Project name: TS14-5-2

Chain sequence(s)	H: QVQLQESGPGLVKPSETLSLTCTVSGQSLTNFGVHWIRQPPGKGLEWIGVIWAGGSTNYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARDGYNGYYYTMDYWGQGTSVTVSSDIQMTQSPSSLSASVGDRVTITCSASSTVSFMNWYQQKPGKAPKLLIYSTSILASGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQRSSLPLITFGAGTKLEIK
Distance of aggregation	5 Å
Dynamic mode	No

• Minimal score value: -2.0058
• Maximal score value: 1.4876
• Average score: -0.1909
• Total score value: -43.3343

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	Q	H	-1.2570
2	V	H	0.0000
3	Q	H	-1.2224
4	L	H	0.0000
5	Q	H	-0.7616
6	E	H	0.0000
7	S	H	-0.2837
8	G	H	-0.5209
9	P	H	-0.3710
10	G	H	-0.1251
11	L	H	1.4806
12	V	H	0.0000
13	K	H	-1.4092
14	P	H	-0.4114
15	S	H	-0.5364
16	E	H	-1.5127
17	T	H	-0.3406
18	L	H	0.0000
19	S	H	-0.2965
20	L	H	0.0000
21	T	H	-0.0231
22	C	H	0.0000
23	T	H	-0.0552
24	V	H	0.0000
25	S	H	-0.4192
26	G	H	-0.7918
27	Q	H	-1.0107
28	S	H	-0.2257
29	L	H	0.0000
30	T	H	-0.2030
31	N	H	-0.7730
32	F	H	0.0000
33	G	H	0.0000
34	V	H	0.0000
35	H	H	0.0000
36	W	H	0.0000
37	I	H	0.0000
38	R	H	0.0000
39	Q	H	-0.1496
40	P	H	-0.1047
41	P	H	-0.3469
42	G	H	-0.8280
43	K	H	-1.8080
44	G	H	-0.4331
45	L	H	0.0000
46	E	H	-0.5784
47	W	H	0.0000
48	I	H	0.0000
49	G	H	0.0000
50	V	H	0.0000
51	I	H	0.0000
52	W	H	0.1996
53	A	H	-0.1079
54	G	H	-0.5026
55	G	H	-0.3553
56	S	H	-0.2600
57	T	H	-0.1363
58	N	H	-0.3474
59	Y	H	0.1833
60	N	H	-0.1742
61	P	H	-0.3269
62	S	H	-0.2594
63	L	H	0.0000
64	K	H	-1.7392
65	S	H	-0.5959
66	R	H	-0.4292
67	V	H	0.0000
68	T	H	-0.0254
69	I	H	0.0000
70	S	H	-0.0501
71	V	H	0.3823
72	D	H	-0.4569
73	T	H	-0.2517
74	S	H	-0.5383
75	K	H	-1.8066
76	N	H	-0.7304
77	Q	H	-0.3041
78	F	H	0.0000
79	S	H	-0.0580
80	L	H	0.0000
81	K	H	-0.9094
82	L	H	0.0000
83	S	H	-0.1458
84	S	H	-0.2585
85	V	H	0.0000
86	T	H	-0.0416
87	A	H	0.0594
88	A	H	0.0691
89	D	H	0.0000
90	T	H	-0.0210
91	A	H	0.0000
92	V	H	0.4751
93	Y	H	0.0000
94	Y	H	0.0000
95	C	H	0.0000
96	A	H	0.0000
97	R	H	-0.1844
98	D	H	0.0000
99	G	H	0.0000
100	Y	H	1.0311
101	N	H	-0.9600
102	G	H	-0.5328
103	Y	H	0.8859
104	Y	H	0.8329
105	Y	H	0.6487
106	T	H	0.0000
107	M	H	0.0000
108	D	H	-0.1743
109	Y	H	0.5340
110	W	H	0.2395
111	G	H	0.0000
112	Q	H	-1.1983
113	G	H	0.0000
114	T	H	-0.0512
115	S	H	-0.1440
116	V	H	0.0000
117	T	H	-0.0375
118	V	H	0.0000
119	S	H	-0.1500
120	S	H	-0.2334
121	D	H	-1.7471
122	I	H	-0.2951
123	Q	H	-1.0318
124	M	H	0.0000
125	T	H	-0.0709
126	Q	H	0.0000
127	S	H	-0.1795
128	P	H	-0.1774
129	S	H	-0.2691
130	S	H	-0.3106
131	L	H	0.4294
132	S	H	-0.0978
133	A	H	0.0000
134	S	H	-0.0200
135	V	H	1.3731
136	G	H	-0.2133
137	D	H	-1.2349
138	R	H	-2.0058
139	V	H	0.0000
140	T	H	-0.0503
141	I	H	0.0000
142	T	H	-0.0352
143	C	H	0.0000
144	S	H	-0.3228
145	A	H	-0.0572
146	S	H	-0.2494
147	S	H	-0.2599
148	T	H	-0.1268
149	V	H	0.0000
150	S	H	-0.0027
151	F	H	0.4665
152	M	H	0.0000
153	N	H	0.0000
154	W	H	0.0000
155	Y	H	0.0000
156	Q	H	0.0000
157	Q	H	0.0000
158	K	H	-0.5235
159	P	H	-0.4287
160	G	H	-0.8248
161	K	H	-1.7834
162	A	H	-0.3087
163	P	H	0.0000
164	K	H	-1.4846
165	L	H	0.0000
166	L	H	0.0000
167	I	H	0.0000
168	Y	H	0.2044
169	S	H	0.0049
170	T	H	-0.0558
171	S	H	-0.0054
172	I	H	1.2073
173	L	H	0.6270
174	A	H	0.0475
175	S	H	-0.2992
176	G	H	-0.5066
177	V	H	0.0000
178	P	H	-0.1498
179	S	H	-0.2918
180	R	H	-0.3634
181	F	H	0.0000
182	S	H	-0.1729
183	G	H	-0.1580
184	S	H	-0.2631
185	G	H	-0.2864
186	S	H	-0.2739
187	G	H	-0.1724
188	T	H	-0.3731
189	D	H	-1.8063
190	F	H	0.0000
191	T	H	-0.0260
192	L	H	0.0000
193	T	H	-0.0244
194	I	H	0.0000
195	S	H	-0.3413
196	S	H	-0.1383
197	L	H	0.0000
198	Q	H	-0.3843
199	P	H	-0.6493
200	E	H	-1.8665
201	D	H	0.0000
202	F	H	0.8566
203	A	H	0.0000
204	T	H	-0.2042
205	Y	H	0.0000
206	Y	H	0.0000
207	C	H	0.0000
208	Q	H	0.0000
209	Q	H	0.0000
210	R	H	0.0000
211	S	H	0.0000
212	S	H	0.0707
213	L	H	1.4876
214	P	H	0.2140
215	L	H	0.2604
216	I	H	0.0000
217	T	H	0.0301
218	F	H	0.2051
219	G	H	0.0000
220	A	H	0.0585
221	G	H	0.0000
222	T	H	0.0000
223	K	H	-1.2765
224	L	H	0.0000
225	E	H	-0.8855
226	I	H	0.0873
227	K	H	-1.6036