Project name: Full TAU and FKBP12

Status: done

submitted: 2019-02-19 20:12:41, status changed: 2019-02-19 20:30:08
Settings
Chain sequence(s) A: MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQARMVSKSKDGTGSDDKKAKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
B: GVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE
Distance of aggregation 10 Å
Dynamic mode No
Show buried residues

Minimal score value
-4.4927
Maximal score value
1.8034
Average score
-1.1677
Total score value
-639.8949

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index residue name chain Aggrescan3D score mutation
residue index residue name chain Aggrescan3D score
mutation
1 M A -0.0392
2 A A -1.2791
3 E A -2.3675
4 P A -2.2444
5 R A -2.9888
6 Q A -2.4180
7 E A -1.5907
8 F A 0.0000
9 E A -1.8807
10 V A 0.0000
11 M A -1.4410
12 E A -2.5455
13 D A -2.7431
14 H A 0.0000
15 A A -1.8257
16 G A -1.7651
17 T A -1.4647
18 Y A -1.8181
19 G A 0.0000
20 L A -1.3338
21 G A -1.9864
22 D A -3.1093
23 R A -3.0355
24 K A -2.7985
25 D A -2.2208
26 Q A 0.0000
27 G A 0.0000
28 G A -0.0821
29 Y A 0.8256
30 T A 0.7319
31 M A 0.5695
32 H A -0.9709
33 Q A -2.5004
34 D A -3.5665
35 Q A 0.0000
36 E A -2.6867
37 G A -2.7738
38 D A -2.8776
39 T A -2.2438
40 D A -2.4987
41 A A -1.7924
42 G A -1.1172
43 L A -0.3347
44 K A -2.3485
45 E A -2.8360
46 S A -1.3089
47 P A -0.1225
48 L A 0.5833
49 Q A -0.2677
50 T A 0.0000
51 P A 0.0000
52 T A -2.8770
53 E A -3.4243
54 D A -2.1555
55 G A -1.7712
56 S A -1.5596
57 E A -2.7549
58 E A -2.3760
59 P A -1.7780
60 G A -1.6190
61 S A -1.9509
62 E A -2.4729
63 T A -2.2016
64 S A -1.9112
65 D A -2.1797
66 A A -1.5628
67 K A -2.4306
68 S A -1.2002
69 T A -1.0139
70 P A -1.3306
71 T A 0.0000
72 A A 0.0000
73 E A -1.8428
74 D A -1.3384
75 V A -0.0955
76 T A -0.2856
77 A A 0.4737
78 P A 0.6870
79 L A 1.3736
80 V A 0.4428
81 D A -1.8400
82 E A -2.4106
83 G A -1.8485
84 A A -1.4605
85 P A -1.4287
86 G A -1.8105
87 K A -2.7855
88 Q A -2.1562
89 A A -1.4617
90 A A -1.3280
91 A A -1.2718
92 Q A -1.6226
93 P A -1.9192
94 H A -2.3465
95 T A -2.1236
96 E A -2.7893
97 I A -1.4595
98 P A -1.9631
99 E A -2.7324
100 G A -2.0887
101 T A -1.8885
102 T A -1.7184
103 A A -2.2095
104 E A -2.8984
105 E A -2.6341
106 A A -2.0950
107 G A -1.9137
108 I A -0.8926
109 G A -1.9547
110 D A -2.5702
111 T A -1.8251
112 P A -1.2950
113 S A -1.3189
114 L A -1.5952
115 E A -2.7892
116 D A -2.7108
117 E A -1.9113
118 A A 0.0000
119 A A -0.5558
120 G A -1.0712
121 H A -1.0768
122 V A 0.8381
123 T A -0.5071
124 Q A -0.6911
125 A A -0.9269
126 R A 0.0000
127 M A -0.0759
128 V A -0.0332
129 S A -1.1238
130 K A -2.1444
131 S A -2.0878
132 K A -2.8533
133 D A -3.6533
134 G A -2.0886
135 T A -1.5277
136 G A -1.8125
137 S A -2.7247
138 D A -3.3109
139 D A -3.8267
140 K A -3.3380
141 K A -2.2020
142 A A 0.0000
143 K A -1.3178
144 G A -1.5569
145 A A -1.8487
146 D A -3.0999
147 G A -2.6244
148 K A -2.5953
149 T A -1.9548
150 K A -1.4678
151 I A 0.8231
152 A A 0.1867
153 T A -0.2744
154 P A -1.2429
155 R A -2.5877
156 G A -1.9392
157 A A -1.1675
