Project name: 5cb1b8c4e1b4bea

Chain sequence(s)	A: DHHEGQPRSVCALEENAKRALISCVQTHLTADTTQKLSAVKDQLHCDDVYCVFVRICDRNNGTLEHPSNEFFSNAEKTDIRSAVVTCRENLQRQAEAAKTSGGGGSQQLLKLEECKASAKESIPGFKNITLSPCDKDPCVINKGEKYNVTFYAEATDDADYLMVSDSEQQQTDTINIQSARSISCYYIDVPCNVTKGEVFRGSVTLRILGAFAPGNLTYKLGVGHGKRTFACGVSNLIVEGGGGSMIAVYTNDRMSALEGYAFVGSACTTHRQLLGEDTAYTFRGIRIVTHEIGHALGCSHDGTSAPGIVKAFVPNSLHCPWGDGYIMSYEQHDSRSMRFSSCCRYDISQMSWSREASCLHVNDSMKYPLNWLIKYKLPGDFLSLNRQCEIAYPNLWRTYYVQKTYKWYCKGYCFVPGHQFRAADHYWDFLFVDGTVCLNELRMDTTAGYASTENAFQIKEGIENYPTRNKNKFGGGGSSEIKYHNYNSNGFNPKGPGPGILFGDAFIPAIVQPVSQIFPGPGPGILFNSLQYTNVVKDYWGNDLGPGPGKETVLRVAVTAQHPKPASLMGPGPGYDAGIELAHLLAFNKYGPGPGHDKKQFAALMLYEEDGTLRVEGVGPGPGKRHGKRLRVTKVIPHAKYNEKSEAAAKFYPSYHSTPQRPGTP
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.5537
• Maximal score value: 2.4319
• Average score: -0.6959
• Total score value: -463.4461

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	D	A	-3.0030
2	H	A	-3.0755
3	H	A	-3.2487
4	E	A	-3.2636
5	G	A	-2.5174
6	Q	A	-3.1274
7	P	A	-2.0658
8	R	A	-2.1239
9	S	A	-0.2748
10	V	A	1.4868
11	C	A	0.5072
12	A	A	0.0000
13	L	A	-0.0290
14	E	A	-0.7951
15	E	A	-2.4099
16	N	A	-2.2268
17	A	A	0.0000
18	K	A	-2.0870
19	R	A	-2.5105
20	A	A	-1.4039
21	L	A	0.0000
22	I	A	-1.0090
23	S	A	-1.0135
24	C	A	-0.6911
25	V	A	0.0000
26	Q	A	-0.9890
27	T	A	-0.4913
28	H	A	-0.1385
29	L	A	0.0015
30	T	A	-0.6431
31	A	A	-1.0203
32	D	A	-2.3882
33	T	A	0.0000
34	T	A	-1.4850
35	Q	A	-2.2001
36	K	A	-1.8954
37	L	A	0.0000
38	S	A	-1.7064
39	A	A	-1.7027
40	V	A	0.0000
41	K	A	-2.1716
42	D	A	-3.1066
43	Q	A	-2.3836
44	L	A	-1.8005
45	H	A	-2.7383
46	C	A	0.0000
47	D	A	-3.1554
48	D	A	-2.1598
49	V	A	-0.2550
50	Y	A	-0.4133
51	C	A	0.0000
52	V	A	0.0000
53	F	A	0.0000
54	V	A	0.0000
55	R	A	0.0000
56	I	A	-0.3716
57	C	A	-0.8030
58	D	A	-2.1690
59	R	A	-3.0735
60	N	A	-2.9723
61	N	A	-2.7631
62	G	A	-1.5670
63	T	A	-1.0646
64	L	A	-0.3750
65	E	A	-0.2468
66	H	A	-0.7318
67	P	A	0.0000
68	S	A	0.0000
69	N	A	0.0000
70	E	A	-0.2621
71	F	A	1.0563
72	F	A	-0.0649
73	S	A	-0.9474
74	N	A	-1.9433
75	A	A	-2.1456
76	E	A	-2.6701
77	K	A	-2.1897
78	T	A	-2.4998
79	D	A	-3.1142
80	I	A	-1.9801
81	R	A	-1.7524
82	S	A	-1.4748
83	A	A	0.0000
84	V	A	0.0000
85	V	A	0.0000
86	T	A	-0.3970
87	C	A	0.0000
88	R	A	0.0000
89	E	A	-0.4646
90	N	A	0.0000
91	L	A	-0.8295
92	Q	A	-0.8464
93	R	A	-1.2253
94	Q	A	0.0000
95	A	A	-1.6045
96	E	A	-2.2302
97	A	A	-1.8356
98	A	A	-2.1911
99	K	A	-2.5831
100	T	A	-1.5773
101	S	A	-1.4097
102	G	A	-1.4127
103	G	A	-1.2749
104	G	A	-1.3298
105	G	A	-1.2713
106	S	A	-0.7705
107	Q	A	-1.4851
108	Q	A	-1.3922
109	L	A	0.0806
110	L	A	-0.7686
111	K	A	-1.8551
112	L	A	-1.2406
113	E	A	-2.3815
114	E	A	-2.0311
115	C	A	0.0000
116	K	A	-1.8260
117	A	A	-2.0188
118	S	A	0.0000
119	A	A	0.0000
120	K	A	-2.5035
121	E	A	-2.6734
122	S	A	-1.5963
123	I	A	-0.5899
124	P	A	-0.8617
125	G	A	0.0000
126	F	A	-0.7656
127	K	A	-2.2113
128	N	A	-1.6884
129	I	A	-0.8699
130	T	A	-0.3943
131	L	A	0.0000
132	S	A	-0.5441
133	P	A	0.0000
134	C	A	-1.7728
135	D	A	-2.9999
136	K	A	-2.8087
137	D	A	-2.4143
138	P	A	-1.5918
139	C	A	0.2632
140	V	A	0.2034
141	I	A	-0.8973
142	N	A	-2.0102
143	K	A	-2.8458
144	G	A	-2.7699
145	E	A	-3.1936
146	K	A	-3.3041
147	Y	A	-2.1263
148	N	A	-1.7366
149	V	A	0.0000
150	T	A	-0.4439
151	F	A	0.0000
152	Y	A	0.4288
153	A	A	0.0000
154	E	A	0.0000
155	A	A	0.0000
156	T	A	-1.1404
157	D	A	-2.1866
158	D	A	-1.5067
159	A	A	0.0000
160	D	A	-0.3982
161	Y	A	0.8426
162	L	A	1.0803
163	M	A	1.0291
164	V	A	0.6241
165	S	A	-0.9827
166	D	A	-2.5259
167	S	A	-2.0370
168	E	A	0.0000
169	Q	A	-2.5760
170	Q	A	-2.9376
171	Q	A	-2.4177
172	T	A	-1.8986
173	D	A	-1.9812
174	T	A	0.0000
175	I	A	0.0000
176	N	A	-0.3159
177	I	A	0.0000
178	Q	A	-1.0406
179	S	A	-1.3784
180	A	A	-1.0112
181	R	A	-1.7498
182	S	A	-0.3832
183	I	A	1.4527
184	S	A	0.5944
185	C	A	0.7346
186	Y	A	0.5526
187	Y	A	0.0000
188	I	A	0.0000
189	D	A	0.1628
190	V	A	0.0000
191	P	A	-0.3694
192	C	A	-0.4964
193	N	A	-1.3105
194	V	A	-1.0374
195	T	A	-1.4823
196	K	A	-2.3253
197	G	A	-1.5449
198	E	A	-1.4900
199	V	A	0.0045
200	F	A	-0.4591
201	R	A	-1.8052
202	G	A	-1.2496
203	S	A	-0.9509
204	V	A	-0.3549
205	T	A	-0.3820
206	L	A	0.0000
207	R	A	-0.2819
208	I	A	0.1012
209	L	A	0.0000
210	G	A	0.4681
211	A	A	0.7026
212	F	A	0.5234
213	A	A	0.2171
214	P	A	-0.2812
215	G	A	0.0000
216	N	A	-0.3802
217	L	A	0.0000
218	T	A	0.0000
219	Y	A	0.1814
220	K	A	-0.1798
221	L	A	0.0000
222	G	A	0.3380
223	V	A	1.0214
224	G	A	-0.6702
225	H	A	-1.7581
226	G	A	-2.0343
227	K	A	-2.6525
228	R	A	-2.3735
229	T	A	-0.7910
230	F	A	0.7951
231	A	A	0.7413
232	C	A	1.2919
233	G	A	1.2138
234	V	A	1.7750
