Project name: 5x8m:B

Chain sequence(s)	B: EVQLVESGGGLVQPGGSLRLSCAASGFTFSRYWMSWVRQAPGKGLEWVANIKQDGSEKYYVDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCAREGGWFGELAFDYWGQGTLVTVSSASTKGPSVFPLAPTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -2.8318
• Maximal score value: 2.6087
• Average score: -0.5261
• Total score value: -112.5902

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	B	-1.9882
2	V	B	-0.9172
3	Q	B	-0.6918
4	L	B	0.0000
5	V	B	1.2942
6	E	B	0.0000
7	S	B	-0.3475
8	G	B	-0.9090
9	G	B	-0.4586
10	G	B	0.0025
11	L	B	0.0665
12	V	B	-0.5793
13	Q	B	-1.5686
14	P	B	-1.8177
15	G	B	-1.5726
16	G	B	-1.2978
17	S	B	-1.5811
18	L	B	-1.2314
19	R	B	-2.0056
20	L	B	0.0000
21	S	B	-0.4004
22	C	B	0.0000
23	A	B	-0.0919
24	A	B	0.0000
25	S	B	-0.6976
26	G	B	-1.1021
27	F	B	-0.6996
28	T	B	-0.7093
29	F	B	0.0000
30	S	B	-1.7508
31	R	B	-1.6969
32	Y	B	-0.4587
33	W	B	-0.1475
34	M	B	0.0000
35	S	B	0.0000
36	W	B	0.0000
37	V	B	0.0000
38	R	B	0.0000
39	Q	B	-0.4407
40	A	B	-1.0779
41	P	B	-1.0349
42	G	B	-1.4199
43	K	B	-2.0981
44	G	B	-0.9917
45	L	B	0.4769
46	E	B	-0.3463
47	W	B	0.2768
48	V	B	0.0000
49	A	B	0.0000
50	N	B	-0.0695
51	I	B	0.0000
52	K	B	-1.3922
53	Q	B	-1.6502
54	D	B	-2.6765
55	G	B	-1.8783
56	S	B	-1.5181
57	E	B	-1.4120
58	K	B	-0.6644
59	Y	B	0.2414
60	Y	B	-0.2975
61	V	B	-0.8180
62	D	B	-2.1625
63	S	B	-1.5936
64	V	B	0.0000
65	K	B	-2.3083
66	G	B	-1.7979
67	R	B	-1.7341
68	F	B	0.0000
69	T	B	-1.0004
70	I	B	0.0000
71	S	B	-0.8751
72	R	B	-1.3643
73	D	B	-1.9616
74	N	B	-2.1267
75	A	B	-1.4185
76	K	B	-2.3585
77	N	B	-1.8476
78	S	B	-1.0802
79	L	B	0.0000
80	Y	B	-0.6332
81	L	B	0.0000
82	Q	B	-1.6018
83	M	B	0.0000
84	N	B	-2.1920
85	S	B	-1.5960
86	L	B	0.0000
87	R	B	-2.5239
88	A	B	-1.7995
89	E	B	-2.2702
90	D	B	0.0000
91	T	B	-0.7449
92	A	B	0.0000
93	V	B	0.4574
94	Y	B	0.0000
95	Y	B	0.4626
96	C	B	0.0000
97	A	B	0.0000
98	R	B	0.0000
99	E	B	0.6622
100	G	B	0.0000
101	G	B	0.7186
102	W	B	1.5599
103	F	B	1.8874
104	G	B	0.8034
105	E	B	-0.2892
106	L	B	1.0697
107	A	B	0.6116
108	F	B	0.7652
109	D	B	0.4205
110	Y	B	0.8008
111	W	B	0.7885
112	G	B	0.3292
113	Q	B	-0.6025
114	G	B	0.0000
115	T	B	0.1283
116	L	B	0.3573
117	V	B	0.0000
118	T	B	0.0000
119	V	B	0.0000
120	S	B	-0.9950
121	S	B	-0.6629
122	A	B	-0.5547
123	S	B	-0.7091
124	T	B	-0.9360
125	K	B	-1.6666
126	G	B	-1.7684
127	P	B	-0.8060
128	S	B	-0.2163
129	V	B	0.0000
130	F	B	1.2018
131	P	B	0.1878
132	L	B	0.6144
133	A	B	-0.5807
134	P	B	-0.7343
143	T	B	-0.2795
144	A	B	-0.1942
145	A	B	0.0645
146	L	B	0.0000
147	G	B	0.0000
148	C	B	0.0000
149	L	B	0.8237
150	V	B	0.0000
151	K	B	-0.5319
152	D	B	-1.0425
153	Y	B	0.0000
154	F	B	0.0000
155	P	B	0.0000
156	E	B	-0.4786
157	P	B	-0.7298
158	V	B	-0.6632
159	T	B	-0.5833
160	V	B	-0.0780
161	S	B	-0.3340
162	W	B	0.0000
163	N	B	-0.7248
164	S	B	-0.6491
165	G	B	-0.5531
166	A	B	-0.2397
167	L	B	-0.0029
168	T	B	-0.2650
169	S	B	-0.3479
170	G	B	-0.4266
171	V	B	0.0969
172	H	B	-0.2689
173	T	B	0.2890
174	F	B	1.1071
175	P	B	0.8088
176	A	B	1.3300
177	V	B	2.6087
178	L	B	2.1392
179	Q	B	0.7290
180	S	B	0.1280
181	S	B	-0.2315
182	G	B	0.2073
183	L	B	0.0852
184	Y	B	0.5930
185	S	B	0.0000
186	L	B	0.8561
187	S	B	0.7744
188	S	B	0.0000
189	V	B	0.5012
190	V	B	0.0000
191	T	B	-0.2251
192	V	B	0.0000
193	P	B	-0.4854
194	S	B	-0.4546
195	S	B	-0.5243
196	S	B	-0.5560
197	L	B	-0.7410
198	G	B	-1.0219
199	T	B	-0.6316
200	Q	B	-1.0956
201	T	B	-1.0269
202	Y	B	0.0000
203	I	B	-1.3831
204	C	B	0.0000
205	N	B	-1.4970
206	V	B	0.0000
207	N	B	-1.8973
208	H	B	0.0000
209	K	B	-2.7486
210	P	B	-1.6874
211	S	B	-1.9509
212	N	B	-2.6598
213	T	B	-2.0918
214	K	B	-2.6562
215	V	B	-1.7265
216	D	B	-2.6821
217	K	B	-2.0509
218	K	B	-2.5691
219	V	B	0.0000
220	E	B	-2.8318
221	P	B	-1.8425
222	K	B	-2.2354