158 A A -1.0940
159 P A -1.0289
160 P A -1.4998
161 G A -2.3156
162 Q A -2.9844
163 K A -3.3988
164 G A -2.7445
165 Q A -2.8618
166 A A -2.3135
167 N A -2.6057
168 A A -1.2323
169 T A -1.1029
170 R A -1.4518
171 I A 0.3851
172 P A -0.0970
173 A A -0.9954
174 K A -2.0378
175 T A -1.0791
176 P A -1.0746
177 P A -0.9119
178 A A -0.7369
179 P A -1.4529
180 K A -1.9534
181 T A -1.1302
182 P A -1.1791
183 P A -1.4669
184 S A 0.0000
185 S A -0.5968
186 G A -1.2048
187 E A -1.8978
188 P A -2.1314
189 P A -1.9119
190 K A -2.8374
191 S A -2.4374
192 G A -2.0328
193 D A -3.3546
194 R A -3.4551
195 S A 0.0000
196 G A -1.3170
197 Y A 0.0000
198 S A -0.5359
199 S A 0.0000
200 P A 0.0000
201 G A -1.1937
202 S A -0.9843
203 P A -0.4926
204 G A -1.0025
205 T A -0.9331
206 P A -1.2487
207 G A -0.4434
208 S A 0.0000
209 R A -1.1410
210 S A -1.2618
211 R A -2.3632
212 T A -1.3130
213 P A -1.2847
214 S A -1.2053
215 L A -1.3356
216 P A 0.0000
217 T A -2.2217
218 P A -2.1655
219 P A -1.1917
220 T A -1.4505
221 R A -3.2384
222 E A -3.2299
223 P A 0.0000
224 K A -3.3911
225 K A -2.4216
226 V A -0.6612
227 A A 0.3441
228 V A 1.8034
229 V A 1.7516
230 R A -0.9712
231 T A -1.2967
232 P A -1.2716
233 P A -1.5533
234 K A -2.0796
235 S A 0.0000
236 P A 0.0000
237 S A -0.7291
238 S A 0.0000
239 A A -1.0024
240 K A -1.3545
241 S A -1.8686
242 R A -2.3614
243 L A -0.8172
244 Q A -1.1774
245 T A -0.8605
246 A A -0.2928
247 P A -0.2750
248 V A -0.1254
249 P A 0.0000
250 M A -1.0054
251 P A -1.2561
252 D A -1.9894
253 L A -0.7762
254 K A -1.6636
255 N A -1.7081
256 V A -0.8470
257 K A -1.9557
258 S A -1.5996
259 K A -1.2306
260 I A 0.1844
261 G A -1.1666
262 S A -1.1999
263 T A -1.0580
264 E A -2.0902
265 N A -2.2791
266 L A -1.0680
267 K A -2.3971
268 H A -2.2580
269 Q A -2.0608
270 P A -1.7047
271 G A -1.9327
272 G A -1.0920
273 G A -0.4348
274 K A -0.5425
275 V A -0.1622
276 Q A -1.7253
277 I A -1.1235
278 I A 0.0000
279 N A -2.6352
280 K A -2.8663
281 K A -2.0163
282 L A -0.9040
283 D A 0.0000
284 L A -1.5206
285 S A -1.5249
286 N A -1.9083
287 V A -1.0793
288 Q A -1.9104
289 S A -1.8779
290 K A -2.3577
291 C A -2.1593
292 G A -2.2140
293 S A -2.2284
294 K A -3.1573
295 D A -3.1650
296 N A -2.0865
297 I A -1.3606
298 K A -2.0304
299 H A 0.0000
300 V A 0.0000
301 P A 0.1356
302 G A -0.7769
303 G A -0.8485
304 G A -0.2947
305 S A 0.1812
306 V A 1.5780
307 Q A 0.3327
308 I A 0.0000
309 V A 0.9419
310 Y A 0.8088
311 K A -0.8592
312 P A 0.0932
313 V A 1.1618
314 D A -0.6724
315 L A 0.3746
316 S A -0.5526
317 K A -1.6911
318 V A -0.3100
319 T A -0.2776
320 S A -0.8628
321 K A -1.6028
322 C A -0.8315
323 G A -0.2972
324 S A 0.0000
325 L A 0.0047
326 G A -0.5133
327 N A -0.4749
328 I A 0.6512
329 H A -0.8415
330 H A -1.2684
331 K A -0.8979
332 P A -1.1438
333 G A -1.5648
334 G A -1.4840
335 G A -1.9362
336 Q A -2.8435
337 V A -1.9125
338 E A -2.0651
339 V A -0.4633
340 K A -1.9968
341 S A -1.9213
342 E A -2.6920
343 K A -1.5473
344 L A -0.2953
345 D A -1.0747
346 F A 0.3504
347 K A -0.9050
348 D A -1.6711
349 R A -1.6661
350 V A -0.0504
