Project name: 2b1a

Chain sequence(s)	A: QSVLTQPPSASGTPGQRISISCSGTSSNVENNYVYWYQHLPGTAPKLLIYRNDHRSSGIPDRFSASKSGTSASLAISGLRPEDEGDYYCAAWDDSRGGPDWVFGGGTKLTVLAQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHKSYSCQVTHEGSTVEKTVAPTEIQLEQSGAEVKKSGESLKISCQTSGYSFSDYWIGWVRQMPGKGLEWMGIFYPGDSDSRYSPSFEGQVTMSADRSTNTAHLQWSSLKPSDTALYYCARLGGDYEDSGADAFDFWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKS
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.1235
• Maximal score value: 1.375
• Average score: -0.8725
• Total score value: -383.0439

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	Q	A	-1.3761
2	S	A	-0.0376
3	V	A	1.3314
4	L	A	0.0000
5	T	A	0.0533
6	Q	A	-0.2864
7	P	A	-0.5461
8	P	A	-0.6156
9	S	A	0.0000
11	A	A	-0.3742
12	S	A	-0.4216
13	G	A	0.0000
14	T	A	-1.0085
15	P	A	-1.5319
16	G	A	-1.9030
17	Q	A	-2.4931
18	R	A	-2.5398
19	I	A	-1.0899
20	S	A	-0.5561
21	I	A	0.0000
22	S	A	-0.3033
23	C	A	0.0000
24	S	A	-0.2287
25	G	A	-0.2614
26	T	A	-0.6574
27	S	A	-1.5844
27A	S	A	-1.8048
27B	N	A	0.0000
28	V	A	0.0000
29	E	A	-2.8408
30	N	A	-2.6431
31	N	A	-1.7379
32	Y	A	-0.8922
33	V	A	0.0000
34	Y	A	0.0000
35	W	A	0.0000
36	Y	A	0.0000
37	Q	A	-0.9320
38	H	A	0.0000
39	L	A	0.2009
40	P	A	-0.2092
41	G	A	-0.5285
42	T	A	-0.4954
43	A	A	0.0000
44	P	A	0.0000
45	K	A	-1.4351
46	L	A	-0.8372
47	L	A	0.0000
48	I	A	0.0000
49	Y	A	-1.0671
50	R	A	-1.2517
51	N	A	-1.8476
52	D	A	-2.7846
53	H	A	-2.2976
54	R	A	-2.3886
55	S	A	-1.3653
56	S	A	-0.8127
57	G	A	-0.8469
58	I	A	-0.8955
59	P	A	-1.4377
60	D	A	-2.2803
61	R	A	-1.5433
62	F	A	0.0000
63	S	A	-1.4688
64	A	A	-1.2074
65	S	A	-1.1434
66	K	A	-1.6554
67	S	A	-1.1018
68	G	A	-1.2609
69	T	A	-1.2030
70	S	A	-0.8870
71	A	A	-0.7457
72	S	A	-0.5017
73	L	A	0.0000
74	A	A	-0.5442
75	I	A	0.0000
76	S	A	-1.8614
77	G	A	-1.7153
78	L	A	0.0000
79	R	A	-2.6401
80	P	A	-2.0235
81	E	A	-2.6256
82	D	A	0.0000
83	E	A	-1.4998
84	G	A	-0.8128
85	D	A	-0.8064
86	Y	A	0.0000
87	Y	A	0.0000
88	C	A	0.0000
89	A	A	0.0000
90	A	A	0.0000
91	W	A	0.0000
92	D	A	0.0000
93	D	A	-2.8681
94	S	A	-2.2054
95	R	A	-2.6316
95A	G	A	-1.9339
95B	G	A	-1.5376
95C	P	A	-1.2016
95D	D	A	-1.2390
96	W	A	0.0000
97	V	A	0.0000
98	F	A	0.0000
99	G	A	0.0000
100	G	A	-0.7139
101	G	A	-0.8372
102	T	A	0.0000
103	K	A	-0.7024
104	L	A	0.0000
105	T	A	0.0000
106	V	A	0.0000
106A	L	A	-0.3577
107	A	A	-0.3758
108	Q	A	-0.6944
109	P	A	-0.9414
110	K	A	-1.7773
111	A	A	-1.1448
112	A	A	-0.7373
113	P	A	-0.5038
114	S	A	-0.1064
115	V	A	-0.3752
116	T	A	-0.3636
117	L	A	0.0000
