Project name: 4XWH

Chain sequence(s)	A: DEAREAAAVRALVARLLGPGPAADFSVSVERALAAKPGLDTYSLGGGGAARVRVRGSTGVAAAAGLHRYLRDFCGCHVAWSGSQLRLPRPLPAVPGELTEATPNRYRYYQNVCTQSYSFVWWDWARWERREIDWMALNGINLALAWSGQEAIWQRVYLALGLTQAEINEFFTGPAFLAWGRMGNLHTWDGPLPPSWHIKQLYLQHRVLDQMRSFGMTPVLPAFAGHVPEAVTRVFPQVNVTTKMGSWGHFNCSYSCSFLLAPEDPIFPIIGSLFLRELIKEFGTDIYGADTFNEMQPPSSEPSYLAAATTAVYEAMTAVDTEAVWLLQGWLFQHQPQFWGPAQIRAVLGAVPRGRLLVLDLFAESQPVYTRRTASFQGQPFIWCMLHNFGGNHGLFGALEAVNGGPEAARLFPNSTMVGTGMAPEGISQNEVVYSLMAELGWRKDPVPDLAAWVTSFAARRYGVSHPDAGAAWRLLLRSVYNCSGEACRGHHNRSPLVRRPSLQMNTSIWYNRSDVFEAWRLLLTSAPSLATSPAFRRYDLLDLTRQAVQELVSLYYEEARSAYLSKELASLLRAGGVLAYELLPALDEVLASDSRFLLGSWLEEQARAAAVSEAEADFYEQNSRYQLTLWGPEGNILDYANKQLAGLVANYYTPRWRRLFLLEALVDSVAQGIPFQQHQFDKNVFQLEQAFVLSKQRYPSQPRGDTVDLAKKIFLKYYPRWVAGSW
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.296
• Maximal score value: 1.8714
• Average score: -0.5313
• Total score value: -381.984

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
24	D	A	-3.0605
25	E	A	-2.6862
26	A	A	-1.9055
27	R	A	-2.9343
28	E	A	0.0000
29	A	A	0.0000
30	A	A	-1.4029
31	A	A	0.0000
32	V	A	0.0000
33	R	A	-2.1024
34	A	A	-0.9904
35	L	A	0.0000
36	V	A	0.0000
37	A	A	-0.7724
38	R	A	-0.7985
39	L	A	-0.2887
40	L	A	-0.2078
41	G	A	-0.4165
42	P	A	-0.8219
43	G	A	-0.6821
44	P	A	-0.3949
45	A	A	-0.9396
46	A	A	-0.9042
47	D	A	-1.3771
48	F	A	0.0000
49	S	A	-1.5217
50	V	A	0.0000
51	S	A	-0.9053
52	V	A	0.0000
53	E	A	-1.4150
54	R	A	-1.7040
55	A	A	-0.7213
56	L	A	-0.4409
57	A	A	-0.8146
58	A	A	-0.8261
59	K	A	-1.6892
60	P	A	-1.3695
61	G	A	-1.1761
62	L	A	-0.6699
63	D	A	0.0000
64	T	A	0.0000
65	Y	A	0.0000
66	S	A	0.0000
67	L	A	0.0000
68	G	A	0.0000
69	G	A	-1.5399
70	G	A	0.0000
71	G	A	-0.8979
72	A	A	-0.4735
73	A	A	-1.2164
74	R	A	-2.3961
75	V	A	0.0000
76	R	A	-2.1825
77	V	A	0.0000
78	R	A	-0.7831
79	G	A	0.0000
80	S	A	0.0000
81	T	A	-0.8904
82	G	A	0.0000
83	V	A	0.0000
84	A	A	0.0000
85	A	A	0.0000
86	A	A	0.0000
87	A	A	0.0000
88	G	A	0.0000
89	L	A	0.0000
90	H	A	-0.4766
91	R	A	-0.8033
92	Y	A	0.0000
93	L	A	0.0000
94	R	A	-0.8603
95	D	A	-1.1628
96	F	A	-0.2125
97	C	A	-0.6818
98	G	A	-0.6565
99	C	A	0.0000
100	H	A	0.0000
101	V	A	0.2380
102	A	A	0.1278
103	W	A	-0.0584
104	S	A	-0.1780
105	G	A	-0.1171
106	S	A	-0.2400
107	Q	A	-0.5802
108	L	A	-0.5246
109	R	A	-1.8122
110	L	A	-0.9741
111	P	A	-1.2871
112	R	A	-2.2058
113	P	A	-1.4045
114	L	A	0.0000
115	P	A	-0.3763
116	A	A	-0.3992
117	V	A	0.0000
