Project name: C5_DS

Chain sequence(s)	H: EVQLVESGGGLVQPGGSLRLSCAASGFTFSNYAMHWVRQAPGKGLEWVSGISSTGSDKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKSTVWWYLADFDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDRKL; L: DIQMTQSPSSLSASVGDRVTITCRASQSISSWLNWYQQKPGKAPKLLIYATSRLHSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSYSTPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.8491
• Maximal score value: 2.8318
• Average score: -0.6873
• Total score value: -296.2381

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	D	L	-2.3670
2	I	L	-1.6009
3	Q	L	-2.2058
4	M	L	0.0000
5	T	L	-1.3420
6	Q	L	0.0000
7	S	L	-0.7693
8	P	L	-0.6104
9	S	L	-0.7715
10	S	L	-0.7202
11	L	L	-0.5288
12	S	L	-0.7414
13	A	L	0.0000
14	S	L	-1.0018
15	V	L	-0.4680
16	G	L	-0.9793
17	D	L	-1.7783
18	R	L	-2.3826
19	V	L	0.0000
20	T	L	-0.6549
21	I	L	0.0000
22	T	L	-0.7976
23	C	L	0.0000
24	R	L	-2.6321
25	A	L	0.0000
26	S	L	-1.9076
27	Q	L	-2.1162
28	S	L	-1.2156
29	I	L	0.0000
30	S	L	-0.1542
31	S	L	-0.0436
32	W	L	0.9098
33	L	L	0.0000
34	N	L	0.0000
35	W	L	0.0000
36	Y	L	0.0000
37	Q	L	0.0000
38	Q	L	0.0000
39	K	L	-1.6856
40	P	L	-1.3407
41	G	L	-1.7763
42	K	L	-2.4962
43	A	L	-1.5486
44	P	L	0.0000
45	K	L	-1.4508
46	L	L	0.0000
47	L	L	0.0000
48	I	L	0.0000
49	Y	L	0.0000
50	A	L	-0.0298
51	T	L	-0.6366
52	S	L	-1.0883
53	R	L	-1.6971
54	L	L	-0.4629
55	H	L	-0.7784
56	S	L	-0.5831
57	G	L	-0.4947
58	V	L	-0.2881
59	P	L	-0.3028
60	S	L	-0.3731
61	R	L	-0.6810
62	F	L	0.0000
63	S	L	-0.5711
64	G	L	-0.6116
65	S	L	-0.8195
66	G	L	-0.9516
67	S	L	-0.8815
68	G	L	-1.0489
69	T	L	-1.5214
70	D	L	-1.7062
71	F	L	0.0000
72	T	L	-0.6867
73	L	L	0.0000
74	T	L	-0.6350
75	I	L	0.0000
76	S	L	-1.3783
77	S	L	-1.2121
78	L	L	0.0000
79	Q	L	-1.1740
80	P	L	-1.7145
81	E	L	-2.2487
82	D	L	0.0000
83	F	L	-1.1681
84	A	L	0.0000
85	T	L	-0.7057
86	Y	L	0.0000
87	Y	L	0.0000
88	C	L	0.0000
89	Q	L	0.0000
90	Q	L	0.0000
91	S	L	0.0000
92	Y	L	1.0992
93	S	L	0.5821
94	T	L	0.2980
95	P	L	-0.4427
96	W	L	0.0000
97	T	L	-0.7494
98	F	L	0.0000
99	G	L	0.0000
100	Q	L	-1.4646
101	G	L	0.0000
102	T	L	0.0000
103	K	L	-1.3077
104	V	L	0.0000
105	E	L	-1.0892
106	I	L	0.0000
107	K	L	-1.4544
108	R	L	-0.9929
109	T	L	-0.2423
110	V	L	0.0313
111	A	L	-0.0651
112	A	L	-0.2418
113	P	L	0.0000
114	S	L	-0.2659
115	V	L	0.0000
116	F	L	0.0000
117	I	L	0.0000
118	F	L	0.0000
119	P	L	-0.6372
120	P	L	-0.6993
121	S	L	-1.3901
122	D	L	-2.6010
123	E	L	-2.2600
124	Q	L	0.0000
125	L	L	-1.9891
126	K	L	-2.5496
127	S	L	-1.5681
128	G	L	-1.0687
129	T	L	-0.8950
130	A	L	0.0000
131	S	L	0.0000
132	V	L	0.0000
133	V	L	0.0000
134	C	L	0.0000
135	L	L	0.0000
136	L	L	0.0000
137	N	L	-0.4315
138	N	L	-0.9619
139	F	L	0.0000
140	Y	L	0.0000
141	P	L	-1.8345
142	R	L	-3.0193
143	E	L	-3.1944
144	A	L	-2.3737
145	K	L	-2.4064
146	V	L	0.0000
147	Q	L	-0.5298
148	W	L	0.0000
149	K	L	-0.5629
150	V	L	0.0000
151	D	L	-2.0443
152	N	L	-1.4274
153	A	L	-0.3379
154	L	L	0.6952
155	Q	L	-0.2519
156	S	L	-0.6613
157	G	L	-1.1797
158	N	L	-1.3692
159	S	L	-1.4029
160	Q	L	-1.4445
161	E	L	-1.7588
162	S	L	-0.9177
163	V	L	-0.8040
164	T	L	-1.1281
165	E	L	-2.1306
166	Q	L	0.0000
167	D	L	-2.0525
168	S	L	-2.1300
169	K	L	-2.4668
170	D	L	-1.6200
171	S	L	0.0000
172	T	L	0.0000
173	Y	L	0.0000
174	S	L	0.0000
175	L	L	0.0000
176	S	L	0.0000
177	S	L	0.0000
178	T	L	-0.6959
179	L	L	0.0000
180	T	L	-0.6392
181	L	L	-0.8816
182	S	L	-1.1603
183	K	L	-2.1302
184	A	L	-2.1496
185	D	L	-3.0423
186	Y	L	0.0000
187	E	L	-3.8117
188	K	L	-3.8491
189	H	L	-3.1901
190	K	L	-3.2074
191	V	L	-1.7128
192	Y	L	0.0000
193	A	L	0.0000
194	C	L	0.0000
195	E	L	-0.5787
196	V	L	0.0000
197	T	L	-1.1767
198	H	L	0.0000
199	Q	L	-1.7818
200	G	L	-0.5742
201	L	L	-0.2936
202	S	L	-0.4738
203	S	L	-0.4068
204	P	L	-0.4746
205	V	L	0.0677
206	T	L	-0.3996
207	K	L	-0.8675
208	S	L	-0.8861
209	F	L	0.0000
210	N	L	-2.3511
211	R	L	-2.7362
212	G	L	-2.3133
213	E	L	-2.6503
1	E	H	-1.8560
2	V	H	-0.7823
3	Q	H	-0.8602
4	L	H	0.0000
5	V	H	0.9573
6	E	H	0.0000
7	S	H	-0.3772
8	G	H	-0.7537
9	G	H	-0.4481
10	G	H	-0.4763
11	L	H	-0.0617
12	V	H	-0.6375
13	Q	H	-1.5995
14	P	H	-1.8237
15	G	H	-1.5891
16	G	H	-1.3396
17	S	H	-1.6724
18	L	H	-1.3644
19	R	H	-2.2232
20	L	H	0.0000
21	S	H	-0.3954
22	C	H	0.0000
23	A	H	-0.0910
24	A	H	0.0000
25	S	H	-0.5598
26	G	H	-1.0256
27	F	H	-0.4892
28	T	H	-0.4649
29	F	H	0.0000
30	S	H	-1.0466
31	N	H	-1.2496
32	Y	H	-0.1246
33	A	H	0.0000
34	M	H	0.0000
35	H	H	0.0000
36	W	H	0.0000
37	V	H	0.0000
38	R	H	0.0000
39	Q	H	-0.8483
40	A	H	-1.1955
41	P	H	-0.9964
42	G	H	-1.4692
43	K	H	-2.3215
44	G	H	-1.5332
45	L	H	0.0000
46	E	H	-1.1237
47	W	H	0.0000
48	V	H	0.0000
49	S	H	0.0000
50	G	H	0.0000
51	I	H	0.0000
52	S	H	-0.8689
53	S	H	-0.9611
54	T	H	-0.9704
55	G	H	-1.1502
56	S	H	-1.1730
57	D	H	-1.7409
58	K	H	-1.7792
59	Y	H	-0.7216
60	Y	H	-0.9566
61	A	H	0.0000
62	D	H	-2.5925
63	S	H	-1.7828
64	V	H	0.0000
65	K	H	-2.5138
