Project name: ADAM(IgG4)

Status: done

submitted: 2021-08-10 01:19:32, status changed: 2021-08-10 01:30:17
Settings
Chain sequence(s) A: TFTGVIPPVMTPLHADGSVDVESLRKLVDHLINGGVDGLFALGSSGEAAFLTRAQRKLALTTIIEHTAGRVPVTAGVIETTTARVIELVEDALEAGAEGLVATAPFYTRTHDVEIEEHFRKIHAAAPELPLFAFNIPVSVHSNLNPVMLLTLAKDGVLAGTKKDSSGNDGAIRSLIEARDDAGLTEQFKILTGSETTVDFAYLAGADGVVPGLGNVDPAAYAALAKLCLDGKWAEAAALQKRINHLFHIVFVGDTSHMSGSSAGLGGFKTALAHLGIIESNAMAVPHQSLSDEETARIHAIVDEFLYT
B: TFTGVIPPVMTPLHADGSVDVESLRKLVDHLINGGVDGLFALGSSGEAAFLTRAQRKLALTTIIEHTAGRVPVTAGVIETTTARVIELVEDALEAGAEGLVATAPFYTRTHDVEIEEHFRKIHAAAPELPLFAFNIPVSVHSNLNPVMLLTLAKDGVLAGTKKDSSGNDGAIRSLIEARDDAGLTEQFKILTGSETTVDFAYLAGADGVVPGLGNVDPAAYAALAKLCLDGKWAEAAALQKRINHLFHIVFVGDTSHMSGSSAGLGGFKTALAHLGIIESNAMAVPHQSLSDEETARIHAIVDEFLY
Distance of aggregation 10 Å
Dynamic mode No
Show buried residues

Minimal score value
-3.3038
Maximal score value
2.1352
Average score
-0.5948
Total score value
-364.5894

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index residue name chain Aggrescan3D score mutation
residue index residue name chain Aggrescan3D score
mutation
5 T A -0.4411
6 F A 0.0000
7 T A -0.5692
8 G A -0.8509
9 V A 0.0000
10 I A 0.0000
11 P A 0.0000
12 P A 0.0000
13 V A 0.0000
14 M A 0.0000
15 T A 0.0000
16 P A 0.0000
17 L A 0.0000
18 H A -1.3590
19 A A -1.1332
20 D A -1.9680
21 G A -1.1436
22 S A -0.8076
23 V A 0.0000
24 D A 0.0000
25 V A -0.9716
26 E A -2.7102
27 S A 0.0000
28 L A 0.0000
29 R A -2.9908
30 K A -3.1085
31 L A 0.0000
32 V A 0.0000
33 D A -1.9412
34 H A -1.4177
35 L A 0.0000
36 I A -1.3378
37 N A -1.6227
38 G A -1.0598
39 G A -1.0777
40 V A 0.0000
41 D A -1.5509
42 G A 0.0000
43 L A 0.0000
44 F A 0.0000
45 A A 0.0000
46 L A 0.0000
47 G A 0.0000
48 S A -0.0661
49 S A -0.0232
50 G A 0.0000
51 E A 0.0000
52 A A 0.0000
53 A A 0.0000
54 F A 0.0000
55 L A 0.0000
56 T A -0.5027
57 R A -1.0081
58 A A -0.4846
59 Q A -0.3817
60 R A 0.0000
61 K A -0.7544
62 L A 0.3541
63 A A 0.0000
64 L A 0.0000
65 T A -0.7207
66 T A 0.0000
67 I A 0.0000
68 I A -1.1063
69 E A -2.0261
70 H A -1.7997
71 T A 0.0000
72 A A -1.0786
73 G A -1.2247
74 R A -1.6033
75 V A -0.8821
76 P A -0.8293
77 V A 0.0000
78 T A 0.0000
79 A A 0.0000
80 G A 0.0000
81 V A 0.0000
82 I A 0.0000
83 E A 0.0000
84 T A 0.0000
85 T A 0.0000
86 T A 0.0000
87 A A 0.0680
88 R A 0.0000
89 V A 0.0000
90 I A -0.4662
91 E A -1.0359
92 L A 0.0000
93 V A 0.0000
94 E A -2.2080
95 D A -1.8507
96 A A 0.0000
97 L A -1.1649
98 E A -2.2073
99 A A -1.4892
100 G A -1.1962
101 A A 0.0000
102 E A -1.3454
103 G A 0.0000
104 L A 0.0000
105 V A 0.0000
106 A A 0.0000
107 T A 0.0000
108 A A 0.0000
109 P A 0.0000
110 F A 0.0000
111 Y A 0.0000
112 T A -0.9388
113 R A -1.9344
114 T A -1.2710
115 H A -1.2411
116 D A -1.2854
117 V A -0.6515
118 E A 0.0000
119 I A 0.0000
120 E A -1.2956
121 E A -1.4126
122 H A 0.0000
123 F A 0.0000
124 R A -1.7181
125 K A -1.3035
126 I A 0.0000
127 H A -1.0648
128 A A -0.7501
129 A A -0.7800
130 A A 0.0000
131 P A -1.3914
132 E A -2.1209
133 L A 0.0000
134 P A -0.8367
135 L A 0.0000
136 F A 0.0000
137 A A 0.0000
138 F A 0.0000
139 N A 0.0000
140 I A 0.0000
141 P A -0.4181
142 V A 0.0713
143 S A -0.3198
144 V A 0.0000
145 H A -1.1793
146 S A -1.3709
147 N A -1.6142
148 L A 0.0000
149 N A -0.5138
150 P A 0.3024
151 V A 1.5516
152 M A 0.0000
153 L A 0.0000
154 L A 0.0000
155 T A -0.7837
156 L A 0.0000
157 A A 0.0000
158 K A -2.9382
159 D A -2.9855
160 G A -2.0999
161 V A 0.0000
162 L A 0.0000
163 A A -1.0690
164 G A 0.0000
165 T A 0.0000
166 K A 0.0000
167 D A 0.0000
168 S A -0.4362
169 S A -0.8403
170 G A -1.2549
171 N A -1.9638
172 D A -1.3841
173 G A -1.2668
174 A A -1.3218
175 I A 0.0000
176 R A -1.3881
177 S A -1.4563
178 L A 0.0000
179 I A 0.0000
180 E A -3.0235
181 A A -1.8742
182 R A 0.0000
183 D A -3.0868
184 D A -2.9725
185 A A -1.9221
186 G A -2.2405
187 L A 0.0000
188 T A -2.3492
189 E A -2.6248
190 Q A -2.5409
191 F A 0.0000
192 K A -1.0918
193 I A 0.0000
194 L A 0.0000
195 T A 0.0000
196 G A -0.3030
197 S A -0.4311
198 E A -0.4057
199 T A -0.5296
200 T A -0.1262
201 V A 0.0000
202 D A 0.0000
203 F A 1.8269
204 A A 0.0000
205 Y A 0.0000
206 L A 2.1352
207 A A 0.3642
208 G A -0.0242
209 A A -0.2140
210 D A -0.8053
211 G A 0.0000
212 V A 0.0000
213 V A 0.0000
214 P A 0.0000
215 G A 0.0000
216 L A 0.0000
217 G A 0.0000
218 N A 0.0000
219 V A 0.0000
220 D A 0.0000
221 P A 0.0000
222 A A -0.1177
223 A A 0.0000
224 Y A 0.0000
225 A A 0.0000
226 A A -0.2911
227 L A 0.0000
228 A A 0.0000
229 K A -1.6444
230 L A -1.3123
231 C A 0.0000
232 L A 0.1388
233 D A -1.7665
234 G A -1.1732
235 K A -1.8125
236 W A -0.2441
237 A A -0.8428
238 E A -2.0000
239 A A 0.0000
240 A A -0.8223
241 A A -1.2843
242 L A 0.0000
243 Q A 0.0000
244 K A -2.4393
245 R A -1.7518
246 I A 0.0000
247 N A -1.4366
248 H A -1.5543
249 L A 0.0000
250 F A -0.1084
251 H A 0.0868
252 I A 0.0000
253 V A 0.9145
254 F A 1.6615
255 V A 0.0588
256 G A 0.0000
257 D A -1.6965
258 T A -1.1595
259 S A -1.3474
260 H A -1.6565
261 M A 0.0000
262 S A 0.0000
263 G A -0.8947
264 S A -0.7065
265 S A 0.0000
266 A A 0.0000
267 G A 0.4327
268 L A 0.0889
269 G A 0.0000
270 G A 0.0000
271 F A 0.0000
272 K A 0.0000
273 T A 0.0000
274 A A 0.0000
275 L A 0.0000
276 A A -0.7957
277 H A -0.8286
