Project name: 3mme

Chain sequence(s)	A: QEQLVESGGGVVQPGGSLRLSCLASGFTFHKYGMHWVRQAPGKGLEWVALISDDGMRKYHSDSMWGRVTISRDNSKNTLYLQFSSLKVEDTAMFFCAREAGGPIWHDDVKYYDFNDGYYNYHYMDVWGKGTTVTVSSASTKGPSVFPLAPSSKSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPALTQPASVSGSPGQTITISCNGTSSDVGGFDSVSWYQQSPGKAPKVMVFDVSHRPSGISNRFSGSKSGNTASLTISGLHIEDEGDYFCSSLTDRSHRIFGGGTKVTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHKSYSCQVTHEGSTVEKTVAPT
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.104
• Maximal score value: 1.5168
• Average score: -0.7659
• Total score value: -340.0412

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	Q	A	-2.1181
2	E	A	-2.2140
3	Q	A	-1.9082
4	L	A	0.0000
5	V	A	-0.2298
6	E	A	-0.7899
7	S	A	-0.8536
8	G	A	-1.2953
9	G	A	-0.7537
10	G	A	0.5077
11	V	A	1.5168
12	V	A	0.3859
13	Q	A	-0.9139
14	P	A	-1.5058
15	G	A	-1.1964
16	G	A	-0.9852
17	S	A	-1.1574
18	L	A	-1.1221
19	R	A	-2.2050
20	L	A	0.0000
21	S	A	-0.8264
22	C	A	0.0000
23	L	A	-0.4260
24	A	A	0.0000
25	S	A	-1.1018
26	G	A	-1.3996
27	F	A	-0.8774
28	T	A	-0.6045
29	F	A	-1.2811
30	H	A	-2.2592
31	K	A	-1.6534
32	Y	A	-1.1012
33	G	A	0.0000
34	M	A	0.0000
35	H	A	0.0000
36	W	A	0.0000
37	V	A	0.0000
38	R	A	-0.4781
39	Q	A	-0.6847
40	A	A	-0.7477
41	P	A	-0.9842
42	G	A	-1.5020
43	K	A	-2.0073
44	G	A	-1.2638
45	L	A	0.0000
46	E	A	-0.6732
47	W	A	0.0000
48	V	A	0.0000
49	A	A	0.0000
50	L	A	0.0000
51	I	A	0.0000
52	S	A	-1.8471
52A	D	A	-2.4220
53	D	A	-2.5327
54	G	A	-1.9305
55	M	A	-0.8649
56	R	A	-2.2420
57	K	A	-1.7866
58	Y	A	-1.4821
59	H	A	-1.6463
60	S	A	0.0000
61	D	A	-1.9901
62	S	A	-0.9093
63	M	A	0.0000
64	W	A	0.1562
65	G	A	-0.6103
66	R	A	-0.7634
67	V	A	0.0000
68	T	A	-0.9130
69	I	A	0.0000
70	S	A	-0.5711
71	R	A	-1.3467
72	D	A	-2.1677
73	N	A	-2.8341
74	S	A	-2.1523
75	K	A	-2.6713
76	N	A	-2.3005
77	T	A	0.0000
78	L	A	0.0000
79	Y	A	-0.5888
80	L	A	0.0000
81	Q	A	-1.5432
82	F	A	0.0000
82A	S	A	-1.0596
82B	S	A	-0.8687
82C	L	A	0.0000
83	K	A	-1.8636
84	V	A	-1.2231
85	E	A	-2.0240
86	D	A	0.0000
87	T	A	-0.3418
88	A	A	0.0000
89	M	A	0.0713
90	F	A	0.0000
91	F	A	0.0000
92	C	A	0.0000
93	A	A	0.0000
94	R	A	0.0000
95	E	A	0.0000
96	A	A	0.0000
97	G	A	-0.2383
98	G	A	0.0000
99	P	A	0.3962
100	I	A	1.0417
100A	W	A	0.2914
100B	H	A	-1.5068
100C	D	A	-2.7607
100D	D	A	-2.4070
100E	V	A	-0.4985
100F	K	A	-0.5787
100G	Y	A	0.9202
100H	Y	A	0.2973
100I	D	A	-0.5177
100J	F	A	0.3845
100K	N	A	-1.4097
100L	D	A	-1.7294
100M	G	A	-0.9135
100N	Y	A	-0.0813
100O	Y	A	0.1333
100P	N	A	-0.5125
100Q	Y	A	-0.0844
100R	H	A	-0.6378
100S	Y	A	-0.1790
100T	M	A	0.0000
101	D	A	-0.5613
102	V	A	-0.6086
103	W	A	-0.7897
104	G	A	-0.7728
105	K	A	-1.6258
106	G	A	-1.2161
107	T	A	0.0000
108	T	A	0.0466
109	V	A	0.0000
110	T	A	0.2553
111	V	A	0.0000
112	S	A	0.0000
113	S	A	-0.5449
114	A	A	-0.7846
115	S	A	-0.7041
116	T	A	-1.3227
117	K	A	-1.8536
118	G	A	-1.6908
119	P	A	-0.8353
120	S	A	-0.6414
121	V	A	-0.5466
122	F	A	0.0000
123	P	A	-1.1308
124	L	A	0.0000
125	A	A	-0.2751
126	P	A	-0.6532
127	S	A	-0.6229
128	S	A	-1.0845
129	K	A	-1.3812
130	S	A	-1.1773
133	G	A	-1.2272
134	G	A	-0.9952
135	T	A	-0.6683
136	A	A	0.0000
137	A	A	-0.1111
138	L	A	0.0000
139	G	A	0.0000
140	C	A	0.0000
141	L	A	0.0000
142	V	A	0.0000
143	K	A	0.0000
144	D	A	0.0000
145	Y	A	0.0000
146	F	A	0.0000
147	P	A	-0.9837
148	E	A	-1.3678
149	P	A	-1.1906
150	V	A	-1.0879
151	T	A	-0.6430
152	V	A	-0.2135
153	S	A	-0.5533
154	W	A	0.0000
155	N	A	-0.9290
156	S	A	-0.7822
157	G	A	-0.6382
158	A	A	-0.3089
159	L	A	-0.0899
160	T	A	-0.2399
161	S	A	-0.3111
162	G	A	-0.3847
163	V	A	0.0666
164	H	A	-0.1469
165	T	A	0.0041
166	F	A	0.0000
167	P	A	-0.1525
168	A	A	-0.1302
169	V	A	0.0000
170	L	A	0.2122
171	Q	A	0.0000
172	S	A	-0.5462
173	S	A	-0.3647
174	G	A	0.0000
175	L	A	-0.0941
176	Y	A	0.1580
177	S	A	0.0000
178	L	A	0.0000
179	S	A	-0.0310
180	S	A	0.0000
181	V	A	0.1462
182	V	A	0.0000
183	T	A	-0.2149
184	V	A	0.0000
185	P	A	-0.4923
186	S	A	-0.8025
187	S	A	-0.6198
188	S	A	-0.5646
189	L	A	-0.8380
190	G	A	-1.2690
191	T	A	-1.0739
192	Q	A	-1.5803
193	T	A	-1.3422
194	Y	A	-1.1249
195	I	A	-1.4089
196	C	A	0.0000
197	N	A	-1.6114
198	V	A	0.0000
199	N	A	-1.9329
200	H	A	0.0000
201	K	A	-2.8519
202	P	A	-1.9276
203	S	A	-1.9352
204	N	A	-2.5749
205	T	A	-2.0805
206	K	A	-2.4977
207	V	A	-1.3055
208	D	A	-2.5304
209	K	A	-2.1264
210	R	A	-2.7799
211	V	A	0.0000
212	E	A	-2.5156
3	A	A	-0.1543
4	L	A	0.0000
5	T	A	-0.6312
6	Q	A	-0.7092
7	P	A	-0.4705
8	A	A	-0.4834
9	S	A	-0.5942
10	V	A	-0.2265
11	S	A	-0.2596
12	G	A	0.0000
13	S	A	-0.7913
14	P	A	-0.8266
15	G	A	-1.1596
16	Q	A	-1.4169
17	T	A	-0.7170
18	I	A	-0.2218
19	T	A	-0.1180
20	I	A	0.0000
21	S	A	-0.4763
22	C	A	0.0000
23	N	A	-1.3845
24	G	A	-0.8696
25	T	A	-0.7593
26	S	A	-0.9593
27	S	A	-1.2703
27A	D	A	0.0000
27B	V	A	0.0000
27C	G	A	-1.3441
28	G	A	-1.2598
29	F	A	-1.1411
30	D	A	-1.9162
31	S	A	-0.9089
32	V	A	0.0000
33	S	A	0.0000
34	W	A	0.0000
35	Y	A	0.0000
36	Q	A	0.0000
37	Q	A	0.0000
38	S	A	-1.2984
39	P	A	-1.1082
40	G	A	-1.5864
41	K	A	-2.4170
42	A	A	-1.5383
43	P	A	0.0000
44	K	A	-1.5046
45	V	A	0.0000
46	M	A	0.0000
47	V	A	0.0000
48	F	A	-0.6891
49	D	A	-1.0843
50	V	A	-0.8474
51	S	A	-1.1131
52	H	A	-1.3724
53	R	A	-1.6614
54	P	A	-0.9893
55	S	A	-0.8327
56	G	A	-0.5876
57	I	A	-0.7066
58	S	A	-1.0621
59	N	A	-1.6946
60	R	A	-1.2786
61	F	A	0.0000
62	S	A	-0.8838
63	G	A	-0.5619
64	S	A	-0.6196
65	K	A	-1.2878
66	S	A	-0.9735
67	G	A	-1.2512
68	N	A	-1.3781
69	T	A	-1.1460
70	A	A	0.0000
71	S	A	-0.4415
72	L	A	0.0000
73	T	A	-0.2044
74	I	A	0.0000
75	S	A	-1.0128
76	G	A	-1.0956
77	L	A	0.0000
78	H	A	-1.0857
79	I	A	0.3669
80	E	A	-1.3143
81	D	A	0.0000
82	E	A	-0.8440
83	G	A	-0.7887
84	D	A	-0.7779
85	Y	A	0.0000
86	F	A	0.0000
87	C	A	0.0000
88	S	A	0.0000
89	S	A	0.0000
90	L	A	-0.7332
91	T	A	-1.5111
92	D	A	-2.8412
93	R	A	-3.1040
94	S	A	-1.8304
95	H	A	-1.4833
95A	R	A	-0.6298
96	I	A	0.2009
97	F	A	0.0000
98	G	A	0.0000
99	G	A	-0.9955
100	G	A	-0.8467
101	T	A	0.0000
102	K	A	-1.0853
103	V	A	0.0000
104	T	A	-0.4288
105	V	A	0.0000
106	L	A	-0.3847
107	G	A	-0.7046
108	Q	A	-1.4631
109	P	A	-1.3688
110	K	A	-2.1033
111	A	A	-1.1745
112	A	A	-0.6164
113	P	A	-0.4773
114	S	A	-0.3354
115	V	A	-0.4805
116	T	A	-0.2999
117	L	A	-0.1451
118	F	A	0.1505
119	P	A	-0.0145
120	P	A	-0.4595
121	S	A	-0.8794
122	S	A	-1.4120
123	E	A	-2.2190
124	E	A	0.0000
125	L	A	-1.8703
126	Q	A	-2.2855
127	A	A	-1.8188
128	N	A	-2.5017
129	K	A	-2.2719
130	A	A	0.0000
131	T	A	0.0000
132	L	A	0.0000
133	V	A	0.0000
134	C	A	0.0000
135	L	A	0.0000
136	I	A	0.0000
137	S	A	-0.6004
138	D	A	-1.6640
139	F	A	0.0000
140	Y	A	0.0000
141	P	A	0.0000
142	G	A	-0.6486
143	A	A	0.0000
144	V	A	0.0007
145	T	A	0.0377
146	V	A	0.0644
147	A	A	-0.5947
148	W	A	0.0000
149	K	A	-1.6904
150	A	A	-1.5338
151	D	A	-2.1149
152	S	A	-1.3515
153	S	A	-0.9788
154	P	A	-1.2263
155	V	A	-1.1099
156	K	A	-1.7387
157	A	A	-0.8129
158	G	A	-0.5599
159	V	A	-0.5369
160	E	A	-0.8059
161	T	A	-0.3404
162	T	A	-0.2659
163	T	A	-0.2319
164	P	A	-0.5563
165	S	A	-1.1394
166	K	A	-2.6172
167	Q	A	-2.3159
168	S	A	-1.7704
169	N	A	-2.4376
170	N	A	-2.7782
171	K	A	-2.6507
172	Y	A	-1.7341
173	A	A	0.0000
174	A	A	0.0000
175	S	A	0.0000
176	S	A	0.0000
177	Y	A	0.0000
178	L	A	0.0000
179	S	A	-0.3703
180	L	A	0.0000
181	T	A	-1.7341
182	P	A	-2.3169
183	E	A	-2.9844
184	Q	A	-2.3109
185	W	A	0.0000
186	K	A	-2.9554
187	S	A	-2.3402
188	H	A	-2.5174
189	K	A	-2.5792
190	S	A	-1.7531
191	Y	A	0.0000
192	S	A	-1.2560
193	C	A	0.0000
194	Q	A	-1.2395
195	V	A	0.0000
196	T	A	-0.5060
197	H	A	0.0000
198	E	A	-1.2420
199	G	A	-0.9665
200	S	A	-0.6330
201	T	A	-0.6702
202	V	A	-0.8894
203	E	A	-2.1901
204	K	A	-1.6768
205	T	A	-1.0915
206	V	A	-0.3171
207	A	A	-0.8773
208	P	A	-1.0593