| Chain sequence(s) |
A: VQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTF C: VQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTF B: VQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTF E: VQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTF D: VQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTF G: VQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTF F: VQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTF I: VQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTF H: VQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTF J: VQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTF |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
| Mutated residues | VB309K, VJ309K |
| Energy difference between WT (input) and mutated protein (by FoldX) | 1.06054 kcal/mol
CAUTION: Your mutation/s can destabilize the protein structure Changes in protein stability upon mutation are calculated using the FoldX forcefield. Computational prediction of protein stability is used with the intention of preventing the experimental characterization of proteins bearing mutations that significantly destabilize their structure. Mutations resulting in a predicted reduction in protein stability ≥ 1 kcal/mol are considered disruptive. |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 306 | V | A | 1.9555 | |
| 307 | Q | A | 0.5729 | |
| 308 | I | A | 1.4477 | |
| 309 | V | A | 1.2485 | |
| 310 | Y | A | 0.3223 | |
| 311 | K | A | -1.2171 | |
| 312 | P | A | -0.2957 | |
| 313 | V | A | 0.8835 | |
| 314 | D | A | -0.1854 | |
| 315 | L | A | 0.8726 | |
| 316 | S | A | -0.6275 | |
| 317 | K | A | -1.5264 | |
| 318 | V | A | -1.0572 | |
| 319 | T | A | -1.3440 | |
| 320 | S | A | -1.5815 | |
| 321 | K | A | -2.4669 | |
| 322 | C | A | -1.1728 | |
| 323 | G | A | -1.0682 | |
| 324 | S | A | -0.6347 | |
| 325 | L | A | -0.0103 | |
| 326 | G | A | -0.7593 | |
| 327 | N | A | -1.5295 | |
| 328 | I | A | -0.5644 | |
| 329 | H | A | -1.1927 | |
| 330 | H | A | -0.6576 | |
| 331 | K | A | -1.3736 | |
| 332 | P | A | -0.9085 | |
| 333 | G | A | -1.0356 | |
| 334 | G | A | -0.9906 | |
| 335 | G | A | -1.0636 | |
| 336 | Q | A | -1.6815 | |
| 337 | V | A | -1.0892 | |
| 338 | E | A | -2.2783 | |
| 339 | V | A | -1.6261 | |
| 340 | K | A | -2.9809 | |
| 341 | S | A | -2.6608 | |
| 342 | E | A | -3.6299 | |
| 343 | K | A | -3.4388 | |
| 344 | L | A | -1.8901 | |
| 345 | D | A | -2.7059 | |
| 346 | F | A | -2.7347 | |
| 347 | K | A | -3.7998 | |
| 348 | D | A | -3.5617 | |
| 349 | R | A | -3.8950 | |
| 350 | V | A | -2.5359 | |
| 351 | Q | A | -2.7135 | |
| 352 | S | A | -1.6013 | |
| 353 | K | A | -2.1089 | |
| 354 | I | A | -1.0212 | |
