Project name: 5igo modified

Chain sequence(s)	A: SRLRVIAEIRHGDIFHSANIVSSIEFDRDDELFATAGVSRCIKVFDFSSVVNEPADMQCPIVEMSTRSKLSCLSWNKHEKNHIASSDYEGIVTVWDVTTRQSLMEYEEHEKRAWSVDFSRTEPSMLVSGSDDCKVKVWCTRQEASVINIDMKANICCCVKYNPGSSNYIAVGSADHHIHYYDLRNISQPLHVFSGHKKAVSYVKFLSNNELASASTDSTLRLWDVKDNLPVRTFRGHTNEKNFVGLTVNSEYLACGSETNEVYVYHKEITRPVTSHRFGSPDMDDAEEEAGSYFISAVCWKSDSPTMLTANSQGTIKVLVLA; U: SDQIVPEY
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.5754
• Maximal score value: 1.9157
• Average score: -0.7859
• Total score value: -258.5692

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
354	S	A	-0.9532
355	R	A	-2.2371
356	L	A	0.0000
357	R	A	-1.7609
358	V	A	-0.2958
359	I	A	0.3356
360	A	A	0.0000
361	E	A	-1.5447
362	I	A	0.0000
363	R	A	-2.1043
364	H	A	-1.6207
365	G	A	-1.6387
366	D	A	-2.2107
367	I	A	0.0000
368	F	A	0.0543
369	H	A	-1.0246
370	S	A	-0.8893
371	A	A	-0.6182
372	N	A	-0.6914
373	I	A	-0.0304
374	V	A	0.0000
375	S	A	0.0000
376	S	A	0.0000
377	I	A	0.0000
378	E	A	-0.4804
379	F	A	0.0000
380	D	A	0.0000
381	R	A	-3.3153
382	D	A	-3.1342
383	D	A	0.0000
384	E	A	-2.3788
385	L	A	-1.1173
386	F	A	0.0000
387	A	A	0.0000
388	T	A	0.0000
389	A	A	0.0000
390	G	A	0.0000
391	V	A	0.0000
392	S	A	-1.2884
393	R	A	-2.2954
394	C	A	-1.4707
395	I	A	0.0000
396	K	A	-0.3101
397	V	A	0.0000
398	F	A	0.0000
399	D	A	-0.0515
400	F	A	-0.5734
401	S	A	-0.9161
402	S	A	-0.8173
403	V	A	0.0000
404	V	A	-0.6349
405	N	A	-1.6993
406	E	A	-2.1054
407	P	A	-1.4912
408	A	A	-1.4717
409	D	A	-1.9796
410	M	A	-0.4954
411	Q	A	-0.5005
412	C	A	0.6074
413	P	A	1.0361
414	I	A	1.9157
415	V	A	0.3594
416	E	A	-0.8261
417	M	A	0.0000
418	S	A	-1.5582
419	T	A	0.0000
420	R	A	-2.5816
421	S	A	0.0000
422	K	A	-1.8958
423	L	A	0.0000
424	S	A	0.0000
425	C	A	0.0092
426	L	A	0.0000
427	S	A	0.0000
428	W	A	0.0000
429	N	A	0.0000
430	K	A	-2.8590
431	H	A	-2.8289
432	E	A	-2.5991
433	K	A	-2.5806
434	N	A	-1.6564
435	H	A	-1.3225
436	I	A	0.0000
437	A	A	0.0000
438	S	A	0.0000
439	S	A	0.0000
440	D	A	0.0000
441	Y	A	-1.7933
442	E	A	-3.2221
443	G	A	0.0000
444	I	A	0.0000
445	V	A	0.0000
446	T	A	0.0000
447	V	A	0.0000
448	W	A	-0.6914
449	D	A	-1.1373
450	V	A	0.0000
451	T	A	-0.6133
452	T	A	-1.1008
453	R	A	-2.1195
454	Q	A	-1.7314
455	S	A	-0.9066
456	L	A	0.0271
457	M	A	-1.2549
458	E	A	-2.3920
459	Y	A	0.0000
460	E	A	-3.4406
461	E	A	-2.6539
462	H	A	0.0000
463	E	A	-3.5176
464	K	A	-3.1723
465	R	A	-2.2623
466	A	A	0.0000
467	W	A	0.0000
468	S	A	0.0000
469	V	A	0.0000
470	D	A	0.0000
471	F	A	0.0000
472	S	A	0.0000
473	R	A	-2.7054
474	T	A	-1.7959
475	E	A	-1.9162
476	P	A	-1.7867
477	S	A	-1.4635
478	M	A	-0.6705
479	L	A	0.0000
480	V	A	0.0000
481	S	A	0.0000
482	G	A	0.0000
483	S	A	0.0000
484	D	A	0.0000
485	D	A	-1.8012
486	C	A	-1.5400
487	K	A	-1.9590
488	V	A	0.0000
489	K	A	0.0000
490	V	A	0.0000
491	W	A	0.0000
492	C	A	0.0000
493	T	A	-1.6873
494	R	A	-2.7724
495	Q	A	-2.8352
496	E	A	-3.1301
497	A	A	-1.5535
498	S	A	-0.6269
499	V	A	0.4143
500	I	A	0.4239
501	N	A	-0.5560
502	I	A	0.0000
503	D	A	-2.3377
504	M	A	-1.9375
505	K	A	-2.1443
506	A	A	0.0000
507	N	A	-0.9106
508	I	A	0.0000
509	C	A	0.0000
510	C	A	0.0000
511	V	A	0.0000
512	K	A	-0.3155
513	Y	A	0.0000
514	N	A	0.0000
515	P	A	-1.1784
516	G	A	-1.1666
517	S	A	-0.9908
518	S	A	-1.1811
519	N	A	-1.2349
520	Y	A	-0.3313
521	I	A	0.0000
522	A	A	0.0000
523	V	A	0.0000
524	G	A	0.0000
525	S	A	0.0000
526	A	A	0.0000
527	D	A	0.0000
528	H	A	-1.1212
529	H	A	-0.5913
530	I	A	0.0000
531	H	A	0.0000
532	Y	A	0.0000
533	Y	A	0.0000
534	D	A	-1.0785
535	L	A	0.0000
536	R	A	-2.4396
537	N	A	-2.1808
538	I	A	-1.1282
539	S	A	-1.2436
540	Q	A	-1.0772
541	P	A	-0.1090
542	L	A	0.4089
543	H	A	-0.0105
544	V	A	0.8319
545	F	A	0.0000
546	S	A	-0.4961
547	G	A	-1.1728
548	H	A	0.0000
549	K	A	-2.1600
550	K	A	-1.9572
551	A	A	0.0000
552	V	A	0.0000
553	S	A	0.0000
554	Y	A	0.0240
555	V	A	0.0000
556	K	A	-0.4314
557	F	A	-0.5787
558	L	A	0.0000
559	S	A	-1.0764
560	N	A	-1.6446
561	N	A	-2.1092
562	E	A	-1.2230
563	L	A	0.0000
564	A	A	0.0000
565	S	A	0.0000
566	A	A	0.0000
567	S	A	0.0000
568	T	A	0.0000
569	D	A	-1.8011
570	S	A	-1.5960
571	T	A	0.0000
572	L	A	0.0000
573	R	A	-0.6899
574	L	A	0.0000
575	W	A	0.0000
576	D	A	-1.6840
577	V	A	0.0000
578	K	A	-3.2141
579	D	A	-3.1248
580	N	A	-2.0140
581	L	A	-0.4276
582	P	A	-0.2506
583	V	A	0.0111
584	R	A	-0.5001
585	T	A	-1.1002
586	F	A	0.0000
587	R	A	-2.5804
588	G	A	-1.8549
589	H	A	0.0000
590	T	A	-1.1305
591	N	A	0.0000
592	E	A	-2.5250
593	K	A	-2.4551
594	N	A	0.0000
595	F	A	0.0000
596	V	A	0.0000
597	G	A	0.0000
598	L	A	0.0000
599	T	A	0.0000
600	V	A	-0.3369
601	N	A	-1.0599
602	S	A	-1.0606
603	E	A	-1.9356
604	Y	A	-0.7953
605	L	A	0.0000
606	A	A	0.0000
607	C	A	0.0000
608	G	A	0.0000
609	S	A	0.0000
610	E	A	-1.0105
611	T	A	-0.7851
612	N	A	0.0000
613	E	A	-1.0645
614	V	A	0.0000
615	Y	A	-0.4023
616	V	A	0.0000
617	Y	A	0.0000
618	H	A	-0.9589
619	K	A	-1.5156
620	E	A	-1.8420
621	I	A	-0.5247
622	T	A	-1.4927
623	R	A	-2.3447
624	P	A	-1.0374
625	V	A	-0.2730
626	T	A	-0.6900
627	S	A	-1.0618
628	H	A	-1.6912
629	R	A	-2.0722
630	F	A	0.0000
631	G	A	-1.7464
632	S	A	-1.6695
633	P	A	-2.0892
634	D	A	-2.2211
635	M	A	0.0000
636	D	A	-4.3835
637	D	A	-4.3343
638	A	A	-2.8954
639	E	A	-4.5754
640	E	A	-4.0767
641	E	A	-3.0559
642	A	A	-2.0507
643	G	A	-1.4209
644	S	A	-1.4283
645	Y	A	0.0000
646	F	A	0.0000
647	I	A	0.0000
648	S	A	0.0000
649	A	A	0.0000
650	V	A	0.0000
651	C	A	-0.0960
652	W	A	0.0000
653	K	A	-1.3104
654	S	A	-1.6784
655	D	A	-2.2560
656	S	A	-1.1258
657	P	A	-0.7060
658	T	A	0.0000
659	M	A	0.0000
660	L	A	0.0000
661	T	A	0.0000
662	A	A	0.0000
663	N	A	0.0000
664	S	A	-0.1118
665	Q	A	-0.1847
666	G	A	0.0000
667	T	A	-0.8421
668	I	A	0.0000
669	K	A	0.0000
670	V	A	0.0000
671	L	A	0.0000
672	V	A	-0.2525
673	L	A	-0.6461
674	A	A	-0.7865
354	S	U	-0.2541
355	D	U	-0.2922
356	Q	U	0.0000
357	I	U	-0.4733
358	V	U	0.0000
359	P	U	-0.7879
360	E	U	-1.4354
361	Y	U	0.2838