Project name: 3JQW ColH ColBnd

Chain sequence(s)	A: YPIGTEKEPNNSKETASGPIVPGIPVSGTIENTSDQDYFYFDVITPGEVKIDINKLGYGGATWVVYDENNNAVSYATDDGQNLSGKFKADKPGRYYIHLYMFNGSYMPYRINIEGSV; C: QVYPIGTEKEPNNSKETASGPIVPGIPVSGTIENTSDQDYFYFDVITPGEVKIDINKLGYGGATWVVYDENNNAVSYATDDGQNLSGKFKADKPGRYYIHLYMFNGSYMPYRINIEGSVGR; B: VYPIGTEKEPNNSKETASGPIVPGIPVSGTIENTSDQDYFYFDVITPGEVKIDINKLGYGGATWVVYDENNNAVSYATDDGQNLSGKFKADKPGRYYIHLYMFNGSYMPYRINIEGSVGR
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.4375
• Maximal score value: 1.7859
• Average score: -0.8417
• Total score value: -301.3301

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
863	Y	A	1.3079
864	P	A	0.7203
865	I	A	0.0000
866	G	A	0.0000
867	T	A	0.0000
868	E	A	-1.7752
869	K	A	-2.9951
870	E	A	-3.1065
871	P	A	-2.2160
872	N	A	0.0000
873	N	A	-2.1130
874	S	A	-1.4495
875	K	A	-1.8461
876	E	A	-2.1862
877	T	A	-1.8228
878	A	A	-1.4145
879	S	A	0.0000
880	G	A	-0.1254
881	P	A	0.1802
882	I	A	0.0000
883	V	A	0.0654
884	P	A	-0.8501
885	G	A	-1.0167
886	I	A	-0.5287
887	P	A	-0.6046
888	V	A	0.0000
889	S	A	0.0000
890	G	A	0.0000
891	T	A	-0.6860
892	I	A	0.0000
893	E	A	-1.7446
894	N	A	-1.2153
895	T	A	-0.4134
896	S	A	-0.8228
897	D	A	-1.5986
898	Q	A	-1.1655
899	D	A	0.0000
900	Y	A	-1.0257
901	F	A	0.0000
902	Y	A	-0.2570
903	F	A	0.0000
904	D	A	-0.1823
905	V	A	0.0000
906	I	A	1.4523
907	T	A	0.0022
908	P	A	-1.6022
909	G	A	-1.7795
910	E	A	-3.1466
911	V	A	0.0000
912	K	A	-3.0035
913	I	A	0.0000
914	D	A	-1.7364
915	I	A	0.0000
916	N	A	-1.0233
917	K	A	0.0000
918	L	A	0.0000
919	G	A	0.0000
920	Y	A	0.2013
921	G	A	0.0000
922	G	A	0.0000
923	A	A	0.0000
924	T	A	0.1985
925	W	A	0.0000
926	V	A	0.0000
927	V	A	0.0000
928	Y	A	-1.1813
929	D	A	-2.4456
930	E	A	-3.3878
931	N	A	-3.2952
932	N	A	-3.0217
933	N	A	-2.4470
934	A	A	-0.6916
935	V	A	-0.0452
936	S	A	0.0000
937	Y	A	0.9899
938	A	A	-0.4572
939	T	A	-1.4375
940	D	A	-2.9911
941	D	A	-3.1710
942	G	A	-2.2549
943	Q	A	-1.8723
944	N	A	-2.0321
945	L	A	0.0000
946	S	A	-1.5575
947	G	A	-1.1877
948	K	A	-2.7269
949	F	A	-1.9924
950	K	A	-3.3264
951	A	A	0.0000
952	D	A	-3.3918
953	K	A	-2.7573
954	P	A	-1.1765
955	G	A	-1.4700
956	R	A	-1.5210
957	Y	A	0.0000
958	Y	A	-0.7266
959	I	A	0.0000
960	H	A	-0.0076
961	L	A	0.0000
962	Y	A	0.2505
963	M	A	0.0000
964	F	A	1.3660
965	N	A	0.0147
966	G	A	-0.0738
967	S	A	-0.2201
968	Y	A	0.0326
969	M	A	0.0000
970	P	A	-0.3885
971	Y	A	0.0000
972	R	A	-0.6274
973	I	A	0.0000
974	N	A	-1.3061
975	I	A	0.0000
976	E	A	-2.7811
977	G	A	-2.1010
978	S	A	-0.8418
979	V	A	-0.0247
862	V	B	1.7859
863	Y	B	0.6340
864	P	B	0.3442
865	I	B	0.0000
866	G	B	0.0000
867	T	B	-1.1966
868	E	B	-1.6657
869	K	B	-2.8382
870	E	B	-3.0665
871	P	B	-2.1832
872	N	B	0.0000
873	N	B	-2.0252
874	S	B	-1.3409
875	K	B	-1.5098
876	E	B	-2.0960
877	T	B	-1.7697
878	A	B	-1.3899
879	S	B	0.0000
880	G	B	-0.0432
881	P	B	-0.0078
882	I	B	0.0000
883	V	B	0.0000
884	P	B	0.0000
885	G	B	-0.6177
886	I	B	0.0000
887	P	B	-0.7089
888	V	B	0.0000
889	S	B	-1.0849
890	G	B	-1.0537
891	T	B	-0.7683
892	I	B	0.0000
893	E	B	-1.8318
894	N	B	-1.1201
895	T	B	-0.4808
896	S	B	-0.7782
897	D	B	-1.4632
898	Q	B	-1.3337
899	D	B	0.0000
900	Y	B	-0.9400
901	F	B	0.0000
902	Y	B	-0.1336
903	F	B	0.0000