| 355 | G | A | -1.0068 | |
| 356 | S | A | -0.8195 | |
| 357 | L | A | -0.1850 | |
| 358 | D | A | -0.2069 | |
| 359 | N | A | 0.1093 | |
| 360 | I | A | 1.2266 | |
| 361 | T | A | 0.0000 | |
| 362 | H | A | -0.5056 | |
| 363 | V | A | -0.0602 | |
| 364 | P | A | -0.3903 | |
| 365 | G | A | 0.0000 | |
| 366 | G | A | -1.2023 | |
| 367 | G | A | -1.1256 | |
| 368 | N | A | -1.5800 | |
| 369 | K | A | -2.3294 | |
| 370 | K | A | -1.3166 | |
| 371 | I | A | 0.0879 | |
| 372 | E | A | -0.5217 | |
| 373 | T | A | -0.6509 | |
| 374 | H | A | -1.1901 | |
| 375 | K | A | -2.0610 | |
| 376 | L | A | -0.3171 | |
| 377 | T | A | 0.5385 | |
| 378 | F | A | 1.8382 | |
| 306 | V | B | 1.9565 | |
| 307 | Q | B | -0.2654 | |
| 308 | I | B | -0.2576 | |
| 309 | K | B | -2.2207 | mutated: VB309K |
| 310 | Y | B | -1.4256 | |
| 311 | K | B | -2.0965 | |
| 312 | P | B | -0.7710 | |
| 313 | V | B | 0.6982 | |
| 314 | D | B | -0.0689 | |
| 315 | L | B | 0.9216 | |
| 316 | S | B | -0.6301 | |
| 317 | K | B | -1.6853 | |
| 318 | V | B | -1.1355 | |
| 319 | T | B | -1.3486 | |
| 320 | S | B | -1.4750 | |
| 321 | K | B | -2.3735 | |
| 322 | C | B | -1.0587 | |
| 323 | G | B | -0.9609 | |
| 324 | S | B | -0.5204 | |
| 325 | L | B | 0.1989 | |
| 326 | G | B | -0.6403 | |
| 327 | N | B | -1.4710 | |
| 328 | I | B | -0.6376 | |
| 329 | H | B | -1.1864 | |
| 330 | H | B | -0.7720 | |
| 331 | K | B | -1.1436 | |
| 332 | P | B | -0.9201 | |
| 333 | G | B | -0.9181 | |
| 334 | G | B | -0.7107 | |
| 335 | G | B | -0.6223 | |
| 336 | Q | B | -0.8812 | |
| 337 | V | B | -0.7732 | |
| 338 | E | B | -2.1690 | |
| 339 | V | B | -1.5505 | |
| 340 | K | B | -2.9355 | |
| 341 | S | B | -2.6097 | |
| 342 | E | B | -3.6509 | |
| 343 | K | B | -3.5503 | |
| 344 | L | B | -1.9797 | |
| 345 | D | B | -2.8340 | |
| 346 | F | B | -2.8121 | |
| 347 | K | B | -3.9590 | |
| 348 | D | B | -3.6869 | |
| 349 | R | B | -3.9749 | |
| 350 | V | B | -2.5944 | |
| 351 | Q | B | -2.7512 | |
| 352 | S | B | -1.5863 | |
| 353 | K | B | -2.1014 | |
| 354 | I | B | -0.9877 | |
| 355 | G | B | -0.9369 | |
| 356 | S | B | -0.8073 | |
| 357 | L | B | -0.0874 | |
| 358 | D | B | -0.4131 | |
| 359 | N | B | -0.0721 | |
| 360 | I | B | 1.1311 | |
| 361 | T | B | 0.0000 | |
| 362 | H | B | -0.4408 | |
| 363 | V | B | -0.0252 | |
| 364 | P | B | -0.3522 | |
| 365 | G | B | 0.0000 | |
| 366 | G | B | -1.1678 | |
| 367 | G | B | -1.0793 | |
| 368 | N | B | -1.4898 | |
| 369 | K | B | -2.1608 | |
| 370 | K | B | -1.2147 | |
| 371 | I | B | 0.0962 | |
| 372 | E | B | -0.6763 | |
| 373 | T | B | -0.7048 | |
| 374 | H | B | 0.0000 | |
| 375 | K | B | -2.0837 | |
| 376 | L | B | -0.3216 | |
| 377 | T | B | 0.5162 | |
