Project name: 6305af3e77221be

Chain sequence(s)	B: AIRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACL
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.1229
• Maximal score value: 1.6279
• Average score: -0.845
• Total score value: -234.9114

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
879	A	B	-0.1789
880	I	B	-0.6949
881	R	B	-1.8114
882	V	B	-0.6836
883	A	B	-0.6434
884	D	B	-1.7258
885	L	B	0.0000
886	L	B	-0.2100
887	Q	B	-1.5324
888	H	B	-1.3992
889	I	B	0.0000
890	T	B	-1.2194
891	Q	B	-1.4966
892	M	B	-1.4902
893	K	B	-1.8828
894	C	B	-0.7730
895	A	B	-0.8768
896	E	B	-1.9164
897	G	B	-1.8946
898	Y	B	-0.8937
899	G	B	-1.5410
900	F	B	0.0000
901	K	B	-3.6142
902	E	B	-3.1141
903	E	B	-2.2537
904	Y	B	-2.5087
905	E	B	-3.1587
906	S	B	-1.7401
907	F	B	0.0000
908	F	B	0.1843
909	E	B	-1.4701
910	G	B	-1.1436
911	Q	B	-1.3218
912	S	B	-0.6735
913	A	B	-1.0241
914	P	B	-1.5283
915	W	B	0.0000
916	D	B	-2.9006
917	S	B	-2.5697
918	A	B	0.0000
919	K	B	-3.9777
920	K	B	-3.6577
921	D	B	-4.1229
922	E	B	-3.6218
923	N	B	0.0000
924	R	B	-3.3706
925	M	B	-1.2356
926	K	B	-1.3562
927	N	B	-1.1527
928	R	B	-0.6007
929	Y	B	-0.4489
930	G	B	-1.4811
931	N	B	-1.7359
932	I	B	0.0000
933	I	B	0.0000
934	A	B	0.0000
935	Y	B	0.0000
936	D	B	-1.9735
937	H	B	-1.4841
938	S	B	0.0000
939	R	B	-1.2565
940	V	B	0.0000
941	R	B	-2.4130
942	L	B	0.0000
943	Q	B	-2.1596
944	T	B	-1.7836
945	I	B	-1.4524
946	E	B	-2.5070
947	G	B	-2.0754
948	D	B	-2.5461
949	T	B	-1.5816
950	N	B	-1.5488
951	S	B	-1.6850
952	D	B	-1.4841
953	Y	B	0.0000
954	I	B	0.0000
955	N	B	0.0000
956	G	B	0.0000
957	N	B	0.0000
958	Y	B	-0.7010
959	I	B	0.0000
960	D	B	-1.9391
961	G	B	-1.4034
962	Y	B	-1.2974
963	H	B	-1.8129
964	R	B	-2.0616
965	P	B	-1.6479
966	N	B	-1.4949
967	H	B	-1.2992
968	Y	B	0.0000
969	I	B	0.0000
970	A	B	0.0000
971	T	B	0.0000
972	Q	B	0.0000
973	G	B	0.0000
974	P	B	0.0000
975	M	B	-0.9595
976	Q	B	-1.7677
977	E	B	-1.5550
978	T	B	0.0000
979	I	B	0.0000
980	Y	B	-0.5556
981	D	B	-0.4295
982	F	B	0.0000
983	W	B	0.0000
984	R	B	-1.0533
985	M	B	0.0000
986	V	B	0.0000
987	W	B	0.0000
988	H	B	-1.6507
989	E	B	-1.4214
990	N	B	-1.7339
991	T	B	0.0000
992	A	B	-1.2207
993	S	B	0.0000
994	I	B	0.0000
995	I	B	0.0000
996	M	B	0.0000
997	V	B	0.0000
998	T	B	0.0000
999	N	B	-0.5395
1000	L	B	0.4302
1001	V	B	1.0276
1002	E	B	0.0000
1003	V	B	0.8169
1004	G	B	-0.0103
1005	R	B	-0.4123
1006	V	B	1.2399
1007	K	B	0.3923
1008	C	B	0.0000
1009	C	B	-0.2355
1010	K	B	-0.9057
1011	Y	B	0.0000