118	F	A	0.0000
119	P	A	-0.0468
120	P	A	0.0000
121	S	A	-1.0285
122	S	A	-1.5418
123	E	A	-2.6341
124	E	A	0.0000
125	L	A	-2.4464
126	Q	A	-2.3903
127	A	A	-2.0037
128	N	A	-2.7764
129	K	A	-2.9338
130	A	A	0.0000
131	T	A	0.0000
132	L	A	0.0000
133	V	A	0.0000
134	C	A	0.0000
135	L	A	0.0000
136	I	A	0.0000
137	S	A	-0.4668
138	D	A	-0.9991
139	F	A	0.0000
140	Y	A	0.0000
141	P	A	0.0000
142	G	A	0.0000
143	A	A	-0.3750
144	V	A	0.0000
145	T	A	-0.3103
146	V	A	-0.1852
147	A	A	-0.5043
148	W	A	0.0000
149	K	A	-1.2924
150	A	A	0.0000
151	D	A	-2.6351
152	S	A	-1.5436
153	S	A	-0.9739
154	P	A	-1.0876
155	V	A	-0.9573
156	K	A	-1.7347
157	A	A	-0.9543
158	G	A	-0.9147
159	V	A	-0.8485
160	E	A	-1.4672
161	T	A	-0.6412
162	T	A	0.0000
163	T	A	-0.3102
164	P	A	-0.4011
165	S	A	-0.8030
166	K	A	-1.5281
167	Q	A	-1.4196
168	S	A	-1.2939
170	N	A	-1.7767
171	N	A	-1.6458
172	K	A	-1.6422
173	Y	A	-1.0170
174	A	A	0.0000
175	A	A	0.0000
176	S	A	0.0000
177	S	A	0.0000
178	Y	A	0.0000
179	L	A	0.0000
180	S	A	-0.7405
181	L	A	-1.0160
182	T	A	-1.9223
183	P	A	-2.4712
184	E	A	-3.1235
185	Q	A	-2.4293
186	W	A	0.0000
187	K	A	-3.0518
188	S	A	0.0000
189	H	A	-2.6672
190	K	A	-2.8866
191	S	A	-1.9264
192	Y	A	0.0000
193	S	A	0.0000
194	C	A	0.0000
195	Q	A	-1.2466
196	V	A	0.0000
197	T	A	-0.6889
198	H	A	0.0000
199	E	A	-1.9198
200	G	A	-1.4462
203	S	A	-0.6397
204	T	A	-0.6176
205	V	A	-0.5627
206	E	A	-1.7106
207	K	A	-1.4720
208	T	A	-0.9919
209	V	A	-0.4033
210	A	A	-0.9992
211	P	A	-1.0437
1	E	A	-1.9445
2	I	A	-1.1483
3	Q	A	-1.8751
4	L	A	0.0000
5	E	A	-2.7185
6	Q	A	-1.7608
7	S	A	-1.2201
8	G	A	-0.7355
9	A	A	-0.7654
10	E	A	-1.3198
11	V	A	0.0701
12	K	A	-1.6941
13	K	A	-2.6258
14	S	A	-2.2878
15	G	A	-2.2686
16	E	A	-2.6870
17	S	A	-1.8213
18	L	A	0.0000
19	K	A	-2.1667
20	I	A	0.0000
21	S	A	-1.3289
22	C	A	0.0000
23	Q	A	-2.3226
24	T	A	0.0000
25	S	A	-1.5380
26	G	A	-1.1146
27	Y	A	-0.7446
28	S	A	-0.8411
29	F	A	0.0000
30	S	A	-1.6510
31	D	A	-1.9002
32	Y	A	-0.5520
33	W	A	-0.1519
34	I	A	0.0000
35	G	A	0.0000
36	W	A	0.0000
37	V	A	0.0000
38	R	A	-0.3338
39	Q	A	-0.4579
40	M	A	-0.7344
41	P	A	-1.1107
42	G	A	-1.5544
43	K	A	-2.0646
44	G	A	-1.3135
45	L	A	0.0000
46	E	A	-0.6008
47	W	A	0.0000
48	M	A	0.0000
49	G	A	0.0000
50	I	A	0.0000
51	F	A	0.0000
52	Y	A	-1.2048
52A	P	A	0.0000
53	G	A	-2.0941
54	D	A	-2.6468
55	S	A	-2.0279
56	D	A	-2.4649
57	S	A	-1.3030
58	R	A	-1.1343
59	Y	A	-0.8546
60	S	A	0.0000
61	P	A	-1.4082
62	S	A	-1.2100
63	F	A	0.0000
64	E	A	-2.5819
65	G	A	-1.9737
66	Q	A	-2.1806
67	V	A	0.0000
68	T	A	-1.1376