| 378 | F | B | 1.8227 | |
| 306 | V | C | 2.5280 | |
| 307 | Q | C | 1.0577 | |
| 308 | I | C | 0.0000 | |
| 309 | V | C | 0.1862 | |
| 310 | Y | C | 0.0000 | |
| 311 | K | C | -1.0145 | |
| 312 | P | C | 0.0000 | |
| 313 | V | C | 0.5544 | |
| 314 | D | C | 0.6286 | |
| 315 | L | C | 0.8216 | |
| 316 | S | C | 0.0000 | |
| 317 | K | C | -1.0948 | |
| 318 | V | C | 0.0000 | |
| 319 | T | C | -1.6050 | |
| 320 | S | C | 0.0000 | |
| 321 | K | C | -2.9884 | |
| 322 | C | C | 0.0000 | |
| 323 | G | C | -1.2810 | |
| 324 | S | C | -0.6819 | |
| 325 | L | C | 0.0000 | |
| 326 | G | C | -0.9326 | |
| 327 | N | C | -1.5325 | |
| 328 | I | C | 0.0000 | |
| 329 | H | C | -0.9910 | |
| 330 | H | C | 0.0000 | |
| 331 | K | C | 0.0000 | |
| 332 | P | C | 0.0000 | |
| 333 | G | C | 0.0000 | |
| 334 | G | C | 0.0000 | |
| 335 | G | C | 0.0000 | |
| 336 | Q | C | 0.0000 | |
| 337 | V | C | 0.0000 | |
| 338 | E | C | -1.5413 | |
| 339 | V | C | 0.0000 | |
| 340 | K | C | -2.7293 | |
| 341 | S | C | -2.8548 | |
| 342 | E | C | -3.4007 | |
| 343 | K | C | -3.3956 | |
| 344 | L | C | 0.0000 | |
| 345 | D | C | -2.7416 | |
| 346 | F | C | 0.0000 | |
| 347 | K | C | -3.8571 | |
| 348 | D | C | -3.9240 | |
| 349 | R | C | -4.7751 | |
| 350 | V | C | 0.0000 | |
| 351 | Q | C | -2.8215 | |
| 352 | S | C | -1.5141 | |
| 353 | K | C | -1.3960 | |
| 354 | I | C | 0.0000 | |
| 355 | G | C | 0.0000 | |
| 356 | S | C | 0.0000 | |
| 357 | L | C | 0.0000 | |
| 358 | D | C | 0.0000 | |
| 359 | N | C | 0.0000 | |
| 360 | I | C | 0.5555 | |
| 361 | T | C | 0.0000 | |
| 362 | H | C | -0.2889 | |
| 363 | V | C | 0.0000 | |
| 364 | P | C | 0.0000 | |
| 365 | G | C | 0.0000 | |
| 366 | G | C | 0.0000 | |
| 367 | G | C | -1.0153 | |
| 368 | N | C | 0.0000 | |
| 369 | K | C | -1.9686 | |
| 370 | K | C | 0.0000 | |
| 371 | I | C | 0.0207 | |
| 372 | E | C | 0.0000 | |
| 373 | T | C | -0.4873 | |
| 374 | H | C | 0.0000 | |
| 375 | K | C | -1.6294 | |
| 376 | L | C | 0.0000 | |
| 377 | T | C | 0.5953 | |
| 378 | F | C | 1.9244 | |
| 306 | V | D | 2.5366 | |
| 307 | Q | D | 0.5885 | |
| 308 | I | D | 0.0000 | |
| 309 | V | D | -1.0876 | |
| 310 | Y | D | 0.0000 | |
| 311 | K | D | -1.5821 | |
| 312 | P | D | 0.0000 | |
| 313 | V | D | 0.3620 | |
| 314 | D | D | 0.0000 | |
| 315 | L | D | 0.9108 | |
| 316 | S | D | 0.0000 | |
| 317 | K | D | -1.5779 | |
| 318 | V | D | 0.0000 | |
| 319 | T | D | -1.7230 | |
| 320 | S | D | 0.0000 | |
| 321 | K | D | -2.7010 | |
| 322 | C | D | 0.0000 | |
| 323 | G | D | -1.1908 | |
| 324 | S | D | -0.5605 | |
| 325 | L | D | 0.0000 | |
| 326 | G | D | -0.8210 | |
| 327 | N | D | -1.4244 | |
| 328 | I | D | 0.0000 | |
| 329 | H | D | -0.9941 | |
| 330 | H | D | 0.0000 | |
