Project name: 653602904d4a781

Chain sequence(s)	A: KELEFKNGKCIFNGMNMAKTTVQYTDPTRCTAYFCEPGKHEMIIKGCPPPDDYDYEAYYDPTRWPDCCEAYKGGGGSNRKGQSFQCGGTILTQRHILTAAHCIYPNGLVAVGAEAYYGNIHKRHGKRLRVTKVIPHAKYNEKSFSHDIAVFVVEKPFQFGTNARPICIPTALVNIAGTDNIVAGWGFIREGGPDTNYLKYTTVTAQPNHICSANYLAFDSRVMYCAYLTATDSCQGDSGGPAMYRVSGGRRYVQVGIVSFGRGCARENVGGGGSVQSHPRCRVPPQIEHCNNLVLQWSFIRRDGRCEQSLVCHQSPNSFQTRAECEALCPPVPKRGPPARTVKCSYWLLHMDRCSANWEASRRDIFGRNHDYMVFTGCGYQKRVVYIYSLRTKSCRVKPWWWKLPRPKKILFGDAFIPAIVQPVSQIFPAFPVVNAPLQIPHGGGGSSEIKYHNYNSNGFNPKGPGPGILFGDAFIPAIVQPVSQIFPGPGPGILFNSLQYTNVVKDYWGNDLGPGPGKETVLRVAVTAQHPKPASLMGPGPGYDAGIELAHLLAFNKYGPGPGHDKKQFAALMLYEEDGTLRVEGVGPGPGKRHGKRLRVTKVIPHAKYNEKSEAAAKFYPSYHSTPQRPGTP
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.704
• Maximal score value: 1.7954
• Average score: -0.7611
• Total score value: -482.5462

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	K	A	-2.2655
2	E	A	-1.4195
3	L	A	0.0216
4	E	A	-1.3142
5	F	A	-1.1565
6	K	A	-2.4931
7	N	A	-2.2292
8	G	A	-1.5830
9	K	A	-1.5089
10	C	A	-0.5306
11	I	A	-0.2140
12	F	A	-0.4245
13	N	A	-1.5361
14	G	A	-1.5688
15	M	A	-0.6204
16	N	A	-0.7728
17	M	A	0.0229
18	A	A	-0.0615
19	K	A	-0.7663
20	T	A	-0.5563
21	T	A	0.0000
22	V	A	0.0000
23	Q	A	-1.3888
24	Y	A	0.0000
25	T	A	-1.0001
26	D	A	-1.1486
27	P	A	-1.1903
28	T	A	-1.0185
29	R	A	-1.4858
30	C	A	-0.6139
31	T	A	0.0000
32	A	A	0.0000
33	Y	A	0.3314
34	F	A	0.2486
35	C	A	-0.9743
36	E	A	-1.6937
37	P	A	-1.3955
38	G	A	-1.7492
39	K	A	-2.3312
40	H	A	-1.9748
41	E	A	-2.2406
42	M	A	0.0000
43	I	A	0.0000
44	I	A	0.0000
45	K	A	-1.5099
46	G	A	-1.2824
47	C	A	-0.5722
48	P	A	-0.8508
49	P	A	-1.1079
50	P	A	-1.3754
51	D	A	-2.6280
52	D	A	-2.2740
53	Y	A	-0.5929
54	D	A	-0.4778
55	Y	A	0.0000
56	E	A	0.0000
57	A	A	0.0000
58	Y	A	0.0000
59	Y	A	0.0000
60	D	A	-0.5729
61	P	A	0.0000
62	T	A	-0.8405
63	R	A	-1.3798
64	W	A	0.0000
65	P	A	0.0000
66	D	A	0.0000
67	C	A	0.0000
68	C	A	0.0000
69	E	A	0.0000
70	A	A	0.0000
71	Y	A	0.0000
72	K	A	-1.9356
73	G	A	-1.8881
74	G	A	0.0000
75	G	A	-2.1864
76	G	A	-2.0769
77	S	A	-1.7425
78	N	A	-3.2215
79	R	A	-3.7040
80	K	A	-3.3468
81	G	A	-2.1662
82	Q	A	-2.3912
83	S	A	-1.4418
84	F	A	-0.6377
85	Q	A	-0.9159
86	C	A	0.0000
87	G	A	0.0000
88	G	A	0.0000
89	T	A	0.0000
90	I	A	0.0000
91	L	A	0.0000
92	T	A	0.0000
93	Q	A	-1.5421
94	R	A	-1.4726
95	H	A	0.0000
96	I	A	0.0000
97	L	A	0.0000
98	T	A	0.0000
99	A	A	0.0000
100	A	A	0.0000
101	H	A	-0.7134
102	C	A	0.0000
103	I	A	0.0000
104	Y	A	0.0379
105	P	A	-0.6498
106	N	A	-1.2040
107	G	A	-0.4235
108	L	A	0.0907
109	V	A	0.0000
110	A	A	-0.2946
111	V	A	0.5392
112	G	A	-0.9628
113	A	A	0.0000
114	E	A	-2.4325
115	A	A	0.0000
116	Y	A	0.0000
117	Y	A	0.0000
118	G	A	-1.0776
119	N	A	0.0000
120	I	A	-1.2056
121	H	A	-2.1034
122	K	A	-2.5219
123	R	A	-3.0330
124	H	A	-2.5997
125	G	A	-2.5401
126	K	A	-2.6617
127	R	A	-2.8431
128	L	A	0.0000
129	R	A	-3.1099
130	V	A	0.0000
131	T	A	-1.4805
132	K	A	-1.1517
133	V	A	0.0872
134	I	A	-0.0437
135	P	A	-0.2782
136	H	A	-0.6666
137	A	A	-0.8865
138	K	A	-1.9891
139	Y	A	-1.7070
140	N	A	-2.4430
141	E	A	-3.0338
142	K	A	-2.5870
143	S	A	-1.5247
144	F	A	-1.1635
145	S	A	-1.1632
146	H	A	-0.7973
147	D	A	0.0000
148	I	A	0.0000
149	A	A	0.0000
150	V	A	0.0000
151	F	A	0.0000
152	V	A	0.0000
153	V	A	0.0000
154	E	A	-3.3102
155	K	A	-2.6454
156	P	A	-1.7833
157	F	A	0.0000
158	Q	A	-1.6401
159	F	A	-0.7710
160	G	A	-0.9010
161	T	A	-0.6142
162	N	A	-1.0329
163	A	A	0.0000
164	R	A	-1.1803
165	P	A	-0.5663
166	I	A	0.0000
167	C	A	-0.1450
168	I	A	0.0000
169	P	A	0.0000
170	T	A	0.1456
171	A	A	0.8115
172	L	A	1.5551
173	V	A	0.7478
174	N	A	-0.6973
175	I	A	0.0000
176	A	A	-1.1760
177	G	A	-1.2298
178	T	A	-1.4013
179	D	A	-2.0677
180	N	A	0.0000
181	I	A	-0.4528
182	V	A	0.0000
183	A	A	0.0000
184	G	A	0.0150
185	W	A	0.0684
186	G	A	0.0000
187	F	A	-0.7141
188	I	A	-0.4113
189	R	A	-2.3855
190	E	A	-2.8874
191	G	A	-1.7926
192	G	A	-1.4550
193	P	A	-1.4956
194	D	A	-2.0459
195	T	A	-1.0809
196	N	A	-1.3877
197	Y	A	-0.6463
198	L	A	0.0000
199	K	A	-0.6377
200	Y	A	0.0000
201	T	A	0.0000
202	T	A	-0.6575
203	V	A	0.0000
204	T	A	-0.9120
205	A	A	0.0000
206	Q	A	-1.2743
207	P	A	-1.3205
208	N	A	-2.3088
209	H	A	-1.5880
210	I	A	-0.7042
211	C	A	0.0000
212	S	A	-1.0172
213	A	A	-0.4237
214	N	A	-1.0091
215	Y	A	0.1103
216	L	A	1.0457
217	A	A	0.3313
218	F	A	-0.2262
219	D	A	-1.5470
220	S	A	-1.6595
221	R	A	-2.2535
222	V	A	-0.7515
223	M	A	0.0000
224	Y	A	-0.5349
225	C	A	0.0000
226	A	A	0.0000
227	Y	A	-0.7934
228	L	A	0.0000
229	T	A	-1.4263
230	A	A	-0.6657
231	T	A	-0.1687
232	D	A	-0.4610
233	S	A	-0.5512
234	C	A	-1.1721
235	Q	A	-1.4989
236	G	A	-0.8734
237	D	A	0.0000
238	S	A	-0.4692
239	G	A	0.0000
240	G	A	0.0000
241	P	A	0.0000
242	A	A	0.0000
243	M	A	0.0000
244	Y	A	-0.7125
245	R	A	-1.7733
246	V	A	-1.0915
247	S	A	-1.0478
248	G	A	-1.4751
249	G	A	-1.8532
250	R	A	-2.9102
251	R	A	-2.6248
252	Y	A	-1.1305
253	V	A	0.0000
254	Q	A	0.0000
255	V	A	0.0000
256	G	A	0.0000
257	I	A	0.0000
258	V	A	0.0000
259	S	A	0.0000
260	F	A	-0.2905
261	G	A	-0.7984
262	R	A	-2.3492
263	G	A	-2.7216
264	C	A	0.0000
265	A	A	-2.0898
266	R	A	-3.2404
267	E	A	-3.2254
268	N	A	-2.6149
269	V	A	-2.0424
270	G	A	-1.5568
271	G	A	-0.4501
272	G	A	-0.0486
273	G	A	0.0000
274	S	A	0.0000
275	V	A	0.2872
276	Q	A	0.0000
277	S	A	0.0000
278	H	A	0.2010
279	P	A	-0.2246
280	R	A	-0.6469
281	C	A	0.0000
282	R	A	0.0000
283	V	A	0.0000
284	P	A	0.0000
285	P	A	-0.8558
286	Q	A	-1.1569
287	I	A	0.0000
288	E	A	-1.9118
289	H	A	-1.6227
290	C	A	0.0000
291	N	A	-2.4036
292	N	A	-2.2484
293	L	A	0.0000
294	V	A	-0.8027
295	L	A	0.0000
296	Q	A	-1.0533
297	W	A	-0.2001
298	S	A	0.7724
299	F	A	1.6681
300	I	A	0.8866
301	R	A	-2.0430
302	R	A	-3.0939
303	D	A	-3.1674
304	G	A	-2.6719
305	R	A	-2.9536
306	C	A	-1.7333
307	E	A	-1.1857
308	Q	A	-0.1969
309	S	A	0.0000
310	L	A	0.0000
311	V	A	0.0000
312	C	A	0.0000
313	H	A	-1.7205
314	Q	A	0.0000
315	S	A	-1.2371
316	P	A	-0.9839
317	N	A	-1.0303
318	S	A	-0.0926
319	F	A	1.1722
320	Q	A	-0.4573
321	T	A	-0.9086
322	R	A	-2.1772
323	A	A	-1.3809
324	E	A	0.0000
325	C	A	0.0000
326	E	A	0.0000
327	A	A	0.0000
328	L	A	0.0000
329	C	A	0.0000
330	P	A	0.0000
331	P	A	-0.5549
332	V	A	0.0000
333	P	A	-1.8593
334	K	A	-2.9124
335	R	A	-3.0506
336	G	A	-1.9997
337	P	A	-1.4947
338	P	A	-1.6363
339	A	A	-1.6604
340	R	A	-1.9418
341	T	A	-1.4624
342	V	A	-1.1101
343	K	A	-1.8058
344	C	A	0.0000
345	S	A	0.8883
346	Y	A	1.7954
347	W	A	0.9548
348	L	A	0.3897
349	L	A	0.0000
350	H	A	-0.9782
351	M	A	-1.0671
352	D	A	-2.9226
353	R	A	-2.5722
354	C	A	-1.1003
355	S	A	-0.3547
356	A	A	0.0000
357	N	A	-0.3833
358	W	A	-0.2994
359	E	A	-0.5663
360	A	A	0.0000
361	S	A	0.0000
362	R	A	0.0000
363	R	A	0.0000
364	D	A	0.0000
365	I	A	0.6227
366	F	A	-0.1970
367	G	A	0.0000
368	R	A	-2.4436
369	N	A	-2.1472
370	H	A	0.0000
371	D	A	-0.4600
372	Y	A	0.8032
373	M	A	0.0000
374	V	A	0.0000
375	F	A	0.0000
376	T	A	0.0000
377	G	A	0.0000
378	C	A	-0.5212
379	G	A	-0.6488
380	Y	A	-0.1566
381	Q	A	-1.7310
382	K	A	-2.3906
383	R	A	-2.0858
384	V	A	-0.8093
385	V	A	0.0000
386	Y	A	0.0000
387	I	A	0.0000
388	Y	A	0.0000
389	S	A	0.0000
390	L	A	-0.7489
391	R	A	-2.3801
392	T	A	-2.3025
393	K	A	-2.6850
394	S	A	-1.5760
395	C	A	-1.1968
396	R	A	-1.4523
397	V	A	0.0000
398	K	A	-0.6121
399	P	A	0.0729
400	W	A	0.3331
401	W	A	0.3037
402	W	A	0.1792
403	K	A	-1.0213
404	L	A	-0.0542
405	P	A	-1.3068
406	R	A	-2.7213
407	P	A	-2.2241
408	K	A	-3.0819
409	K	A	-3.1081
410	I	A	-1.1562
411	L	A	0.0000
412	F	A	0.0000
413	G	A	0.0000
414	D	A	-1.8010
415	A	A	-0.2838
416	F	A	0.7585
417	I	A	0.0000
418	P	A	0.0000
419	A	A	0.0000
420	I	A	0.0000
421	V	A	-0.1649
422	Q	A	-0.4532
423	P	A	-0.5220
424	V	A	0.0000
425	S	A	-0.8409
426	Q	A	-1.0206
427	I	A	0.0274
428	F	A	0.2749
429	P	A	-0.3452
430	A	A	-0.3837
431	F	A	0.0000
432	P	A	0.0000
433	V	A	0.0000
434	V	A	0.0000
435	N	A	0.0000
436	A	A	0.0000
437	P	A	-0.6648
438	L	A	0.0000
439	Q	A	-1.4307
440	I	A	0.0000
441	P	A	-0.9532
442	H	A	-1.2736
443	G	A	-1.0794
444	G	A	0.0000
445	G	A	-1.3139
446	G	A	-1.3780
447	S	A	-1.0427
448	S	A	-0.5366
449	E	A	0.0000
450	I	A	0.0000
451	K	A	-0.0195
452	Y	A	-0.1176
453	H	A	0.0000
454	N	A	-0.7103
455	Y	A	-0.0279
456	N	A	-0.7223
457	S	A	-0.8342
458	N	A	-0.8413
459	G	A	0.0000
460	F	A	0.9737
461	N	A	-0.5412
462	P	A	-0.9096
463	K	A	-1.9125
464	G	A	-1.1221
465	P	A	-0.8239
466	G	A	-0.9003
467	P	A	-0.7903
468	G	A	-0.3266
469	I	A	0.0000
470	L	A	0.0000
471	F	A	0.3647
472	G	A	-0.3098
473	D	A	-1.3359
474	A	A	-0.3648
475	F	A	0.1393
476	I	A	0.2328
477	P	A	-0.5388
478	A	A	-0.3993
479	I	A	-0.0259
480	V	A	-0.3155
481	Q	A	-0.8930
482	P	A	-0.9561
483	V	A	0.0000
484	S	A	-0.3969
485	Q	A	-0.9447
486	I	A	0.0000
487	F	A	0.0000
488	P	A	-0.6246
489	G	A	-0.6642
490	P	A	-0.4987
491	G	A	-0.6490
492	P	A	-0.5374
493	G	A	0.0000
494	I	A	0.3151
495	L	A	0.8093
496	F	A	0.0000
497	N	A	-0.0724
498	S	A	-0.1224
499	L	A	0.0000
500	Q	A	-0.2002
501	Y	A	0.0000
502	T	A	-0.1953
503	N	A	-0.5126
504	V	A	-0.1865
505	V	A	0.0000
506	K	A	-0.9390
507	D	A	-0.7669
508	Y	A	0.0161
509	W	A	-0.7664
510	G	A	-0.9121
511	N	A	-1.7246
512	D	A	-1.9307
513	L	A	-1.3815
514	G	A	-1.4887
515	P	A	-1.5931
516	G	A	-1.3460
517	P	A	-1.5827
518	G	A	-1.9121
519	K	A	-2.9632
520	E	A	-2.7577
521	T	A	0.0000
522	V	A	0.0000
523	L	A	0.0000
524	R	A	0.0000
525	V	A	0.0000
526	A	A	0.0000
527	V	A	0.0000
528	T	A	-0.3086
529	A	A	-0.4521
530	Q	A	-1.3435
531	H	A	0.0000
532	P	A	-0.9623
533	K	A	-0.6350
534	P	A	-0.3639
535	A	A	-0.5665
536	S	A	-0.7984
537	L	A	0.0000
538	M	A	0.0000
539	G	A	0.0000
540	P	A	-0.4667
541	G	A	-0.9388
542	P	A	-0.8504
543	G	A	-0.9585
544	Y	A	-1.0711
545	D	A	-1.8910
546	A	A	-0.8512
547	G	A	-0.6185
548	I	A	0.0000
549	E	A	-1.0676
550	L	A	0.0000
551	A	A	0.0000
552	H	A	0.0000
553	L	A	0.0000
554	L	A	0.0000
555	A	A	0.0000
556	F	A	-0.6579
557	N	A	-1.5463
558	K	A	-1.2440
559	Y	A	-0.6305
560	G	A	-0.8095
561	P	A	-1.0783
562	G	A	-0.9659
563	P	A	-0.9333
564	G	A	-1.3798
565	H	A	-1.8597
566	D	A	-2.5348
567	K	A	-2.8159
568	K	A	-2.6864
569	Q	A	-1.4713
570	F	A	-0.7805
571	A	A	-0.8146
572	A	A	0.0000
573	L	A	-0.1208
574	M	A	0.0000
575	L	A	1.2140
576	Y	A	0.8509
577	E	A	-0.6492
578	E	A	-1.9379
579	D	A	-1.4662
580	G	A	-0.8441
581	T	A	-0.7514
582	L	A	0.0000
583	R	A	0.0000
584	V	A	0.0000
585	E	A	0.0000
586	G	A	-0.6082
587	V	A	0.0000
588	G	A	0.0000
589	P	A	-0.7251
590	G	A	-0.5928
591	P	A	-0.8446
592	G	A	-1.1581
593	K	A	-1.4163
594	R	A	-1.3989
595	H	A	-0.9087
596	G	A	0.0000
597	K	A	0.0000
598	R	A	-1.1410
599	L	A	0.0000
600	R	A	-1.7533
601	V	A	0.0000
602	T	A	0.0000
603	K	A	-1.2236
604	V	A	0.0000
605	I	A	-0.4752
606	P	A	-0.1111
607	H	A	-0.7065
608	A	A	-0.8354
609	K	A	-1.5375
610	Y	A	-1.2263
611	N	A	-2.7062
612	E	A	-3.4020
613	K	A	-3.5735
614	S	A	0.0000
615	E	A	-2.9908
616	A	A	-2.1101
617	A	A	0.0000
618	A	A	-1.1524
619	K	A	-1.9812
620	F	A	-0.8855
621	Y	A	0.0000
622	P	A	-1.0445
623	S	A	-0.4678
624	Y	A	-0.0057
625	H	A	-0.9888
626	S	A	-1.0641
627	T	A	-1.0166
628	P	A	-1.3787
629	Q	A	-2.5450
630	R	A	-2.8962
631	P	A	-1.7707
632	G	A	-1.3297
633	T	A	-1.3113
634	P	A	-1.1271