Project name: RH5.2TS

Chain sequence(s)	A: SIDILQEKEGHLDFVIIPHYTFLEYYKHLSYNSIYHKSSTYGKYIAVDAFIKKINEAYDKVKSKCNDIKNDLIKTIKKLEHPYDAFKKMFDEYNTKKNKFINCIKNHENDFNKICNDMKNYGTNLFEQLSCYNNNFCNTNGIRYHYDEYIHKLILAVKSKNLNKDLNDMKNILQQSEKLLNNLEIYIDTIKFIHKEMKHIFNRIEYHTKIINDKTKIIQDKIKLNIWRTFQKDELLKKILDMSKEYALFITSDHLRQMLYNTFYSKEKHLNNIFHHLIYVL
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.271
• Maximal score value: 3.4409
• Average score: -1.0965
• Total score value: -308.1148

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
160	S	A	0.1302
161	I	A	0.7194
162	D	A	0.0000
163	I	A	0.1479
164	L	A	0.0000
165	Q	A	-1.8487
166	E	A	-2.4744
167	K	A	-3.3522
168	E	A	-3.5563
169	G	A	-2.7348
170	H	A	-2.7317
171	L	A	0.0000
172	D	A	-1.3266
173	F	A	0.0000
174	V	A	0.2635
175	I	A	0.0000
176	I	A	0.5395
177	P	A	0.2709
178	H	A	0.3463
179	Y	A	0.6199
180	T	A	0.3183
181	F	A	0.3558
182	L	A	0.0997
183	E	A	0.0000
184	Y	A	-0.0710
185	Y	A	-0.1988
186	K	A	-0.2238
187	H	A	0.0000
188	L	A	0.0000
189	S	A	0.0000
190	Y	A	0.0000
191	N	A	0.0000
192	S	A	0.0000
193	I	A	0.0000
194	Y	A	0.0000
195	H	A	0.0000
196	K	A	-0.9795
197	S	A	-0.7923
198	S	A	-0.6978
199	T	A	-0.5682
200	Y	A	-0.0161
201	G	A	-0.1117
202	K	A	-0.1238
203	Y	A	1.2267
204	I	A	2.0035
205	A	A	0.7388
206	V	A	0.0000
207	D	A	-0.1475
208	A	A	-0.2027
209	F	A	-0.6686
210	I	A	0.0000
211	K	A	-3.2231
212	K	A	-3.3182
213	I	A	0.0000
214	N	A	-3.5660
215	E	A	-4.2710
216	A	A	-3.0857
217	Y	A	-2.8361
218	D	A	-3.9224
219	K	A	-3.6058
220	V	A	0.0000
221	K	A	-2.3633
222	S	A	-2.6755
223	K	A	-2.9780
224	C	A	0.0000
225	N	A	-2.5476
226	D	A	-2.8390
227	I	A	-2.1199
228	K	A	-2.6034
229	N	A	-2.6451
230	D	A	-2.4526
231	L	A	0.0000
232	I	A	0.0000
233	K	A	-2.9278
234	T	A	0.0000
235	I	A	0.0000
236	K	A	-2.7815
237	K	A	-2.6642
238	L	A	0.0000
239	E	A	0.0000
240	H	A	-1.5026
241	P	A	-0.6496
242	Y	A	-0.7863
243	D	A	-1.8174
299	A	A	-0.3040
300	F	A	0.0000
301	K	A	-2.5356
302	K	A	-2.8528
303	M	A	-1.7262
304	F	A	-1.5380
305	D	A	-2.9010
306	E	A	-2.1616
307	Y	A	-1.9792
308	N	A	-2.0770
309	T	A	-2.0442
310	K	A	-2.3867
311	K	A	-2.3647
312	N	A	-2.7402
313	K	A	-2.8723
314	F	A	0.0000
315	I	A	-1.7247
316	N	A	-2.8416
317	C	A	-2.4565
318	I	A	0.0000
319	K	A	-3.4931
320	N	A	-3.1351
321	H	A	-3.1174
322	E	A	-3.4939
323	N	A	-3.4635
324	D	A	-3.2407
325	F	A	0.0000
326	N	A	-2.5722
327	K	A	-3.0704
328	I	A	-2.0304
329	C	A	0.0000
330	N	A	-1.9908
331	D	A	-1.8170
332	M	A	0.0000
333	K	A	-1.7836
334	N	A	-2.1202
335	Y	A	-1.3695
336	G	A	0.0000
337	T	A	-1.7654
338	N	A	-2.5170