69	M	A	0.0000
70	S	A	-0.7735
71	A	A	-1.2132
72	D	A	-2.3027
73	R	A	-2.7234
74	S	A	-1.6013
75	T	A	-1.5617
76	N	A	-2.1437
77	T	A	0.0000
78	A	A	0.0000
79	H	A	-0.9422
80	L	A	0.0000
81	Q	A	-1.3690
82	W	A	0.0000
82A	S	A	-1.2998
82B	S	A	-1.8187
82C	L	A	0.0000
83	K	A	-2.5579
84	P	A	0.0000
85	S	A	-0.9502
86	D	A	-0.9727
87	T	A	-0.1980
88	A	A	0.0000
89	L	A	0.9187
90	Y	A	0.0000
91	Y	A	0.0000
92	C	A	0.0000
93	A	A	0.0000
94	R	A	0.0000
95	L	A	0.0000
96	G	A	0.0000
97	G	A	-1.3051
98	D	A	-2.7330
99	Y	A	-1.6993
100	E	A	-3.0321
100A	D	A	-3.0496
100B	S	A	-2.0812
100C	G	A	-1.5306
100D	A	A	-1.1201
100E	D	A	-0.6054
100F	A	A	0.0000
100G	F	A	0.0000
101	D	A	-0.6796
102	F	A	-0.5132
103	W	A	-0.6744
104	G	A	0.0000
105	Q	A	-1.5515
106	G	A	-0.5342
107	T	A	0.0000
108	L	A	1.3750
109	V	A	0.0000
110	T	A	-0.1447
111	V	A	0.0000
112	S	A	0.0000
113	S	A	-1.3267
114	A	A	-0.6782
115	S	A	-0.5364
116	T	A	-1.0401
117	K	A	-1.5686
118	G	A	-1.4112
119	P	A	-1.0501
120	S	A	-0.6159
121	V	A	-0.5388
122	F	A	-0.6134
123	P	A	-0.9183
124	L	A	0.0000
125	A	A	0.0000
126	P	A	-1.1972
127	S	A	-1.7787
128	S	A	-2.1376
129	K	A	-2.3083
130	S	A	-1.2625
133	T	A	-1.1575
134	S	A	-1.0486
135	G	A	-0.9672
136	G	A	-0.9074
137	T	A	-0.5683
138	A	A	-0.1818
139	A	A	-0.0483
140	L	A	0.0000
141	G	A	0.0000
142	C	A	0.0000
143	L	A	0.0000
144	V	A	0.0000
145	K	A	-0.4156
146	D	A	-0.9864
147	Y	A	0.0000
148	F	A	-1.1372
149	P	A	-1.4672
150	E	A	-2.1552
151	P	A	-1.7588
152	V	A	0.0000
153	T	A	-0.8631
154	V	A	-0.3472
156	S	A	-0.3543
157	W	A	0.0000
162	N	A	-0.6734
163	S	A	-0.5781
164	G	A	-0.3864
165	A	A	-0.1984
166	L	A	-0.0235
167	T	A	-0.2089
168	S	A	-0.3376
169	G	A	-0.6372
171	V	A	-0.1617
172	H	A	-0.4258
173	T	A	-0.0899
174	F	A	0.0000
175	P	A	-0.1409
176	A	A	-0.1472
177	V	A	0.0241
178	L	A	0.0000
179	Q	A	-0.8256
180	S	A	-0.8620
182	S	A	-0.7174
183	G	A	0.0000
184	L	A	0.0000
185	Y	A	-0.5840
186	S	A	0.0000
187	L	A	0.0000
188	S	A	0.0000
189	S	A	0.0000
190	V	A	0.0000
191	V	A	0.0000
192	T	A	-0.2186
193	V	A	0.0000
194	P	A	-0.6200
195	S	A	-1.0864
196	S	A	-1.0497
197	S	A	0.0000
198	L	A	-1.3434
199	G	A	-1.9004
200	T	A	-1.1347
203	Q	A	-1.6193
205	T	A	-1.2724
206	Y	A	0.0000
207	I	A	-1.3135
208	C	A	0.0000
209	N	A	0.0000
210	V	A	0.0000
211	N	A	-2.1774
212	H	A	0.0000
213	K	A	-3.0113
214	P	A	-2.0195
215	S	A	-1.9602
216	N	A	-2.5086
217	T	A	-2.0533
218	K	A	-2.6287
219	V	A	-1.3956
220	D	A	-2.4182
221	K	A	-1.9328
222	K	A	-2.5264
225	V	A	0.0000
226	E	A	-2.8978
227	P	A	-2.2869
228	K	A	-2.5891