| 331 | K | D | 0.0000 | |
| 332 | P | D | 0.0000 | |
| 333 | G | D | 0.0000 | |
| 334 | G | D | 0.0000 | |
| 335 | G | D | 0.0000 | |
| 336 | Q | D | 0.0000 | |
| 337 | V | D | 0.0000 | |
| 338 | E | D | -1.5158 | |
| 339 | V | D | 0.0000 | |
| 340 | K | D | -2.7397 | |
| 341 | S | D | 0.0000 | |
| 342 | E | D | -3.5881 | |
| 343 | K | D | -3.7330 | |
| 344 | L | D | 0.0000 | |
| 345 | D | D | -3.1226 | |
| 346 | F | D | 0.0000 | |
| 347 | K | D | -4.3358 | |
| 348 | D | D | -4.2718 | |
| 349 | R | D | -5.0402 | |
| 350 | V | D | 0.0000 | |
| 351 | Q | D | -2.9474 | |
| 352 | S | D | 0.0000 | |
| 353 | K | D | -1.3808 | |
| 354 | I | D | 0.0000 | |
| 355 | G | D | 0.0000 | |
| 356 | S | D | 0.0000 | |
| 357 | L | D | 0.0000 | |
| 358 | D | D | 0.0000 | |
| 359 | N | D | 0.0000 | |
| 360 | I | D | 0.5032 | |
| 361 | T | D | 0.0000 | |
| 362 | H | D | -0.3050 | |
| 363 | V | D | 0.0000 | |
| 364 | P | D | 0.0000 | |
| 365 | G | D | 0.0000 | |
| 366 | G | D | 0.0000 | |
| 367 | G | D | -0.9410 | |
| 368 | N | D | 0.0000 | |
| 369 | K | D | -1.6577 | |
| 370 | K | D | 0.0000 | |
| 371 | I | D | 0.0097 | |
| 372 | E | D | 0.0000 | |
| 373 | T | D | -0.5564 | |
| 374 | H | D | 0.0000 | |
| 375 | K | D | -1.7575 | |
| 376 | L | D | 0.0000 | |
| 377 | T | D | 0.5661 | |
| 378 | F | D | 2.0011 | |
| 306 | V | E | 2.6839 | |
| 307 | Q | E | 0.7539 | |
| 308 | I | E | 0.0000 | |
| 309 | V | E | -0.0659 | |
| 310 | Y | E | 0.0000 | |
| 311 | K | E | -1.3931 | |
| 312 | P | E | 0.0000 | |
| 313 | V | E | 0.6643 | |
| 314 | D | E | 0.0000 | |
| 315 | L | E | 1.1669 | |
| 316 | S | E | 0.0000 | |
| 317 | K | E | -1.2844 | |
| 318 | V | E | 0.0000 | |
| 319 | T | E | 0.0000 | |
| 320 | S | E | 0.0000 | |
| 321 | K | E | -2.6539 | |
| 322 | C | E | 0.0000 | |
| 323 | G | E | -1.3017 | |
| 324 | S | E | -0.6617 | |
| 325 | L | E | 0.0000 | |
| 326 | G | E | -1.0332 | |
| 327 | N | E | -1.5696 | |
| 328 | I | E | 0.0000 | |
| 329 | H | E | -0.7281 | |
| 330 | H | E | 0.0000 | |
| 331 | K | E | 0.0000 | |
| 332 | P | E | 0.0000 | |
| 333 | G | E | 0.0000 | |
| 334 | G | E | 0.0000 | |
| 335 | G | E | 0.0000 | |
| 336 | Q | E | 0.0000 | |
| 337 | V | E | 0.0000 | |
| 338 | E | E | -0.9899 | |
| 339 | V | E | 0.0000 | |
| 340 | K | E | -2.0725 | |
| 341 | S | E | -2.5936 | |
| 342 | E | E | -3.1136 | |
| 343 | K | E | -2.9996 | |
| 344 | L | E | 0.0000 | |
| 345 | D | E | -2.6310 | |
| 346 | F | E | 0.0000 | |
| 347 | K | E | -3.7038 | |
| 348 | D | E | -4.0107 | |
| 349 | R | E | -4.8034 | |
| 350 | V | E | 0.0000 | |
| 351 | Q | E | -2.5398 | |
| 352 | S | E | 0.0000 | |
| 353 | K | E | -1.1262 | |
| 354 | I | E | 0.0000 | |
| 355 | G | E | 0.0000 | |
