Project name: 1UYM Human Hsp90-beta

Chain sequence(s)	A: EVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKE
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.5849
• Maximal score value: 1.6732
• Average score: -0.7962
• Total score value: -166.4116

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
16	E	A	-1.5930
17	V	A	-0.2418
18	E	A	-1.3224
19	T	A	-0.5774
20	F	A	0.1676
21	A	A	0.1354
22	F	A	-0.2961
23	Q	A	-0.6809
24	A	A	-0.6922
25	E	A	-1.3151
26	I	A	0.0000
27	A	A	-0.8518
28	Q	A	-1.2723
29	L	A	0.0000
30	M	A	0.0000
31	S	A	-0.5648
32	L	A	-0.0244
33	I	A	0.0000
34	I	A	0.3781
35	N	A	-0.2823
36	T	A	0.6280
37	F	A	1.6732
38	Y	A	0.3640
39	S	A	-0.4349
40	N	A	-1.3535
41	K	A	-1.1029
42	E	A	-0.9613
43	I	A	0.0000
44	F	A	0.0000
45	L	A	0.0000
46	R	A	-1.2605
47	E	A	0.0000
48	L	A	0.0000
49	I	A	0.0000
50	S	A	-1.1799
51	N	A	-1.9647
52	A	A	0.0000
53	S	A	-1.6019
54	D	A	-2.7047
55	A	A	-1.6667
56	L	A	0.0000
57	D	A	-1.8746
58	K	A	-1.8331
59	I	A	0.0000
60	R	A	-1.2673
61	Y	A	0.0413
62	E	A	-1.2300
63	S	A	-0.7076
64	L	A	0.8930
65	T	A	-0.0948
66	D	A	-0.9106
67	P	A	-1.1132
68	S	A	-1.3932
69	K	A	-2.0297
70	L	A	-2.3968
71	D	A	-2.5052
72	S	A	-1.8257
73	G	A	-2.1335
74	K	A	-3.1990
75	E	A	-2.7510
76	L	A	-1.6526
77	K	A	-1.1968
78	I	A	0.0000
79	D	A	0.0000
80	I	A	0.0000
81	I	A	0.7945
82	P	A	0.0000
83	N	A	-1.8652
84	P	A	-2.2414
85	Q	A	-2.7037
86	E	A	-2.9062
87	R	A	-2.3644
88	T	A	0.0000
89	L	A	0.0000
90	T	A	0.2174
91	L	A	0.0000
92	V	A	0.1498
93	D	A	0.0000
94	T	A	-0.7618
95	G	A	0.0000
96	I	A	-0.7750
97	G	A	0.0000
98	M	A	-0.5878
99	T	A	-1.3507
100	K	A	-1.6375
101	A	A	-0.9217
102	D	A	-0.6394
103	L	A	0.0000
104	I	A	-0.6467
105	N	A	-1.2583
106	N	A	-0.8197
107	L	A	0.3413
108	G	A	-0.0395
109	T	A	0.1632
110	I	A	1.4210
111	A	A	0.2204
112	K	A	-0.6234
113	S	A	-0.5846
114	G	A	-0.5697
115	T	A	0.0000
116	K	A	-1.9843
117	A	A	-1.4816
118	F	A	0.0000
119	M	A	-1.6522
120	E	A	-2.4409
121	A	A	-1.4743
122	L	A	-1.2650
123	Q	A	-1.9173
124	A	A	-1.1918
125	G	A	-1.2317
126	A	A	-1.0326
127	D	A	-1.1263
128	I	A	0.0000
129	S	A	-0.7323
130	M	A	-0.2839
131	I	A	0.0000
132	G	A	-0.9105
133	Q	A	-1.2127
134	F	A	-0.7835
135	G	A	-0.5555
136	V	A	0.0000
137	G	A	-0.4400
138	F	A	0.0234
139	Y	A	0.3092
140	S	A	0.0000
141	A	A	0.0000
142	Y	A	0.0000
143	L	A	0.0000
144	V	A	0.0000
145	A	A	0.0000
146	E	A	-2.1311
147	K	A	-1.5884
148	V	A	0.0000
149	V	A	-0.1804
150	V	A	0.0000
151	I	A	-0.0254
152	T	A	0.0000
153	K	A	-1.3997
154	H	A	-1.7128
155	N	A	-2.2862
156	D	A	-2.7552
157	D	A	-2.6334
158	E	A	-2.8198
159	Q	A	0.0000
160	Y	A	0.0000
161	A	A	0.0000
162	W	A	0.0000
163	E	A	-0.7015
164	S	A	0.0000
165	S	A	-1.2068
166	A	A	-0.8126
167	G	A	-0.7111
168	G	A	-0.5437
169	S	A	-0.3009
170	F	A	0.0000
171	T	A	-0.5763
172	V	A	0.0000
173	R	A	-1.4457
174	A	A	-1.4321
175	D	A	-1.7783
176	H	A	-2.0477
177	G	A	-1.8270
178	E	A	-2.3423
179	P	A	-1.5577
180	I	A	-0.5180
181	G	A	-0.8066
182	R	A	0.0000
183	G	A	0.0000
184	T	A	0.0000
185	K	A	-0.1816
186	V	A	0.1479
187	I	A	0.1531
188	L	A	0.0000
189	H	A	-1.4930
190	L	A	0.0000
191	K	A	-2.4694
192	E	A	-3.2851
193	D	A	-3.0019
194	Q	A	0.0000
195	T	A	-2.0384
196	E	A	-2.3376
197	Y	A	0.0000
198	L	A	0.0000
199	E	A	-1.7118
200	E	A	-1.6991
201	R	A	-3.0039
202	R	A	-2.6524
203	V	A	0.0000
204	K	A	-3.5185
205	E	A	-3.5343
206	V	A	0.0000
207	V	A	0.0000
208	K	A	-3.5849
209	K	A	-3.2827
210	H	A	-1.9758
211	S	A	0.0000
212	Q	A	-1.5538
213	F	A	0.9737
214	I	A	0.8069
215	G	A	0.0090
216	Y	A	0.0000
217	P	A	-0.2215
218	I	A	0.0894
219	T	A	0.3621
220	L	A	0.4062
221	Y	A	1.0578
222	L	A	0.8756
223	E	A	-0.8344
224	K	A	-1.6200