| Chain sequence(s) |
A: GSHSMRYFDTAMSRPGRGEPRFISVGYVDDTQFVRFDSDAASPREEPRAPWIEQEGPEYWDRNTQIFKTNTQTDRESLRNLRGYYNQSEAGSHTLQSMYGCDVGPDGRLLRGHNQYAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAARVAEQDRAYLEGTCVEWLRRYLENGKDTLERADPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWEP C: GGKKKYRL B: IQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | -1.0025 | |
| 2 | S | A | -1.0217 | |
| 3 | H | A | -1.0345 | |
| 4 | S | A | -0.6879 | |
| 5 | M | A | 0.0000 | |
| 6 | R | A | -0.8623 | |
| 7 | Y | A | 0.0000 | |
| 8 | F | A | 0.0000 | |
| 9 | D | A | 0.0000 | |
| 10 | T | A | 0.0000 | |
| 11 | A | A | 0.0000 | |
| 12 | M | A | -0.7781 | |
| 13 | S | A | -1.7666 | |
| 14 | R | A | -2.0622 | |
| 15 | P | A | -1.9858 | |
| 16 | G | A | -1.9323 | |
| 17 | R | A | -2.8984 | |
| 18 | G | A | -2.5924 | |
| 19 | E | A | -3.1165 | |
| 20 | P | A | -2.3044 | |
| 21 | R | A | -1.6289 | |
| 22 | F | A | 0.0000 | |
| 23 | I | A | 0.0000 | |
| 24 | S | A | 0.0000 | |
| 25 | V | A | 0.0000 | |
| 26 | G | A | 0.0000 | |
| 27 | Y | A | -0.7311 | |
| 28 | V | A | 0.0000 | |
| 29 | D | A | -1.0176 | |
| 30 | D | A | -1.2983 | |
| 31 | T | A | -0.8712 | |
| 32 | Q | A | -1.0989 | |
| 33 | F | A | 0.0000 | |
| 34 | V | A | 0.0000 | |
| 35 | R | A | -1.5705 | |
| 36 | F | A | 0.0000 | |
| 37 | D | A | 0.0000 | |
| 38 | S | A | -1.5926 | |
| 39 | D | A | -2.0645 | |
| 40 | A | A | -1.0881 | |
| 41 | A | A | -0.6103 | |
| 42 | S | A | -0.7417 | |
| 43 | P | A | -1.5550 | |
| 44 | R | A | -2.1804 | |
| 45 | E | A | 0.0000 | |
| 46 | E | A | -2.5969 | |
| 47 | P | A | -2.5938 | |
| 48 | R | A | -2.6965 | |
| 49 | A | A | 0.0000 | |
| 50 | P | A | -1.5554 | |
| 51 | W | A | 0.0000 | |
| 52 | I | A | 0.0000 | |
| 53 | E | A | -3.1314 | |
| 54 | Q | A | -2.5147 | |
| 55 | E | A | -1.9596 | |
| 56 | G | A | -1.9458 | |
| 57 | P | A | -2.3687 | |
| 58 | E | A | -3.1863 | |
| 59 | Y | A | 0.0000 | |
| 60 | W | A | 0.0000 | |
| 61 | D | A | -3.8221 | |
| 62 | R | A | -3.5625 | |
| 63 | N | A | 0.0000 | |
| 64 | T | A | 0.0000 | |
| 65 | Q | A | -2.8400 | |
| 66 | I | A | 0.0000 | |
| 67 | F | A | 0.0000 | |
| 68 | K | A | -2.0409 | |
| 69 | T | A | -1.6469 | |
| 70 | N | A | 0.0000 | |
| 71 | T | A | 0.0000 | |
| 72 | Q | A | -2.1645 | |
| 73 | T | A | 0.0000 | |
| 74 | D | A | 0.0000 | |
| 75 | R | A | -2.1444 | |
| 76 | E | A | -1.9745 | |
| 77 | S | A | 0.0000 | |
| 78 | L | A | 0.0000 | |
| 79 | R | A | -2.7444 | |
| 80 | N | A | -1.7793 | |
| 81 | L | A | 0.0000 | |
| 82 | R | A | -2.2869 | |
| 83 | G | A | -1.7527 | |
| 84 | Y | A | -0.6636 | |
| 85 | Y | A | -0.5892 | |
| 86 | N | A | -1.7613 | |
| 87 | Q | A | -1.9156 | |
| 88 | S | A | -1.7540 | |
