Project name: 1HGH

Chain sequence(s)	A: PTIPLSRLFQNAMLRAHRLHQLAFDTYEEFEEAYIQKYSFLQAPQASLCFSESIPTPSNREQAQQKSNLQLLRISLLLIQSWLEPVGFLRSVFANSLVYGASDSDVYDLLKDLEEGIQTLMGRLEDGSPRTGQAFKQTYAKFDANSHNDDALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCG
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.763
• Maximal score value: 1.7672
• Average score: -0.8794
• Total score value: -162.6893

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
2	P	A	0.4189
3	T	A	0.6930
4	I	A	1.7672
5	P	A	0.6875
6	L	A	0.6323
7	S	A	-0.7188
8	R	A	-1.6034
9	L	A	-0.5942
10	F	A	0.0000
11	Q	A	-1.6171
12	N	A	-1.2774
13	A	A	0.0000
14	M	A	0.0000
15	L	A	-0.5439
16	R	A	-1.5767
17	A	A	0.0000
18	H	A	-1.6373
19	R	A	-2.5273
20	L	A	0.0000
21	H	A	-1.7569
22	Q	A	-2.0425
23	L	A	-0.9199
24	A	A	0.0000
25	F	A	-1.1778
26	D	A	-1.1001
27	T	A	-0.8026
28	Y	A	0.0000
29	E	A	-2.7707
30	E	A	-2.3396
31	F	A	-1.1082
32	E	A	-1.5340
33	E	A	-2.3724
34	A	A	-0.7985
35	Y	A	0.3861
36	I	A	0.1367
40	Q	A	-0.6913
41	K	A	-0.2127
42	Y	A	1.1154
43	S	A	0.6746
44	F	A	1.6759
45	L	A	0.4726
46	Q	A	-0.5728
47	A	A	-0.2207
48	P	A	-0.4521
49	Q	A	-0.8578
50	A	A	-0.5207
51	S	A	-0.4163
52	L	A	0.1543
53	C	A	-0.2576
54	F	A	-0.4791
55	S	A	-0.9630
56	E	A	-1.7328
57	S	A	-0.8088
58	I	A	-0.4909
59	P	A	-0.7822
60	T	A	-0.7859
61	P	A	0.0000
62	S	A	-1.9566
63	N	A	-2.9698
64	R	A	-3.6810
65	E	A	-3.7630
66	Q	A	-3.2431
67	A	A	-2.5401
68	Q	A	-2.4348
69	Q	A	-2.5923
70	K	A	-2.5190
71	S	A	-1.5272
72	N	A	-1.4766
73	L	A	0.0000
74	Q	A	-1.1109
75	L	A	0.0000
76	L	A	0.0000
77	R	A	-0.7023
78	I	A	0.1210
79	S	A	0.0000
80	L	A	-0.4815
81	L	A	-0.0432
82	L	A	0.0000
83	I	A	0.0000
84	Q	A	-1.0599
85	S	A	0.0000
86	W	A	0.0000
87	L	A	-1.0265
88	E	A	-1.7250
89	P	A	0.0000
90	V	A	0.0000
91	G	A	-0.2481
92	F	A	1.0969
93	L	A	-0.3549
94	R	A	-1.3088
95	S	A	-0.8119
96	V	A	0.3446
97	F	A	0.0000
98	A	A	-0.3358
99	N	A	-0.3741
100	S	A	0.5551
101	L	A	1.5072
102	V	A	1.1893
103	Y	A	1.3149
104	G	A	0.0725
105	A	A	-0.7090
106	S	A	-1.4119
107	D	A	-2.6972
108	S	A	-2.1498
109	D	A	-2.3886
110	V	A	-1.2697
111	Y	A	-0.9483
112	D	A	-2.2045
113	L	A	0.0000
114	L	A	0.0000
115	K	A	-1.7948
116	D	A	-2.2416
117	L	A	0.0000
118	E	A	-2.1027
119	E	A	-2.8658
120	G	A	-1.7153
121	I	A	0.0000
122	Q	A	-2.2262
123	T	A	-1.4024
124	L	A	0.0000
125	M	A	-1.9012
126	G	A	-2.1817
127	R	A	-2.6785
128	L	A	-2.0556
129	E	A	-3.4889
130	D	A	-3.4139
131	G	A	-1.9620
132	S	A	-1.8283
133	P	A	-2.3499
134	R	A	-2.7072
135	T	A	-1.8850
136	G	A	-1.0633
137	Q	A	-0.9183
138	A	A	-0.1637
139	F	A	0.6837
140	K	A	-1.4037
141	Q	A	-1.5237
142	T	A	-1.1682
143	Y	A	-0.0512
144	A	A	-0.4672
145	K	A	0.1882
146	F	A	0.5574
147	D	A	-1.6435
149	N	A	-2.1509
150	S	A	-1.1142
151	H	A	-2.3148
152	N	A	-3.1980
153	D	A	-3.2917
154	D	A	-3.2600
155	A	A	0.0000
156	L	A	0.0000
157	L	A	-1.0459
158	K	A	-2.0436
159	N	A	0.0000
160	Y	A	0.0616
161	G	A	-0.1345
162	L	A	0.0000
163	L	A	0.0000
164	Y	A	-0.3608
165	C	A	0.0000
166	F	A	0.0000
167	R	A	-1.5389
168	K	A	-1.2402
169	D	A	0.0000
170	M	A	0.0000
171	D	A	-1.0660
172	K	A	0.0000
173	V	A	0.0000
174	E	A	0.0000
175	T	A	-0.5259
176	F	A	0.0000
177	L	A	0.0000
178	R	A	-0.9531
179	I	A	0.0000
180	V	A	0.0000
181	Q	A	-1.3498
182	C	A	-1.4029
183	R	A	-2.3779
184	S	A	-1.3384
185	V	A	-1.0539
186	E	A	-2.1950
187	G	A	-1.5312
188	S	A	-0.6188
189	C	A	-0.1669
190	G	A	-0.5897