| Chain sequence(s) |
A: GGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFREN B: SHPSPQAKPSNPSNPRVFFDVDIGGERVGRIVLELFADIVPKTAENFRALCTGEKGIGPTTGKPLHFKGCPFHRIIKKFMIQGGDFSNQNGTGGESIYGEKFEDENFHYKHDKEGLLSMANAGSNTNGSQFFITTVPTPHLDGKHVVFGQVIKGMGVAKILENVEVKGEKPAKLCVIAECGELKEGDDWGIFPKDGSGDSHPDFPEDADVDLKDVDKILLISEDLKNIGNTFFKSQNWEMAIKKYTKVLRYVEGSRAAAEDADGAKLQPVALSCVLNIGACKLKMSDWQGAVDSCLEALEIDPSNTKALYRRAQGWQGLKEYDQALADLKKAQEIAPEDKAIQAELLKVKQKIKAQKDKEKAAY |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | -0.7451 | |
| 2 | G | A | -0.4235 | |
| 3 | S | A | 0.0404 | |
| 4 | V | A | 1.2476 | |
| 5 | Q | A | 1.0027 | |
| 6 | I | A | 2.9177 | |
| 7 | V | A | 2.6550 | |
| 8 | Y | A | 2.0016 | |
| 9 | K | A | -0.2299 | |
| 10 | P | A | -0.2505 | |
| 11 | V | A | 0.7571 | |
| 12 | D | A | -0.6415 | |
| 13 | L | A | 0.5476 | |
| 14 | S | A | -0.5985 | |
| 15 | K | A | -1.5851 | |
| 16 | V | A | -1.2578 | |
| 17 | T | A | -0.9822 | |
| 18 | S | A | -1.2430 | |
| 19 | K | A | -1.6957 | |
| 20 | C | A | -0.3772 | |
| 21 | G | A | -0.4135 | |
| 22 | S | A | -0.1150 | |
| 23 | L | A | 0.8893 | |
| 24 | G | A | -0.3721 | |
| 25 | N | A | -1.0159 | |
| 26 | I | A | -0.2727 | |
| 27 | H | A | -1.8357 | |
| 28 | H | A | -2.3784 | |
| 29 | K | A | -2.7825 | |
| 30 | P | A | -2.0922 | |
| 31 | G | A | -1.4137 | |
| 32 | G | A | -1.4052 | |
| 33 | G | A | -0.8718 | |
| 34 | Q | A | -1.0817 | |
| 35 | V | A | 0.2709 | |
| 36 | E | A | -1.2510 | |
| 37 | V | A | -0.2018 | |
| 38 | K | A | -2.1484 | |
| 39 | S | A | -1.8672 | |
| 40 | E | A | -2.7976 | |
| 41 | K | A | -2.3137 | |
| 42 | L | A | -0.3422 | |
| 43 | D | A | -1.0105 | |
| 44 | F | A | -0.4577 | |
| 45 | K | A | -2.3916 | |
| 46 | D | A | -3.0726 | |
| 47 | R | A | -2.7925 | |
| 48 | V | A | -1.4394 | |
| 49 | Q | A | -1.9564 | |
| 50 | S | A | -0.9985 | |
| 51 | K | A | -1.4205 | |
| 52 | I | A | 0.5587 | |
| 53 | G | A | -0.2050 | |
| 54 | S | A | -0.2525 | |
| 55 | L | A | 0.2144 | |
| 56 | D | A | -1.6912 | |
| 57 | N | A | -2.0464 | |
| 58 | I | A | -0.8115 | |
| 59 | T | A | -0.5724 | |
| 60 | H | A | -0.8446 | |
| 61 | V | A | 0.2750 | |
| 62 | P | A | -0.3924 | |
| 63 | G | A | -0.6926 | |
| 64 | G | A | -1.0115 | |
| 65 | G | A | -1.4719 | |
| 66 | N | A | -2.4440 | |
| 67 | K | A | -2.8104 | |
| 68 | K | A | -2.2036 | |
| 69 | I | A | -0.8968 | |
| 70 | E | A | -2.1036 | |
| 71 | T | A | -1.6231 | |
| 72 | H | A | -1.9169 | |
| 73 | K | A | -1.6595 | |
| 74 | L | A | 0.2889 | |
| 75 | T | A | -0.0470 | |
| 76 | F | A | -0.0888 | |