| 89 | E | A | -2.7265 | |
| 90 | A | A | -1.2569 | |
| 91 | G | A | -1.1600 | |
| 92 | S | A | -1.0543 | |
| 93 | H | A | -0.9800 | |
| 94 | T | A | 0.0000 | |
| 95 | L | A | 0.0000 | |
| 96 | Q | A | 0.0000 | |
| 97 | S | A | 0.0000 | |
| 98 | M | A | 0.0000 | |
| 99 | Y | A | 0.0000 | |
| 100 | G | A | 0.0000 | |
| 101 | C | A | 0.0000 | |
| 102 | D | A | -0.7442 | |
| 103 | V | A | 0.0000 | |
| 104 | G | A | 0.0000 | |
| 105 | P | A | -1.5455 | |
| 106 | D | A | -2.6832 | |
| 107 | G | A | -2.1973 | |
| 108 | R | A | -2.5521 | |
| 109 | L | A | -0.9329 | |
| 110 | L | A | 0.1603 | |
| 111 | R | A | -1.0230 | |
| 112 | G | A | 0.0000 | |
| 113 | H | A | -1.0180 | |
| 114 | N | A | 0.0000 | |
| 115 | Q | A | -0.5599 | |
| 116 | Y | A | 0.0000 | |
| 117 | A | A | 0.0000 | |
| 118 | Y | A | 0.0000 | |
| 119 | D | A | -0.9202 | |
| 120 | G | A | 0.0000 | |
| 121 | K | A | -2.5319 | |
| 122 | D | A | -2.9997 | |
| 123 | Y | A | 0.0000 | |
| 124 | I | A | 0.0000 | |
| 125 | A | A | -0.7241 | |
| 126 | L | A | 0.0000 | |
| 127 | N | A | -2.0410 | |
| 128 | E | A | -2.8565 | |
| 129 | D | A | -2.8268 | |
| 130 | L | A | 0.0000 | |
| 131 | R | A | -3.4282 | |
| 132 | S | A | -2.0779 | |
| 133 | W | A | 0.0000 | |
| 134 | T | A | -0.6288 | |
| 135 | A | A | -0.8240 | |
| 136 | A | A | -1.2833 | |
| 137 | D | A | -1.3243 | |
| 138 | T | A | -0.6816 | |
| 139 | A | A | 0.0000 | |
| 140 | A | A | 0.0000 | |
| 141 | Q | A | -1.6784 | |
| 142 | I | A | -0.8062 | |
| 143 | T | A | 0.0000 | |
| 144 | Q | A | -1.7106 | |
| 145 | R | A | -2.7583 | |
| 146 | K | A | -2.2678 | |
| 147 | W | A | 0.0000 | |
| 148 | E | A | -2.6979 | |
| 149 | A | A | -1.6975 | |
| 150 | A | A | -1.7408 | |
| 151 | R | A | -3.1667 | |
| 152 | V | A | 0.0000 | |
| 153 | A | A | 0.0000 | |
| 154 | E | A | -2.8843 | |
| 155 | Q | A | -2.3116 | |
| 156 | D | A | 0.0000 | |
| 157 | R | A | -2.4650 | |
| 158 | A | A | -1.4623 | |
| 159 | Y | A | 0.0000 | |
| 160 | L | A | 0.0000 | |
| 161 | E | A | -2.3263 | |
| 162 | G | A | -1.4433 | |
| 163 | T | A | -1.0832 | |
| 164 | C | A | 0.0000 | |
| 165 | V | A | 0.0000 | |
| 166 | E | A | -2.4061 | |
| 167 | W | A | -1.5984 | |
| 168 | L | A | 0.0000 | |
| 169 | R | A | -3.3464 | |
| 170 | R | A | -3.5759 | |
| 171 | Y | A | 0.0000 | |
| 172 | L | A | 0.0000 | |
| 173 | E | A | -4.2692 | |
| 174 | N | A | -3.4949 | |
| 175 | G | A | 0.0000 | |
| 176 | K | A | -4.5505 | |
| 177 | D | A | -3.7764 | |
| 178 | T | A | -2.5369 | |
| 179 | L | A | 0.0000 | |
| 180 | E | A | -3.6995 | |
| 181 | R | A | -2.9099 | |
| 182 | A | A | -1.6656 | |
| 183 | D | A | -1.2234 | |
| 184 | P | A | -1.2428 | |
| 185 | P | A | 0.0000 | |
| 186 | K | A | -1.8612 | |