351 Q A -1.5438
352 S A -1.0072
353 K A -1.0865
354 I A 0.6285
355 G A -0.1331
356 S A -0.0215
357 L A 0.1069
358 D A -1.4422
359 N A -0.7577
360 I A 1.0091
361 T A 0.2243
362 H A 0.1428
363 V A 1.4174
364 P A 0.1938
365 G A -0.8656
366 G A -1.4658
367 G A -1.7709
368 N A -2.2411
369 K A -2.2535
370 K A -1.9881
371 I A -0.4058
372 E A -1.9713
373 T A -1.5483
374 H A -1.7389
375 K A -1.4267
376 L A 0.7267
377 T A 0.5434
378 F A 0.5763
379 R A -1.8940
380 E A -3.0240
381 N A -2.6791
382 A A -2.1303
383 K A -2.7882
384 A A -1.7919
385 K A -2.6776
386 T A -1.8560
387 D A -2.0909
388 H A -2.0917
389 G A -0.9809
390 A A -0.4740
391 E A -0.8511
392 I A 0.1416
393 V A 0.2466
394 Y A -0.6696
395 K A -1.5589
396 S A -0.1320
397 P A 0.5736
398 V A 1.3624
399 V A 1.6858
400 S A 0.2659
401 G A -0.1738
402 D A -0.5761
403 T A -0.6414
404 S A -0.5083
405 P A -0.6424
406 R A -1.4834
407 H A -1.0164
408 L A 0.2612
409 S A -0.4754
410 N A -1.2151
411 V A -0.6399
412 S A -0.7193
413 S A -0.5263
414 T A 0.1400
415 G A 0.0000
416 S A 0.5670
417 I A 1.5806
418 D A -0.2816
419 M A 0.7632
420 V A 0.1739
421 D A -1.1230
422 S A -0.7011
423 P A -0.2779
424 Q A -0.8505
425 L A 0.0000
426 A A 0.5862
427 T A 0.2933
428 L A 0.7953
429 A A -0.3120
430 D A -1.8533
431 E A -1.7147
432 V A 0.2825
433 S A -0.3685
434 A A -0.1437
435 S A -0.2216
436 L A -0.5279
437 A A -0.8236
438 K A -1.8942
439 Q A -1.0161
440 G A -0.4789
441 L A 0.9111
1 G B -0.9476
2 V B 0.0000
3 Q B -1.3006
4 V B -1.1634
5 E B -1.9964
6 T B -0.9107
7 I B -0.0471
8 S B -0.5330
9 P B -0.7127
10 G B -1.1373
11 D B -1.5121
12 G B -1.6718
13 R B -2.0482
14 T B -1.1087
15 F B -0.5266
16 P B 0.0000
17 K B -2.5515
18 R B -3.0697
19 G B -2.1822
20 Q B -2.0827
21 T B -1.7953
22 C B 0.0000
23 V B 0.0000
24 V B 0.0000
25 H B -1.8525
26 Y B 0.0000
27 T B 0.0000
28 G B 0.0000
29 M B -1.7761
30 L B -1.8248
31 E B -3.0259
32 D B -3.3418
33 G B -2.6438
34 K B -3.2296
35 K B -2.6601
36 F B -0.5438
37 D B -1.4768
38 S B 0.0000
39 S B 0.0000
40 R B -4.2387
41 D B -4.3741
42 R B -4.4927
43 N B -4.2475
44 K B -3.7106
45 P B -1.9205
46 F B -1.0599
47 K B -1.4306
48 F B 0.0000
49 M B -1.6834
50 L B 0.0000
51 G B -2.2697
52 K B -2.7749
53 Q B -1.9997
54 E B -2.3958
55 V B -1.1897
56 I B -0.5243
57 R B -1.0073
58 G B 0.0000
59 W B 0.0000
60 E B 0.0000
61 E B 0.0000
62 G B 0.0000
63 V B 0.0000
64 A B -0.5977
65 Q B -0.4099
66 M B 0.0000
67 S B 0.0000
68 V B -0.7265
69 G B -1.0088
70 Q B -0.9621
71 R B -1.2680
72 A B 0.0000
73 K B -1.4284
74 L B 0.0000
75 T B -0.9197
76 I B 0.0000
77 S B -1.0238
78 P B 0.0000
79 D B -1.9739
80 Y B 0.0000
81 A B -0.4858
82 Y B -0.3457
83 G B -0.9822
84 A B -0.7922
85 T B -0.5648
86 G B -0.5260
87 H B -0.5819
88 P B -0.4797
89 G B 0.0001
90 I B 1.1975
91 I B 0.0000
92 P B -0.4174
93 P B -0.7869
94 H B -1.4034
95 A B 0.0000
96 T B -1.1163
97 L B 0.0000
98 V B -0.9882
99 F B 0.0000
100 D B -0.7470
101 V B 0.0000
102 E B -1.2424
103 L B 0.0000
104 L B -0.6108
105 K B -1.4865
106 L B -1.4061
107 E B -2.2287

 

Laboratory of Theory of Biopolymers 2015