904	D	B	0.0000
905	V	B	0.0000
906	I	B	-0.5324
907	T	B	0.0000
908	P	B	-1.5453
909	G	B	-1.7546
910	E	B	-2.7342
911	V	B	0.0000
912	K	B	-2.5004
913	I	B	0.0000
914	D	B	-1.4784
915	I	B	0.0000
916	N	B	-1.2620
917	K	B	0.0000
918	L	B	0.7396
919	G	B	0.9624
920	Y	B	1.2342
921	G	B	0.5766
922	G	B	0.0357
923	A	B	0.0000
924	T	B	0.2091
925	W	B	0.0000
926	V	B	0.0000
927	V	B	0.0000
928	Y	B	-1.1329
929	D	B	-2.2373
930	E	B	-3.3571
931	N	B	-3.2890
932	N	B	-3.0489
933	N	B	-2.5192
934	A	B	-0.6928
935	V	B	-0.0762
936	S	B	0.0000
937	Y	B	0.9791
938	A	B	-0.4085
939	T	B	-1.4156
940	D	B	-3.0266
941	D	B	-3.3241
942	G	B	-2.5833
943	Q	B	-2.1489
944	N	B	-2.2290
945	L	B	0.0000
946	S	B	-1.5731
947	G	B	-1.1043
948	K	B	-2.5178
949	F	B	0.0000
950	K	B	-3.1635
951	A	B	0.0000
952	D	B	-3.2606
953	K	B	-2.9238
954	P	B	-1.6340
955	G	B	-1.6311
956	R	B	-1.4560
957	Y	B	0.0000
958	Y	B	-0.6337
959	I	B	0.0000
960	H	B	0.0123
961	L	B	0.0000
962	Y	B	0.0246
963	M	B	0.0000
964	F	B	1.0880
965	N	B	-0.2958
966	G	B	-0.2928
967	S	B	-0.1063
968	Y	B	0.4770
969	M	B	0.0000
970	P	B	0.1293
971	Y	B	0.0000
972	R	B	-1.0821
973	I	B	0.0000
974	N	B	-1.1126
975	I	B	0.0000
976	E	B	-1.6885
977	G	B	-1.6578
978	S	B	0.0000
979	V	B	0.0000
980	G	B	0.0000
981	R	B	-1.5489
861	Q	C	-0.3314
862	V	C	1.0994
863	Y	C	0.8788
864	P	C	0.5605
865	I	C	0.0000
866	G	C	-0.4133
867	T	C	-1.0128
868	E	C	-1.7025
869	K	C	-2.7363
870	E	C	-3.0078
871	P	C	-2.1359
872	N	C	0.0000
873	N	C	-2.0876
874	S	C	-1.5348
875	K	C	-2.0574
876	E	C	-2.2859
877	T	C	-1.8456
878	A	C	-1.4830
879	S	C	0.0000
880	G	C	0.0000
881	P	C	0.0000
882	I	C	0.0000
883	V	C	0.0000
884	P	C	-0.9354
885	G	C	-0.3864
886	I	C	0.4507
887	P	C	-0.2915
888	V	C	0.0000
889	S	C	-0.7522
890	G	C	-0.9410
891	T	C	-0.4838
892	I	C	0.0000
893	E	C	-1.7749
894	N	C	-1.2935
895	T	C	-0.5701
896	S	C	-0.7743
897	D	C	-1.5137
898	Q	C	-1.3934
899	D	C	0.0000
900	Y	C	-1.0463
901	F	C	0.0000
902	Y	C	-0.4010
903	F	C	0.0000
904	D	C	-0.8713
905	V	C	0.0000
906	I	C	0.0000
907	T	C	0.0000
908	P	C	-1.9732
909	G	C	-2.2435
910	E	C	-3.1033
911	V	C	0.0000
912	K	C	-2.9735
913	I	C	0.0000
914	D	C	-2.0886
915	I	C	0.0000
916	N	C	-1.4279
917	K	C	-0.8290
918	L	C	0.4855
919	G	C	0.7038
920	Y	C	0.9615
921	G	C	0.3369
922	G	C	-0.1598
923	A	C	0.0000
924	T	C	0.1491
925	W	C	0.0000
926	V	C	0.0000
927	V	C	0.0000
928	Y	C	-1.1821
929	D	C	-2.1580
930	E	C	-3.0867
931	N	C	-3.0838
932	N	C	-2.9573
933	N	C	-2.4072
934	A	C	-0.6742
935	V	C	-0.1038
936	S	C	0.0000
937	Y	C	0.9700
938	A	C	-0.4912
939	T	C	-1.4922
940	D	C	-3.2560
941	D	C	-3.4375
942	G	C	-2.5676
943	Q	C	-2.4764
944	N	C	-2.6489
945	L	C	0.0000
946	S	C	-1.7304
947	G	C	-1.1618
948	K	C	-2.7578
949	F	C	0.0000
950	K	C	-3.2763
951	A	C	0.0000
952	D	C	-3.2170
953	K	C	-2.9173
954	P	C	-1.6331
955	G	C	-1.7564
956	R	C	-1.8245
957	Y	C	0.0000
958	Y	C	0.0000
959	I	C	0.0000
960	H	C	-0.0729
961	L	C	0.0000
962	Y	C	0.0336
963	M	C	0.0000
964	F	C	1.1347
965	N	C	-0.5084
966	G	C	-0.5856
967	S	C	-0.4556
968	Y	C	0.4180
969	M	C	0.0000
970	P	C	0.0805
971	Y	C	0.0000
972	R	C	-1.2512
973	I	C	0.0000
974	N	C	-1.2948
975	I	C	0.0000
976	E	C	-2.7587
977	G	C	-2.0054
978	S	C	-1.0459
979	V	C	0.0000
980	G	C	-0.7895
981	R	C	-0.8617