| 187 | T | A | -1.0260 | |
| 188 | H | A | -1.2100 | |
| 189 | V | A | -0.7537 | |
| 190 | T | A | -1.1324 | |
| 191 | H | A | -0.6238 | |
| 192 | H | A | -0.9350 | |
| 193 | P | A | -0.4764 | |
| 194 | I | A | 0.8122 | |
| 195 | S | A | -0.9406 | |
| 196 | D | A | -2.2867 | |
| 197 | H | A | -2.0066 | |
| 198 | E | A | -1.2975 | |
| 199 | A | A | 0.0000 | |
| 200 | T | A | 0.3299 | |
| 201 | L | A | 0.0000 | |
| 202 | R | A | -0.6594 | |
| 203 | C | A | 0.0000 | |
| 204 | W | A | 0.0000 | |
| 205 | A | A | 0.0000 | |
| 206 | L | A | -0.7482 | |
| 207 | G | A | -0.8723 | |
| 208 | F | A | 0.0000 | |
| 209 | Y | A | 0.0000 | |
| 210 | P | A | -1.5240 | |
| 211 | A | A | -1.2727 | |
| 212 | E | A | -2.1781 | |
| 213 | I | A | -1.2652 | |
| 214 | T | A | -0.7358 | |
| 215 | L | A | 0.0000 | |
| 216 | T | A | -0.7023 | |
| 217 | W | A | 0.0000 | |
| 218 | Q | A | -2.9409 | |
| 219 | R | A | -3.0583 | |
| 220 | D | A | -3.5528 | |
| 221 | G | A | -3.0147 | |
| 222 | E | A | -3.7467 | |
| 223 | D | A | -3.7580 | |
| 224 | Q | A | -3.1149 | |
| 225 | T | A | -2.2117 | |
| 226 | Q | A | -2.6881 | |
| 227 | D | A | -2.6875 | |
| 228 | T | A | -1.8124 | |
| 229 | E | A | -1.6956 | |
| 230 | L | A | -0.0116 | |
| 231 | V | A | 0.0000 | |
| 232 | E | A | -1.1196 | |
| 233 | T | A | -0.5577 | |
| 234 | R | A | 0.0000 | |
| 235 | P | A | -0.5439 | |
| 236 | A | A | 0.0000 | |
| 237 | G | A | -1.0592 | |
| 238 | D | A | -1.5397 | |
| 239 | R | A | -1.1356 | |
| 240 | T | A | -0.7009 | |
| 241 | F | A | -0.4461 | |
| 242 | Q | A | 0.0000 | |
| 243 | K | A | -0.0585 | |
| 244 | W | A | 0.0000 | |
| 245 | A | A | 0.0000 | |
| 246 | A | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | V | A | 0.8985 | |
| 249 | V | A | 0.0000 | |
| 250 | P | A | -0.8307 | |
| 251 | S | A | -1.3439 | |
| 252 | G | A | -1.3294 | |
| 253 | E | A | -1.4734 | |
| 254 | E | A | 0.0000 | |
| 255 | Q | A | -2.3145 | |
| 256 | R | A | -2.5339 | |
| 257 | Y | A | 0.0000 | |
| 258 | T | A | -1.6083 | |
| 259 | C | A | 0.0000 | |
| 260 | H | A | -0.7052 | |
| 261 | V | A | 0.0000 | |
| 262 | Q | A | -1.9766 | |
| 263 | H | A | 0.0000 | |
| 264 | E | A | -2.7440 | |
| 265 | G | A | -1.6103 | |
| 266 | L | A | -1.4080 | |
| 267 | P | A | -1.5125 | |
| 268 | K | A | -2.2271 | |
| 269 | P | A | -1.5834 | |
| 270 | L | A | -0.4234 | |
| 271 | T | A | -0.4516 | |
| 272 | L | A | -0.5644 | |
| 273 | R | A | -1.7466 | |
| 274 | W | A | -1.5919 | |
| 275 | E | A | -2.2545 | |
| 276 | P | A | -1.2923 | |
| 1 | I | B | 0.7786 | |
| 2 | Q | B | -0.3163 | |
| 3 | R | B | -0.6153 | |
| 4 | T | B | -0.6308 | |
| 5 | P | B | 0.0000 | |
| 6 | K | B | -1.5776 | |
| 7 | I | B | -0.7856 | |
| 8 | Q | B | 0.0000 | |
