Project name: 1axc modified

Chain sequence(s)	A: MFEARLVQGSILKKVLEALKDLINEACWDISSSGVNLQSMDSSHVSLVQLTLRSEGFDTYRCDRNLAMGVNLTSMSKILKCAGNEDIITLRAEDNADTLALVFEAPEKVSDYEMKLMDLDVEQLGIPEQEYSCVVKMPSGEFARICRDLSHIGDAVVISCAKDGVKFSASGELGNGNIKLSQTSEEEAVTIEMNEPVQLTFALRYLNFFTKATPLSSTVTLSMSADVPLVVEYKIADMGHLKYYLAPKI; C: MFEARLVQGSILKKVLEALKDLINEACWDISSSGVNLQSMDSSHVSLVQLTLRSEGFDTYRCDRNLAMGVNLTSMSKILKCAGNEDIITLRAEDNADTLALVFEAPEKVSDYEMKLMDLDVEQLGIPEQEYSCVVKMPSGEFARICRDLSHIGDAVVISCAKDGVKFSASGELGNGNIKLSQTEEEAVTIEMNEPVQLTFALRYLNFFTKATPLSSTVTLSMSADVPLVVEYKIADMGHLKYYLAPKI; B: RQTSMTDFYHSKRRLIFS; E: MFEARLVQGSILKKVLEALKDLINEACWDISSSGVNLQSMDSSHVSLVQLTLRSEGFDTYRCDRNLAMGVNLTSMSKILKCAGNEDIITLRAEDNADTLALVFEAPNQEKVSDYEMKLMDLDVEQLGIPEQEYSCVVKMPSGEFARICRDLSHIGDAVVISCAKDGVKFSASGELGNGNIKLSQTSNVEEEAVTIEMNEPVQLTFALRYLNFFTKATPLSSTVTLSMSADVPLVVEYKIADMGHLKYYLAPKI
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.1726
• Maximal score value: 1.2315
• Average score: -1.0087
• Total score value: -774.7027

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	M	A	-2.5598
2	F	A	0.0000
3	E	A	-1.8309
4	A	A	0.0000
5	R	A	-1.2557
6	L	A	0.0000
7	V	A	-0.0764
8	Q	A	-1.2208
9	G	A	0.0000
10	S	A	-1.1824
11	I	A	-0.3239
12	L	A	0.0000
13	K	A	-1.3995
14	K	A	-1.3748
15	V	A	0.0000
16	L	A	0.0000
17	E	A	-2.1156
18	A	A	0.0000
19	L	A	0.0000
20	K	A	-2.2913
21	D	A	-2.5173
22	L	A	-1.3936
23	I	A	0.0000
24	N	A	-2.3477
25	E	A	-1.9570
26	A	A	0.0000
27	C	A	0.0000
28	W	A	0.0000
29	D	A	-0.7224
30	I	A	0.0000
31	S	A	-1.8655
32	S	A	-1.8638
33	S	A	-1.4547
34	G	A	0.0000
35	V	A	0.0000
36	N	A	-1.0070
37	L	A	0.0000
38	Q	A	-0.4227
39	S	A	0.0000
40	M	A	-0.4013
41	D	A	0.0000
42	S	A	-0.6196
43	S	A	-0.4308
44	H	A	-0.7164
45	V	A	0.0000
46	S	A	0.0000
47	L	A	0.0000
48	V	A	0.0000
49	Q	A	-0.4545
50	L	A	0.0000
51	T	A	-1.1149
52	L	A	0.0000
53	R	A	-2.9734
54	S	A	-2.4378
55	E	A	-3.1601
56	G	A	-2.5652
57	F	A	0.0000
58	D	A	-2.0906
59	T	A	-1.5257
60	Y	A	-1.8367
61	R	A	-2.2733
62	C	A	-2.7876
63	D	A	-3.5527
64	R	A	-3.7829
65	N	A	-2.6844
66	L	A	-1.7472
67	A	A	-0.1924
68	M	A	0.0000
69	G	A	0.0000
70	V	A	0.0000
71	N	A	-1.4256
72	L	A	0.0000
73	T	A	-1.4762
