Project name: laccase

Chain sequence(s)	A: AIGPVANLTISDADIAPDGFTRAAVVVNGVSPGPLITGNKGDNFQINVINQMTNHTMNKTTSIHWHGLFQEGTNWADGPAFVTQCPIVSGNSFLYNFHVPDQAGTFWYHSHLSTQYCDGLRGPLVVYDPHDPLAHMYDVDDDSTVIALTEWYWTASHLGTRFPAGLANSTLINGLGRTTATSSAELAVVNVTQGKRYRFRLVSMACDPSFNFSIDGHDLTVIEADGVETQPVTVNSINIFAAQRYSFVLTANQTIDNYWIRANPSLGVMGFDAGINSAILRYDGAAPVEPVTSPQSTQILLNETDLHPYVPRKTPGKPEKGGVDLPLNMAFGFDGTDFFINNATFVPPTVPVLLQILSGAQAAQDLLPAGSVYTLPKNASIEITFPANANAAGSPHPFHLHGHTFAVIRSAGSTAYNYDNPVWRDTVSTGLATNNDNATIRFQTDNAGPWFLHCHIDFHLNAGFAVVLAEDVPDIARANPVPQAWKNLCPTYDALSPNDQ
Distance of aggregation	5 Å
Dynamic mode	No

• Minimal score value: -2.1799
• Maximal score value: 1.8079
• Average score: -0.1877
• Total score value: -93.8283

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
22	A	A	0.1413
23	I	A	0.4323
24	G	A	0.1096
25	P	A	0.1919
26	V	A	1.6834
27	A	A	0.0998
28	N	A	-1.3098
29	L	A	0.0000
30	T	A	0.0232
31	I	A	0.0000
32	S	A	-0.1661
33	D	A	-0.5193
34	A	A	-0.4008
35	D	A	-1.7268
36	I	A	-0.0211
37	A	A	0.0769
38	P	A	-0.0223
39	D	A	0.0000
40	G	A	-0.3801
41	F	A	0.3552
42	T	A	0.0164
43	R	A	0.0000
44	A	A	-0.2319
45	A	A	0.0000
46	V	A	0.0000
47	V	A	0.0000
48	V	A	0.0000
49	N	A	-0.6207
50	G	A	-0.3729
51	V	A	0.9650
52	S	A	0.1308
53	P	A	-0.0599
54	G	A	0.0000
55	P	A	-0.0332
56	L	A	0.0000
57	I	A	0.0000
58	T	A	-0.0203
59	G	A	-0.1943
60	N	A	-0.9244
61	K	A	-1.2227
62	G	A	-0.6961
63	D	A	-0.6550
64	N	A	-0.6549
65	F	A	0.0000
66	Q	A	-0.3127
67	I	A	0.0000
68	N	A	-0.3901
69	V	A	0.0000
70	I	A	0.3389
71	N	A	0.0000
72	Q	A	-1.1983
73	M	A	0.0000
74	T	A	-0.1424
75	N	A	-0.5820
76	H	A	-1.0856
77	T	A	-0.1957
78	M	A	0.0000
79	N	A	-0.3379
80	K	A	-0.2384
81	T	A	0.0000
82	T	A	0.0000
83	S	A	0.0000
84	I	A	0.0000
85	H	A	0.0000
86	W	A	0.0000
87	H	A	0.0000
88	G	A	-0.0479
89	L	A	0.0000
90	F	A	0.3102
91	Q	A	0.0000
92	E	A	-1.8494
93	G	A	-0.4962
94	T	A	-0.0376
95	N	A	0.0000
96	W	A	0.0000
97	A	A	0.0000
98	D	A	0.0000
99	G	A	0.0000
100	P	A	0.0000
101	A	A	0.0000
102	F	A	0.1941
103	V	A	0.0000
104	T	A	0.0000
105	Q	A	0.0000
106	C	A	0.0000
107	P	A	0.0000
108	I	A	0.0000
109	V	A	0.1771
110	S	A	-0.0981
111	G	A	-0.6535
112	N	A	-1.0919
113	S	A	-0.2727
114	F	A	0.0000
115	L	A	0.5128
116	Y	A	0.0000
117	N	A	-0.6363
118	F	A	0.0000
119	H	A	-1.0502
120	V	A	0.0000
121	P	A	-0.6011
122	D	A	-1.8272
123	Q	A	0.0000
124	A	A	0.0000
125	G	A	0.0000
126	T	A	0.0000
127	F	A	0.0000
128	W	A	0.0000
129	Y	A	0.0000
130	H	A	0.0000
131	S	A	0.0000
132	H	A	0.0000
133	L	A	0.0000
134	S	A	-0.0705
135	T	A	0.0000
136	Q	A	0.0000
137	Y	A	0.0000
138	C	A	0.0000
139	D	A	0.0000
140	G	A	0.0000
141	L	A	0.0000
142	R	A	0.0000
143	G	A	0.0000
144	P	A	0.0000
145	L	A	0.0000
146	V	A	0.0000
147	V	A	0.0000
148	Y	A	0.0929
149	D	A	-0.2585
150	P	A	-0.4756
151	H	A	-1.0686
152	D	A	-0.4156
153	P	A	-0.2128
154	L	A	0.0000
155	A	A	-0.1371
156	H	A	-0.9569
157	M	A	-0.0117
158	Y	A	-0.2365
159	D	A	-1.7101
160	V	A	-0.0799
161	D	A	-0.5150
162	D	A	-1.4782
163	D	A	-2.0234
164	S	A	-0.5235
165	T	A	0.0000
166	V	A	0.0000
167	I	A	0.0000
168	A	A	0.0000
169	L	A	0.0000
170	T	A	0.0000
171	E	A	0.0000
172	W	A	0.0000
173	Y	A	0.0000
174	W	A	0.2899
175	T	A	0.0008
176	A	A	0.0000
177	S	A	-0.1370
178	H	A	-0.3205
179	L	A	1.3865
180	G	A	-0.0236
181	T	A	-0.2876
182	R	A	-0.8351
183	F	A	0.2442
184	P	A	0.0486
185	A	A	-0.0168
186	G	A	-0.2949
187	L	A	0.0000
188	A	A	0.0000
189	N	A	-0.7841
190	S	A	0.0000
191	T	A	0.0000
192	L	A	0.0000
193	I	A	0.0000
194	N	A	-0.4731
195	G	A	0.0000
196	L	A	0.5209
197	G	A	0.0000
198	R	A	0.0000
199	T	A	0.0000
200	T	A	-0.0603
201	A	A	0.0439
202	T	A	-0.0296
203	S	A	-0.2015
204	S	A	-0.2418
205	A	A	0.0000
206	E	A	-1.8199
207	L	A	0.0000
208	A	A	0.0000
209	V	A	0.8820
210	V	A	0.0000
211	N	A	-1.2730
212	V	A	0.0000
213	T	A	-0.2179
214	Q	A	-1.2240
215	G	A	-0.8198
216	K	A	-0.9982
217	R	A	-0.6892
218	Y	A	0.0000
219	R	A	0.0000
220	F	A	0.0000
221	R	A	0.0000
222	L	A	0.0000
223	V	A	0.0000
224	S	A	0.0000
225	M	A	0.0000
226	A	A	0.0000
227	C	A	0.0000
228	D	A	-0.1846
229	P	A	0.0000
230	S	A	0.0000
231	F	A	0.0000
232	N	A	-1.0152
233	F	A	0.0000
234	S	A	-0.0207
235	I	A	0.0000
236	D	A	0.0000
237	G	A	-0.3575
238	H	A	0.0000
239	D	A	-1.2657
240	L	A	0.0000
241	T	A	-0.0199
242	V	A	0.0000
243	I	A	0.0000
244	E	A	0.0000
245	A	A	0.0000
246	D	A	0.0000
247	G	A	-0.0125
248	V	A	0.1349
249	E	A	-0.2698
250	T	A	0.0000
251	Q	A	-1.1623
252	P	A	-0.2677
253	V	A	0.1723
254	T	A	-0.0354
255	V	A	0.0000
256	N	A	-0.4169
257	S	A	0.0000
258	I	A	0.0000
259	N	A	-0.2939
260	I	A	0.0000
261	F	A	0.0000
262	A	A	0.0000
263	A	A	0.0000
264	Q	A	0.0000
265	R	A	0.0000
266	Y	A	0.0000
267	S	A	0.0000
268	F	A	0.0000
269	V	A	0.0000
270	L	A	0.0000
271	T	A	-0.1029
272	A	A	0.0000
273	N	A	-1.3705
274	Q	A	-0.7764
275	T	A	0.1551
276	I	A	1.5596
277	D	A	-0.6865
278	N	A	0.0000
279	Y	A	0.0000
280	W	A	0.1263
281	I	A	0.0000
282	R	A	0.0000
283	A	A	0.0000
284	N	A	-0.3183
285	P	A	0.0000
286	S	A	-0.0657
287	L	A	0.6392
288	G	A	-0.1048
289	V	A	0.6354
290	M	A	1.0238
291	G	A	0.1466
292	F	A	0.1928
293	D	A	-1.6856
294	A	A	-0.2873
295	G	A	0.0000
296	I	A	0.0000
297	N	A	0.0000
298	S	A	0.0000
299	A	A	0.0000
300	I	A	0.0000
301	L	A	0.0000
302	R	A	-0.2271
303	Y	A	0.0000
304	D	A	-1.0726
305	G	A	-0.6438
306	A	A	-0.0650
307	A	A	0.0133
308	P	A	0.0765
309	V	A	1.5236
310	E	A	-0.7850
311	P	A	0.0000
312	V	A	1.7698
313	T	A	0.2762
314	S	A	-0.2148
315	P	A	-0.4492
316	Q	A	-1.2517
317	S	A	-0.3251
318	T	A	-0.2802
319	Q	A	-0.9510
320	I	A	0.4861
321	L	A	0.0000
322	L	A	0.8240
323	N	A	0.0743
324	E	A	0.0000
325	T	A	-0.3946
326	D	A	-1.8022
327	L	A	0.0000
328	H	A	-0.2146
329	P	A	0.0161
330	Y	A	0.6250
331	V	A	1.8079
332	P	A	-0.0531
333	R	A	-0.9880
334	K	A	-1.8159
335	T	A	0.0000
336	P	A	-0.0514
337	G	A	-0.4673
338	K	A	-1.7799
339	P	A	-0.8885
340	E	A	-2.1799
341	K	A	-2.0979
342	G	A	-0.6942
343	G	A	-0.5263
344	V	A	0.0000
345	D	A	-1.7257
346	L	A	-0.0133
347	P	A	-0.1158
348	L	A	-0.0086
349	N	A	-0.9334
350	M	A	0.0000
351	A	A	-0.0135
352	F	A	0.0000
353	G	A	-0.0509
354	F	A	0.2092
355	D	A	-1.7776
356	G	A	-0.7990
357	T	A	-0.2276
358	D	A	-0.4794
359	F	A	0.0000
360	F	A	0.3875
361	I	A	0.0000
362	N	A	-0.6377
363	N	A	-1.3459
364	A	A	-0.1849
365	T	A	0.0355
366	F	A	0.0000
367	V	A	1.7277
368	P	A	0.0588
369	P	A	0.0000
370	T	A	0.0831
371	V	A	0.8242
372	P	A	0.0000
373	V	A	0.0000
374	L	A	0.0000
375	L	A	0.3748
376	Q	A	0.0000
377	I	A	0.0000
378	L	A	0.3958
379	S	A	-0.2253
380	G	A	-0.5036
381	A	A	-0.2924
382	Q	A	-1.1929
383	A	A	-0.1996
384	A	A	-0.2080
385	Q	A	-1.5176
386	D	A	-2.0040
387	L	A	0.0000
388	L	A	1.2114
389	P	A	0.0000
390	A	A	0.1009
391	G	A	-0.4557
392	S	A	0.0000
393	V	A	0.0000
394	Y	A	0.1929
395	T	A	0.0001
396	L	A	0.0000
397	P	A	-0.4788
398	K	A	-1.8299
399	N	A	-1.5561
400	A	A	0.0000
401	S	A	0.0000
402	I	A	0.0000
403	E	A	0.0000
404	I	A	0.0000
405	T	A	-0.1180
406	F	A	0.0000
407	P	A	-0.0794
408	A	A	-0.1214
409	N	A	-0.6491
410	A	A	-0.2891
411	N	A	-1.2691
412	A	A	0.0000
413	A	A	-0.0094
414	G	A	-0.3802
415	S	A	-0.1733
416	P	A	-0.0871
417	H	A	0.0000
418	P	A	0.0000
419	F	A	0.0000
420	H	A	0.0000
421	L	A	0.0000
422	H	A	0.0000
423	G	A	0.0000
424	H	A	0.0000
425	T	A	0.0000
426	F	A	0.0000
427	A	A	0.0000
428	V	A	0.0000
429	I	A	0.0000
430	R	A	-0.1568
431	S	A	0.0000
432	A	A	-0.0775
433	G	A	-0.4711
434	S	A	-0.1301
435	T	A	-0.0660
436	A	A	0.0929
437	Y	A	0.1822
438	N	A	-0.2756
439	Y	A	-0.1687
440	D	A	-1.8776
441	N	A	-1.0250
442	P	A	0.0000
443	V	A	0.0000
444	W	A	0.0000
445	R	A	0.0000
446	D	A	0.0000
447	T	A	0.0000
448	V	A	0.0000
449	S	A	0.0000
450	T	A	0.0000
451	G	A	0.0000
452	L	A	0.6565
453	A	A	-0.0739
454	T	A	-0.2020
455	N	A	-0.9804
456	N	A	-1.4023
457	D	A	0.0000
458	N	A	-0.2532
459	A	A	0.0000
460	T	A	0.0000
461	I	A	0.0000
462	R	A	0.0000
463	F	A	0.0000
464	Q	A	-0.5234
465	T	A	0.0000
466	D	A	-1.7894
467	N	A	0.0000
468	A	A	0.0066
469	G	A	0.0000
470	P	A	0.0000
471	W	A	0.0000
472	F	A	0.0000
473	L	A	0.0000
474	H	A	0.0000
475	C	A	0.0000
476	H	A	0.0000
477	I	A	0.0000
478	D	A	0.0000
479	F	A	0.0000
480	H	A	0.0000
481	L	A	0.0310
482	N	A	-0.7144
483	A	A	0.0000
484	G	A	0.0000
485	F	A	0.0000
486	A	A	0.0000
487	V	A	0.0000
488	V	A	0.0000
489	L	A	0.0000
490	A	A	0.0000
491	E	A	0.0000
492	D	A	0.0000
493	V	A	0.0000
494	P	A	-0.2958
495	D	A	-0.4654
496	I	A	0.0000
497	A	A	-0.2905
498	R	A	-1.8564
499	A	A	-0.3195
500	N	A	0.0000
501	P	A	-0.1990
502	V	A	0.2442
503	P	A	-0.2381
504	Q	A	-1.2064
505	A	A	-0.1863
506	W	A	0.0000
507	K	A	-1.8029
508	N	A	-1.5579
509	L	A	0.0000
510	C	A	0.0403
511	P	A	-0.2477
512	T	A	-0.0509
513	Y	A	-0.1850
514	D	A	-1.7542
515	A	A	-0.2103
516	L	A	0.2725
517	S	A	-0.2021
518	P	A	-0.5229
519	N	A	-1.4814
520	D	A	-1.2516
521	Q	A	-0.7998