1012	W	B	0.0000
1013	P	B	0.0000
1014	D	B	-2.7576
1015	D	B	-2.8126
1016	T	B	-1.5164
1017	E	B	-1.4220
1018	I	B	-0.4211
1019	Y	B	-0.7171
1020	K	B	-2.0360
1021	D	B	-2.1212
1022	I	B	0.0000
1023	K	B	-1.3187
1024	V	B	0.0000
1025	T	B	-1.1476
1026	L	B	-1.2301
1027	I	B	-0.5181
1028	E	B	-1.9923
1029	T	B	-1.4745
1030	E	B	-1.4494
1031	L	B	0.7694
1032	L	B	0.6722
1033	A	B	0.2162
1034	E	B	-0.4678
1035	Y	B	0.0000
1036	V	B	0.0000
1037	I	B	0.0000
1038	R	B	-1.1564
1039	T	B	0.0000
1040	F	B	0.0000
1041	A	B	-0.5321
1042	V	B	0.0000
1043	E	B	-1.5692
1044	K	B	-2.1848
1045	R	B	-2.9266
1046	G	B	-1.6597
1047	V	B	-0.7585
1048	H	B	-1.2582
1049	E	B	-1.0038
1050	I	B	0.4643
1051	R	B	-0.9714
1052	E	B	-1.6833
1053	I	B	0.0000
1054	R	B	-1.3991
1055	Q	B	0.0000
1056	F	B	0.0000
1057	H	B	0.0000
1058	F	B	0.0000
1059	T	B	-0.4766
1060	G	B	-0.8024
1061	W	B	0.0000
1062	P	B	-1.2254
1063	D	B	-1.9411
1064	H	B	-1.7359
1065	G	B	-1.3014
1066	V	B	-0.6952
1067	P	B	-0.0883
1068	Y	B	0.6892
1069	H	B	-0.6342
1070	A	B	0.0000
1071	T	B	-0.6864
1072	G	B	-0.5037
1073	L	B	0.0000
1074	L	B	0.0000
1075	G	B	-0.9525
1076	F	B	0.0000
1077	V	B	0.0000
1078	R	B	-2.2176
1079	Q	B	-1.7149
1080	V	B	0.0000
1081	K	B	-1.8218
1082	S	B	-1.7335
1083	K	B	-2.0299
1084	S	B	-1.3723
1085	P	B	-0.8004
1086	P	B	-0.7168
1087	S	B	-0.5543
1088	A	B	-0.6686
1089	G	B	-0.9939
1090	P	B	-0.8666
1091	L	B	0.0000
1092	V	B	0.0000
1093	V	B	0.0000
1094	H	B	0.0000
1095	C	B	0.0000
1096	S	B	0.0000
1097	A	B	-0.2919
1098	G	B	0.0000
1099	A	B	0.0000
1100	G	B	0.0000
1101	R	B	-0.2883
1102	T	B	0.0000
1103	G	B	0.0000
1104	C	B	0.0000
1105	F	B	0.0000
1106	I	B	0.0000
1107	V	B	0.0000
1108	I	B	0.0000
1109	D	B	0.0000
1110	I	B	0.0000
1111	M	B	0.0000
1112	L	B	0.0000
1113	D	B	-2.0933
1114	M	B	-1.8812
1115	A	B	-2.0586
1116	E	B	-3.1597
1117	R	B	-3.3844
1118	E	B	-2.7679
1119	G	B	-1.7965
1120	V	B	-1.4806
1121	V	B	0.0000
1122	D	B	-0.3219
1123	I	B	0.0000
1124	Y	B	-0.8108
1125	N	B	-1.5691
1126	C	B	0.0000
1127	V	B	0.0000
1128	R	B	-2.6301
1129	E	B	-3.0417
1130	L	B	0.0000
1131	R	B	0.0000
1132	S	B	-1.4238
1133	R	B	-1.4497
1134	R	B	0.0000
1135	V	B	0.0000
1136	N	B	0.0000
1137	M	B	0.0000
1138	V	B	0.0000
1139	Q	B	-1.4402
1140	T	B	-1.8551
1141	E	B	-3.3880
1142	E	B	-2.6655
1143	Q	B	-1.6770
1144	Y	B	0.0000
1145	V	B	-1.3694
1146	F	B	0.0000
1147	I	B	0.0000
1148	H	B	0.0000
1149	D	B	-1.1734
1150	A	B	0.0000
1151	I	B	0.0000
1152	L	B	0.0000
1153	E	B	-0.4133
1154	A	B	0.0707
1155	C	B	0.6640
1156	L	B	1.6279