74	S	A	-1.3170
75	M	A	0.0000
76	S	A	0.0000
77	K	A	-1.5810
78	I	A	0.0000
79	L	A	0.0000
80	K	A	-2.3772
81	C	A	0.0000
82	A	A	0.0000
83	G	A	-1.9329
84	N	A	-2.6647
85	E	A	-2.6202
86	D	A	0.0000
87	I	A	-0.5108
88	I	A	0.0000
89	T	A	0.0000
90	L	A	0.0000
91	R	A	-1.9950
92	A	A	0.0000
93	E	A	-3.3926
94	D	A	-3.0898
95	N	A	-2.4811
96	A	A	-2.4505
97	D	A	-2.7572
98	T	A	-2.2696
99	L	A	0.0000
100	A	A	-1.3535
101	L	A	0.0000
102	V	A	-0.4506
103	F	A	0.0000
104	E	A	-1.1530
105	A	A	-1.3653
106	P	A	-1.1527
109	E	A	-2.4380
110	K	A	-1.9670
111	V	A	-1.0771
112	S	A	0.0000
113	D	A	-0.9833
114	Y	A	0.0000
115	E	A	-1.8850
116	M	A	0.0000
117	K	A	-2.3138
118	L	A	0.0000
119	M	A	-1.0602
120	D	A	-1.3870
121	L	A	0.0000
122	D	A	-1.9781
123	V	A	-1.8097
124	E	A	-2.0663
125	Q	A	0.0000
126	L	A	0.0000
127	G	A	-0.8798
128	I	A	-0.4047
129	P	A	-1.4101
130	E	A	-2.5026
131	Q	A	-2.2833
132	E	A	-2.5418
133	Y	A	-1.6857
134	S	A	-1.7816
135	C	A	0.0000
136	V	A	-0.8494
137	V	A	0.0000
138	K	A	-1.2851
139	M	A	0.0000
140	P	A	-1.6351
141	S	A	0.0000
142	G	A	-1.2692
143	E	A	-1.4098
144	F	A	0.0000
145	A	A	0.0000
146	R	A	-2.4532
147	I	A	0.0000
148	C	A	0.0000
149	R	A	-2.0466
150	D	A	-1.8237
151	L	A	0.0000
152	S	A	-1.8791
153	H	A	-1.4703
154	I	A	0.0000
155	G	A	-1.8396
156	D	A	-2.3798
157	A	A	-1.1888
158	V	A	0.0000
159	V	A	0.0551
160	I	A	0.0000
161	S	A	-0.7841
162	C	A	0.0000
163	A	A	-2.3228
164	K	A	-3.2840
165	D	A	-2.6666
166	G	A	-1.9226
167	V	A	0.0000
168	K	A	-1.0554
169	F	A	0.0000
170	S	A	-0.3891
171	A	A	0.0000
172	S	A	-1.3347
173	G	A	-1.8516
174	E	A	-2.2065
175	L	A	-1.7099
176	G	A	0.0000
177	N	A	-1.4817
178	G	A	0.0000
179	N	A	-0.8511
180	I	A	0.0000
181	K	A	-1.3083
182	L	A	0.0000
183	S	A	-1.6284
184	Q	A	-1.4514
185	T	A	-1.3955
186	S	A	-0.3780
191	E	A	-3.3133
192	E	A	-3.7267
193	E	A	-3.4492
194	A	A	-2.2935
195	V	A	0.0000
196	T	A	-1.1844
197	I	A	0.0000
198	E	A	-2.5091
199	M	A	-2.5206
200	N	A	-2.9541
201	E	A	-2.9388
202	P	A	-1.9385
203	V	A	0.0000
204	Q	A	-1.4133
205	L	A	0.0000
206	T	A	-0.2287
207	F	A	0.0000
208	A	A	0.0000
209	L	A	0.0000
210	R	A	-2.3451
211	Y	A	0.0000
212	L	A	0.0000
213	N	A	-1.2449
214	F	A	-0.7875
215	F	A	0.0000