| 9 | V | B | 0.0000 | |
| 10 | Y | B | 0.0000 | |
| 11 | S | B | -1.0765 | |
| 12 | R | B | -1.0179 | |
| 13 | H | B | -1.3723 | |
| 14 | P | B | -1.6562 | |
| 15 | A | B | -2.3354 | |
| 16 | E | B | -3.1835 | |
| 17 | N | B | -2.9942 | |
| 18 | G | B | -2.1660 | |
| 19 | K | B | -2.2631 | |
| 20 | S | B | -1.7109 | |
| 21 | N | B | 0.0000 | |
| 22 | F | B | -0.7891 | |
| 23 | L | B | 0.0000 | |
| 24 | N | B | 0.0000 | |
| 25 | C | B | 0.0000 | |
| 26 | Y | B | 0.0000 | |
| 27 | V | B | 0.0000 | |
| 28 | S | B | 0.0000 | |
| 29 | G | B | -0.9280 | |
| 30 | F | B | 0.0000 | |
| 31 | H | B | 0.0000 | |
| 32 | P | B | -0.4992 | |
| 33 | S | B | -0.9886 | |
| 34 | D | B | -1.8224 | |
| 35 | I | B | -1.3283 | |
| 36 | E | B | -2.1853 | |
| 37 | V | B | -1.4809 | |
| 38 | D | B | -1.7360 | |
| 39 | L | B | 0.0000 | |
| 40 | L | B | -2.8132 | |
| 41 | K | B | -2.9503 | |
| 42 | N | B | -3.4777 | |
| 43 | G | B | -2.9282 | |
| 44 | E | B | -3.6501 | |
| 45 | R | B | -3.7777 | |
| 46 | I | B | -2.6982 | |
| 47 | E | B | -3.3065 | |
| 48 | K | B | -3.1794 | |
| 49 | V | B | -2.3778 | |
| 50 | E | B | -2.7703 | |
| 51 | H | B | -1.6469 | |
| 52 | S | B | -0.9254 | |
| 53 | D | B | -0.9026 | |
| 54 | L | B | 0.0000 | |
| 55 | S | B | 0.0000 | |
| 56 | F | B | 0.0000 | |
| 57 | S | B | -1.3125 | |
| 58 | K | B | -2.4446 | |
| 59 | D | B | -2.8251 | |
| 60 | W | B | 0.0000 | |
| 61 | S | B | 0.0000 | |
| 62 | F | B | 0.0000 | |
| 63 | Y | B | 0.0059 | |
| 64 | L | B | 0.0000 | |
| 65 | L | B | 0.0000 | |
| 66 | Y | B | 0.0000 | |
| 67 | Y | B | -1.0731 | |
| 68 | T | B | 0.0000 | |
| 69 | E | B | -2.1125 | |
| 70 | F | B | 0.0000 | |
| 71 | T | B | -1.4749 | |
| 72 | P | B | 0.0000 | |
| 73 | T | B | -2.7928 | |
| 74 | E | B | -3.5239 | |
| 75 | K | B | -3.4792 | |
| 76 | D | B | -3.1648 | |
| 77 | E | B | -3.8942 | |
| 78 | Y | B | 0.0000 | |
| 79 | A | B | 0.0000 | |
| 80 | C | B | 0.0000 | |
| 81 | R | B | -2.0843 | |
| 82 | V | B | 0.0000 | |
| 83 | N | B | -1.5711 | |
| 84 | H | B | 0.0000 | |
| 85 | V | B | 0.8581 | |
| 86 | T | B | 0.3681 | |
| 87 | L | B | -0.0299 | |
| 88 | S | B | -0.5795 | |
| 89 | Q | B | -1.5176 | |
| 90 | P | B | -1.6090 | |
| 91 | K | B | -1.8854 | |
| 92 | I | B | -0.9722 | |
| 93 | V | B | -0.9417 | |
| 94 | K | B | -2.4907 | |
| 95 | W | B | -2.2105 | |
| 96 | D | B | -3.3069 | |
| 97 | R | B | -2.9831 | |
| 98 | D | B | -2.8680 | |
| 99 | M | B | -1.5283 | |
| 1 | G | C | 0.0000 | |
| 2 | G | C | 0.0000 | |
| 3 | K | C | 0.0000 | |
| 4 | K | C | -1.8712 | |
| 5 | K | C | 0.0000 | |
| 6 | Y | C | -1.2497 | |
| 7 | R | C | -2.1377 | |
| 8 | L | C | 0.0000 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine