Project name: 3mn5

Chain sequence(s)	A: TTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRVGDERTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPSIVHRKC; S: PSPREQLMESIRKGKELKQI
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.6663
• Maximal score value: 1.513
• Average score: -0.763
• Total score value: -280.0289

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
5	T	A	-0.4690
6	T	A	-0.3167
7	A	A	0.0000
8	L	A	0.0000
9	V	A	0.0000
10	C	A	0.0000
11	D	A	0.0000
12	N	A	0.0000
13	G	A	0.0000
14	S	A	0.0000
15	G	A	-0.1186
16	L	A	0.8070
17	V	A	0.0000
18	K	A	0.0070
19	A	A	0.0000
20	G	A	0.0000
21	F	A	-0.1807
22	A	A	-0.2604
23	G	A	-1.0147
24	D	A	0.0000
25	D	A	-2.0805
26	A	A	-1.0529
27	P	A	0.0000
28	R	A	-1.4474
29	A	A	0.0000
30	V	A	0.1704
31	F	A	0.0000
32	P	A	-0.1433
33	S	A	0.0000
34	I	A	-0.4735
35	V	A	0.0000
36	G	A	-1.7915
37	R	A	-3.0282
38	V	A	-2.0783
39	G	A	0.0000
40	D	A	-2.8330
41	E	A	-3.1517
65	R	A	-2.2454
66	T	A	-0.6642
67	L	A	-0.1446
68	K	A	-0.8625
69	Y	A	-0.1745
70	P	A	0.0000
71	I	A	0.0000
72	E	A	-1.9733
73	H	A	-1.4564
74	G	A	-0.6646
75	I	A	-0.2404
76	I	A	-0.3594
77	T	A	-0.6558
78	N	A	-1.0881
79	W	A	-1.2945
80	D	A	-2.2815
81	D	A	0.0000
82	M	A	0.0000
83	E	A	-1.9194
84	K	A	-1.9970
85	I	A	0.0000
86	W	A	0.0000
87	H	A	-1.1695
88	H	A	0.0000
89	T	A	0.0000
90	F	A	0.0000
91	Y	A	-0.8860
92	N	A	-1.7632
93	E	A	-1.8250
94	L	A	0.0000
95	R	A	-1.9943
96	V	A	-1.3037
97	A	A	-1.3208
98	P	A	0.0000
99	E	A	-2.6151
100	E	A	-2.6818
101	H	A	-1.5030
102	P	A	-0.8949
103	T	A	0.0000
104	L	A	0.0000
105	L	A	0.0000
106	T	A	0.0000
107	E	A	0.0000
108	A	A	0.0000
109	P	A	0.0000
110	L	A	0.4787
111	N	A	-0.0609
112	P	A	-0.8357
113	K	A	-2.0684
114	A	A	-1.4157
115	N	A	-1.2975
116	R	A	-1.5262
117	E	A	-1.7267
118	K	A	-1.6824
119	M	A	0.0000
120	T	A	0.0000
121	Q	A	-1.6227
122	I	A	-1.1454
123	M	A	0.0000
124	F	A	0.0000
125	E	A	-2.4252
126	T	A	-1.4703
127	F	A	0.0000
128	N	A	-2.2557
129	V	A	0.0000
130	P	A	-1.5403
131	A	A	0.0000
132	M	A	0.0000
133	Y	A	0.1912
134	V	A	0.0000
135	A	A	0.0000
136	I	A	0.6633
137	Q	A	0.0232
138	A	A	0.0000
139	V	A	0.0000
140	L	A	0.0000
141	S	A	0.0000
142	L	A	0.0000
143	Y	A	0.0000
144	A	A	-0.4539
145	S	A	-0.4116
146	G	A	-1.4428
147	R	A	-1.2676
148	T	A	0.0000
149	T	A	-0.2069
150	G	A	0.0000
151	I	A	0.0000
152	V	A	0.0000
153	L	A	0.0000
154	D	A	-0.6318
155	S	A	0.0000
156	G	A	-0.7189
157	D	A	-0.9834
158	G	A	0.0000
159	V	A	0.0000
160	T	A	0.0000
161	H	A	0.0000
162	N	A	0.0000
163	V	A	0.0000
164	P	A	0.0000
165	I	A	0.0000
166	Y	A	0.9163
167	E	A	-0.4239
168	G	A	0.4721
169	Y	A	1.5130
170	A	A	0.0000
171	L	A	0.3588
172	P	A	-0.1943
173	H	A	-1.1830
174	A	A	0.0000
175	I	A	0.0000
176	M	A	-0.8956
177	R	A	-1.4503
178	L	A	0.0000
179	D	A	-1.2545
180	L	A	0.0000
181	A	A	0.0000
182	G	A	0.0000
183	R	A	-1.1168
184	D	A	-0.6988
185	L	A	0.0000
186	T	A	0.0000
187	D	A	-0.9455
188	Y	A	-0.6333
189	L	A	0.0000
190	M	A	0.0000
191	K	A	-2.0531
192	I	A	0.0000
193	L	A	0.0000
194	T	A	-1.8098
195	E	A	-3.0343
196	R	A	-2.5982
197	G	A	-1.7929
198	Y	A	-0.9349
199	S	A	-0.6036
200	F	A	0.0000
201	V	A	1.1798
202	T	A	0.3516
203	T	A	-0.1141
204	A	A	-0.4536
205	E	A	-0.6695
206	R	A	-1.1397
207	E	A	-1.8957
208	I	A	-1.2752
209	V	A	0.0000
210	R	A	-2.4895
211	D	A	-2.7166
212	I	A	0.0000
213	K	A	0.0000
214	E	A	-3.1769
215	K	A	-3.0490
216	L	A	0.0000
217	C	A	0.0000
218	Y	A	-0.4471
219	V	A	0.0000
220	A	A	0.0000
221	L	A	-0.6167
222	D	A	-1.3378
223	F	A	-1.3463
224	E	A	-2.4267
225	N	A	-2.2364
226	E	A	-1.4325
227	M	A	-1.0375
228	A	A	-0.8239
229	T	A	-0.7296
230	A	A	-0.5263
231	A	A	-0.1335
232	S	A	-0.2848
233	S	A	-0.4760
234	S	A	-0.7575
235	S	A	-0.6883
236	L	A	-0.7916
237	E	A	-1.5074
238	K	A	-1.6908
239	S	A	-0.8862
240	Y	A	-1.0973
241	E	A	-1.8347
242	L	A	-1.4116
243	P	A	-1.6105
244	D	A	-2.4477
245	G	A	-1.9004
246	Q	A	-1.4203
247	V	A	-0.2952
248	I	A	0.0000
249	T	A	-0.6082
250	I	A	0.0000
251	G	A	-0.9084
252	N	A	-0.6574
253	E	A	0.0000
254	R	A	-1.0638
255	F	A	0.0000
256	R	A	-0.4492
257	C	A	0.0000
258	P	A	0.0000
259	E	A	0.0000
260	T	A	0.0000
261	L	A	0.0000
262	F	A	0.0000
263	Q	A	-0.5606
264	P	A	0.0000
265	S	A	-0.5769
266	F	A	0.1856
267	I	A	-0.0022
268	G	A	-0.5339
269	M	A	-0.8436
270	E	A	-1.8390
271	S	A	-1.1773
272	A	A	-0.8691
273	G	A	0.0000
274	I	A	0.0000
275	H	A	-0.6999
276	E	A	-0.8848
277	T	A	-0.7961
278	T	A	0.0000
279	Y	A	-0.5169
280	N	A	-1.3610
281	S	A	0.0000
282	I	A	0.0000
283	M	A	-0.8910
284	K	A	-2.1279
285	C	A	0.0000
286	D	A	-1.8014
287	I	A	-0.4418
288	D	A	-2.0300
289	I	A	0.0000
290	R	A	-1.9220
291	K	A	-2.8658
292	D	A	-2.5900
293	L	A	0.0000
294	Y	A	0.0000
295	A	A	-1.9229
296	N	A	-1.3769
297	N	A	0.0000
298	V	A	0.0000
299	M	A	0.0000
300	S	A	0.0000
301	G	A	-1.0513
302	G	A	-1.3060
303	T	A	0.0000
304	T	A	0.0000
305	M	A	-0.6207
306	Y	A	0.0000
307	P	A	-0.4104
308	G	A	-0.6199
309	I	A	0.0000
310	A	A	-1.1552
311	D	A	-2.0977
312	R	A	0.0000
313	M	A	0.0000
314	Q	A	-1.6937
315	K	A	-1.5229
316	E	A	-0.9560
317	I	A	0.0000
318	T	A	-0.7956
319	A	A	-0.1509
320	L	A	0.2345
321	A	A	-0.0834
322	P	A	-0.5795
323	S	A	-0.4752
324	T	A	-0.6062
325	M	A	-1.4141
326	K	A	-2.5194
327	I	A	0.0000
328	K	A	-1.6769
329	I	A	0.0000
330	I	A	-0.1905
331	A	A	-0.5697
332	P	A	-0.6458
333	P	A	-0.9995
334	E	A	-1.7177
335	R	A	-1.4088
336	K	A	-1.8262
337	Y	A	-0.9822
338	S	A	0.0000
339	V	A	0.0000
340	W	A	0.0000
341	I	A	0.0000
342	G	A	0.0000
343	G	A	0.0000
344	S	A	0.0000
345	I	A	0.0000
346	L	A	0.0000
347	A	A	0.0000
348	S	A	-0.2905
349	L	A	0.0000
350	S	A	-0.7629
351	T	A	-1.4532
352	F	A	0.0000
353	Q	A	-1.5159
354	Q	A	-1.7361
355	M	A	-0.8961
356	W	A	0.0000
357	I	A	0.0000
358	T	A	-1.2555
359	K	A	-2.4569
360	Q	A	-2.7942
361	E	A	-2.3991
362	Y	A	0.0000
363	D	A	-3.6138
364	E	A	-3.2154
365	A	A	-1.9842
366	G	A	-1.6170
367	P	A	-1.2254
368	S	A	-1.2678
369	I	A	0.0000
370	V	A	0.0000
371	H	A	-1.6039
372	R	A	-2.0617
373	K	A	-1.1065
374	C	A	-0.2766
461	P	S	-1.5049
462	S	S	-1.4888
463	P	S	-1.9797
464	R	S	-2.7633
465	E	S	-3.4280
466	Q	S	-2.8946
467	L	S	0.0000
468	M	S	0.0000
469	E	S	-3.6663
470	S	S	-2.5548
471	I	S	0.0000
472	R	S	-2.7711
473	K	S	-2.9172
474	G	S	-2.2401
475	K	S	-2.2614
476	E	S	-2.7929
477	L	S	-2.2005
478	K	S	-2.5303
479	Q	S	-1.6368
480	I	S	0.3819