216	T	A	0.0000
217	K	A	-1.3073
218	A	A	0.0000
219	T	A	-0.6069
220	P	A	-0.6705
221	L	A	0.0000
222	S	A	-0.8646
223	S	A	-1.4762
224	T	A	-1.6136
225	V	A	0.0000
226	T	A	-0.4860
227	L	A	0.0000
228	S	A	-0.4475
229	M	A	0.0000
230	S	A	-1.2510
231	A	A	-1.2333
232	D	A	-1.4675
233	V	A	-0.6671
234	P	A	0.0000
235	L	A	0.0000
236	V	A	0.0000
237	V	A	0.0000
238	E	A	0.0000
239	Y	A	0.0000
240	K	A	-2.1295
241	I	A	0.0000
242	A	A	-1.3377
243	D	A	-2.7027
244	M	A	0.0000
245	G	A	-1.9674
246	H	A	-1.5362
247	L	A	0.0000
248	K	A	-0.6857
249	Y	A	0.0000
250	Y	A	0.0000
251	L	A	0.0000
252	A	A	0.0000
253	P	A	0.0000
254	K	A	-0.2842
255	I	A	0.6787
143	R	B	-1.2356
144	Q	B	-0.8288
145	T	B	-0.6212
146	S	B	-0.9211
147	M	B	0.0000
148	T	B	-1.0563
149	D	B	-1.6542
150	F	B	-0.5787
151	Y	B	-0.7249
152	H	B	-1.5556
153	S	B	-2.1298
154	K	B	-3.0990
155	R	B	-3.1238
156	R	B	-1.4451
157	L	B	0.1107
158	I	B	0.0000
159	F	B	1.0391
160	S	B	-0.5302
1	M	C	-2.6794
2	F	C	0.0000
3	E	C	-1.7444
4	A	C	0.0000
5	R	C	-1.4149
6	L	C	0.0000
7	V	C	-0.2366
8	Q	C	-1.4119
9	G	C	0.0000
10	S	C	-1.3777
11	I	C	-0.4558
12	L	C	0.0000
13	K	C	-1.2488
14	K	C	-1.1514
15	V	C	0.0000
16	L	C	0.0000
17	E	C	-1.3683
18	A	C	0.0000
19	L	C	0.0000
20	K	C	-2.0048
21	D	C	-2.0674
22	L	C	-1.2109
23	I	C	0.0000
24	N	C	-2.6357
25	E	C	-2.3743
26	A	C	0.0000
27	C	C	-1.0130
28	W	C	0.0000
29	D	C	-1.4596
30	I	C	0.0000
31	S	C	-1.8785
32	S	C	-1.7450
33	S	C	-1.3393
34	G	C	0.0000
35	V	C	0.0000
36	N	C	-1.1581
37	L	C	0.0000
38	Q	C	-0.6781
39	S	C	0.0000
40	M	C	-0.7144
41	D	C	0.0000
42	S	C	-0.8224
43	S	C	-0.5712
44	H	C	-0.8392
45	V	C	-0.1437
46	S	C	0.0000
47	L	C	0.0000
48	V	C	0.0000
49	Q	C	-0.4589
50	L	C	0.0000
51	T	C	-1.0575
52	L	C	0.0000
53	R	C	-2.5297
54	S	C	-2.2448
55	E	C	-3.0047
56	G	C	-2.4217
57	F	C	0.0000
58	D	C	-2.1794
59	T	C	-1.6285
60	Y	C	-1.8337
61	R	C	-2.1833
62	C	C	-2.6925
63	D	C	-3.2828
64	R	C	-3.8094
65	N	C	-2.9124
66	L	C	-2.1374
67	A	C	-0.9534
68	M	C	0.0000
69	G	C	0.0000
70	V	C	0.0000
71	N	C	-1.6370
72	L	C	0.0000
73	T	C	-1.4209
74	S	C	0.0000
75	M	C	0.0000
76	S	C	0.0000
77	K	C	-1.3522
78	I	C	0.0000
79	L	C	0.0000
80	K	C	-2.0822
81	C	C	0.0000
82	A	C	0.0000