235	S	A	0.9682
236	N	A	0.4213
237	L	A	0.7681
238	I	A	0.4784
239	V	A	0.5580
240	E	A	-0.5496
241	G	A	-1.3312
242	G	A	-0.9709
243	G	A	-1.1132
244	G	A	-1.3386
245	S	A	-0.8640
246	M	A	0.0000
247	I	A	0.8413
248	A	A	0.7475
249	V	A	0.9132
250	Y	A	0.3646
251	T	A	-1.0435
252	N	A	-2.2110
253	D	A	-3.1370
254	R	A	-2.6352
255	M	A	-0.8156
256	S	A	0.1723
257	A	A	0.6548
258	L	A	0.9407
259	E	A	-0.0648
260	G	A	0.1999
261	Y	A	1.0184
262	A	A	0.0000
263	F	A	1.3501
264	V	A	1.6377
265	G	A	0.6364
266	S	A	0.0515
267	A	A	0.0000
268	C	A	-0.5248
269	T	A	-0.3119
270	T	A	-0.1191
271	H	A	-0.5356
272	R	A	0.0000
273	Q	A	0.1394
274	L	A	0.0000
275	L	A	0.0741
276	G	A	0.0000
277	E	A	-1.5330
278	D	A	-1.8194
279	T	A	-0.4702
280	A	A	0.0670
281	Y	A	1.3946
282	T	A	0.7959
283	F	A	1.2823
284	R	A	-0.5075
285	G	A	0.1723
286	I	A	1.6822
287	R	A	0.0000
288	I	A	0.0000
289	V	A	0.9767
290	T	A	0.8179
291	H	A	0.0000
292	E	A	0.0000
293	I	A	1.0175
294	G	A	0.0000
295	H	A	0.8969
296	A	A	0.0000
297	L	A	0.5483
298	G	A	0.0000
299	C	A	0.0000
300	S	A	0.4366
301	H	A	-0.1225
302	D	A	0.0000
303	G	A	0.2722
304	T	A	0.6482
305	S	A	1.2151
306	A	A	1.2515
307	P	A	0.9586
308	G	A	0.9248
309	I	A	2.4319
310	V	A	2.0564
311	K	A	0.2258
312	A	A	1.1000
313	F	A	2.0751
314	V	A	0.0000
315	P	A	-0.0557
316	N	A	-0.2547
317	S	A	0.0000
318	L	A	1.0560
319	H	A	-0.4743
320	C	A	0.0869
321	P	A	0.0244
322	W	A	0.3171
323	G	A	-1.4650
324	D	A	-2.4026
325	G	A	0.0000
326	Y	A	0.0000
327	I	A	0.0000
328	M	A	0.0000
329	S	A	0.0000
330	Y	A	-2.1192
331	E	A	-2.6926
332	Q	A	-2.8563
333	H	A	-3.5537
334	D	A	-3.5126
335	S	A	-2.3368
336	R	A	-2.2420
337	S	A	-1.7658
338	M	A	-0.4067
339	R	A	-1.5487
340	F	A	-0.7412
341	S	A	0.0000
342	S	A	-0.9255
343	C	A	0.0000
344	C	A	0.0000
345	R	A	-1.5366
346	Y	A	-0.6270
347	D	A	0.0000
348	I	A	-0.2184
349	S	A	-0.3003
350	Q	A	-0.6709
351	M	A	-0.5873
352	S	A	-0.3963
353	W	A	0.0502
354	S	A	-1.1663
355	R	A	-2.5523
356	E	A	-2.4746
357	A	A	0.0000
358	S	A	-1.3186
359	C	A	-0.6870
360	L	A	-0.1514
361	H	A	-0.7551
362	V	A	-0.8188
363	N	A	-2.4928
364	D	A	-2.7613
365	S	A	-1.4044
366	M	A	-1.1612
367	K	A	-1.9309
368	Y	A	-0.2853
369	P	A	0.0350
370	L	A	0.1734
371	N	A	0.0701
372	W	A	1.0155
373	L	A	2.1476
374	I	A	2.0029
375	K	A	0.0601
376	Y	A	1.5229
377	K	A	0.5238
378	L	A	1.0611
379	P	A	1.2434
380	G	A	0.0000
381	D	A	0.9485
382	F	A	2.1057
383	L	A	1.6472
384	S	A	0.7580
385	L	A	0.5903
386	N	A	-0.2743
387	R	A	0.3223
388	Q	A	0.0000
389	C	A	0.0000
390	E	A	0.0000
391	I	A	0.0000
392	A	A	0.2247
393	Y	A	0.2797
394	P	A	0.5727
395	N	A	-0.7589
396	L	A	-0.3124
397	W	A	0.0000
398	R	A	-1.7014
399	T	A	-0.2170
400	Y	A	1.4038
401	Y	A	1.7561
402	V	A	1.5968
403	Q	A	-0.3716
404	K	A	-0.2207
405	T	A	0.0112
406	Y	A	0.5742
407	K	A	-0.8974
408	W	A	0.1379
409	Y	A	0.2705
410	C	A	0.0000
411	K	A	0.3017
412	G	A	0.0000
413	Y	A	0.2600
414	C	A	0.0000
415	F	A	0.0000
416	V	A	0.0000
417	P	A	-0.4676
418	G	A	-1.0116
419	H	A	-0.7805
420	Q	A	-0.8801
421	F	A	-0.0439
422	R	A	-1.5705
423	A	A	-1.2425
424	A	A	-1.2483
425	D	A	-2.3431
426	H	A	-1.8762
427	Y	A	-1.2051
428	W	A	-0.8900
429	D	A	-1.0027
430	F	A	0.4708
431	L	A	1.2403
432	F	A	0.0000
433	V	A	0.5778
434	D	A	-0.8975
435	G	A	-0.7411
436	T	A	0.1242
437	V	A	0.0451
438	C	A	0.0000
439	L	A	-0.3039
440	N	A	-1.7646
441	E	A	-2.2025
442	L	A	-1.3124
443	R	A	-1.5118
444	M	A	-0.8495
445	D	A	-1.0900
446	T	A	-0.5311
447	T	A	-0.2898
448	A	A	0.1189
449	G	A	-0.2499
450	Y	A	0.2217
451	A	A	0.0000
452	S	A	-0.9659
453	T	A	-1.4057
454	E	A	-2.2014
455	N	A	-1.6741
456	A	A	-1.0552
457	F	A	0.4972
458	Q	A	0.0000
459	I	A	-1.2656
460	K	A	-1.7121
461	E	A	-2.3663
462	G	A	-2.2026
463	I	A	0.0000
464	E	A	-3.4064
465	N	A	-2.3751
466	Y	A	-1.1920
467	P	A	-1.2477
468	T	A	-1.1530
469	R	A	-2.1605
470	N	A	-1.8103
471	K	A	-1.8828
472	N	A	-1.9215
473	K	A	-1.5045
474	F	A	-1.4550
475	G	A	-1.6078
476	G	A	-1.2807
477	G	A	-1.6147
478	G	A	-1.3041
479	S	A	-1.4817
480	S	A	-1.5932
481	E	A	-1.7963
482	I	A	-0.1847
483	K	A	0.0000
484	Y	A	-0.2827
485	H	A	-1.0895
486	N	A	-1.1928
487	Y	A	-0.2611
488	N	A	-1.2120
489	S	A	-0.8620
490	N	A	-1.2782
491	G	A	-0.4042
492	F	A	-0.2697
493	N	A	0.0000
494	P	A	-0.8438
495	K	A	-1.0542
496	G	A	0.0000
497	P	A	0.0000
498	G	A	0.0000
499	P	A	-0.3965
500	G	A	-0.1244
501	I	A	0.0000
502	L	A	0.1741
503	F	A	0.0905
504	G	A	-1.1429
505	D	A	-2.5633
506	A	A	-1.9077
507	F	A	0.0000
508	I	A	-0.7628
509	P	A	0.0000
510	A	A	0.0000
511	I	A	0.0000
512	V	A	0.0000
513	Q	A	0.0000
514	P	A	0.0360
515	V	A	0.6109
516	S	A	0.3425
517	Q	A	0.0545
518	I	A	0.0000
519	F	A	1.5824
520	P	A	0.4892
521	G	A	-0.2202
522	P	A	-0.5456
523	G	A	-0.4386
524	P	A	-0.1083
525	G	A	0.3881
526	I	A	0.5874
527	L	A	0.5880
528	F	A	0.0000
529	N	A	-0.7945
530	S	A	0.0000
531	L	A	-0.3235
532	Q	A	-0.2071
533	Y	A	0.0313
534	T	A	-0.2688
535	N	A	-0.7592
536	V	A	0.0000
537	V	A	0.0000
538	K	A	-1.4071
539	D	A	-1.4659
540	Y	A	-0.6320
541	W	A	-0.8808
542	G	A	-1.5067
543	N	A	-2.2247
544	D	A	-2.1365
545	L	A	-0.1235
546	G	A	-1.1114
547	P	A	-1.5854
548	G	A	-1.1218
549	P	A	-1.4326
550	G	A	-1.8822
551	K	A	-3.0516
552	E	A	-3.1953
553	T	A	-1.5713
554	V	A	-0.4702
555	L	A	0.0000
556	R	A	0.0000
557	V	A	0.0000
558	A	A	0.0000
559	V	A	0.0000
560	T	A	-1.0111
561	A	A	-1.0138
562	Q	A	-1.8872
563	H	A	-1.6996
564	P	A	-1.5300
565	K	A	-1.8544
566	P	A	0.0000
567	A	A	-0.3194
568	S	A	0.0000
569	L	A	-0.0540
570	M	A	0.2659
571	G	A	-0.2094
572	P	A	-0.3751
573	G	A	-0.2313
574	P	A	-0.4798
575	G	A	-0.9014
576	Y	A	-0.1180
577	D	A	0.0000
578	A	A	0.0000
579	G	A	0.0000
580	I	A	0.1957
581	E	A	0.0000
582	L	A	0.0000
583	A	A	0.0000
584	H	A	0.0000
585	L	A	0.0000
586	L	A	0.0000
587	A	A	0.0000
588	F	A	0.0000
589	N	A	-1.7098
590	K	A	-2.4824
591	Y	A	0.0000
592	G	A	-1.7144
593	P	A	-1.0659
594	G	A	-1.0152
595	P	A	-1.0835
596	G	A	-1.1237
597	H	A	-1.6119
598	D	A	-2.3414
599	K	A	-2.3587
600	K	A	-2.5226
601	Q	A	-1.7421
602	F	A	0.0000
603	A	A	0.0000
604	A	A	-0.4918
605	L	A	-0.0827
606	M	A	0.3276
607	L	A	-0.0657
608	Y	A	0.0000
609	E	A	-1.9894
610	E	A	-2.8889
611	D	A	-2.9759
612	G	A	-2.3671
613	T	A	-1.3324
614	L	A	-0.3830
615	R	A	-0.5107
616	V	A	-0.2085
617	E	A	0.0000
618	G	A	0.0000
619	V	A	0.0000
620	G	A	-1.3539
621	P	A	-1.8742
622	G	A	-1.5706
623	P	A	-1.1517
624	G	A	-1.6960
625	K	A	-2.5313
626	R	A	-3.4647
627	H	A	-2.7397
628	G	A	-2.6623
629	K	A	-3.4481
630	R	A	-3.0010
631	L	A	0.0000
632	R	A	-0.8990
633	V	A	0.0000
634	T	A	0.0000
635	K	A	-0.8444
636	V	A	0.0000
637	I	A	0.0000
638	P	A	-0.6073
639	H	A	-0.9327
640	A	A	-1.0609
641	K	A	-1.5467
642	Y	A	-1.2431
643	N	A	-2.4141
644	E	A	-3.1368
645	K	A	-3.1895
646	S	A	0.0000
647	E	A	-2.4647
648	A	A	-1.9169
649	A	A	-1.4390
650	A	A	-1.0118
651	K	A	-1.3635
652	F	A	-0.3473
653	Y	A	0.0000
654	P	A	0.0000
655	S	A	0.0000
656	Y	A	-0.5664
657	H	A	-1.0343
658	S	A	-0.9189
659	T	A	-0.8575
660	P	A	-1.3562
661	Q	A	-2.3761
662	R	A	-2.4485
663	P	A	-1.6218
664	G	A	-1.3926
665	T	A	-1.3119
666	P	A	-1.2111