| 356 | S | E | 0.0000 | |
| 357 | L | E | 0.0000 | |
| 358 | D | E | 0.0000 | |
| 359 | N | E | 0.0000 | |
| 360 | I | E | 0.5078 | |
| 361 | T | E | 0.0000 | |
| 362 | H | E | -0.4825 | |
| 363 | V | E | 0.0000 | |
| 364 | P | E | 0.0000 | |
| 365 | G | E | 0.0000 | |
| 366 | G | E | 0.0000 | |
| 367 | G | E | -0.6936 | |
| 368 | N | E | 0.0000 | |
| 369 | K | E | -1.8250 | |
| 370 | K | E | 0.0000 | |
| 371 | I | E | 0.2940 | |
| 372 | E | E | 0.0000 | |
| 373 | T | E | -0.3005 | |
| 374 | H | E | 0.0000 | |
| 375 | K | E | -1.4028 | |
| 376 | L | E | 0.0000 | |
| 377 | T | E | 0.5647 | |
| 378 | F | E | 1.7563 | |
| 306 | V | F | 2.7204 | |
| 307 | Q | F | 0.8145 | |
| 308 | I | F | 0.0000 | |
| 309 | V | F | -0.3514 | |
| 310 | Y | F | 0.0000 | |
| 311 | K | F | -1.2592 | |
| 312 | P | F | 0.0000 | |
| 313 | V | F | 0.6455 | |
| 314 | D | F | 0.0000 | |
| 315 | L | F | 1.1881 | |
| 316 | S | F | 0.0000 | |
| 317 | K | F | -1.5468 | |
| 318 | V | F | 0.0000 | |
| 319 | T | F | 0.0000 | |
| 320 | S | F | 0.0000 | |
| 321 | K | F | -2.7846 | |
| 322 | C | F | 0.0000 | |
| 323 | G | F | -1.2909 | |
| 324 | S | F | -0.7194 | |
| 325 | L | F | 0.0000 | |
| 326 | G | F | -1.0487 | |
| 327 | N | F | -1.5857 | |
| 328 | I | F | 0.0000 | |
| 329 | H | F | -0.7528 | |
| 330 | H | F | 0.0000 | |
| 331 | K | F | 0.0000 | |
| 332 | P | F | 0.0000 | |
| 333 | G | F | 0.0000 | |
| 334 | G | F | 0.0000 | |
| 335 | G | F | 0.0000 | |
| 336 | Q | F | 0.0000 | |
| 337 | V | F | 0.0000 | |
| 338 | E | F | -0.9779 | |
| 339 | V | F | 0.0000 | |
| 340 | K | F | -2.3889 | |
| 341 | S | F | -2.8426 | |
| 342 | E | F | -3.4321 | |
| 343 | K | F | -3.2866 | |
| 344 | L | F | 0.0000 | |
| 345 | D | F | -3.0284 | |
| 346 | F | F | 0.0000 | |
| 347 | K | F | -4.5605 | |
| 348 | D | F | -4.8561 | |
| 349 | R | F | -5.2988 | |
| 350 | V | F | 0.0000 | |
| 351 | Q | F | -2.6393 | |
| 352 | S | F | 0.0000 | |
| 353 | K | F | -1.0560 | |
| 354 | I | F | 0.0000 | |
| 355 | G | F | 0.0000 | |
| 356 | S | F | 0.0000 | |
| 357 | L | F | 0.0000 | |
| 358 | D | F | 0.0000 | |
| 359 | N | F | 0.0000 | |
| 360 | I | F | 0.5142 | |
| 361 | T | F | 0.0000 | |
| 362 | H | F | -0.4676 | |
| 363 | V | F | 0.0000 | |
| 364 | P | F | 0.0000 | |
| 365 | G | F | 0.0000 | |
| 366 | G | F | 0.0000 | |
| 367 | G | F | -0.6676 | |
| 368 | N | F | 0.0000 | |
| 369 | K | F | -1.7624 | |
| 370 | K | F | 0.0000 | |
| 371 | I | F | 0.3179 | |
| 372 | E | F | 0.0000 | |
| 373 | T | F | -0.3480 | |
| 374 | H | F | 0.0000 | |
| 375 | K | F | -1.6546 | |
| 376 | L | F | 0.0000 | |
| 377 | T | F | 0.5810 | |
| 378 | F | F | 1.9183 | |
| 306 | V | G | 2.6306 | |
| 307 | Q | G | 1.0048 | |
| 308 | I | G | 0.0000 | |
| 309 | V | G | -0.2701 | |
| 310 | Y | G | 0.0000 | |
| 311 | K | G | -1.4857 | |
| 312 | P | G | 0.0000 | |
| 313 | V | G | 0.3075 | |
| 314 | D | G | 0.0000 | |
| 315 | L | G | 0.6229 | |
| 316 | S | G | 0.0000 | |
| 317 | K | G | -1.1171 | |
| 318 | V | G | 0.0000 | |
| 319 | T | G | -1.3303 | |
| 320 | S | G | 0.0000 | |
| 321 | K | G | -2.6116 | |
| 322 | C | G | 0.0000 | |
| 323 | G | G | -1.1597 | |
| 324 | S | G | -0.7092 | |
| 325 | L | G | 0.0000 | |
| 326 | G | G | -1.0538 | |
| 327 | N | G | -1.4101 | |
| 328 | I | G | 0.0000 | |
| 329 | H | G | -0.8263 | |
| 330 | H | G | 0.0000 | |
| 331 | K | G | 0.0000 | |
| 332 | P | G | 0.0000 | |
| 333 | G | G | 0.0000 | |
| 334 | G | G | 0.0000 | |
| 335 | G | G | 0.0000 | |
| 336 | Q | G | 0.0000 | |
| 337 | V | G | 0.0000 | |
| 338 | E | G | -1.2213 | |
| 339 | V | G | 0.0000 | |
| 340 | K | G | -2.6665 | |
| 341 | S | G | -3.0648 | |
| 342 | E | G | -3.9291 | |
| 343 | K | G | -3.6798 | |
| 344 | L | G | 0.0000 | |
| 345 | D | G | -2.6227 | |
| 346 | F | G | 0.0000 | |
| 347 | K | G | -3.8936 | |
| 348 | D | G | -3.9466 | |
| 349 | R | G | -5.0409 | |
| 350 | V | G | 0.0000 | |
| 351 | Q | G | -2.7558 | |
| 352 | S | G | 0.0000 | |
| 353 | K | G | -1.1505 | |
| 354 | I | G | 0.0000 | |
| 355 | G | G | 0.0000 | |
| 356 | S | G | 0.0000 | |
| 357 | L | G | 0.0000 | |
| 358 | D | G | -0.6573 | |
| 359 | N | G | 0.0000 | |
| 360 | I | G | -0.1267 | |
| 361 | T | G | 0.0000 | |
| 362 | H | G | -0.4490 | |
| 363 | V | G | 0.0000 | |
| 364 | P | G | 0.0000 | |
| 365 | G | G | 0.0000 | |
| 366 | G | G | 0.0000 | |
| 367 | G | G | -0.9317 | |
| 368 | N | G | 0.0000 | |
| 369 | K | G | -2.2504 | |
| 370 | K | G | 0.0000 | |
| 371 | I | G | -0.4985 | |
| 372 | E | G | 0.0000 | |
| 373 | T | G | -0.8110 | |
| 374 | H | G | 0.0000 | |
| 375 | K | G | -1.7377 | |
| 376 | L | G | 0.0000 | |
| 377 | T | G | 0.8296 | |
| 378 | F | G | 2.1134 | |
| 306 | V | H | 2.7085 | |
| 307 | Q | H | 0.9854 | |
| 308 | I | H | 0.0000 | |
| 309 | V | H | -0.4072 | |
| 310 | Y | H | 0.0000 | |
| 311 | K | H | -0.9259 | |
| 312 | P | H | 0.0000 | |
| 313 | V | H | 0.7596 | |
| 314 | D | H | 0.0000 | |
| 315 | L | H | 0.9079 | |
| 316 | S | H | 0.0000 | |
| 317 | K | H | -1.1766 | |
| 318 | V | H | 0.0000 | |
| 319 | T | H | -1.3385 | |
| 320 | S | H | 0.0000 | |
| 321 | K | H | -2.4582 | |
| 322 | C | H | 0.0000 | |
| 323 | G | H | -1.2524 | |
| 324 | S | H | -0.7477 | |
| 325 | L | H | 0.0000 | |
| 326 | G | H | -1.1770 | |
| 327 | N | H | -1.6268 | |
| 328 | I | H | 0.0000 | |
| 329 | H | H | -1.0718 | |
| 330 | H | H | 0.0000 | |
| 331 | K | H | -1.1027 | |
| 332 | P | H | 0.0000 | |
| 333 | G | H | 0.0000 | |
| 334 | G | H | 0.0000 | |
| 335 | G | H | 0.0000 | |
| 336 | Q | H | 0.0000 | |
| 337 | V | H | 0.0000 | |
| 338 | E | H | -0.8749 | |
| 339 | V | H | 0.0000 | |
| 340 | K | H | -2.5989 | |
| 341 | S | H | 0.0000 | |
| 342 | E | H | -3.7298 | |
| 343 | K | H | -3.4947 | |
| 344 | L | H | 0.0000 | |
| 345 | D | H | -2.6750 | |
| 346 | F | H | 0.0000 | |
| 347 | K | H | -4.5962 | |
| 348 | D | H | -4.8252 | |
| 349 | R | H | -5.5338 | |
| 350 | V | H | 0.0000 | |
| 351 | Q | H | -2.8074 | |
| 352 | S | H | -1.1768 | |
| 353 | K | H | -0.8286 | |
| 354 | I | H | 0.0000 | |
| 355 | G | H | 0.0000 | |
| 356 | S | H | 0.0000 | |
| 357 | L | H | 0.0000 | |
| 358 | D | H | 0.0000 | |
| 359 | N | H | 0.0000 | |
| 360 | I | H | -0.1195 | |
| 361 | T | H | 0.0000 | |
| 362 | H | H | -0.3947 | |
| 363 | V | H | 0.0000 | |
| 364 | P | H | 0.0000 | |
| 365 | G | H | 0.0000 | |
| 366 | G | H | 0.0000 | |
| 367 | G | H | -0.9552 | |
| 368 | N | H | 0.0000 | |
| 369 | K | H | -2.2874 | |
| 370 | K | H | 0.0000 | |
| 371 | I | H | -0.5423 | |
| 372 | E | H | 0.0000 | |
| 373 | T | H | -0.6849 | |
| 374 | H | H | 0.0000 | |
| 375 | K | H | -1.7908 | |
| 376 | L | H | 0.0000 | |
| 377 | T | H | 0.8488 | |
| 378 | F | H | 2.4241 | |
| 306 | V | I | 2.0460 | |
| 307 | Q | I | 0.3505 | |
| 308 | I | I | 1.1156 | |
| 309 | V | I | -0.0777 | |
| 310 | Y | I | -0.1336 | |
| 311 | K | I | -1.6244 | |
| 312 | P | I | -0.9393 | |
| 313 | V | I | 0.4508 | |
| 314 | D | I | -0.4141 | |
| 315 | L | I | 0.6588 | |
| 316 | S | I | -0.8077 | |
| 317 | K | I | -1.5535 | |
| 318 | V | I | -1.4399 | |
| 319 | T | I | -1.2254 | |
| 320 | S | I | -1.3936 | |
| 321 | K | I | -2.0839 | |
| 322 | C | I | -1.2773 | |
| 323 | G | I | -1.1171 | |
| 324 | S | I | -0.8204 | |
| 325 | L | I | -0.4834 | |
| 326 | G | I | -1.2448 | |
| 327 | N | I | -1.6445 | |
| 328 | I | I | -0.7508 | |
| 329 | H | I | -0.9098 | |
| 330 | H | I | -0.5135 | |
| 331 | K | I | -0.8812 | |
| 332 | P | I | -0.5906 | |
| 333 | G | I | 0.0000 | |
| 334 | G | I | -0.6124 | |
| 335 | G | I | 0.0000 | |
| 336 | Q | I | -0.6808 | |
| 337 | V | I | -0.4263 | |
| 338 | E | I | -1.5234 | |
| 339 | V | I | -1.4021 | |
| 340 | K | I | -2.9993 | |
| 341 | S | I | -3.2575 | |
| 342 | E | I | -3.8600 | |
| 343 | K | I | -3.6993 | |
| 344 | L | I | -2.4927 | |
| 345 | D | I | -2.5099 | |
| 346 | F | I | -1.9421 | |
| 347 | K | I | -3.7481 | |
| 348 | D | I | -4.2205 | |
| 349 | R | I | -4.3480 | |
| 350 | V | I | -3.0017 | |
| 351 | Q | I | -2.6654 | |
| 352 | S | I | -1.4132 | |
| 353 | K | I | -1.7222 | |
| 354 | I | I | -0.2062 | |
| 355 | G | I | -0.6459 | |
| 356 | S | I | -0.7546 | |
| 357 | L | I | -0.4353 | |
| 358 | D | I | -1.6391 | |
| 359 | N | I | -1.0596 | |
| 360 | I | I | -0.1227 | |
| 361 | T | I | -0.2131 | |
| 362 | H | I | -0.8014 | |
| 363 | V | I | -0.1403 | |
| 364 | P | I | -0.4919 | |
| 365 | G | I | -0.7866 | |
| 366 | G | I | -0.8018 | |
| 367 | G | I | -1.0241 | |
| 368 | N | I | -2.0827 | |
| 369 | K | I | -2.9143 | |
| 370 | K | I | -2.6790 | |
| 371 | I | I | -1.1082 | |
| 372 | E | I | -1.2448 | |
| 373 | T | I | -1.1445 | |
| 374 | H | I | -1.9796 | |
| 375 | K | I | -2.1706 | |
| 376 | L | I | -0.0386 | |
| 377 | T | I | 0.9985 | |
| 378 | F | I | 2.5011 | |
| 306 | V | J | 2.1451 | |
| 307 | Q | J | 0.3195 | |
| 308 | I | J | 0.8882 | |
| 309 | K | J | -0.6909 | mutated: VJ309K |
| 310 | Y | J | -0.1959 | |
| 311 | K | J | -1.0454 | |
| 312 | P | J | -0.2903 | |
| 313 | V | J | 1.2361 | |
| 314 | D | J | 0.3129 | |
| 315 | L | J | 1.1819 | |
| 316 | S | J | -0.4680 | |
| 317 | K | J | -1.1691 | |
| 318 | V | J | -1.2708 | |
| 319 | T | J | -1.1224 | |
| 320 | S | J | -1.3471 | |
| 321 | K | J | -2.1876 | |
| 322 | C | J | -1.3011 | |
| 323 | G | J | -1.1515 | |
| 324 | S | J | -0.8972 | |
| 325 | L | J | -0.6045 | |
| 326 | G | J | -1.3502 | |
| 327 | N | J | -1.7424 | |
| 328 | I | J | -0.7989 | |
| 329 | H | J | -1.2153 | |
| 330 | H | J | -1.0616 | |
| 331 | K | J | -1.9749 | |
| 332 | P | J | -1.2382 | |
| 333 | G | J | -0.8357 | |
| 334 | G | J | -0.8989 | |
| 335 | G | J | -0.3380 | |
| 336 | Q | J | -0.4279 | |
| 337 | V | J | -0.0019 | |
| 338 | E | J | -0.6537 | |
| 339 | V | J | -0.8647 | |
| 340 | K | J | -2.6680 | |
| 341 | S | J | -2.9650 | |
| 342 | E | J | -3.5547 | |
| 343 | K | J | -3.1940 | |
| 344 | L | J | -2.2956 | |
| 345 | D | J | -2.5286 | |
| 346 | F | J | -2.2271 | |
| 347 | K | J | -4.0638 | |
| 348 | D | J | -4.5922 | |
| 349 | R | J | -4.6233 | |
| 350 | V | J | -3.2361 | |
| 351 | Q | J | -2.5688 | |
| 352 | S | J | -1.0522 | |
| 353 | K | J | -0.8323 | |
| 354 | I | J | 0.3381 | |
| 355 | G | J | -0.0275 | |
| 356 | S | J | -0.1356 | |
| 357 | L | J | 0.0615 | |
| 358 | D | J | -1.3916 | |
| 359 | N | J | -1.1274 | |
| 360 | I | J | -0.1316 | |
| 361 | T | J | -0.2224 | |
| 362 | H | J | -0.7555 | |
| 363 | V | J | -0.0208 | |
| 364 | P | J | -0.4344 | |
| 365 | G | J | -0.7919 | |
| 366 | G | J | -0.8275 | |
| 367 | G | J | -1.0273 | |
| 368 | N | J | -2.1652 | |
| 369 | K | J | -2.9929 | |
| 370 | K | J | -2.7419 | |
| 371 | I | J | -1.1297 | |
| 372 | E | J | -1.0076 | |
| 373 | T | J | -0.8740 | |
| 374 | H | J | -1.4604 | |
| 375 | K | J | -2.1562 | |
| 376 | L | J | -0.2583 | |
| 377 | T | J | 0.9035 | |
| 378 | F | J | 2.5761 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine