Project name: FAB_Sumit

Chain sequence(s)	H: VQLQQPGAELVKPGASVKMSCKASGYTFTSYNMHWVKQTPGRGLEWIGAIYPGNGDTSYNQKFKGKATLTADKSSSTAYMQLSSLTSEDSAVYYCARSTYYGGDWYFNVWGAGTTVTVSAASTTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEP; L: VLSQSPAILSASPGEKVTMTCRASSSVSYIHWFQQKPGSSPKPWIYATSNLASGVPVRFSGSSGSGTSYSLTISRVEAEDAATYYCQQWTSNPPTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPRREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADDYEKHKVYACEVTHQGLSSPVTKSFNRGEC
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.6082
• Maximal score value: 1.6462
• Average score: -0.6636
• Total score value: -286.0283

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
3	V	L	1.3839
4	L	L	0.2082
5	S	L	-0.5923
6	Q	L	-0.7367
7	S	L	-0.3272
8	P	L	0.2525
9	A	L	0.4377
10	I	L	1.2367
11	L	L	0.4106
12	S	L	-0.5848
13	A	L	0.0000
14	S	L	-2.2454
15	P	L	-2.4387
16	G	L	-2.9944
17	E	L	-3.4881
18	K	L	-3.4068
19	V	L	0.0000
20	T	L	-0.4504
21	M	L	0.0000
22	T	L	-0.6568
23	C	L	0.0000
24	R	L	-1.6550
25	A	L	-0.5455
26	S	L	-0.1648
27	S	L	-0.3391
28	S	L	-0.6770
29	V	L	-0.3268
30	S	L	-0.2065
31	Y	L	0.0521
32	I	L	0.0000
33	H	L	0.0000
34	W	L	0.0000
35	F	L	0.0000
36	Q	L	0.0000
37	Q	L	0.0000
38	K	L	-1.5226
39	P	L	-1.1040
40	G	L	-0.9824
41	S	L	-0.7768
42	S	L	-0.5555
43	P	L	0.0000
44	K	L	-1.3500
45	P	L	-0.5648
46	W	L	-0.3056
47	I	L	0.0000
48	Y	L	0.3291
49	A	L	0.0000
50	T	L	-0.2247
51	S	L	-0.3139
52	N	L	-0.0918
53	L	L	0.4707
54	A	L	-0.2338
55	S	L	-0.3489
56	G	L	-0.2668
57	V	L	0.0000
58	P	L	0.6424
59	V	L	1.6268
60	R	L	-0.1658
61	F	L	0.0000
62	S	L	0.0466
63	G	L	-0.3369
64	S	L	-0.5467
65	G	L	-0.7940
66	S	L	-0.7226
67	G	L	-0.7232
68	T	L	-0.9419
69	S	L	-1.1209
70	Y	L	0.0000
71	S	L	-0.5923
72	L	L	0.0000
73	T	L	-0.7430
74	I	L	0.0000
75	S	L	-1.9850
76	R	L	-3.5849
77	V	L	0.0000
78	E	L	-3.2913
79	A	L	-2.6823
80	E	L	-3.0075
81	D	L	0.0000
82	A	L	-1.9846
83	A	L	0.0000
84	T	L	0.0000
85	Y	L	0.0000
86	Y	L	-0.3601
87	C	L	0.0000
88	Q	L	0.0000
89	Q	L	0.0000
90	W	L	-0.0235
91	T	L	-0.3164
92	S	L	-0.6835
93	N	L	-1.4931
94	P	L	-0.9206
95	P	L	0.0000
96	T	L	0.1019
97	F	L	0.0000
98	G	L	0.0000
99	G	L	-0.8922
100	G	L	-0.4099
101	T	L	0.0000
102	K	L	-0.9681
103	L	L	0.0000
104	E	L	-1.4141
105	I	L	0.0000
106	K	L	-1.8103
107	R	L	-1.1784
108	T	L	-0.0233
109	V	L	0.5459
110	A	L	0.0443
111	A	L	-0.0426
112	P	L	0.0000
113	S	L	-0.0899
114	V	L	-0.2045
115	F	L	0.0000
116	I	L	0.0000
117	F	L	0.0000
118	P	L	-0.6750
119	P	L	-1.0797
120	S	L	-1.7197
121	D	L	-3.0969
122	E	L	-3.2771
123	Q	L	0.0000
124	L	L	-2.1644
125	K	L	-2.9422
126	S	L	-1.8390
127	G	L	-1.4541
128	T	L	-1.3112
129	A	L	0.0000
130	S	L	0.0000
131	V	L	0.0000
132	V	L	0.0000
133	C	L	0.0000
134	L	L	0.0000
135	L	L	0.0000
136	N	L	0.0000
137	N	L	-0.8526
138	F	L	0.0000
139	Y	L	0.0000
140	P	L	-1.7447
141	R	L	-2.9231
142	E	L	-3.2514
143	A	L	-2.3883
144	K	L	-2.4033
145	V	L	0.0000
146	Q	L	-0.9448
147	W	L	0.0000
148	K	L	-0.7851
149	V	L	0.0000
150	D	L	-1.6967
151	N	L	-1.5631
152	A	L	-0.4007
153	L	L	0.3615
154	Q	L	-0.3449
155	S	L	-0.4918
156	G	L	-0.8754
157	N	L	-0.7684
158	S	L	-1.1427
159	Q	L	-1.3274
160	E	L	-1.8124
161	S	L	-0.6897
162	V	L	-0.9382
163	T	L	-1.0182
164	E	L	-1.9998
165	Q	L	-2.0370
166	D	L	-1.9774
167	S	L	-2.4640
168	K	L	-2.8377
169	D	L	-2.1320
170	S	L	0.0000
171	T	L	0.0000
172	Y	L	0.0000
173	S	L	0.0000
174	L	L	0.0000
175	S	L	0.0000
176	S	L	0.0000
177	T	L	-0.6805
178	L	L	0.0000
179	T	L	-0.4628
180	L	L	-0.7554
181	S	L	-1.1626
182	K	L	-2.1535
183	A	L	-1.9447
184	D	L	-2.8846
185	Y	L	0.0000
186	E	L	-3.5148
187	K	L	-3.6082
188	H	L	-3.0425
189	K	L	-3.3064
190	V	L	-1.5460
191	Y	L	0.0000
192	A	L	0.0000
193	C	L	0.0000
194	E	L	-0.8080
195	V	L	0.0000
196	T	L	-1.2588
197	H	L	0.0000
198	Q	L	-1.7192
199	G	L	-0.3844
200	L	L	-0.2240
201	S	L	-0.4617
202	S	L	-0.4278
203	P	L	-0.6153
204	V	L	0.0267
205	T	L	-0.4631
206	K	L	-0.9296
207	S	L	-0.9245
208	F	L	0.0000
209	N	L	-1.9098
210	R	L	-2.4359
211	G	L	-1.9957
212	E	L	-2.2066
213	C	L	-0.4322
2	V	H	1.0422
3	Q	H	-0.8240
4	L	H	0.0000
5	Q	H	-1.8977
6	Q	H	-1.0702
7	P	H	-0.8982
8	G	H	-0.9023
9	A	H	0.0000
10	E	H	-1.1884
11	L	H	-0.6271
12	V	H	0.0000
13	K	H	-1.9346
14	P	H	-1.2346
15	G	H	-1.1132
16	A	H	-0.9185
17	S	H	-1.0651
18	V	H	0.0000
19	K	H	-1.7387
20	M	H	0.0000
21	S	H	-0.8692
22	C	H	0.0000
23	K	H	-1.8031
24	A	H	0.0000
25	S	H	-0.5951
26	G	H	-0.0043
27	Y	H	0.2877
28	T	H	0.1712
29	F	H	0.0000
30	T	H	-0.6863
31	S	H	-0.0171
32	Y	H	0.4817
33	N	H	-0.3160
34	M	H	0.0000
35	H	H	0.0000
36	W	H	0.0000
37	V	H	0.0000
38	K	H	0.0000
39	Q	H	-0.7560
40	T	H	-1.2301
41	P	H	-1.0752
42	G	H	-1.6116
43	R	H	-2.4118
44	G	H	-1.5443
45	L	H	0.0000
46	E	H	-0.9450
47	W	H	0.0000
48	I	H	0.0000
49	G	H	0.0000
50	A	H	0.0000
51	I	H	0.0000
52	Y	H	-0.9922
53	P	H	0.0000
54	G	H	-1.3464
55	N	H	-2.2380
56	G	H	-2.2338
57	D	H	-2.3716
58	T	H	-1.1751
59	S	H	-0.7993
60	Y	H	-1.2061
61	N	H	0.0000
62	Q	H	-2.7335
63	K	H	-2.8942
64	F	H	0.0000
65	K	H	-2.8627
66	G	H	-1.9557
67	K	H	-1.4488
68	A	H	0.0000
69	T	H	-0.8240
70	L	H	0.0000
71	T	H	-0.7992
72	A	H	-1.3421
73	D	H	-1.8067
74	K	H	-2.4529
75	S	H	-1.3885
76	S	H	-1.2413
77	S	H	-1.2455
78	T	H	0.0000
79	A	H	0.0000
80	Y	H	-0.4793
81	M	H	0.0000
82	Q	H	-1.1765
83	L	H	0.0000
84	S	H	-0.8600
85	S	H	-0.8511
86	L	H	0.0000
87	T	H	-1.2520
88	S	H	-1.4083
89	E	H	-1.9626
90	D	H	0.0000
91	S	H	-0.7085
92	A	H	0.0000
93	V	H	0.2635
94	Y	H	0.0000
95	Y	H	0.0000
96	C	H	0.0000
97	A	H	0.0000
98	R	H	0.0000
99	S	H	0.0000
100	T	H	0.9606
101	Y	H	1.6462
102	Y	H	1.1970
103	G	H	0.1095
104	G	H	0.0188
105	D	H	0.0000
106	W	H	1.1495
107	Y	H	0.0000
108	F	H	0.0000
109	N	H	-0.0812
110	V	H	0.0524
111	W	H	-0.2284
112	G	H	0.0000
113	A	H	-0.3615
114	G	H	-0.2086
115	T	H	0.0000
116	T	H	-0.1182
117	V	H	0.0000
118	T	H	-0.6008
119	V	H	0.0000
120	S	H	-0.6657
121	A	H	-0.6492
122	A	H	-0.3777
123	S	H	-0.5217
124	T	H	-0.6047
125	K	H	-1.0785
126	G	H	-1.3596
127	P	H	-0.4285
128	S	H	-0.5098
129	V	H	0.0000
130	F	H	0.0000
131	P	H	-1.2868
132	L	H	0.0000
133	A	H	-0.9073
134	P	H	0.0000
135	S	H	-0.9220
136	S	H	-0.9679
137	K	H	-1.5889
138	S	H	0.0000
139	T	H	-0.8242
140	S	H	-0.7149
141	G	H	-0.7967
142	G	H	-0.8688
143	T	H	-0.5878
144	A	H	0.0000
145	A	H	0.0000
146	L	H	0.0000
147	G	H	0.0000
148	C	H	0.0000
149	L	H	0.0000
150	V	H	0.0000
151	K	H	0.0000
152	D	H	-0.3304
153	Y	H	0.0000
154	F	H	-0.1055
155	P	H	0.0000
156	E	H	-0.4786
157	P	H	-0.7613
158	V	H	0.0000
159	T	H	-0.6361
160	V	H	-0.2108
161	S	H	-0.4114
162	W	H	0.0000
163	N	H	-0.8401
164	S	H	-0.7289
165	G	H	-0.5711
166	A	H	-0.2809
167	L	H	-0.0688
168	T	H	-0.2112
169	S	H	-0.2312
170	G	H	-0.3468
171	V	H	0.1201
172	H	H	-0.2651
173	T	H	-0.1481
174	F	H	0.0000
175	P	H	-0.3659
176	A	H	0.2153
177	V	H	0.4883
178	L	H	1.2707
179	Q	H	0.4258
180	S	H	-0.0025
181	S	H	-0.1526
182	G	H	0.1784
183	L	H	0.3119
184	Y	H	0.5857
185	S	H	0.0000
186	L	H	0.0000
187	S	H	0.0000
188	S	H	0.0000
189	V	H	0.0000
190	V	H	0.0000
191	T	H	-0.1677
192	V	H	0.0000
193	P	H	-0.5921
194	S	H	-0.6506
195	S	H	-0.5628
196	S	H	-0.5399
197	L	H	-0.7737
198	G	H	-0.9603
199	T	H	-0.6629
200	Q	H	-1.1300
201	T	H	-1.0963
202	Y	H	0.0000
203	I	H	-1.5027
204	C	H	0.0000
205	N	H	-1.5788
206	V	H	0.0000
207	N	H	-1.7944
208	H	H	0.0000
209	K	H	-2.7874
210	P	H	-1.6101
211	S	H	-1.7929
212	N	H	-2.5150
213	T	H	-2.2723
214	K	H	-2.6943
215	V	H	-1.9164
216	D	H	-2.7544
217	K	H	-2.3932
218	K	H	-2.7818
219	V	H	0.0000
220	E	H	-2.5378
221	P	H	-1.2143