83	G	C	-1.7199
84	N	C	-2.6304
85	E	C	-2.6047
86	D	C	0.0000
87	I	C	-0.4733
88	I	C	0.0000
89	T	C	0.0000
90	L	C	0.0000
91	R	C	-1.8362
92	A	C	0.0000
93	E	C	-3.8531
94	D	C	-4.1726
95	N	C	-3.0261
96	A	C	-2.7903
97	D	C	-3.0944
98	T	C	-2.2690
99	L	C	0.0000
100	A	C	-1.2962
101	L	C	0.0000
102	V	C	-0.4002
103	F	C	0.0000
104	E	C	-0.8886
105	A	C	-1.2742
106	P	C	-1.1007
109	E	C	-2.5221
110	K	C	-1.6499
111	V	C	-0.8318
112	S	C	0.0000
113	D	C	-0.9332
114	Y	C	0.0000
115	E	C	-1.8587
116	M	C	0.0000
117	K	C	-2.0869
118	L	C	-1.2594
119	M	C	-1.2562
120	D	C	-2.0809
121	L	C	-1.4672
122	D	C	-2.0058
123	V	C	-1.2453
124	E	C	-2.0258
125	Q	C	-1.5784
126	L	C	-0.1521
127	G	C	-0.2057
128	I	C	-0.0847
129	P	C	-1.2528
130	E	C	-2.6580
131	Q	C	-2.6492
132	E	C	-2.7501
133	Y	C	-1.8023
134	S	C	-1.8636
135	C	C	0.0000
136	V	C	-0.8986
137	V	C	0.0000
138	K	C	-1.6433
139	M	C	0.0000
140	P	C	0.0000
141	S	C	0.0000
142	G	C	-1.1737
143	E	C	-1.5315
144	F	C	0.0000
145	A	C	-1.2266
146	R	C	-1.8285
147	I	C	0.0000
148	C	C	0.0000
149	R	C	-1.7335
150	D	C	0.0000
151	L	C	0.0000
152	S	C	-1.6429
153	H	C	-1.2781
154	I	C	0.0000
155	G	C	-1.5906
156	D	C	-2.3467
157	A	C	-1.2990
158	V	C	0.0000
159	V	C	-0.0966
160	I	C	0.0000
161	S	C	-0.8701
162	C	C	0.0000
163	A	C	-1.9514
164	K	C	-2.5335
165	D	C	-2.5645
166	G	C	-2.0520
167	V	C	0.0000
168	K	C	-1.2701
169	F	C	0.0000
170	S	C	-0.4456
171	A	C	0.0000
172	S	C	-1.3639
173	G	C	-1.8769
174	E	C	-2.2717
175	L	C	0.0000
176	G	C	0.0000
177	N	C	-1.4959
178	G	C	0.0000
179	N	C	-0.8814
180	I	C	0.0000
181	K	C	-2.0599
182	L	C	0.0000
183	S	C	-2.0659
184	Q	C	-1.9945
185	T	C	-1.3358
191	E	C	-3.3558
192	E	C	-3.7688
193	E	C	-3.5835
194	A	C	-2.4835
195	V	C	0.0000
196	T	C	-1.2835
197	I	C	0.0000
198	E	C	-2.6167
199	M	C	-2.3247
200	N	C	-2.8408
201	E	C	-2.8248
202	P	C	-1.7722
203	V	C	0.0000
204	Q	C	-1.4235
205	L	C	0.0000
206	T	C	-0.2624
207	F	C	0.0000
208	A	C	-1.1883
209	L	C	0.0000
210	R	C	-2.2754
211	Y	C	-0.6110
212	L	C	0.0000
213	N	C	-1.0856
214	F	C	-0.6180
215	F	C	0.0000
216	T	C	0.0000
217	K	C	-0.9612
218	A	C	0.0000
219	T	C	-0.5769
220	P	C	-0.5780
221	L	C	0.0000
222	S	C	-0.9244
223	S	C	-1.6334
224	T	C	-1.7914
