	-2.6932
169	I	A	0.0000
170	L	A	-1.6725
171	G	A	-1.8312
172	P	A	-1.7138
173	D	A	-2.5885
174	G	A	-2.0084
175	N	A	-2.1859
176	T	A	-1.2824
177	P	A	-0.8752
178	Q	A	-0.8742
179	F	A	-0.6780
180	E	A	-1.3064
181	N	A	-1.6503
182	I	A	0.0000
183	S	A	-0.9084
184	I	A	0.0000
185	Y	A	0.0000
186	N	A	0.0000
187	Y	A	0.0000
188	F	A	0.0000
189	V	A	0.0000
190	W	A	0.0000
191	T	A	0.0000
192	H	A	0.0000
193	Y	A	0.0000
194	Y	A	0.0000
195	S	A	0.0000
196	V	A	-0.3622
197	K	A	0.0000
198	K	A	-1.2725
199	T	A	0.0000
200	F	A	-0.3217
201	L	A	-0.5148
202	G	A	0.1898
203	V	A	1.2779
204	G	A	-0.3967
205	Q	A	-1.6665
206	E	A	-2.2723
207	S	A	-1.3602
208	F	A	-1.2180
209	G	A	-1.7342
210	E	A	-2.2465
211	V	A	0.0000
212	D	A	-0.8735
213	F	A	0.0000
214	S	A	0.0000
215	H	A	0.0000
216	E	A	-0.4218
217	G	A	0.0000
218	P	A	0.0000
219	A	A	0.0000
220	F	A	0.0000
221	L	A	0.0000
222	T	A	0.0000
223	W	A	0.0000
224	H	A	0.0000
225	R	A	0.0000
226	Y	A	0.0567
227	H	A	0.0000
228	L	A	0.0000
229	L	A	-0.0592
230	R	A	-0.3480
231	L	A	0.0000
232	E	A	0.0000
233	K	A	-1.2306
234	D	A	0.0000
235	M	A	0.0000
236	Q	A	-1.8766
237	E	A	-2.5934
238	M	A	-1.2769
239	L	A	-1.2782
240	Q	A	-2.2014
241	E	A	-1.8616
242	P	A	-1.4695
243	S	A	-0.3011
244	F	A	0.0000
245	S	A	-0.0367
246	L	A	0.0000
247	P	A	0.0000
248	Y	A	0.0000
249	W	A	0.0000
250	N	A	-0.4601
251	F	A	0.0000
252	A	A	0.0000
253	T	A	-1.6534
254	G	A	-2.1349
255	K	A	-2.3606
256	N	A	-1.8793
257	V	A	-0.0970
258	C	A	-0.5490
259	D	A	-1.0239
260	I	A	0.0000
261	C	A	-0.5887
262	T	A	-1.2428
263	D	A	-1.5743
264	D	A	-1.7556
265	L	A	0.0000
266	M	A	0.0000
267	G	A	0.0000
268	S	A	-1.4925
269	R	A	-1.7351
270	S	A	0.0000
271	N	A	-0.8639
272	F	A	0.8176
273	D	A	-0.4104
274	S	A	-0.7786
275	T	A	-0.7584
276	L	A	-0.5185
277	I	A	0.0000
278	S	A	0.0000
279	P	A	-1.0538
280	N	A	-1.7751
281	S	A	0.0000
282	V	A	-0.3143
283	F	A	0.0000
284	S	A	-0.9350
285	Q	A	-1.3247
286	W	A	0.0000
287	R	A	-1.9055
288	V	A	0.0000
289	V	A	0.0000
290	C	A	0.0000
291	D	A	-1.7709
292	S	A	-1.7151
293	L	A	-1.4287
294	E	A	-2.4881
295	D	A	-2.2657
296	Y	A	0.0000
297	D	A	-1.1353
298	T	A	-0.4758
299	L	A	1.0331
300	G	A	0.0000
301	T	A	-0.4641
302	L	A	0.0000
303	C	A	0.0000
304	N	A	-1.0723
305	S	A	-1.0952
306	T	A	-1.2070
307	E	A	-2.1955
308	D	A	-2.6634
309	G	A	-1.8120
310	P	A	-1.3643
311	I	A	0.0000
312	R	A	-1.2506
313	R	A	0.0000
314	N	A	-0.6701
315	P	A	-0.5536
316	A	A	-0.6176
317	G	A	-0.2678
318	N	A	-0.2204
319	V	A	0.9829
320	A	A	-0.0669
321	R	A	-1.2820
322	P	A	-0.7539
323	M	A	-0.3057
324	V	A	0.0000
325	Q	A	-1.2476
326	R	A	-2.3318
327	L	A	0.0000
328	P	A	0.0000
329	E	A	-2.7275
330	P	A	-1.8973
331	Q	A	-2.0906
332	D	A	-1.6840
333	V	A	0.0000
334	A	A	-1.3592
335	Q	A	-1.4692
336	C	A	0.0000
337	L	A	0.0000
338	E	A	-2.1553
339	V	A	0.0000
340	G	A	-0.8003
341	L	A	0.1050
342	F	A	0.0000
343	D	A	0.0000
344	T	A	-0.2405
345	P	A	-0.6305
346	P	A	-0.5236
347	F	A	-0.2659
348	Y	A	-0.1103
349	S	A	0.0000
350	N	A	-1.0723
351	S	A	0.0000
352	T	A	-1.1927
353	N	A	-1.6279
354	S	A	0.0000
355	F	A	0.0000
356	R	A	0.0000
357	N	A	0.0000
358	T	A	0.0000
359	V	A	0.0000
360	E	A	0.0000
361	G	A	0.0000
362	Y	A	-0.5613
363	S	A	0.0000
364	D	A	-1.1563
365	P	A	-1.3815
366	T	A	-1.2709
367	G	A	0.0000
368	K	A	-2.1593
369	Y	A	-1.3461
370	D	A	-1.5689
371	P	A	-0.9296
372	A	A	-0.2920
373	V	A	-0.4513
374	R	A	-0.4335
375	S	A	0.0000
376	L	A	0.0000
377	H	A	0.0000
378	N	A	-0.1620
379	L	A	0.0000
380	A	A	0.0000
381	H	A	-0.2722
382	L	A	-0.4579
383	F	A	0.0000
384	L	A	0.0000
385	N	A	-0.7343
386	G	A	-0.8059
387	T	A	0.0000
388	G	A	0.0000
389	G	A	-0.7020
390	Q	A	-1.1708
391	T	A	-0.5950
392	H	A	-0.5402
393	L	A	-0.4294
394	S	A	0.0000
395	P	A	0.0000
396	N	A	0.0000
397	D	A	0.0000
398	P	A	0.0000
399	I	A	0.0000
400	F	A	0.0000
401	V	A	0.0000
402	L	A	0.0000
403	L	A	0.0000
404	H	A	0.0000
405	T	A	0.0000
406	F	A	0.0000
407	T	A	0.0000
408	D	A	0.0000
409	A	A	0.0000
410	V	A	0.0000
411	F	A	0.0000
412	D	A	0.0000
413	E	A	-1.3913
414	W	A	0.0000
415	L	A	0.0000
416	R	A	-3.0771
417	R	A	-3.0458
418	Y	A	-2.0201
419	N	A	-2.4535
420	A	A	-1.6169
421	D	A	-1.5250
422	I	A	-0.2514
423	S	A	-0.2006
424	T	A	0.0343
425	F	A	0.0000
426	P	A	-0.5698
427	L	A	-0.7594
428	E	A	-2.1997
429	N	A	-2.2052
430	A	A	0.0000
431	P	A	0.0000
432	I	A	0.0000
433	G	A	0.0000
434	H	A	0.0000
435	N	A	0.0000
436	R	A	-0.7753
437	Q	A	-1.0913
438	Y	A	0.0000
439	N	A	0.0000
440	M	A	0.0000
441	V	A	0.0000
442	P	A	0.0000
443	F	A	0.0000
444	W	A	0.0000
445	P	A	-0.2700
446	P	A	-0.1778
447	V	A	0.0000
448	T	A	-0.5803
449	N	A	0.0000
450	T	A	-0.5242
451	E	A	-0.9619
452	M	A	0.0000
453	F	A	0.0000
454	V	A	-0.8249
455	T	A	-1.4610
456	A	A	0.0000
457	P	A	-0.9918
458	D	A	-2.0910
459	N	A	-1.8568
460	L	A	0.0000
461	G	A	-0.4408
462	Y	A	0.0000
463	T	A	-0.2808
464	Y	A	-0.7890
465	E	A	-1.8357
466	I	A	-1.1246
467	Q	A	-1.3484
468	W	A	-0.6211
469	P	A	-0.7649
470	S	A	-0.5895