339	L	A	0.0000
340	F	A	-1.4453
341	E	A	-2.7123
342	Q	A	-2.3233
343	L	A	0.0000
344	S	A	-0.8124
345	C	A	-0.2098
346	Y	A	0.6380
347	N	A	-0.6238
348	N	A	-1.9631
349	N	A	-1.8256
350	F	A	0.0510
351	C	A	0.0000
352	N	A	-1.1607
353	T	A	0.0000
354	N	A	-1.6297
355	G	A	0.0000
356	I	A	0.0000
357	R	A	-1.6929
358	Y	A	-1.2415
359	H	A	0.0000
360	Y	A	0.0000
361	D	A	-2.7904
362	E	A	-2.3860
363	Y	A	-1.1383
364	I	A	0.0000
365	H	A	-1.6565
366	K	A	-1.8108
367	L	A	-0.6814
368	I	A	0.0000
369	L	A	-0.4075
370	A	A	-0.9325
371	V	A	-1.5130
372	K	A	-2.1720
373	S	A	-1.7098
374	K	A	-3.0109
375	N	A	-3.1917
376	L	A	-2.9961
377	N	A	-3.4299
378	K	A	-3.7109
379	D	A	-2.8312
380	L	A	-2.3958
381	N	A	-2.9846
382	D	A	-3.1128
383	M	A	0.0000
384	K	A	-2.4938
385	N	A	-2.2509
386	I	A	-1.5041
387	L	A	0.0000
388	Q	A	-2.3502
389	Q	A	-2.2885
390	S	A	0.0000
391	E	A	-2.8625
392	K	A	-2.9642
393	L	A	-1.1107
394	L	A	-1.5443
395	N	A	-2.1802
396	N	A	-1.6350
397	L	A	0.3221
398	E	A	-1.3447
405	I	A	1.5927
406	Y	A	1.1235
407	I	A	0.3749
408	D	A	0.0110
409	T	A	0.0000
410	I	A	0.0000
411	K	A	-2.0740
412	F	A	0.0000
413	I	A	0.0000
414	H	A	0.0000
415	K	A	-2.7542
416	E	A	-1.9326
417	M	A	0.0000
418	K	A	-2.4206
419	H	A	-2.3971
420	I	A	0.0000
421	F	A	-1.5217
422	N	A	-1.8685
423	R	A	-1.6264
424	I	A	0.0000
425	E	A	-1.5299
426	Y	A	-0.5564
427	H	A	0.0000
428	T	A	0.0000
429	K	A	-2.6673
430	I	A	-1.5633
431	I	A	0.0000
432	N	A	-3.3516
433	D	A	-3.2905
434	K	A	-2.1086
435	T	A	0.0000
436	K	A	-2.6940
437	I	A	-1.3640
438	I	A	0.0000
439	Q	A	-1.4488
440	D	A	-1.5974
441	K	A	-1.1441
442	I	A	0.0000
443	K	A	-1.4892
444	L	A	0.2434
445	N	A	0.0000
446	I	A	0.0000
447	W	A	-0.1405
448	R	A	-1.2504
449	T	A	-1.1101
450	F	A	0.0000
451	Q	A	-2.0616
452	K	A	-2.7045
453	D	A	-3.5412
454	E	A	-3.2120
455	L	A	0.0000
456	L	A	-2.0620
457	K	A	-2.7833
458	K	A	-1.8383
459	I	A	0.0000
460	L	A	-0.7662
461	D	A	-1.4982
462	M	A	0.0000
463	S	A	0.0000
464	K	A	-1.4808
465	E	A	-1.0574
466	Y	A	0.0000
467	A	A	0.0000
468	L	A	-0.0463
469	F	A	0.0000
470	I	A	-0.0205
471	T	A	0.0000
472	S	A	0.0000
473	D	A	-0.7830
474	H	A	-0.6913
475	L	A	0.0000
476	R	A	0.0000
477	Q	A	-1.3917
478	M	A	-1.0362
479	L	A	0.0000
480	Y	A	-0.3261
481	N	A	-1.0428
482	T	A	0.0000
483	F	A	0.0000
484	Y	A	-0.6586
485	S	A	-1.6553
486	K	A	0.0000
487	E	A	-1.3231
488	K	A	-2.4752
489	H	A	0.0000
490	L	A	0.0000
491	N	A	-2.0110
492	N	A	-2.2420
493	I	A	0.0000
494	F	A	0.0000
495	H	A	-0.1716
496	H	A	0.5322
497	L	A	1.9978
498	I	A	2.8438
499	Y	A	3.0789
500	V	A	3.4409
501	L	A	3.1627