Project name: n1025

Chain sequence(s)	A: MDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVV
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.558
• Maximal score value: 2.5372
• Average score: -0.6575
• Total score value: -253.1355

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
73	M	A	0.5800
74	D	A	-1.0678
75	Y	A	0.3270
76	F	A	0.2016
77	P	A	-1.4281
78	K	A	-2.2096
79	I	A	0.0000
80	E	A	-2.2118
81	I	A	-1.1021
82	N	A	-1.2341
83	L	A	-0.4988
84	S	A	-0.4626
85	T	A	-0.6432
86	R	A	-1.1310
87	M	A	0.3932
88	D	A	0.2375
89	H	A	0.0000
90	M	A	1.4822
91	V	A	2.5372
92	S	A	0.0000
93	S	A	0.0000
94	F	A	1.8528
95	C	A	0.4631
96	I	A	0.0000
97	E	A	-1.1676
98	N	A	-1.9117
99	C	A	0.0000
100	H	A	-2.5435
101	R	A	-2.8489
102	V	A	0.0000
103	E	A	-2.3610
104	S	A	-1.8735
105	L	A	0.0000
106	S	A	-1.0816
107	L	A	0.0000
108	G	A	0.0733
109	F	A	1.1878
110	L	A	1.4230
111	H	A	-0.0588
112	N	A	0.0000
113	M	A	-0.2556
114	P	A	0.0000
115	K	A	-2.0094
116	E	A	-2.2964
117	E	A	-3.3728
118	E	A	-3.3439
119	E	A	-4.5580
120	E	A	-4.3238
121	E	A	-4.2358
122	K	A	-4.3422
123	E	A	-4.2247
124	G	A	-3.0196
125	R	A	-2.0992
126	H	A	0.0000
127	L	A	0.0000
128	D	A	0.2207
129	M	A	0.6014
130	V	A	0.0000
131	Q	A	0.0000
132	C	A	0.5379
133	V	A	0.7224
134	L	A	0.0000
135	P	A	-0.4284
136	S	A	-0.2230
137	S	A	-0.4901
138	S	A	-0.6861
139	H	A	-1.2809
140	A	A	0.0000
141	A	A	0.0000
142	C	A	-1.2083
143	S	A	-1.0680
144	H	A	0.0000
145	G	A	-0.3538
146	L	A	0.0000
147	V	A	-0.0147
148	N	A	-0.5612
149	S	A	0.0000
150	H	A	-1.1798
151	L	A	0.0000
152	T	A	-0.6502
153	S	A	-0.7019
154	S	A	-1.1268
155	F	A	-1.1229
156	C	A	0.0000
157	R	A	-1.8004
158	G	A	-0.9692
159	L	A	0.0000
160	F	A	-0.4584
161	S	A	-0.3118
162	V	A	0.0000
163	L	A	0.0000
164	S	A	-0.6518
165	T	A	-0.2285
166	S	A	0.0000
167	Q	A	-1.5291
168	S	A	-1.0204
169	L	A	0.0000
170	T	A	-1.5193
171	E	A	-1.2370
172	L	A	0.0000
173	D	A	-0.5740
174	L	A	0.0000
175	S	A	-1.2167
176	D	A	-2.0000
177	N	A	0.0000
178	S	A	-1.1371
179	L	A	0.0000
180	G	A	-0.7451
181	D	A	0.0000
182	P	A	-0.7747
183	G	A	0.0000
184	M	A	0.0000
185	R	A	-1.2757
186	V	A	-1.1302
187	L	A	0.0000
188	C	A	0.0000
189	E	A	-2.2321
190	T	A	0.0000
191	L	A	0.0000
192	Q	A	-1.4822
193	H	A	-1.4079
194	P	A	-0.9017
195	G	A	-0.9278
196	C	A	0.0000
197	N	A	-1.9918
198	I	A	0.0000
199	R	A	-2.6557
200	R	A	-1.9676
201	L	A	0.0000
202	W	A	-0.4279
203	L	A	0.0000
204	G	A	-1.5590
205	R	A	-2.8957
206	C	A	0.0000
207	G	A	-1.4740
208	L	A	0.0000
209	S	A	-1.2797
210	H	A	-1.1903
211	E	A	-2.0684
212	C	A	0.0000
213	C	A	0.0000
214	F	A	1.4643
215	D	A	-0.0769
216	I	A	0.0000
217	S	A	0.8205
218	L	A	0.4195
219	V	A	0.0000
220	L	A	0.0000
221	S	A	-0.3570
222	S	A	-0.8584
223	N	A	0.0000
224	Q	A	-1.8598
225	K	A	-2.5616
226	L	A	0.0000
227	V	A	-1.7047
228	E	A	0.0000
229	L	A	0.0000
230	D	A	0.0000
231	L	A	0.0000
232	S	A	-1.0993
233	D	A	-2.4079
234	N	A	0.0000
235	A	A	-0.7476
236	L	A	0.0000
237	G	A	0.2195
238	D	A	0.4567
239	F	A	1.5863
240	G	A	0.0000
241	I	A	0.0000
242	R	A	0.1190
243	L	A	1.4009
244	L	A	0.0000
245	C	A	0.0000
246	V	A	0.3908
247	G	A	0.3882
248	L	A	0.0000
249	K	A	-0.9705
250	H	A	-0.7839
251	L	A	0.0000
252	L	A	0.2376
253	C	A	-1.2499
254	N	A	-1.9358
255	L	A	0.0000
256	K	A	-1.6031
257	K	A	0.0000
258	L	A	0.0000
259	W	A	0.1688
260	L	A	0.0000
261	V	A	-0.4943
262	S	A	-1.1543
263	C	A	0.0000
264	C	A	0.2053
265	L	A	0.0000
266	T	A	-0.0135
267	S	A	-0.3817
268	A	A	-0.1768
269	C	A	0.0000
270	C	A	0.0000
271	Q	A	-1.6327
272	D	A	-0.8801
273	L	A	0.0000
274	A	A	-1.0945
275	S	A	-0.8331
276	V	A	0.0000
277	L	A	0.0000
278	S	A	-1.3574
279	T	A	-0.9618
280	S	A	-1.2395
281	H	A	-1.9461
282	S	A	-1.4799
283	L	A	0.0000
284	T	A	-1.1936
285	R	A	-0.9136
286	L	A	0.0000
287	Y	A	0.0473
288	V	A	0.0000
289	G	A	0.0000
290	E	A	-1.8159
291	N	A	0.0000
292	A	A	-0.5622
293	L	A	0.0000
294	G	A	-0.4150
295	D	A	-0.1865
296	S	A	-0.1456
297	G	A	0.0000
298	V	A	0.0000
299	A	A	-0.3677
300	I	A	-0.7327
301	L	A	0.0000
302	C	A	0.0000
303	E	A	-2.2374
304	K	A	0.0000
305	A	A	0.0000
306	K	A	-1.8371
307	N	A	-1.8712
308	P	A	-1.3700
309	Q	A	-1.8854
310	C	A	0.0000
311	N	A	-1.9006
312	L	A	0.0000
313	Q	A	-1.5863
314	K	A	-0.9255
315	L	A	0.0000
316	G	A	0.0000
317	L	A	0.0000
318	V	A	-1.0319
319	N	A	-1.6836
320	S	A	0.0000
321	G	A	-1.0056
322	L	A	0.0000
323	T	A	-0.0534
324	S	A	-0.0598
325	V	A	1.3523
326	C	A	0.0000
327	C	A	0.0000
328	S	A	0.2964
329	A	A	-0.1020
330	L	A	0.0000
331	S	A	-0.5064
332	S	A	-0.2553
333	V	A	0.0000
334	L	A	0.0000
335	S	A	-1.3004
336	T	A	-1.3421
337	N	A	-1.8659
338	Q	A	-2.6639
339	N	A	-2.2382
340	L	A	0.0000
341	T	A	-1.4280
342	H	A	-0.9325
343	L	A	0.0000
344	Y	A	-0.3048
345	L	A	0.0000
346	R	A	-1.7207
347	G	A	-1.8139
348	N	A	0.0000
349	T	A	-0.9470
350	L	A	0.0000
351	G	A	-1.5565
352	D	A	-2.0543
353	K	A	-2.2633
354	G	A	0.0000
355	I	A	0.0000
356	K	A	-2.1392
357	L	A	-1.1701
358	L	A	0.0000
359	C	A	0.0000
360	E	A	-1.9653
361	G	A	0.0000
362	L	A	0.0000
363	L	A	-0.7623
364	H	A	-1.3186
365	P	A	-1.5148
366	D	A	-2.1907
367	C	A	0.0000
368	K	A	-2.9349
369	L	A	0.0000
370	Q	A	-1.4391
371	V	A	-0.9279
372	L	A	0.0000
373	E	A	-0.8034
374	L	A	0.0000
375	D	A	-1.8825
376	N	A	-2.8246
377	C	A	0.0000
378	N	A	-2.4834
379	L	A	0.0000
380	T	A	-1.1728
381	S	A	-0.4110
382	H	A	-1.0815
383	C	A	0.0000
384	C	A	0.0000
385	W	A	0.4795
386	D	A	-0.7657
387	L	A	0.0000
388	S	A	0.0000
389	T	A	-0.3648
390	L	A	0.0000
391	L	A	0.0000
392	T	A	-0.9952
393	S	A	-0.7039
394	S	A	0.0000
395	Q	A	-1.7524
396	S	A	-1.6505
397	L	A	0.0000
398	R	A	-1.7507
399	K	A	-1.1705
400	L	A	0.0000
401	S	A	-0.5774
402	L	A	0.0000
403	G	A	0.0000
404	N	A	-2.4200
405	N	A	0.0000
406	D	A	-2.0298
407	L	A	0.0000
408	G	A	0.1736
409	D	A	0.0376
410	L	A	1.1493
411	G	A	0.0000
412	V	A	0.0000
413	M	A	0.0734
414	M	A	0.1327
415	F	A	0.0000
416	C	A	0.0000
417	E	A	-1.8814
418	V	A	0.0000
419	L	A	0.0000
420	K	A	-2.2693
421	Q	A	-1.8314
422	Q	A	-1.7921
423	S	A	-1.2531
424	C	A	0.0000
425	L	A	-1.2162
426	L	A	0.0000
427	Q	A	-0.6584
428	N	A	-0.0812
429	L	A	0.0000
430	G	A	0.0116
431	L	A	0.0000
432	S	A	-0.7779
433	E	A	-2.0617
434	M	A	0.0000
435	Y	A	0.3316
436	F	A	0.3979
437	N	A	-0.2377
438	Y	A	-0.2883
439	E	A	-1.6662
440	T	A	0.0000
441	K	A	-2.3445
442	S	A	-1.9123
443	A	A	-1.8522
444	L	A	0.0000
445	E	A	-3.4938
446	T	A	-2.7368
447	L	A	0.0000
448	Q	A	-3.1806
449	E	A	-3.7720
450	E	A	-3.6689
451	K	A	0.0000
452	P	A	-1.9732
453	E	A	-1.7312
454	L	A	-1.0658
455	T	A	0.1882
456	V	A	1.4400
457	V	A	1.9761