66	G	H	-1.8293
67	R	H	-1.7788
68	F	H	0.0000
69	T	H	-1.2737
70	I	H	0.0000
71	S	H	-0.9115
72	R	H	-1.1107
73	D	H	-1.8049
74	N	H	-1.9970
75	S	H	-1.6870
76	K	H	-2.4125
77	N	H	-1.7267
78	T	H	0.0000
79	L	H	0.0000
80	Y	H	-0.7023
81	L	H	0.0000
82	Q	H	-1.9167
83	M	H	0.0000
84	N	H	-2.2226
85	S	H	-1.5727
86	L	H	0.0000
87	R	H	-2.6587
88	A	H	-1.8593
89	E	H	-2.3196
90	D	H	0.0000
91	T	H	-0.7732
92	A	H	0.0000
93	V	H	0.1546
94	Y	H	0.0000
95	Y	H	0.0000
96	C	H	0.0000
97	A	H	0.0000
98	K	H	0.0000
99	S	H	0.0000
100	T	H	1.0321
101	V	H	2.0550
102	W	H	2.8318
103	W	H	2.1113
104	Y	H	1.9608
105	L	H	2.6157
106	A	H	0.0000
107	D	H	0.0000
108	F	H	0.0000
109	D	H	-0.4837
110	V	H	-0.3614
111	W	H	0.0000
112	G	H	0.0000
113	Q	H	-1.4053
114	G	H	-0.6844
115	T	H	-0.1198
116	L	H	0.0922
117	V	H	0.0000
118	T	H	-0.5094
119	V	H	0.0000
120	S	H	-0.8098
121	S	H	-0.7081
122	A	H	-0.5069
123	S	H	-0.6860
124	T	H	-0.9059
125	K	H	-1.5580
126	G	H	-1.5269
127	P	H	-0.6934
128	S	H	-0.4316
129	V	H	0.0000
130	F	H	0.0000
131	P	H	-0.7751
132	L	H	0.0000
133	A	H	-0.2405
134	P	H	-0.3583
135	S	H	-0.8219
136	S	H	-1.1285
137	K	H	-2.0395
138	S	H	0.0000
139	T	H	-1.0798
140	S	H	-1.0817
141	G	H	-1.0768
142	G	H	-0.9198
143	T	H	-0.6627
144	A	H	0.0000
145	A	H	0.0000
146	L	H	0.0000
147	G	H	0.0000
148	C	H	0.0000
149	L	H	0.0000
150	V	H	0.0000
151	K	H	0.0000
152	D	H	-0.5509
153	Y	H	0.0000
154	F	H	0.0000
155	P	H	0.0000
156	E	H	-0.4952
157	P	H	-0.7209
158	V	H	-0.6188
159	T	H	-0.5324
160	V	H	-0.1939
161	S	H	-0.4461
162	W	H	0.0000
163	N	H	-0.8332
164	S	H	-0.7396
165	G	H	-0.6117
166	A	H	-0.2880
167	L	H	-0.0618
168	T	H	-0.2178
169	S	H	-0.2074
170	G	H	-0.2774
171	V	H	0.1247
172	H	H	-0.3599
173	T	H	0.0013
174	F	H	0.0000
175	P	H	-0.3239
176	A	H	0.2036
177	V	H	0.4957
178	L	H	1.0940
179	Q	H	0.2377
180	S	H	-0.0820
181	S	H	-0.2360
182	G	H	0.0063
183	L	H	0.0370
184	Y	H	0.3485
185	S	H	0.2139
186	L	H	0.0000
187	S	H	0.0000
188	S	H	0.0000
189	V	H	0.0000
190	V	H	0.0000
191	T	H	-0.1709
192	V	H	0.0000
193	P	H	-0.5959
194	S	H	-0.5438
195	S	H	-0.5676
196	S	H	-0.5083
197	L	H	-0.2178
198	G	H	-0.5866
199	T	H	-0.6501
200	Q	H	-0.9613
201	T	H	-0.8002
202	Y	H	0.0000
203	I	H	-1.2592
204	C	H	0.0000
205	N	H	-1.5926
206	V	H	0.0000
207	N	H	-1.8287
208	H	H	0.0000
209	K	H	-2.7269
210	P	H	-1.6587
211	S	H	-1.8789
212	N	H	-2.6021
213	T	H	-2.0906
214	K	H	-2.7338
215	V	H	-1.8850
216	D	H	-2.7354
217	R	H	-2.2923
218	K	H	-2.2798