278 L A -0.2895
279 G A -0.7702
280 I A -1.1995
281 I A 0.0000
282 E A -2.4610
283 S A -1.2796
284 N A -0.8915
285 A A -0.7920
286 M A -0.2064
287 A A 0.0000
288 V A -0.0221
289 P A 0.0000
290 H A 0.0000
291 Q A -0.4071
292 S A -0.5678
293 L A 0.0000
294 S A -2.1202
295 D A -3.0837
296 E A -3.2778
297 E A -2.4283
298 T A -2.0894
299 A A -2.1751
300 R A -2.7179
301 I A 0.0000
302 H A -1.6277
303 A A -1.7907
304 I A 0.0000
305 V A 0.0000
306 D A -2.4759
307 E A -2.5367
308 F A -1.0757
309 L A -0.3710
310 Y A 0.4305
311 T A 0.4334
5 T B -0.4317
6 F B 0.0000
7 T B -0.5342
8 G B -0.8178
9 V B 0.0000
10 I B 0.0000
11 P B 0.0000
12 P B 0.0000
13 V B 0.0000
14 M B 0.0000
15 T B 0.0000
16 P B 0.0000
17 L B 0.0000
18 H B -1.4213
19 A B -1.3503
20 D B -1.9238
21 G B -1.0241
22 S B -0.7884
23 V B 0.0000
24 D B 0.0000
25 V B -0.9565
26 E B -2.6218
27 S B 0.0000
28 L B 0.0000
29 R B -2.8597
30 K B -2.7304
31 L B 0.0000
32 V B 0.0000
33 D B -1.7461
34 H B -1.3092
35 L B 0.0000
36 I B -1.2585
37 N B -1.4959
38 G B -1.0622
39 G B -1.1143
40 V B 0.0000
41 D B -1.4879
42 G B 0.0000
43 L B 0.0000
44 F B 0.0000
45 A B 0.0000
46 L B 0.0000
47 G B 0.0000
48 S B -0.0667
49 S B -0.0259
50 G B 0.0000
51 E B 0.0000
52 A B 0.0000
53 A B 0.0000
54 F B 0.0000
55 L B 0.0000
56 T B -0.5301
57 R B -1.0629
58 A B -0.4843
59 Q B -0.3643
60 R B 0.0000
61 K B -0.6929
62 L B 0.4770
63 A B 0.0000
64 L B 0.0000
65 T B -0.6169
66 T B 0.0000
67 I B 0.0000
68 I B -1.2002
69 E B -2.0409
70 H B -1.7571
71 T B 0.0000
72 A B -1.0811
73 G B -1.2024
74 R B -1.4027
75 V B -0.8310
76 P B -0.8401
77 V B 0.0000
78 T B 0.0000
79 A B 0.0000
80 G B -0.0532
81 V B 0.0000
82 I B 0.0000
83 E B 0.0000
84 T B 0.0000
85 T B 0.0000
86 T B 0.0000
87 A B -0.0075
88 R B 0.0000
89 V B 0.0000
90 I B -0.4298
91 E B -1.0563
92 L B 0.0000
93 V B 0.0000
94 E B -2.2401
95 D B -1.8611
96 A B 0.0000
97 L B -1.1996
98 E B -2.2046
99 A B -1.4920
100 G B -1.4138
101 A B 0.0000
102 E B -1.4960
103 G B 0.0000
104 L B 0.0000
105 V B 0.0000
106 A B 0.0000
107 T B 0.0000
108 A B 0.0000
109 P B 0.0000
110 F B 0.0000
111 Y B 0.0000
112 T B -0.8661
113 R B -1.9261
114 T B -1.2628
115 H B -1.2100
116 D B -1.2118
117 V B -0.5398
118 E B 0.0000
119 I B 0.0000
120 E B -1.0269
121 E B -1.0030
122 H B 0.0000
123 F B 0.0000
124 R B -1.4862
125 K B -1.1387
126 I B 0.0000
127 H B -0.9618
128 A B -0.7080
129 A B -0.7583
130 A B 0.0000
131 P B -1.3737
132 E B -2.1440
133 L B 0.0000
134 P B -0.8627
135 L B 0.0000
136 F B 0.0000
137 A B 0.0000
138 F B 0.0000
139 N B 0.0000
140 I B 0.0000
141 P B -0.4016
142 V B 0.0561
143 S B -0.3122
144 V B 0.0000
145 H B -1.0577