118	P	A	-0.8878
119	G	A	-1.4240
120	E	A	-2.1974
121	L	A	-0.8774
122	T	A	-0.6815
123	E	A	-0.9256
124	A	A	-0.6294
125	T	A	0.0000
126	P	A	-0.9706
127	N	A	0.0000
128	R	A	-0.6888
129	Y	A	-0.1151
130	R	A	0.0000
131	Y	A	0.0000
132	Y	A	0.0000
133	Q	A	0.0000
134	N	A	0.0000
135	V	A	0.0000
136	C	A	0.0000
137	T	A	0.0000
138	Q	A	-0.1178
139	S	A	0.0000
140	Y	A	0.0000
141	S	A	-0.0460
142	F	A	0.0000
143	V	A	0.0000
144	W	A	0.0000
145	W	A	-1.0262
146	D	A	-1.9329
147	W	A	-1.2679
148	A	A	-1.0612
149	R	A	-1.4498
150	W	A	0.0000
151	E	A	-1.4643
152	R	A	-1.5821
153	E	A	0.0000
154	I	A	0.0000
155	D	A	0.0000
156	W	A	0.0000
157	M	A	0.0000
158	A	A	0.0000
159	L	A	0.0000
160	N	A	-0.2753
161	G	A	0.0000
162	I	A	0.0000
163	N	A	-0.3224
164	L	A	0.0000
165	A	A	0.0000
166	L	A	0.0000
167	A	A	0.0000
168	W	A	0.0000
169	S	A	-0.0429
170	G	A	0.0000
171	Q	A	0.0000
172	E	A	0.0000
173	A	A	0.0000
174	I	A	0.0000
175	W	A	0.0106
176	Q	A	-0.3181
177	R	A	-0.2913
178	V	A	0.0000
179	Y	A	0.0000
180	L	A	0.4739
181	A	A	0.3615
182	L	A	0.5478
183	G	A	-0.0676
184	L	A	0.0000
185	T	A	-0.4135
186	Q	A	-1.0588
187	A	A	-1.1220
188	E	A	-1.3773
189	I	A	0.0000
190	N	A	-1.7369
191	E	A	-2.2784
192	F	A	-1.2820
193	F	A	0.0000
194	T	A	0.0000
195	G	A	0.0000
196	P	A	0.0000
197	A	A	0.0000
198	F	A	0.0000
199	L	A	0.0000
200	A	A	0.0000
201	W	A	0.0000
202	G	A	-0.2528
203	R	A	-0.4504
204	M	A	0.0000
205	G	A	0.0000
206	N	A	0.0000
207	L	A	0.0000
208	H	A	-0.3763
209	T	A	-0.7858
210	W	A	0.0000
211	D	A	-0.6040
212	G	A	-0.8593
213	P	A	-0.9983
214	L	A	0.0000
215	P	A	0.0852
216	P	A	0.1699
217	S	A	0.0000
218	W	A	0.0000
219	H	A	0.7374
220	I	A	1.8714
221	K	A	0.3192
222	Q	A	0.2097
223	L	A	0.8238
224	Y	A	0.9454
225	L	A	0.0000
226	Q	A	0.0000
227	H	A	-1.0674
228	R	A	-1.6535
229	V	A	0.0000
230	L	A	0.0000
231	D	A	-2.5231
232	Q	A	-1.6344
233	M	A	0.0000
234	R	A	-1.9755
235	S	A	-1.7306
236	F	A	0.0000
237	G	A	-1.2938
238	M	A	0.0000
239	T	A	-0.5933
240	P	A	0.0000
241	V	A	0.0000
242	L	A	0.0000
243	P	A	0.0000
244	A	A	-0.0395
245	F	A	0.0000
246	A	A	-0.1464
247	G	A	0.0000
248	H	A	-0.4629
249	V	A	0.0000
250	P	A	0.0000
251	E	A	-2.1377
252	A	A	-1.3335
253	V	A	0.0000
254	T	A	-1.3869
255	R	A	-1.7264
256	V	A	-0.6094
257	F	A	-0.4828
258	P	A	-1.1653
259	Q	A	-1.5087
260	V	A	-1.0138
261	N	A	-1.5283
262	V	A	-0.9138
263	T	A	-0.9346
264	K	A	-1.8211
265	M	A	0.0000
266	G	A	-1.3618
267	S	A	-1.1301
268	W	A	0.0000
269	G	A	-0.9163
270	H	A	-1.6181
271	F	A	0.0000
272	N	A	-1.3580
273	C	A	-0.4599
274	S	A	-0.1805
275	Y	A	-0.2179
276	S	A	0.0000
277	C	A	0.0000
278	S	A	0.0000
279	F	A	-0.9946
280	L	A	0.0000
281	L	A	0.0000
282	A	A	-0.7679
283	P	A	-1.0314
284	E	A	-2.0370
285	D	A	0.0000
286	P	A	-0.4626
287	I	A	0.1623
288	F	A	0.0000
289	P	A	0.0899
290	I	A	1.6095
291	I	A	0.0000
292	G	A	0.0000
293	S	A	-0.0003
294	L	A	0.2105
295	F	A	0.0000
296	L	A	0.0000
297	R	A	-2.0240
298	E	A	-1.6179
299	L	A	0.0000
300	I	A	-1.4304
301	K	A	-2.3088
302	E	A	-1.4899
303	F	A	0.0000
304	G	A	-1.2038
305	T	A	-1.0696
306	D	A	-1.8674
308	I	A	-0.4801
309	Y	A	0.0000
310	G	A	0.0000
311	A	A	0.0000
312	D	A	-0.4027
313	T	A	-0.4160
314	F	A	0.0000
315	N	A	0.0000
316	E	A	-1.2683
317	M	A	0.0000
318	Q	A	-1.5934
319	P	A	0.0000
320	P	A	-0.9933
321	S	A	-0.8876
322	S	A	-1.1391
323	E	A	-1.7484
324	P	A	-1.2617
325	S	A	-0.6723
326	Y	A	-0.6700
327	L	A	0.0000
328	A	A	-0.5802
329	A	A	-0.3256
330	A	A	0.0000
331	T	A	0.0000
332	T	A	-0.7857
333	A	A	-1.0320
334	V	A	0.0000
335	Y	A	0.0000
336	E	A	-1.8336
337	A	A	0.0000
338	M	A	0.0000
339	T	A	-1.0050
340	A	A	-0.4388
341	V	A	-0.5418
342	D	A	-1.1958
343	T	A	-1.1601
344	E	A	-2.0521
345	A	A	0.0000
346	V	A	-0.5073
347	W	A	0.0000
348	L	A	0.0000
349	L	A	0.0000
350	Q	A	-0.1437
351	G	A	0.0000
352	W	A	-0.3571
353	L	A	0.0000
354	F	A	0.0000
355	Q	A	-0.8247
356	H	A	-1.2060
357	Q	A	-1.6462
358	P	A	-1.2259
359	Q	A	-1.4869
360	F	A	-1.0622
361	W	A	0.0000
362	G	A	-1.0640
363	P	A	-1.1046
364	A	A	-1.1306
365	Q	A	-1.1670
366	I	A	0.0000
367	R	A	-2.2491
368	A	A	0.0000
369	V	A	0.0000
370	L	A	0.0000
371	G	A	-1.5219
372	A	A	-0.8117
373	V	A	0.0000
374	P	A	-1.3974
375	R	A	-2.4066
376	G	A	-1.4061
377	R	A	-1.2958
378	L	A	0.0000
379	L	A	0.0000
380	V	A	0.0000
381	L	A	0.0000
382	D	A	0.0000
383	L	A	0.0000
384	F	A	0.0000
385	A	A	0.0000
386	E	A	-0.7209
387	S	A	-1.0142
388	Q	A	-0.9204
389	P	A	-0.5442
390	V	A	0.0000
391	Y	A	0.0000
392	T	A	-0.9075
393	R	A	-1.9231
394	T	A	0.0000
395	A	A	-0.9239
396	S	A	0.0000
397	F	A	0.0000
398	Q	A	-1.7398
399	G	A	-1.1432
400	Q	A	0.0000
401	P	A	-0.5244
402	F	A	0.0000
403	I	A	0.0000
404	W	A	0.0000
405	C	A	0.0000
406	M	A	0.0000
407	L	A	0.0000
408	H	A	0.0000
409	N	A	0.0000
410	F	A	0.0000
411	G	A	0.0000
412	G	A	0.0000
413	N	A	0.0000
414	H	A	0.0000
415	G	A	-0.3726
416	L	A	0.0000
417	F	A	0.0000
418	G	A	0.0000
419	A	A	0.0000
420	L	A	0.0000
421	E	A	-2.1547
422	A	A	-1.1222
423	V	A	0.0000
424	N	A	0.0000
425	G	A	-1.3509
426	G	A	-0.9757
427	P	A	-1.1779
428	E	A	-1.8844
429	A	A	-0.2837
430	A	A	0.0000
431	R	A	-0.4625
432	L	A	0.7820
433	F	A	0.2391
434	P	A	-0.4296
435	N	A	-1.2708
436	S	A	-0.5430
437	T	A	-0.5361
438	M	A	0.0000
439	V	A	-0.0269
440	G	A	0.0000
441	T	A	0.0000
442	G	A	0.0000
443	M	A	0.0000
444	A	A	0.0000
445	P	A	0.0000
446	E	A	0.0000
447	G	A	0.0000
448	I	A	0.0000
449	S	A	-0.1967
450	Q	A	0.0000
451	N	A	0.0000
452	E	A	0.0000
453	V	A	0.0000
454	V	A	0.0000
455	Y	A	0.0000
456	S	A	-0.0967
457	L	A	0.0000
458	M	A	0.0000
459	A	A	0.0000
460	E	A	-0.4753
461	L	A	0.0000
462	G	A	0.0000
463	W	A	0.0000
464	R	A	-2.1637
465	K	A	-3.0844
466	D	A	-3.1626
467	P	A	-2.2396
468	V	A	0.0000
469	P	A	-1.3592
470	D	A	-1.7644
471	L	A	-1.3254
472	A	A	-1.0189
473	A	A	-0.6174
474	W	A	-0.4414
475	V	A	0.0000
476	T	A	-0.3637
477	S	A	-0.1537
478	F	A	0.0000
479	A	A	0.0000
480	A	A	0.0389
481	R	A	-0.5454
482	R	A	0.0000
483	Y	A	0.0000
484	G	A	-0.0337
485	V	A	0.8183
486	S	A	0.0801
487	H	A	-0.1869
488	P	A	-0.3850
489	D	A	-0.7168
490	A	A	0.0000
491	G	A	0.0000
492	A	A	-0.6300
493	A	A	0.0000
494	W	A	0.0000
495	R	A	-1.6637
496	L	A	-1.0552
497	L	A	0.0000
498	L	A	-1.4160
499	R	A	-2.4433
500	S	A	0.0000
501	V	A	0.0000
502	Y	A	0.0000
503	N	A	-1.3152
504	C	A	0.0000
505	S	A	-1.1304
506	G	A	-1.4193
507	E	A	-2.2831
508	A	A	-1.2803
509	C	A	0.0000
510	R	A	-1.5544
511	G	A	-0.8662
512	H	A	-0.9585
513	N	A	0.0000
514	R	A	-2.2010
515	S	A	-1.2202
516	P	A	0.0000
517	L	A	0.0000
518	V	A	0.0000
519	R	A	-0.8976
520	R	A	-0.6847
521	P	A	0.0000
522	S	A	-0.8376
523	L	A	-0.5262
524	Q	A	-1.3737
525	M	A	-1.5055
526	N	A	-1.7999
527	T	A	-1.0076
528	S	A	-0.3302
529	I	A	0.2453
530	W	A	0.3443
531	Y	A	-0.5277
532	N	A	-1.3432
533	R	A	-0.7524
534	S	A	-0.4042
535	D	A	0.0000
536	V	A	0.0000
537	F	A	0.0000
538	E	A	-0.6240
539	A	A	0.0000
540	W	A	0.0000
541	R	A	-0.6998
542	L	A	-0.4048
543	L	A	0.0000
544	L	A	0.0000
545	T	A	-0.4424
546	S	A	0.0000
547	A	A	0.0000
548	P	A	-0.3465
549	S	A	-0.2329
550	L	A	0.0000
551	A	A	-0.2593
552	T	A	-0.2910
553	S	A	-0.2550
554	P	A	-0.5208
555	A	A	0.0000
556	F	A	0.0000
557	R	A	-0.6367
558	Y	A	0.0000
559	D	A	0.0000
560	L	A	0.0000
561	L	A	0.0000
562	D	A	-0.2508
563	L	A	0.0000
564	T	A	0.0000
565	R	A	0.0000
566	Q	A	0.0000
567	A	A	0.0000
568	V	A	0.0000
569	Q	A	-0.1051
570	E	A	0.0000
571	L	A	0.0000
572	V	A	0.0000
573	S	A	0.0000
574	L	A	-0.2134
575	Y	A	0.0000
576	Y	A	0.0000
577	E	A	-1.2161
578	E	A	-1.4374
579	A	A	0.0000
580	R	A	-0.7474
581	S	A	-0.6847
582	A	A	0.0000
583	Y	A	0.0000
584	L	A	0.6203
585	S	A	-0.6815
586	K	A	-1.7157
587	E	A	-1.4394
588	L	A	-0.6375
589	A	A	-0.4240
590	S	A	-1.0216
591	L	A	0.0000
592	L	A	0.0089
593	R	A	-1.3099
594	A	A	0.0000
595	G	A	0.0000
596	G	A	-0.6130
597	V	A	-0.3495
598	L	A	0.0000
599	A	A	0.0000
600	Y	A	-0.0377
601	E	A	-0.9676
602	L	A	0.0000
603	L	A	0.0000
604	P	A	-0.8021
605	A	A	-1.1273
606	L	A	0.0000
607	D	A	0.0000
608	E	A	-2.3068
609	V	A	0.0000
610	L	A	0.0000
611	A	A	0.0000
612	S	A	0.0000
613	D	A	-1.5356
614	S	A	-1.1135
615	R	A	-0.8895
616	F	A	0.0000
617	L	A	0.0000
618	L	A	0.0000
619	G	A	0.0000
620	S	A	-1.0101
621	W	A	-0.6647
622	L	A	0.0000
623	E	A	-1.9864
624	Q	A	-1.6513
625	A	A	0.0000
626	R	A	-1.1873
627	A	A	-0.5773
628	A	A	-0.5370
629	A	A	-0.0958
630	V	A	1.2117
631	S	A	-0.4120
632	E	A	-1.8902
633	A	A	-1.0835
634	E	A	-0.7253
635	A	A	0.0000
636	D	A	-2.2470
637	F	A	-0.9460
638	Y	A	0.0000
639	E	A	0.0000
640	Q	A	-0.6032
641	N	A	0.0000
642	S	A	0.0000
643	R	A	0.0000
644	Y	A	0.1142
645	Q	A	0.0000
646	L	A	0.0000
647	T	A	0.0000
648	L	A	0.0000
649	W	A	0.0000
650	G	A	0.0000
651	P	A	-0.9776
652	E	A	-1.9708
653	G	A	-0.9239
654	N	A	-1.0060
655	I	A	0.0197
656	L	A	0.0863
657	D	A	0.0000
658	Y	A	0.0872
659	A	A	0.0000
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669	N	A	-0.5120
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680	E	A	-1.6012
681	A	A	-1.4261
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683	V	A	-1.0067
684	D	A	-1.9556
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687	A	A	-1.1218
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689	G	A	-0.6040
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714	R	A	-3.0132
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717	S	A	-1.5856
718	Q	A	-1.8456
719	P	A	-2.2045
720	R	A	-2.9429
721	G	A	-2.3642
722	D	A	-2.2709
723	T	A	0.0000
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725	D	A	-2.6567
726	L	A	-1.9278
727	A	A	0.0000
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729	K	A	-2.2362
730	I	A	0.0000
731	F	A	-0.7051
732	L	A	0.0137
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734	Y	A	0.0000
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738	W	A	0.4649
739	V	A	1.4933
740	A	A	0.4607
741	G	A	-0.0847
742	S	A	-0.2379
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