Project name: 6f719a5d50ab269

Chain sequence(s)	A: MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.1109
• Maximal score value: 1.7382
• Average score: -0.7627
• Total score value: -211.2564

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	M	A	-1.4539
2	E	A	-2.5157
3	N	A	-2.2042
4	F	A	-2.5122
5	Q	A	-3.1109
6	K	A	-2.7648
7	V	A	-1.2851
8	E	A	-2.6039
9	K	A	-2.4210
10	I	A	-0.6929
11	G	A	-1.2598
12	E	A	-1.9480
13	G	A	-0.9983
14	T	A	0.0110
15	Y	A	0.8354
16	G	A	0.1221
17	V	A	-0.5084
18	V	A	-0.8215
19	Y	A	-1.5559
20	K	A	-1.2843
21	A	A	0.0000
22	R	A	-2.9891
23	N	A	-2.6145
24	K	A	-2.5489
25	L	A	0.0686
26	T	A	-0.6335
27	G	A	-1.4299
28	E	A	-2.2238
29	V	A	-1.4404
30	V	A	0.0000
31	A	A	-0.2866
32	L	A	0.0000
33	K	A	0.0000
34	K	A	-0.1611
35	I	A	0.5366
44	V	A	-0.3227
45	P	A	-0.4601
46	S	A	-0.6923
47	T	A	-0.9634
48	A	A	-0.6682
49	I	A	-0.7733
50	R	A	-2.0437
51	E	A	-1.6418
52	I	A	0.0000
53	S	A	-1.1939
54	L	A	-0.6282
55	L	A	-1.0785
56	K	A	-2.0752
57	E	A	-2.3344
58	L	A	-1.5906
59	N	A	-2.1596
60	H	A	-1.2611
61	P	A	-0.8619
62	N	A	0.0000
63	I	A	0.0000
64	V	A	0.0000
65	K	A	-1.6523
66	L	A	-1.0685
67	L	A	-0.6127
68	D	A	-1.1768
69	V	A	-0.3220
70	I	A	-0.7055
71	H	A	-1.5120
72	T	A	-1.8667
73	E	A	-2.8453
74	N	A	-2.7472
75	K	A	-2.3500
76	L	A	0.0000
77	Y	A	-0.3431
78	L	A	0.0000
79	V	A	0.0000
80	F	A	0.0518
81	E	A	-0.3205
82	F	A	0.4268
83	L	A	0.3881
84	H	A	-0.1971
85	Q	A	0.0000
86	D	A	-1.0260
87	L	A	0.0000
88	K	A	-2.0907
89	K	A	-2.3581
90	F	A	0.0000
91	M	A	-1.7851
92	D	A	-2.3701
93	A	A	-1.0151
94	S	A	-0.7080
95	A	A	-0.7254
96	L	A	0.9894
97	T	A	0.3927
98	G	A	-0.2350
99	I	A	0.0000
100	P	A	0.0338
101	L	A	0.4162
102	P	A	-0.2978
103	L	A	0.0000
104	I	A	0.0000
105	K	A	0.0000
106	S	A	0.0000
107	Y	A	0.0000
108	L	A	0.0000
109	F	A	0.2680
110	Q	A	0.0000
111	L	A	0.0000
112	L	A	0.0000
113	Q	A	-0.5226
114	G	A	0.0000
115	L	A	0.0000
116	A	A	0.0000
117	F	A	-0.5162
118	C	A	0.0000
119	H	A	0.0000
120	S	A	-1.1666
121	H	A	-1.5292
122	R	A	-2.0109
123	V	A	-0.7813
124	L	A	-0.6485
125	H	A	0.0000
126	R	A	-1.8358
127	D	A	-1.3723
128	L	A	0.0000
129	K	A	0.0000
130	P	A	0.0000
131	Q	A	-1.7358
132	N	A	0.0000
133	L	A	0.0000
134	L	A	-0.1779
135	I	A	0.0000
136	N	A	-0.6018
137	T	A	-0.8150
138	E	A	-1.6815
139	G	A	0.0000
140	A	A	-0.5977
141	I	A	0.0000
142	K	A	-0.3680
143	L	A	0.0000
144	A	A	-0.4663
145	D	A	-0.5324
146	F	A	-0.2667
147	G	A	-0.1691
148	L	A	0.4224
162	E	A	-0.7678
163	V	A	1.4592
164	V	A	1.7382
165	T	A	0.6009
166	L	A	-0.0009
167	W	A	-0.0662
168	Y	A	0.0000
169	R	A	-0.6851
170	A	A	0.0000
171	P	A	0.0000
172	E	A	0.0000
173	I	A	-0.3873
174	L	A	0.0000
175	L	A	0.0000
176	G	A	-0.7811
177	C	A	-0.4129
178	K	A	-0.8734
179	Y	A	0.6844
180	Y	A	0.3149
181	S	A	-0.3420
182	T	A	-0.6492
183	A	A	0.0000
184	V	A	0.0000
185	D	A	0.0000
186	I	A	0.0000
187	W	A	0.0000
188	S	A	0.0000
189	L	A	0.0000
190	G	A	0.0000
191	C	A	0.0000
192	I	A	0.0000
193	F	A	0.0000
194	A	A	0.0000
195	E	A	-1.3318
196	M	A	0.0000
197	V	A	-0.7363
198	T	A	-1.5222
199	R	A	-2.7654
200	R	A	-2.7145
201	A	A	-1.1934
202	L	A	-0.5879
203	F	A	0.0000
204	P	A	-0.7093
205	G	A	0.0000
206	D	A	-1.7510
207	S	A	-1.6106
208	E	A	-1.8393
209	I	A	-0.3547
210	D	A	-1.1490
211	Q	A	0.0000
212	L	A	0.0000
213	F	A	-0.8329
214	R	A	-1.3982
215	I	A	0.0000
216	F	A	0.0000
217	R	A	-2.6738
218	T	A	-2.1521
219	L	A	0.0000
220	G	A	0.0000
221	T	A	-1.3858
222	P	A	0.0000
223	D	A	-1.0999
224	E	A	-0.7444
225	V	A	1.1502
226	V	A	0.5972
227	W	A	0.0000
228	P	A	-0.5407
229	G	A	-0.5624
230	V	A	0.0000
231	T	A	-1.2581
232	S	A	-0.9001
233	M	A	-0.9412
234	P	A	-1.4736
235	D	A	-2.1851
236	Y	A	-1.6950
237	K	A	-2.0180
238	P	A	-1.5160
239	S	A	-1.0591
240	F	A	0.0000
241	P	A	-1.2725
242	K	A	-2.1768
243	W	A	-1.5354
244	A	A	-1.8432
245	R	A	-3.0312
246	Q	A	-2.9444
247	D	A	-2.9352
248	F	A	-1.9433
249	S	A	-1.9885
250	K	A	-2.3541
251	V	A	-1.2217
252	V	A	0.0000
253	P	A	-1.1400
254	P	A	-1.0666
255	L	A	0.0000
256	D	A	-2.3664
257	E	A	-2.9943
258	D	A	-2.5736
259	G	A	0.0000
260	R	A	-1.7575
261	S	A	-1.4395
262	L	A	0.0000
263	L	A	0.0000
264	S	A	-0.7655
265	Q	A	-0.9318
266	M	A	0.0000
267	L	A	0.0000
268	H	A	-1.0310
269	Y	A	0.0000
270	D	A	0.0000
271	P	A	-1.2013
272	N	A	-2.0882
273	K	A	-2.1728
274	R	A	0.0000
275	I	A	-0.9563
276	S	A	-0.9998
277	A	A	0.0000
278	K	A	-1.6651
279	A	A	-0.7147
280	A	A	0.0000
281	L	A	-0.4504
282	A	A	-0.4074
283	H	A	-0.6667
284	P	A	-1.0978
285	F	A	0.0000
286	F	A	0.0000
287	Q	A	-2.1088
288	D	A	-2.2453
289	V	A	-1.1590
290	T	A	-1.1078
291	K	A	-1.4866
292	P	A	-0.4430
293	V	A	0.5560
294	P	A	0.0000
295	H	A	-0.9880
296	L	A	-0.7344
297	R	A	-1.1936
298	L	A	0.6910