146 S B -1.3065
147 N B -1.5879
148 L B 0.0000
149 N B -0.4730
150 P B 0.3867
151 V B 1.6215
152 M B 0.0000
153 L B 0.0000
154 L B -0.2032
155 T B -0.6586
156 L B 0.0000
157 A B 0.0000
158 K B -2.8755
159 D B -2.9332
160 G B -2.0423
161 V B 0.0000
162 L B 0.0000
163 A B -1.0200
164 G B 0.0000
165 T B 0.0000
166 K B 0.0000
167 D B 0.0000
168 S B -0.4488
169 S B -0.8741
170 G B -1.2596
171 N B -1.9621
172 D B -1.4152
173 G B -1.2875
174 A B -1.3202
175 I B 0.0000
176 R B -1.4532
177 S B -1.4609
178 L B 0.0000
179 I B 0.0000
180 E B -2.9605
181 A B -1.8191
182 R B 0.0000
183 D B -3.0261
184 D B -2.9380
185 A B -1.8692
186 G B -2.0207
187 L B 0.0000
188 T B -2.3153
189 E B -2.5952
190 Q B -2.4717
191 F B 0.0000
192 K B -1.0334
193 I B 0.0000
194 L B 0.0000
195 T B 0.0000
196 G B -0.2956
197 S B -0.4423
198 E B -0.3998
199 T B -0.5713
200 T B -0.1780
201 V B 0.0000
202 D B 0.0000
203 F B 1.6603
204 A B 0.0000
205 Y B 0.0000
206 L B 2.0673
207 A B 0.3382
208 G B -0.0234
209 A B -0.2198
210 D B -0.7538
211 G B 0.0000
212 V B 0.0000
213 V B 0.0000
214 P B 0.0000
215 G B 0.0000
216 L B 0.0000
217 G B 0.0000
218 N B 0.0000
219 V B 0.0000
220 D B 0.0000
221 P B 0.0000
222 A B 0.0178
223 A B 0.0000
224 Y B 0.0000
225 A B -0.7132
226 A B -0.2409
227 L B 0.0000
228 A B 0.0000
229 K B -1.6655
230 L B -1.2839
231 C B 0.0000
232 L B 0.1267
233 D B -1.8081
234 G B -1.2059
235 K B -1.8204
236 W B -0.2267
237 A B -0.7314
238 E B -1.7229
239 A B 0.0000
240 A B -0.7756
241 A B -1.2124
242 L B 0.0000
243 Q B 0.0000
244 K B -2.4659
245 R B -1.7698
246 I B 0.0000
247 N B -1.4811
248 H B -1.5856
249 L B 0.0000
250 F B -0.1554
251 H B 0.0397
252 I B 0.0000
253 V B 0.9053
254 F B 1.6419
255 V B 0.0279
256 G B 0.0000
257 D B -1.7300
258 T B -1.1235
259 S B -1.3546
260 H B -1.6513
261 M B 0.0000
262 S B 0.0000
263 G B -0.8547
264 S B -0.6678
265 S B 0.0000
266 A B 0.0000
267 G B 0.4417
268 L B 0.0796
269 G B 0.0000
270 G B 0.0000
271 F B 0.0000
272 K B 0.0000
273 T B 0.0000
274 A B 0.0000
275 L B 0.0000
276 A B -0.8518
277 H B -0.8626
278 L B -0.3164
279 G B -0.8211
280 I B -1.1448
281 I B 0.0000
282 E B -2.4443
283 S B -1.2954
284 N B -0.9130
285 A B -0.7616
286 M B -0.1329
287 A B 0.0000
288 V B 0.2663
289 P B 0.0000
290 H B 0.0000
291 Q B -0.3689
292 S B -0.5254
293 L B 0.0000
294 S B -2.1087
295 D B -3.0615
296 E B -3.3038
297 E B -2.4146
298 T B -2.1226
299 A B -2.2009
300 R B -2.8952
301 I B 0.0000
302 H B -1.8309
303 A B -1.7926
304 I B 0.0000
305 V B 0.0000
306 D B -2.5626
307 E B -2.4502
308 F B -0.9277
309 L B 0.0556
310 Y B 1.0182

 

Laboratory of Theory of Biopolymers 2015