Project name: 6mhr:A

Chain sequence(s)	A: QVQLQQWGAGLLKPSETLSLTCAVYGGSFSGYYWSWIRQSPEKGLEWIGEINHGGYVTYNPSLESRVTISVDTSKNQFSLKLSSVTAADTAVYYCARDYGPGNYDWYFDLWGRGTLVTVSSASTKGPSVFPLAPSSSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -2.8183
• Maximal score value: 2.5023
• Average score: -0.3984
• Total score value: -87.2457

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	Q	A	-1.2113
2	V	A	-0.4906
3	Q	A	-1.2677
4	L	A	0.0000
5	Q	A	-1.4515
6	Q	A	0.0000
7	W	A	0.0949
8	G	A	0.1309
9	A	A	0.1991
10	G	A	0.4623
11	L	A	0.4612
12	L	A	0.0000
13	K	A	-1.2384
14	P	A	-0.9770
15	S	A	-1.2523
16	E	A	-1.8306
17	T	A	-1.3125
18	L	A	0.0000
19	S	A	-0.7453
20	L	A	0.0000
21	T	A	-0.3924
22	C	A	0.0000
23	A	A	0.0000
24	V	A	0.0000
25	Y	A	0.0374
26	G	A	-0.3854
27	G	A	-0.4323
28	S	A	-0.2541
29	F	A	0.0000
30	S	A	-0.7139
31	G	A	-0.5392
32	Y	A	0.0538
33	Y	A	0.4710
34	W	A	0.0000
35	S	A	0.0000
36	W	A	0.0000
37	I	A	0.0000
38	R	A	0.0000
39	Q	A	-0.4701
40	S	A	-1.1156
41	P	A	-1.5610
42	E	A	-2.7409
43	K	A	-2.6056
44	G	A	-1.2077
45	L	A	0.4223
46	E	A	-0.1069
47	W	A	0.2654
48	I	A	0.0000
49	G	A	0.0000
50	E	A	0.2689
51	I	A	0.0000
52	N	A	-0.1027
53	H	A	-0.8617
54	G	A	-0.4486
55	G	A	0.0592
56	Y	A	1.3325
57	V	A	1.3454
58	T	A	0.3620
59	Y	A	-0.3487
60	N	A	-0.8189
61	P	A	-1.0719
62	S	A	-0.9226
63	L	A	0.0000
64	E	A	-2.1826
65	S	A	-1.3939
66	R	A	-1.3766
67	V	A	0.0000
68	T	A	-0.7549
69	I	A	0.0000
70	S	A	-0.2266
71	V	A	-0.5576
72	D	A	-1.5432
73	T	A	-1.4206
74	S	A	-1.4249
75	K	A	-2.1171
76	N	A	-1.4588
77	Q	A	-1.2524
78	F	A	0.0000
79	S	A	-0.4447
80	L	A	0.0000
81	K	A	-1.3278
82	L	A	0.0000
83	S	A	-1.0461
84	S	A	-1.1092
85	V	A	0.0000
86	T	A	-0.4796
87	A	A	-0.1251
88	A	A	-0.4101
89	D	A	0.0000
90	T	A	0.0851
91	A	A	0.0000
92	V	A	0.8124
93	Y	A	0.0000
94	Y	A	-0.0445
95	C	A	0.0000
96	A	A	0.0000
97	R	A	0.2932
98	D	A	0.0000
99	Y	A	1.4069
100	G	A	0.6015
101	P	A	-0.2000
102	G	A	-0.7636
103	N	A	-0.9341
104	Y	A	0.8507
105	D	A	0.8666
106	W	A	1.9338
107	Y	A	2.1984
108	F	A	1.3475
109	D	A	0.2423
110	L	A	0.1655
111	W	A	-0.2570
112	G	A	-1.1674
113	R	A	-1.7789
114	G	A	0.0000
115	T	A	0.3967
116	L	A	1.5030
117	V	A	0.0000
118	T	A	0.3431
119	V	A	0.0000
120	S	A	-0.3298
121	S	A	-0.5576
122	A	A	-0.6248
123	S	A	-0.8042
124	T	A	-1.1954
125	K	A	-2.0714
126	G	A	-1.9583
127	P	A	0.0000
128	S	A	-0.3727
129	V	A	0.0000
130	F	A	0.9021
131	P	A	0.1783
132	L	A	0.3896
133	A	A	-0.7959
134	P	A	0.0000
135	S	A	-0.6945
136	S	A	-0.7374
140	S	A	-0.7125
141	G	A	-0.8696
142	G	A	-0.8856
143	T	A	-0.6169
144	A	A	0.0000
145	A	A	0.1061
146	L	A	0.0000
147	G	A	0.0000
148	C	A	0.0000
149	L	A	0.7157
150	V	A	0.0000
151	K	A	-0.5100
152	D	A	-1.2242
153	Y	A	0.0000
154	F	A	0.0000
155	P	A	-1.0244
156	E	A	-1.1963
157	P	A	-1.0845
158	V	A	-0.8262
159	T	A	-0.5869
160	V	A	-0.3726
161	S	A	-0.3420
162	W	A	0.0000
163	N	A	-0.6496
164	S	A	-0.6616
165	G	A	-0.5868
166	A	A	-0.2665
167	L	A	0.0161
168	T	A	-0.2058
169	S	A	-0.2217
170	G	A	-0.1310
171	V	A	0.1578
172	H	A	-0.3133
173	T	A	0.4540
174	F	A	1.5721
175	P	A	1.0143
176	A	A	1.2830
177	V	A	2.5023
178	L	A	1.8894
179	Q	A	0.5813
180	S	A	0.0693
181	S	A	-0.2567
182	G	A	0.1432
183	L	A	-0.1321
184	Y	A	0.4074
185	S	A	0.5209
186	L	A	0.0000
187	S	A	0.8323
188	S	A	0.0000
189	V	A	0.5801
190	V	A	0.0000
191	T	A	-0.1071
192	V	A	0.0000
193	P	A	-0.5631
194	S	A	-0.5840
195	S	A	-0.5837
196	S	A	-0.6220
197	L	A	-0.8631
198	G	A	-1.1054
199	T	A	-0.8036
200	Q	A	-1.4016
201	T	A	-1.1221
202	Y	A	0.0000
203	I	A	-1.1149
204	C	A	0.0000
205	N	A	-1.4588
206	V	A	0.0000
207	N	A	-1.8473
208	H	A	0.0000
209	K	A	-2.8183
210	P	A	-1.9035
211	S	A	-2.0551
212	N	A	-2.4911
213	T	A	-2.3319
214	K	A	-2.6958
215	V	A	-1.8186
216	D	A	-2.6498
217	K	A	-1.9961
218	K	A	-2.2137
219	V	A	0.0000
220	E	A	-2.7539
221	P	A	-1.9388
222	K	A	-2.2372