| 77 | R | A | -2.5881 | |
| 78 | E | A | -2.9262 | |
| 79 | N | A | -2.6733 | |
| 2 | S | B | -1.0514 | |
| 3 | H | B | -1.3678 | |
| 4 | P | B | -1.2748 | |
| 5 | S | B | 0.0000 | |
| 6 | P | B | -1.3029 | |
| 7 | Q | B | -1.6855 | |
| 8 | A | B | -1.4450 | |
| 9 | K | B | -2.1227 | |
| 10 | P | B | -1.5614 | |
| 11 | S | B | -1.3401 | |
| 12 | N | B | -1.1683 | |
| 13 | P | B | -1.0417 | |
| 14 | S | B | -0.9853 | |
| 15 | N | B | 0.0000 | |
| 16 | P | B | -1.3384 | |
| 17 | R | B | -1.1181 | |
| 18 | V | B | 0.0000 | |
| 19 | F | B | 0.0000 | |
| 20 | F | B | 0.0000 | |
| 21 | D | B | -1.3941 | |
| 22 | V | B | 0.0000 | |
| 23 | D | B | 0.0000 | |
| 24 | I | B | -0.6757 | |
| 25 | G | B | -1.0213 | |
| 26 | G | B | -1.6180 | |
| 27 | E | B | -2.7044 | |
| 28 | R | B | -3.1283 | |
| 29 | V | B | -1.3645 | |
| 30 | G | B | -0.9437 | |
| 31 | R | B | -0.7594 | |
| 32 | I | B | 0.0000 | |
| 33 | V | B | 0.0000 | |
| 34 | L | B | 0.0000 | |
| 35 | E | B | 0.0000 | |
| 36 | L | B | 0.0000 | |
| 37 | F | B | 0.0000 | |
| 38 | A | B | -0.8121 | |
| 39 | D | B | -1.4702 | |
| 40 | I | B | -0.4535 | |
| 41 | V | B | 0.0000 | |
| 42 | P | B | -1.0453 | |
| 43 | K | B | -0.9688 | |
| 44 | T | B | 0.0000 | |
| 45 | A | B | 0.0000 | |
| 46 | E | B | -1.1159 | |
| 47 | N | B | 0.0000 | |
| 48 | F | B | 0.0000 | |
| 49 | R | B | -1.1367 | |
| 50 | A | B | 0.0000 | |
| 51 | L | B | 0.0000 | |
| 52 | C | B | 0.0000 | |
| 53 | T | B | -1.5807 | |
| 54 | G | B | -1.7065 | |
| 55 | E | B | -2.5356 | |
| 56 | K | B | -2.2727 | |
| 57 | G | B | -1.6601 | |
| 58 | I | B | -0.7498 | |
| 59 | G | B | 0.0000 | |
| 60 | P | B | -0.8199 | |
| 61 | T | B | -1.0546 | |
| 62 | T | B | -0.8828 | |
| 63 | G | B | -0.6378 | |
| 64 | K | B | -1.4685 | |
| 65 | P | B | -1.2078 | |
| 66 | L | B | 0.0000 | |
| 67 | H | B | -1.4510 | |
| 68 | F | B | 0.0000 | |
| 69 | K | B | -2.3600 | |
| 70 | G | B | -1.5015 | |
| 71 | C | B | 0.0000 | |
| 72 | P | B | 0.0000 | |
| 73 | F | B | 0.0000 | |
| 74 | H | B | 0.0000 | |
| 75 | R | B | -2.1393 | |
| 76 | I | B | 0.0000 | |
| 77 | I | B | -1.2742 | |
| 78 | K | B | -2.4917 | |
| 79 | K | B | -2.1710 | |
| 80 | F | B | -0.0499 | |
| 81 | M | B | 0.0000 | |
| 82 | I | B | 0.0000 | |
| 83 | Q | B | 0.0000 | |
| 84 | G | B | 0.0000 | |
| 85 | G | B | 0.0000 | |
| 86 | D | B | 0.0000 | |
| 87 | F | B | 0.0000 | |
| 88 | S | B | -1.5264 | |
| 89 | N | B | -2.2510 | |
| 90 | Q | B | -2.1968 | |
| 91 | N | B | -2.4608 | |
| 92 | G | B | -1.5246 | |
| 93 | T | B | -1.0657 | |
| 94 | G | B | -1.1338 | |
| 95 | G | B | -1.1155 | |
| 96 | E | B | 0.0000 | |
| 97 | S | B | 0.0000 | |
| 98 | I | B | -0.3517 | |
| 99 | Y | B | 0.2563 | |
| 100 | G | B | -0.3003 | |
| 101 | E | B | -1.1446 | |
| 102 | K | B | -0.9444 | |
| 103 | F | B | 0.0000 | |
| 104 | E | B | -1.4317 | |
| 105 | D | B | -1.4678 | |
| 106 | E | B | 0.0000 | |
| 107 | N | B | -1.1689 | |
| 108 | F | B | -0.5948 | |
| 109 | H | B | -0.6006 | |
| 110 | Y | B | -0.8603 | |
| 111 | K | B | -1.5993 | |
| 112 | H | B | 0.0000 | |
| 113 | D | B | -1.5074 | |
| 114 | K | B | -1.4550 | |
| 115 | E | B | -1.2675 | |
| 116 | G | B | 0.0000 | |
| 117 | L | B | 0.0000 | |
| 118 | L | B | 0.0000 | |
| 119 | S | B | 0.0000 | |
| 120 | M | B | 0.0000 | |
| 121 | A | B | -0.4043 | |
| 122 | N | B | -0.6945 | |
| 123 | A | B | -0.3693 | |
| 124 | G | B | -0.4911 | |
| 125 | S | B | -0.5826 | |
| 126 | N | B | 0.0000 | |
| 127 | T | B | -0.6900 | |
| 128 | N | B | 0.0000 | |
| 129 | G | B | -0.4819 | |
| 130 | S | B | 0.0000 | |
| 131 | Q | B | -0.3407 | |
| 132 | F | B | 0.0000 | |
| 133 | F | B | 0.0000 | |
| 134 | I | B | 0.0000 | |
| 135 | T | B | 0.0000 | |
| 136 | T | B | 0.0000 | |
| 137 | V | B | -0.8255 | |
| 138 | P | B | -1.0436 | |
| 139 | T | B | 0.0000 | |
| 140 | P | B | -1.4379 | |
| 141 | H | B | -1.7059 | |
| 142 | L | B | 0.0000 | |
| 143 | D | B | -1.8638 | |
| 144 | G | B | -1.7538 | |
| 145 | K | B | -2.1619 | |
| 146 | H | B | -1.2882 | |
| 147 | V | B | 0.0000 | |
| 148 | V | B | 0.0000 | |
| 149 | F | B | 0.0000 | |
| 150 | G | B | 0.0000 | |
| 151 | Q | B | 0.0000 | |
| 152 | V | B | 0.0000 | |
| 153 | I | B | 0.0000 | |
| 154 | K | B | -0.7190 | |
| 155 | G | B | 0.0000 | |
| 156 | M | B | -0.4445 | |
| 157 | G | B | -0.4517 | |
| 158 | V | B | 0.0000 | |
| 159 | A | B | 0.0000 | |
| 160 | K | B | -1.2520 | |
| 161 | I | B | -0.0619 | |
| 162 | L | B | 0.0000 | |
| 163 | E | B | 0.0000 | |
| 164 | N | B | -1.9717 | |
| 165 | V | B | -1.2630 | |
| 166 | E | B | -2.2953 | |
| 167 | V | B | -2.1385 | |
| 168 | K | B | -2.8359 | |
| 169 | G | B | -2.4005 | |
| 170 | E | B | -3.2855 | |
| 171 | K | B | -2.8782 | |
| 172 | P | B | 0.0000 | |
| 173 | A | B | -1.1390 | |
| 174 | K | B | -0.7523 | |
| 175 | L | B | 0.6644 | |
| 176 | C | B | 0.0000 | |
| 177 | V | B | -0.4954 | |
| 178 | I | B | 0.0000 | |
| 179 | A | B | -1.7580 | |
| 180 | E | B | -1.9248 | |
| 181 | C | B | -1.3760 | |
| 182 | G | B | -1.4068 | |
| 183 | E | B | -1.7056 | |
| 184 | L | B | 0.0000 | |
| 185 | K | B | -3.5886 | |
| 186 | E | B | -3.6622 | |
| 187 | G | B | -2.7951 | |
| 188 | D | B | -3.4660 | |
| 189 | D | B | -2.7701 | |
| 190 | W | B | -1.0838 | |
| 191 | G | B | -0.5686 | |
| 192 | I | B | -0.0170 | |
| 193 | F | B | 0.2324 | |
| 194 | P | B | -1.1701 | |
| 195 | K | B | -2.3527 | |
| 196 | D | B | -1.9721 | |
| 197 | G | B | -1.4552 | |
| 198 | S | B | -0.9448 | |
| 199 | G | B | -0.8994 | |
| 200 | D | B | 0.0000 | |
| 201 | S | B | -0.5455 | |
| 202 | H | B | -0.5033 | |
| 203 | P | B | -0.4686 | |
| 204 | D | B | -0.8363 | |
| 205 | F | B | -0.8013 | |
| 206 | P | B | 0.0000 | |
| 207 | E | B | -2.5519 | |
| 208 | D | B | -1.4652 | |
| 209 | A | B | -1.7403 | |
| 210 | D | B | -2.4438 | |
| 211 | V | B | -2.5175 | |
| 212 | D | B | -3.3879 | |
| 213 | L | B | -3.1375 | |
| 214 | K | B | -3.9310 | |
| 215 | D | B | -3.7043 | |
| 216 | V | B | 0.0000 | |
| 217 | D | B | -2.7233 | |
| 218 | K | B | -2.1114 | |
| 219 | I | B | 0.0000 | |
| 220 | L | B | -0.9737 | |
| 221 | L | B | -0.0274 | |
| 222 | I | B | 0.0000 | |
| 223 | S | B | 0.0000 | |
| 224 | E | B | -2.0398 | |
| 225 | D | B | -2.4704 | |
| 226 | L | B | 0.0000 | |
| 227 | K | B | -1.7692 | |
| 228 | N | B | -2.3533 | |
| 229 | I | B | -1.3565 | |
| 230 | G | B | 0.0000 | |
| 231 | N | B | -1.3653 | |
| 232 | T | B | -1.1617 | |
| 233 | F | B | -1.3472 | |
| 234 | F | B | -1.5315 | |
| 235 | K | B | -2.1728 | |
| 236 | S | B | -1.6491 | |
| 237 | Q | B | -2.2521 | |
| 238 | N | B | -1.8275 | |
| 239 | W | B | -1.5800 | |
| 240 | E | B | -2.2191 | |
| 241 | M | B | -1.4668 | |
| 242 | A | B | 0.0000 | |
| 243 | I | B | -1.2416 | |
| 244 | K | B | -1.9098 | |
| 245 | K | B | 0.0000 | |
| 246 | Y | B | 0.0000 | |
| 247 | T | B | -0.8161 | |
| 248 | K | B | 0.0000 | |
| 249 | V | B | 0.0000 | |
| 250 | L | B | -0.8300 | |
| 251 | R | B | -1.7431 | |
| 252 | Y | B | 0.0000 | |
| 253 | V | B | 0.0000 | |
| 254 | E | B | -2.0718 | |
| 255 | G | B | -2.0436 | |
| 256 | S | B | 0.0000 | |
| 257 | R | B | -3.6421 | |
| 258 | A | B | -1.8516 | |
| 259 | A | B | -2.2803 | |
| 260 | A | B | -3.2272 | |
| 261 | E | B | -3.7088 | |
| 262 | D | B | -3.4784 | |
| 263 | A | B | -2.4004 | |
| 264 | D | B | -3.7023 | |
| 265 | G | B | -3.5421 | |
| 266 | A | B | -2.1092 | |
| 267 | K | B | -2.1962 | |
| 268 | L | B | 0.0000 | |
| 269 | Q | B | -1.3132 | |
| 270 | P | B | -0.7415 | |
| 271 | V | B | 0.0000 | |
| 272 | A | B | 0.0000 | |
| 273 | L | B | -0.4924 | |
| 274 | S | B | -0.1830 | |
| 275 | C | B | 0.0000 | |
| 276 | V | B | 0.0000 | |
| 277 | L | B | -0.4825 | |
| 278 | N | B | -0.1579 | |
| 279 | I | B | 0.0000 | |
| 280 | G | B | 0.0000 | |
| 281 | A | B | -0.4909 | |
| 282 | C | B | 0.0000 | |
| 283 | K | B | -1.0930 | |
| 284 | L | B | -0.7217 | |
| 285 | K | B | -1.1304 | |
| 286 | M | B | -0.4395 | |
| 287 | S | B | -0.5439 | |
| 288 | D | B | -0.7145 | |
| 289 | W | B | -0.9927 | |
| 290 | Q | B | -1.4129 | |
| 291 | G | B | -1.2114 | |
| 292 | A | B | 0.0000 | |
| 293 | V | B | 0.0000 | |
| 294 | D | B | -2.2263 | |
| 295 | S | B | -1.6924 | |
| 296 | C | B | 0.0000 | |
| 297 | L | B | -1.2384 | |
| 298 | E | B | -2.1595 | |
| 299 | A | B | 0.0000 | |
| 300 | L | B | 0.0000 | |
| 301 | E | B | -2.0909 | |
| 302 | I | B | -0.9704 | |
| 303 | D | B | -1.2465 | |
| 304 | P | B | -1.1028 | |
| 305 | S | B | -1.0158 | |
| 306 | N | B | -0.9164 | |
| 307 | T | B | -1.4277 | |
| 308 | K | B | -1.9264 | |
| 309 | A | B | 0.0000 | |
| 310 | L | B | 0.0000 | |
| 311 | Y | B | -1.2113 | |
| 312 | R | B | -1.3686 | |
| 313 | R | B | -1.2549 | |
| 314 | A | B | 0.0000 | |
| 315 | Q | B | -0.8844 | |
| 316 | G | B | 0.0000 | |
| 317 | W | B | -1.1789 | |
| 318 | Q | B | 0.0000 | |
| 319 | G | B | -0.6801 | |
| 320 | L | B | -0.7585 | |
| 321 | K | B | -2.2006 | |
| 322 | E | B | -2.0772 | |
| 323 | Y | B | -1.9640 | |
| 324 | D | B | -2.4537 | |
| 325 | Q | B | -1.9427 | |
| 326 | A | B | 0.0000 | |
| 327 | L | B | -1.1730 | |
| 328 | A | B | -1.1979 | |
| 329 | D | B | 0.0000 | |
| 330 | L | B | 0.0000 | |
| 331 | K | B | -2.1098 | |
| 332 | K | B | -2.0370 | |
| 333 | A | B | 0.0000 | |
| 334 | Q | B | -2.4635 | |
| 335 | E | B | -2.4596 | |
| 336 | I | B | -0.7108 | |
| 337 | A | B | -1.5956 | |
| 338 | P | B | -2.3397 | |
| 339 | E | B | -2.9293 | |
| 340 | D | B | -2.6723 | |
| 341 | K | B | -2.7917 | |
| 342 | A | B | -1.4345 | |
| 343 | I | B | 0.0000 | |
| 344 | Q | B | -1.7920 | |
| 345 | A | B | -0.6654 | |
| 346 | E | B | 0.0000 | |
| 347 | L | B | 0.0000 | |
| 348 | L | B | 0.0872 | |
| 349 | K | B | -1.4382 | |
| 350 | V | B | 0.0000 | |
| 351 | K | B | -1.8577 | |
| 352 | Q | B | -2.4726 | |
| 353 | K | B | -2.7478 | |
| 354 | I | B | -3.2869 | |
| 355 | K | B | -3.9705 | |
| 356 | A | B | -3.4923 | |
| 357 | Q | B | -4.2359 | |
| 358 | K | B | -5.0368 | |
| 359 | D | B | -5.2366 | |
| 360 | K | B | -4.9073 | |
| 361 | E | B | -4.9568 | |
| 362 | K | B | -4.1768 | |
| 363 | A | B | -2.2947 | |
| 364 | A | B | -0.3829 | |
| 365 | Y | B | 1.3565 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine