Project name: 59e08a7fc5701e2

Status: done

submitted: 2018-12-17 08:48:40, status changed: 2018-12-17 09:11:49
Settings
Chain sequence(s) A: KLFPWAQIRLPTAVVPLRYELSLHPNLTSMTFRGSVTISVQALQVTWNIILHSTGHNISRVTFMSAVSSQEKQAEILEYAYHGQIAIVAPEALLAGHNYTLKIEYSANISSSYYGFYGFSYTDESNEKKYFAATQFEPLAARSAFPCFDEPAFKATFIIKIIRDEQYTALSNMPKKSSVVLDDGLVQDEFSESVKMSTYLVAFIVGEMKNLSQDVNGTLVSIYAVPEKIGQVHYALETTVKLLEFFQNYFEIQYPLKKLDLVAIPDFEAGAMENWGLLTFREETLLYDSNTSSMADRKLVTKIIAHELAHQWFGNLVTMMKWWNDLWLNEGFATFMEYFSLEKIFKELSSYEDFLDARFKTMKKDSLNSSHPISSSVQSSEQIEEMFDSLSYFKGSSLLLMLKTYLSEDVFQHAVVLYLHNHSYASIQSDDLWDSFNEVNQTLDVKRMMKTWTLQKGFPLVTVQKKGKELFIQQERFFLNMSDTSYLWHIPLSYVTEGRNYSKYQSVSLLDKKSGVINLTEEVLWVKVNINMNGYYIVHYADDDWEALIHQLKINPYVLSDKDRANLINNIFELAGLGKVPLKRAFDLINYLGNENHTAPITEALFQTDLIYNLLEKLGYMDLASRLVTRVFKLLQNQIQQQTWTDEGTPSMMRELRSALLEFACTHNLGNCSTTAMKLFDDWMASNGTQSLPTDVMTTVFKVGAKTDKGWSFLLGKYISIGSEAEKNKILEALASSEDVRKLYWLMKSSLNGDNFRTQKLSFIIRTVGRHHFPGHLLAWDFVKENWNKLVQKFPLGSYTIQNIVAGSTYLFSTKTHLSEVQAFFENQSEATFRLRCVQEALEVIQLNIQWMEKNLKSLTWWL
Distance of aggregation 10 Å
Dynamic mode No
Show buried residues
Minimal score value
-3.8221
Maximal score value
2.2629
Average score
-0.6529
Total score value
-561.5168

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index residue name chain Aggrescan3D score mutation
residue index residue name chain Aggrescan3D score
mutation
159 K A -1.1627
160 L A 0.6743
161 F A 0.4001
162 P A 0.4040
163 W A 0.1815
164 A A -0.1113
165 Q A -0.9548
166 I A -0.4089
167 R A -0.8437
168 L A 0.0000
169 P A -0.3384
170 T A 0.0425
171 A A 0.5369
172 V A 0.0000
173 V A 0.3153
174 P A 0.0000
175 L A -0.1682
176 R A -1.0689
177 Y A 0.0000
178 E A -0.9533
179 L A 0.0000
180 S A -0.7395
181 L A 0.0000
182 H A -0.9760
183 P A 0.0000
184 N A -1.1782
185 L A 0.0000
186 T A -0.3099
187 S A -0.5197
188 M A -0.4851
189 T A -1.0720
190 F A 0.0000
191 R A -1.9433
192 G A 0.0000
193 S A -1.1880
194 V A 0.0000
195 T A -0.6758
196 I A 0.0000
197 S A -0.5443
198 V A 0.0000
199 Q A -0.6456
200 A A 0.0000
201 L A 1.1509
202 Q A 0.6889
203 V A 2.0444
204 T A 1.4125
205 W A 1.3568
206 N A 0.4766
207 I A 0.0000
208 I A 0.0000
209 L A 0.0000
210 H A 0.0000
211 S A -0.5685
212 T A -0.7486
213 G A -1.1074
214 H A -1.4035
215 N A -1.9309
216 I A -1.1272
217 S A -1.5343
218 R A -2.7705
219 V A 0.0000
220 T A 0.0000
221 F A 0.0000
222 M A -1.2112
223 S A -0.7106
224 A A 0.2815
225 V A 1.4242
226 S A -0.0016
227 S A -0.7650
228 Q A -1.9748
229 E A -2.5354
230 K A -2.6649
231 Q A -2.8077
232 A A 0.0000
233 E A -2.0436
234 I A -0.9604
235 L A 0.0000
236 E A -1.3988
237 Y A 0.1528
238 A A 0.2897
239 Y A 1.2212
240 H A 0.2836
241 G A 0.1145
242 Q A 0.0000
243 I A 0.0000
244 A A 0.0000
245 I A 0.0000
246 V A -0.2044
247 A A 0.0000
248 P A -1.1131
249 E A -1.0032
250 A A 0.4458
251 L A 0.0000
252 L A 0.9866
253 A A 0.5564
254 G A -0.4925
255 H A -1.2093
256 N A -1.3158
257 Y A 0.0000
258 T A -0.5965
259 L A 0.0000
260 K A -1.3381
261 I A 0.0000
262 E A -2.1656
263 Y A 0.0000
264 S A -1.5282
265 A A 0.0000
266 N A -1.8074
267 I A 0.0000
268 S A -0.3544
269 S A -0.3374
270 S A -0.2690
271 Y A 0.0022
272 Y A 0.4412
273 G A 0.0000
274 F A 0.0000
275 Y A 0.0000
276 G A 0.0000
277 F A 0.0000
278 S A -0.5392
279 Y A -1.0048
280 T A -2.2363
281 D A -3.0250
282 E A -3.2156
283 S A -2.7067
284 N A -3.2990
285 E A -3.8221
286 K A -3.2288
287 K A -1.6950
288 Y A -0.3912
289 F A 0.0000
290 A A 0.0000
291 A A 0.0000
292 T A 0.0000
293 Q A 0.0931
294 F A 0.0000
295 E A -0.2745
296 P A 0.0000
297 L A -0.0967
298 A A 0.0000
299 A A 0.0000
300 R A -0.3202
301 S A -0.4019
302 A A 0.0000
303 F A 0.0000
304 P A 0.0000
305 C A 0.0000
306 F A 0.0000
307 D A 0.0000
308 E A 0.0000
309 P A 0.0000
310 A A -0.2751
311 F A 0.0000
312 K A -0.5257
313 A A 0.0000
314 T A -1.1993
315 F A 0.0000
316 I A -1.0119
317 I A 0.0000
318 K A -1.1553
319 I A 0.0000
320 I A -0.4145
321 R A -1.1067
322 D A -2.1457
323 E A -2.5061
324 Q A -2.1838
325 Y A -1.3192
326 T A -1.0977
327 A A 0.0000
328 L A 0.0000
329 S A 0.0000
330 N A 0.0000
331 M A 0.0000
332 P A -1.7980
333 K A -2.8337
334 K A -3.0210
335 S A -1.3604
336 S A 0.1432
337 V A 2.2629
338 V A 1.6353
339 L A 0.1518
340 D A -1.9484
341 D A -2.4615
342 G A -1.7053
343 L A -1.0379
344 V A 0.0000
345 Q A 0.1810
346 D A 0.0000
347 E A -1.8236
348 F A 0.0000
349 S A -2.0023
350 E A -2.4572
351 S A 0.0000
352 V A -0.9186
353 K A -1.6926
354 M A 0.0000
355 S A 0.0000
356 T A 0.0000
357 Y A 0.0000
358 L A 0.0000
359 V A 0.0000
360 A A 0.0000
361 F A 0.0000
362 I A 0.0000
363 V A 0.0000
364 G A 0.0000
365 E A -1.1432
366 M A 0.0000
367 K A -2.1143
368 N A -1.7641
369 L A -0.9971
370 S A -1.2168
371 Q A -1.9187
372 D A -2.4737
373 V A -1.9187
374 N A -2.2897
375 G A -1.8396
376 T A 0.0000
377 L A -1.0915
378 V A 0.0000
379 S A 0.0000
380 I A 0.0000
381 Y A -0.7760
382 A A 0.0000
383 V A 0.0000
384 P A -1.5559
385 E A -1.7889
386 K A -1.3368
387 I A -1.1874
388 G A -1.3468
389 Q A -1.1878
390 V A 0.0000
391 H A -1.5515
392 Y A -1.1602
393 A A 0.0000
394 L A 0.0000
395 E A -2.3824
396 T A 0.0000
397 T A 0.0000
398 V A -1.8039
399 K A -2.0018
400 L A 0.0000
401 L A 0.0000
402 E A -2.7007
403 F A -1.6992
404 F A 0.0000
405 Q A -2.1341
406 N A -2.5658
407 Y A 0.0000
408 F A 0.0000
409 E A -2.6626
410 I A -1.6781
411 Q A -2.1024
412 Y A 0.0000
413 P A -0.6950
414 L A 0.0000
415 K A -1.9961
416 K A 0.0000
417 L A 0.0000
418 D A 0.0000
419 L A 0.0000
420 V A 0.0000
421 A A 0.0000
422 I A 0.0000
423 P A -0.7149
424 D A -0.8959
425 F A -0.9063
426 E A -1.7263
427 A A 0.0000
428 G A 0.0000
429 A A -0.4419
430 M A 0.0000
431 E A 0.0000
432 N A 0.0000
433 W A 0.0000
434 G A 0.0000
435 L A 0.0000
436 L A 0.0000
437 T A 0.0000
438 F A 0.0000
439 R A -1.5025
440 E A -1.2474
441 E A -1.3805
442 T A -0.5563
443 L A 0.0000
444 L A -0.8128
445 Y A 0.0000
446 D A -1.5489
447 S A -1.4028
448 N A -1.6283
449 T A -1.0542
450 S A -0.9254
451 S A -0.7986
452 M A 0.0000
453 A A -0.1547
454 D A -0.4899
455 R A -0.4113
456 K A 0.0000
457 L A 0.6930
458 V A 0.0000
459 T A 0.0000
460 K A 0.1051
461 I A 0.4140
462 I A 0.0000
463 A A 0.0000
464 H A -0.1551
465 E A 0.0000
466 L A 0.0000
467 A A 0.0000
468 H A 0.0000
469 Q A 0.0000
470 W A 0.0000
471 F A 0.0000
472 G A 0.0000
473 N A 0.0000
474 L A 0.0000
475 V A 0.0000
476 T A 0.0000
477 M A 0.0000
478 K A -0.9426
479 W A -0.6081
480 W A 0.0000
481 N A -0.9380
482 D A 0.0000
483 L A 0.0000
484 W A 0.0000
485 L A 0.0000
486 N A 0.0000
487 E A -0.1408
488 G A 0.0000
489 F A 0.0000
490 A A 0.0000
491 T A 0.0000
492 F A 0.0000
493 M A 0.0000
494 E A -0.2296
495 Y A 0.0000
496 F A -0.4059
497 S A 0.0000
498 L A 0.0000
499 E A -1.9177
500 K A -2.1540
501 I A -1.2341
502 F A 0.0000
503 K A -2.9517
504 E A -2.8068
505 L A 0.0000
506 S A -1.2127
507 S A 0.0000
508 Y A -0.5008
509 E A -0.7070
510 D A -0.9146
511 F A 0.0000
512 L A 0.0000
513 D A -1.2128
514 A A -0.6260
515 R A 0.0000
516 F A 0.0000
517 K A -1.1563
518 T A 0.0000
519 M A 0.0000
520 K A -1.8258
521 K A -1.8807
522 D A 0.0000
523 S A 0.0000
524 L A 0.0000
525 N A -1.5071
526 S A -1.4532
527 S A 0.0000
528 H A -1.2446
529 P A -0.4583
530 I A 0.0000
531 S A -0.1849
532 S A -0.4032
533 S A -0.6239
534 V A -1.5260
535 Q A -1.6677
536 S A -1.8739
537 S A -2.0354
538 E A -3.4058
539 Q A -2.9384
540 I A 0.0000
541 E A -3.5135
542 E A -3.4651
543 M A 0.0000
544 F A -1.0949
545 D A -0.8515
546 S A -0.0282
547 L A -0.1720
548 S A 0.0000
549 Y A 0.1887
550 F A 0.3238
551 K A 0.0000
552 G A 0.0000
553 S A 0.0000
554 S A 0.0000
555 L A 0.0000
556 L A 0.0000
557 L A -0.0553
558 M A 0.0000
559 L A 0.0000
560 K A -0.7672
561 T A -0.1133
562 Y A 0.4470
563 L A -0.1978
564 S A -1.3405
565 E A -2.6836
566 D A -2.7388
567 V A -1.4757
568 F A 0.0000
569 Q A -1.8654
570 H A -1.8610
571 A A 0.0000
572 V A 0.0000
573 V A -0.9344
574 L A -1.0345
575 Y A 0.0000
576 L A 0.0000
577 H A -1.6824
578 N A -1.6944
579 H A -1.0483
580 S A -0.7987
581 Y A -0.4101
582 A A -0.4672
583 S A -0.4519
584 I A 0.0000
585 Q A -1.3144
586 S A 0.0000
587 D A -1.7435
588 D A -1.6475
589 L A 0.0000
590 W A 0.0000
591 D A -2.6592
592 S A -1.8433
593 F A 0.0000
594 N A -2.0810
595 E A -2.7183
596 V A -1.4668
598 N A -1.8018
599 Q A -2.1025
600 T A -0.8045
601 L A 0.3971
602 D A -0.5217
603 V A -0.6248
604 K A 0.0000
605 R A -2.2831
606 M A 0.0000
607 M A 0.0000
608 K A -1.0674
609 T A -0.6114
610 W A 0.0000
611 T A 0.0000
612 L A 0.4623
613 Q A -0.1620
614 K A -0.8308
615 G A -0.7970
616 F A 0.0000
617 P A 0.0000
618 L A 0.0000
619 V A 0.0000
620 T A -0.6169
621 V A 0.0000
622 Q A -1.3839
623 K A -1.9971
624 K A -2.8385
625 G A -2.8806
626 K A -2.9719
627 E A -2.4467
628 L A 0.0000
629 F A 0.0249
630 I A 0.0000
631 Q A -1.9757
632 Q A -2.3893
633 E A -1.9480
634 R A -1.0699
635 F A 0.0000
636 F A -0.1199
637 L A -0.1782
638 N A -0.6809
639 M A 0.3803
646 S A -1.0741
647 D A -1.9584
648 T A -1.1406
649 S A -0.5856
650 Y A -0.6974
651 L A -0.9833
652 W A 0.0000
653 H A -1.4644
654 I A 0.0000
655 P A 0.0000
656 L A 0.0000
657 S A 0.0000
658 Y A 0.0000
659 V A 0.0000
660 T A 0.0000
661 E A 0.0000
662 G A 0.0000
663 R A -2.4650
664 N A -1.6667
665 Y A -0.1345
666 S A -1.0322
667 K A -1.7986
668 Y A -0.8481
669 Q A -1.1508
670 S A -0.0355
671 V A 0.9649
672 S A 0.6917
673 L A -0.0081
674 L A 0.0000
675 D A -2.5673
676 K A -3.3969
677 K A -3.4703
678 S A -1.9839
679 G A -0.5204
680 V A 0.8496
681 I A 0.0000
682 N A -1.5381
683 L A 0.0000
684 T A -1.2781
685 E A -2.2757
686 E A -2.8836
687 V A -0.8626
688 L A 0.7292
689 W A 0.0000
690 V A 0.0000
691 K A 0.0000
692 V A 0.0000
693 N A 0.0000
694 I A -0.1116
695 N A -0.4985
696 M A 0.0000
697 N A -0.1854
698 G A 0.0000
699 Y A 0.0000
700 Y A 0.0000
701 I A 0.0000
702 V A 0.0000
703 H A -0.7049
704 Y A 0.0000
705 A A -1.8399
706 D A -2.9849
707 D A -3.1031
708 D A 0.0000
709 W A 0.0000
710 E A -2.4547
711 A A -1.2453
712 L A 0.0000
713 I A 0.0000
714 H A -1.3934
715 Q A 0.0000
716 L A 0.0000
717 K A -1.1521
718 I A 0.7018
719 N A -0.6130
720 P A 0.0000
721 Y A 0.1996
722 V A 0.3052
723 L A 0.0000
724 S A -0.1659
725 D A -0.6093
726 K A -0.7746
727 D A 0.0000
728 R A 0.0000
729 A A 0.0000
730 N A 0.0000
731 L A 0.0000
732 I A 0.0000
733 N A 0.0000
734 N A 0.0000
735 I A 0.0000
736 F A 0.0000
737 E A -0.7264
738 L A 0.0000
739 A A 0.0000
740 G A -0.9006
741 L A 0.0000
742 G A -1.4283
743 K A -1.3436
744 V A 0.0000
745 P A -1.3090
746 L A 0.0000
747 K A -1.7002
748 R A -1.5960
749 A A 0.0000
750 F A 0.0000
751 D A -1.6879
752 L A 0.0000
753 I A 0.0000
754 N A -2.1376
755 Y A 0.0000
756 L A 0.0000
757 G A -2.1324
758 N A -2.1713
759 E A 0.0000
760 N A -1.8925
761 H A -1.1314
762 T A 0.0000
763 A A 0.0000
764 P A 0.0000
765 I A 0.0000
766 T A -0.1116
767 E A 0.0000
768 A A 0.0000
769 L A 0.0000
770 F A 0.4188
771 Q A 0.0000
772 T A 0.0000
773 D A -0.1403
774 L A 0.1897
775 I A 0.0000
776 Y A 0.0707
777 N A -0.1584
778 L A 0.0000
779 L A 0.0000
780 E A 0.2199
781 K A 0.3283
782 L A 0.3123
783 G A -0.2087
784 Y A 0.2285
785 M A -0.2197
786 D A -1.6072
787 L A 0.0000
788 A A 0.0000
789 S A -0.8405
790 R A -1.0841
791 L A 0.0000
792 V A 0.0000
793 T A -0.7793
794 R A -1.1115
795 V A 0.0000
796 F A -1.0410
797 K A -2.1657
798 L A -1.6305
799 L A 0.0000
800 Q A -2.2083
801 N A -2.9050
802 Q A 0.0000
803 I A 0.0000
804 Q A -2.7013
805 Q A -2.3027
806 Q A -1.3009
807 T A -0.9100
808 W A -0.3578
809 T A -0.9099
810 D A -1.6189
811 E A -2.3230
812 G A -1.5563
813 T A -1.1500
814 P A 0.0000
815 S A -0.5959
816 M A -0.7255
817 R A -1.0422
818 E A -0.6357
819 L A 0.0000
820 R A 0.0000
821 S A -0.5540
822 A A -0.4501
823 L A 0.0000
824 L A 0.0000
825 E A -1.0872
826 F A 0.0000
827 A A 0.0000
828 C A -1.0686
829 T A -0.7515
830 H A -0.8794
831 N A -1.6662
832 L A -1.0090
833 G A -1.5104
834 N A -1.8190
835 C A 0.0000
836 S A -1.1333
837 T A -1.0221
838 T A -0.8622
839 A A 0.0000
840 M A -1.6103
841 K A -2.5026
842 L A -1.5964
843 F A 0.0000
844 D A -3.1568
845 D A -3.3288
846 W A 0.0000
847 M A -2.0525
848 A A -1.6787
849 S A -1.7030
850 N A -1.9288
851 G A -1.5009
852 T A -1.3307
853 Q A -1.8707
854 S A -1.0175
855 L A 0.0000
856 P A -0.7106
857 T A 0.0000
858 D A 0.0000
859 V A 0.0000
860 M A 0.0000
861 T A -0.4859
862 T A 0.0000
863 V A 0.0000
864 F A 0.0000
865 K A -0.9206
866 V A 0.0000
867 G A 0.0000
868 A A 0.0000
869 K A -2.9307
870 T A -2.5998
871 D A -3.1647
872 K A -2.7566
873 G A 0.0000
874 W A 0.0000
875 S A -1.1575
876 F A -0.8092
877 L A 0.0000
878 L A -0.0006
879 G A 0.1195
880 K A -0.0885
881 Y A 0.0000
882 I A 1.0991
883 S A 0.4664
884 I A 0.3155
885 G A -0.2483
886 S A -0.6190
887 E A -0.7837
888 A A -0.7660
889 E A -0.6800
890 K A -0.5053
891 N A -0.6719
892 K A -0.7489
893 I A 0.0000
894 L A 0.0000
895 E A -0.5832
896 A A 0.0000
897 L A 0.0000
898 A A 0.0000
899 S A -1.2694
900 S A 0.0000
901 E A -2.4997
902 D A -2.5928
903 V A -0.8543
904 R A -2.0313
905 K A -1.7420
906 L A 0.0000
907 Y A -0.3341
908 W A -0.3898
909 L A 0.0000
910 M A 0.0000
911 K A -1.4019
912 S A 0.0000
913 S A 0.0000
914 L A 0.0000
915 N A -2.3662
916 G A -2.3036
917 D A -2.9134
918 N A -1.5885
919 F A 0.0000
920 R A -1.5078
921 T A -1.3184
922 Q A -0.9333
923 K A -0.4790
924 L A 0.0000
925 S A 0.0000
926 F A -0.0629
927 I A 0.0000
928 I A 0.0000
929 R A -1.3424
930 T A 0.0000
931 V A 0.0000
932 G A 0.0000
933 R A -1.2741
934 H A -0.2785
935 F A 1.5000
936 P A 0.1920
937 G A 0.0000
938 H A 0.0000
939 L A 1.3014
940 L A 0.5777
941 A A 0.0000
942 W A 0.0000
943 D A -1.8489
944 F A 0.0000
945 V A 0.0000
946 K A -2.1456
947 E A -2.9040
948 N A -2.2024
949 W A 0.0000
950 N A -2.4285
951 K A -2.2877
952 L A 0.0000
953 V A -1.0736
954 Q A -1.9511
955 K A -1.5977
956 F A -0.6091
957 P A -0.1961
958 L A 0.3195
959 G A -0.7280
960 S A -0.0609
961 Y A 0.9019
962 T A 0.2311
963 I A 0.0000
964 Q A -0.3951
965 N A -0.4529
966 I A 0.0000
967 V A 0.0000
968 A A -0.3814
969 G A 0.0000
970 S A 0.0000
971 T A 0.0000
972 Y A 0.0376
973 L A 0.0000
974 F A 0.0000
975 S A 0.0000
976 T A -1.0878
977 K A -2.0135
978 T A -1.2409
979 H A -1.2265
980 L A 0.0000
981 S A -1.2070
982 E A -1.3198
983 V A 0.0000
984 Q A -1.3932
985 A A -1.2813
986 F A -1.1569
987 F A 0.0000
988 E A -2.8086
989 N A -2.4078
990 Q A -2.0947
991 S A -2.1021
992 E A -2.8919
993 A A -1.5542
994 T A -1.6019
995 F A -2.2570
996 R A -2.6210
997 L A -1.4966
998 R A -1.5978
999 C A 0.0000
1000 V A 0.0000
1001 Q A -1.5909
1002 E A -1.2359
1003 A A 0.0000
1004 L A 0.0000
1005 E A 0.0000
1006 V A -0.1551
1007 I A 0.0000
1008 Q A -0.4684
1009 L A -0.1142
1010 N A -0.6346
1011 I A -1.0654
1012 Q A -1.2198
1013 W A -1.1352
1014 M A 0.0000
1015 E A -2.8458
1016 K A -2.8579
1017 N A -2.0888
1018 L A -1.5283
1019 K A -2.1951
1020 S A -1.0344
1021 L A 0.0000
1022 T A -0.0660
1023 W A 0.9831
1024 W A 0.5148
1025 L A 0.1391

Download PDB file


View in JSmol


 
Laboratory of Theory of Biopolymers 2015