225	V	C	0.0000
226	T	C	-0.6662
227	L	C	0.0000
228	S	C	-0.5490
229	M	C	0.0000
230	S	C	-1.2748
231	A	C	-1.2074
232	D	C	-1.5809
233	V	C	-0.5451
234	P	C	-0.3906
235	L	C	0.0000
236	V	C	0.0000
237	V	C	0.0000
238	E	C	-0.9286
239	Y	C	0.0000
240	K	C	-2.1318
241	I	C	0.0000
242	A	C	-1.3376
243	D	C	-2.6135
244	M	C	0.0000
245	G	C	-1.8112
246	H	C	-1.5083
247	L	C	0.0000
248	K	C	-0.7781
249	Y	C	0.0000
250	Y	C	0.0000
251	L	C	0.0000
252	A	C	-0.1647
253	P	C	-0.2831
254	K	C	-0.2057
255	I	C	1.2315
1	M	E	-2.6985
2	F	E	0.0000
3	E	E	-1.9885
4	A	E	0.0000
5	R	E	-1.4619
6	L	E	0.0000
7	V	E	-0.2335
8	Q	E	-1.4308
9	G	E	0.0000
10	S	E	-1.2591
11	I	E	-0.3564
12	L	E	0.0000
13	K	E	-1.3214
14	K	E	-1.2946
15	V	E	0.0000
16	L	E	0.0000
17	E	E	-1.9704
18	A	E	0.0000
19	L	E	0.0000
20	K	E	-2.1901
21	D	E	-2.0627
22	L	E	-1.1809
23	I	E	0.0000
24	N	E	-2.6655
25	E	E	-2.3993
26	A	E	0.0000
27	C	E	-0.9119
28	W	E	0.0000
29	D	E	-1.0645
30	I	E	0.0000
31	S	E	-1.7231
32	S	E	-1.6410
33	S	E	-1.1543
34	G	E	0.0000
35	V	E	0.0000
36	N	E	-0.9347
37	L	E	0.0000
38	Q	E	-0.6720
39	S	E	-0.8165
40	M	E	-0.6415
41	D	E	0.0000
42	S	E	-0.7638
43	S	E	-0.5002
44	H	E	-0.6407
45	V	E	0.0101
46	S	E	0.0000
47	L	E	0.0000
48	V	E	0.0000
49	Q	E	-0.4299
50	L	E	0.0000
51	T	E	-0.9363
52	L	E	0.0000
53	R	E	-2.3563
54	S	E	-2.1750
55	E	E	-2.9539
56	G	E	-2.3798
57	F	E	0.0000
58	D	E	-2.2087
59	T	E	-1.6145
60	Y	E	-1.8705
61	R	E	-2.1534
62	C	E	-2.5933
63	D	E	-3.0692
64	R	E	-3.6617
65	N	E	-2.7302
66	L	E	-1.9211
67	A	E	-0.6383
68	M	E	0.0000
69	G	E	0.0000
70	V	E	0.0000
71	N	E	-1.7086
72	L	E	0.0000
73	T	E	-1.5055
74	S	E	-1.3810
75	M	E	0.0000
76	S	E	0.0000
77	K	E	-1.5205
78	I	E	0.0000
79	L	E	0.0000
80	K	E	-2.4261
81	C	E	0.0000
82	A	E	0.0000
83	G	E	-2.0125
84	N	E	-2.6934
85	E	E	-2.6341
86	D	E	0.0000
87	I	E	-0.4425
88	I	E	0.0000
89	T	E	0.0000
90	L	E	0.0000
91	R	E	-2.1258
92	A	E	0.0000
93	E	E	-3.8167
94	D	E	-3.9385
95	N	E	-2.9037
96	A	E	-2.7489
97	D	E	-3.1315
98	T	E	-2.3959
99	L	E	0.0000
100	A	E	0.0000
101	L	E	0.0000
102	V	E	-0.4063
103	F	E	0.0000
104	E	E	-1.2031
105	A	E	-1.6240
106	P	E	-1.7248
107	N	E	-2.1492
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