Project name: 12260M

Chain sequence(s)	A: MRKSNKLMQAVMAGILLFTFSGCATNSVSSATNSSQNVSSENTNGSSTNSTPTNPSTASGVTTLTQSVISKELKSKDYEIDYDENSSTKINLLNDQINFSGDGVLVKDKTVTINKAGTYIIDGNLENGQIIVDVDKTEDVRIVLNGVNIHNESSTAIYVKSADKLVMTLKEGTINTLSGGDNYINIYDNNIDGVIFSKDDLTINGNGQLNLTSNYKHAIVSKNDLNIVSGIFNIVSADQGLSGKDSVRIYGGVFNIKSNGQGIRSKNEEELEKGNIYIAGGNFEIESVQDAMNATGSVVIDDGVFNIKTDDDGIHADVEAVINSGDINILESYEGIEGYRVIINGGNINISSSDDGINASNPNVTSNEPAGGRNLPQGNNSTDVTNTLNNNPAPPNDGMMRNGGGRGPMMADENVYITINDGNIVIDAQGDGIDSNGNITINNGNILVSSKSDNGENALDYDGNITINGGILIGVGGSPMHQNLNENSSQPSISYNVSNGNGNDVELKDSNSNVIVSWKAPKTYNSIFITHPSLKLNEKYTLVSGTESIDITIDNLLTTNITRGSGGRGQRPPRSEEFQPSMEPTNVQ
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.9519
• Maximal score value: 1.9608
• Average score: -0.6168
• Total score value: -362.7028

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	M	A	-1.0184
2	R	A	-2.6968
3	K	A	-2.6353
4	S	A	-1.7095
5	N	A	-1.0106
6	K	A	-0.1885
7	L	A	1.2695
8	M	A	0.8710
9	Q	A	0.0595
10	A	A	0.0000
11	V	A	-1.2200
12	M	A	-1.0937
13	A	A	-0.0940
14	G	A	0.0000
15	I	A	1.9608
16	L	A	1.1794
17	L	A	1.0596
18	F	A	0.9368
19	T	A	0.0000
20	F	A	0.0000
21	S	A	0.6262
22	G	A	0.4020
23	C	A	0.5446
24	A	A	0.6508
25	T	A	0.5724
26	N	A	-0.0483
27	S	A	0.5339
28	V	A	1.4805
29	S	A	0.7431
30	S	A	0.2810
31	A	A	0.2114
32	T	A	-0.3645
33	N	A	0.0000
34	S	A	-0.7334
35	S	A	0.0000
36	Q	A	-1.4039
37	N	A	-1.6786
38	V	A	0.7246
39	S	A	0.0083
40	S	A	-0.5137
41	E	A	0.0000
42	N	A	-1.5862
43	T	A	-0.9292
44	N	A	-0.5715
45	G	A	-0.3707
46	S	A	0.0000
47	S	A	-0.4638
48	T	A	-0.6122
49	N	A	-1.6849
50	S	A	-0.8234
51	T	A	-0.8625
52	P	A	0.0000
53	T	A	-0.7147
54	N	A	0.0000
55	P	A	-2.0535
56	S	A	0.0000
57	T	A	-0.6332
58	A	A	0.0000
59	S	A	-0.9811
60	G	A	-0.9086
61	V	A	0.0000
62	T	A	-0.3121
63	T	A	0.0000
64	L	A	0.1304
65	T	A	-0.3107
66	Q	A	-0.7216
67	S	A	-0.1346
68	V	A	1.4294
69	I	A	0.8078
70	S	A	-0.0634
71	K	A	-0.9760
72	E	A	-1.8871
73	L	A	-0.5894
74	K	A	-2.0626
75	S	A	-1.2326
76	K	A	-1.4065
77	D	A	-2.3154
78	Y	A	0.0000
79	E	A	0.0000
80	I	A	0.0000
81	D	A	-0.8699
82	Y	A	0.0000
83	D	A	-3.3285
84	E	A	-3.9519
85	N	A	-3.0752
86	S	A	0.0000
87	S	A	-1.1555
88	T	A	0.0000
89	K	A	-1.4358
90	I	A	0.0000
91	N	A	-0.6892
92	L	A	0.0000
93	L	A	-0.4577
94	N	A	-0.8071
95	D	A	-0.1508
96	Q	A	0.0000
97	I	A	0.0000
98	N	A	0.0000
99	F	A	0.1008
100	S	A	0.0000
101	G	A	0.0000
102	D	A	-3.2728
103	G	A	-2.8510
104	V	A	0.0000
105	L	A	-1.1169
106	V	A	0.0000
107	K	A	-1.5693
108	D	A	-2.2027
109	K	A	-2.6587
110	T	A	-1.5982
111	V	A	0.0000
112	T	A	-0.3956
113	I	A	0.0000
114	N	A	-0.6678
115	K	A	-1.5640
116	A	A	-1.3197
117	G	A	0.0000
118	T	A	0.0000
119	Y	A	0.0000
120	I	A	0.5635
121	I	A	0.0000
122	D	A	-1.4109
123	G	A	0.0000
124	N	A	-1.1411
125	L	A	0.0000
126	E	A	-1.7634
127	N	A	0.0000
128	G	A	0.0000
129	Q	A	-0.1807
130	I	A	0.0000
131	I	A	0.6819
132	V	A	0.0000
133	D	A	-1.8406
134	V	A	-1.6886
135	D	A	-2.8218
136	K	A	-2.8054
137	T	A	-2.3281
138	E	A	0.0000
139	D	A	0.0000
140	V	A	0.0000
141	R	A	0.0000
142	I	A	0.6206
143	V	A	0.0000
144	L	A	-0.4113
145	N	A	-1.5679
146	G	A	-1.5942
147	V	A	-1.2484
148	N	A	-1.2026
149	I	A	0.0000
150	H	A	-1.4270
151	N	A	0.0000
152	E	A	-2.3744
153	S	A	-1.5075
154	S	A	-0.6136
155	T	A	0.0000
156	A	A	0.0000
157	I	A	0.0000
158	Y	A	0.4196
159	V	A	0.0000
160	K	A	-1.1674
161	S	A	-2.3660
162	A	A	-2.7124
163	D	A	-3.2669
164	K	A	-2.6509
165	L	A	0.0000
166	V	A	0.2225
167	M	A	0.0000
168	T	A	0.0000
169	L	A	0.0000
170	K	A	-1.0026
171	E	A	-1.2501
172	G	A	0.0000
173	T	A	0.0000
174	I	A	0.0922
175	N	A	0.0000
176	T	A	0.4587
177	L	A	0.0698
178	S	A	0.0000
179	G	A	-1.2898
180	G	A	-1.4172
181	D	A	-2.5663
182	N	A	-2.0007
183	Y	A	-1.0639
184	I	A	0.0000
185	N	A	0.0000
186	I	A	0.0000
187	Y	A	-0.6252
188	D	A	-1.2018
189	N	A	-1.0055
190	N	A	0.0000
191	I	A	-0.2673
192	D	A	-0.6591
193	G	A	0.0000
194	V	A	0.0000
195	I	A	0.0000
196	F	A	0.5857
197	S	A	-0.4532
198	K	A	-0.9547
199	D	A	0.0000
200	D	A	0.0000
201	L	A	0.0000
202	T	A	0.0000
203	I	A	0.0000
204	N	A	-1.7713
205	G	A	-1.9865
206	N	A	-1.9594
207	G	A	-1.5151
208	Q	A	-1.3030
209	L	A	0.0000
210	N	A	-0.0853
211	L	A	0.2431
212	T	A	0.0000
213	S	A	0.0000
214	N	A	-0.5626
215	Y	A	-0.2766
216	K	A	-1.7486
217	H	A	-1.3596
218	A	A	0.0000
219	I	A	0.0000
220	V	A	0.2193
221	S	A	-0.6662
222	K	A	-1.7042
223	N	A	0.0000
224	D	A	-1.2139
225	L	A	0.0000
226	N	A	-0.9646
227	I	A	0.0000
228	V	A	-1.3543
229	S	A	-1.6932
230	G	A	-1.1418
231	I	A	0.0000
232	F	A	0.6036
233	N	A	-0.0282
234	I	A	0.0000
235	V	A	0.2344
236	S	A	0.0000
237	A	A	0.0000
238	D	A	0.0000
239	Q	A	0.0000
240	G	A	-0.3393
241	L	A	0.0000
242	S	A	-0.4494
243	G	A	0.0000
244	K	A	-1.7968
245	D	A	-2.3469
246	S	A	-1.8074
247	V	A	0.0000
248	R	A	-2.0858
249	I	A	0.0000
250	Y	A	-0.2048
251	G	A	-0.0265
252	G	A	0.0000
253	V	A	0.9507
254	F	A	0.0000
255	N	A	0.7368
256	I	A	0.6906
257	K	A	-0.5000
258	S	A	-0.8067
259	N	A	-1.4964
260	G	A	-0.6452
261	Q	A	0.0000
262	G	A	0.0000
263	I	A	0.8552
264	R	A	0.0000
265	S	A	-0.5442
266	K	A	0.0000
267	N	A	-1.9699
268	E	A	-2.2558
269	E	A	-2.9484
270	E	A	0.0000
271	L	A	0.0000
272	E	A	0.0000
273	K	A	-0.7688
274	G	A	-0.1622
275	N	A	0.0000
276	I	A	0.9908
277	Y	A	0.0000
278	I	A	0.3823
279	A	A	-0.4738
280	G	A	-0.4070
281	G	A	0.0000
282	N	A	0.0000
283	F	A	0.0000
284	E	A	-0.4897
285	I	A	0.0000
286	E	A	-2.1184
287	S	A	0.0000
288	V	A	-0.4631
289	Q	A	-1.9172
290	D	A	-2.2537
291	A	A	0.0000
292	M	A	0.0000
293	N	A	-1.4780
294	A	A	0.0000
295	T	A	-0.6451
296	G	A	-0.8769
297	S	A	-0.3942
298	V	A	0.0000
299	V	A	0.4134
300	I	A	0.0000
301	D	A	-1.5567
302	D	A	-2.4663
303	G	A	0.0000
304	V	A	0.0000
305	F	A	-0.1403
306	N	A	0.0000
307	I	A	-0.0601
308	K	A	0.0000
309	T	A	-0.7339
310	D	A	0.0000
311	D	A	-1.6578
312	D	A	-1.9669
313	G	A	-1.1785
314	I	A	0.0000
315	H	A	-1.6059
316	A	A	0.0000
317	D	A	0.0000
318	V	A	0.0000
319	E	A	-0.8559
320	A	A	-0.2627
321	V	A	-0.0923
322	I	A	0.0000
323	N	A	-2.1199
324	S	A	-1.2471
325	G	A	-0.9048
326	D	A	-1.6104
327	I	A	0.0000
328	N	A	-0.4308
329	I	A	0.0000
330	L	A	-0.2389
331	E	A	-0.8196
332	S	A	-1.1654
333	Y	A	-0.4020
334	E	A	-1.3686
335	G	A	0.0000
336	I	A	-0.1457
337	E	A	0.0000
338	G	A	-0.3068
339	Y	A	0.2374
340	R	A	0.0000
341	V	A	-0.1874
342	I	A	0.0000
343	I	A	-0.8670
344	N	A	-1.6097
345	G	A	-0.7245
346	G	A	0.0000
347	N	A	-0.3251
348	I	A	0.0000
349	N	A	-1.0868
350	I	A	0.0000
351	S	A	-1.4685
352	S	A	-1.4517
353	S	A	-1.9536
354	D	A	-2.6932
355	D	A	-2.5099
356	G	A	-1.6775
357	I	A	0.0000
358	N	A	-1.7505
359	A	A	0.0000
360	S	A	-0.7566
361	N	A	-0.5629
362	P	A	0.0000
363	N	A	-0.2435
364	V	A	0.0000
365	T	A	-0.8189
366	S	A	-1.3221
367	N	A	-1.9017
368	E	A	0.0000
369	P	A	-0.7304
370	A	A	-0.4835
371	G	A	0.0000
372	G	A	0.0000
373	R	A	-2.1272
374	N	A	-1.0018
375	L	A	-0.1007
376	P	A	0.0000
377	Q	A	-1.0178
378	G	A	0.0000
379	N	A	-1.3650
380	N	A	-1.2113
381	S	A	-0.8140
382	T	A	-0.8562
383	D	A	-0.8711
384	V	A	-0.6953
385	T	A	-1.1058
386	N	A	-2.1655
387	T	A	0.0000
388	L	A	-0.8614
389	N	A	-0.4803
390	N	A	-0.6591
391	N	A	0.0000
392	P	A	-0.2994
393	A	A	0.0000
394	P	A	-0.6246
395	P	A	0.0000
396	N	A	-1.0636
397	D	A	-0.8318
398	G	A	-0.9350
399	M	A	-1.0435
400	M	A	-1.3283
401	R	A	-1.4496
402	N	A	-1.9639
403	G	A	-1.5008
404	G	A	-1.4053
405	G	A	-1.6356
406	R	A	-2.1618
407	G	A	-0.8532
408	P	A	-0.5816
409	M	A	0.0000
410	M	A	-0.3713
411	A	A	-0.5810
412	D	A	-1.5459
413	E	A	-1.2077
414	N	A	0.0000
415	V	A	-0.5779
416	Y	A	-0.3599
417	I	A	0.0000
418	T	A	-0.7121
419	I	A	0.0000
420	N	A	-1.7011
421	D	A	-2.6699
422	G	A	-1.6901
423	N	A	0.0000
424	I	A	-0.0710
425	V	A	0.0000
426	I	A	0.8030
427	D	A	0.0000
428	A	A	-0.8621
429	Q	A	-1.6570
430	G	A	-1.3457
431	D	A	0.0000
432	G	A	-0.9456
433	I	A	0.0000
434	D	A	-1.2235
435	S	A	-1.1214
436	N	A	-1.6169
437	G	A	-1.0085
438	N	A	-0.8790
439	I	A	0.0000
440	T	A	-0.2417
441	I	A	0.0000
442	N	A	-1.4486
443	N	A	-2.1820
444	G	A	0.0000
445	N	A	-0.9496
446	I	A	0.0000
447	L	A	0.3444
448	V	A	0.0000
449	S	A	-0.7906
450	S	A	-0.9506
451	K	A	0.0000
452	S	A	-0.2737
453	D	A	0.0000
454	N	A	-1.0430
455	G	A	-1.2934
456	E	A	-1.1639
457	N	A	0.0000
458	A	A	0.0000
459	L	A	0.0000
460	D	A	0.0000
461	Y	A	-0.9728
462	D	A	-2.4765
463	G	A	0.0000
464	N	A	-1.0519
465	I	A	0.0000
466	T	A	-0.4917
467	I	A	0.0000
468	N	A	-1.5686
469	G	A	-1.0422
470	G	A	-0.5897
471	I	A	0.0000
472	L	A	0.7553
473	I	A	0.0000
474	G	A	0.0211
475	V	A	-0.1519
476	G	A	-0.5114
477	G	A	-0.4014
478	S	A	-0.1457
479	P	A	0.0000
480	M	A	-0.0321
481	H	A	-0.9741
482	Q	A	-1.3577
483	N	A	-1.6555
484	L	A	0.0000
485	N	A	-1.1869
486	E	A	0.0000
487	N	A	-0.9550
488	S	A	-1.1860
489	S	A	-1.2270
490	Q	A	-0.8706
491	P	A	0.0000
492	S	A	0.4709
493	I	A	1.0031
494	S	A	0.4503
495	Y	A	0.0000
496	N	A	-0.3277
497	V	A	0.0000
498	S	A	-0.1001
499	N	A	0.0000
500	G	A	-0.7130
501	N	A	-1.5450
502	G	A	-1.3378
503	N	A	0.0000
504	D	A	-1.2947
505	V	A	0.0000
506	E	A	-0.9114
507	L	A	0.0000
508	K	A	-1.0917
509	D	A	-1.7093
510	S	A	-1.6884
511	N	A	-1.6555
512	S	A	-1.3693
513	N	A	0.0000
514	V	A	-0.4571
515	I	A	0.0000
516	V	A	-0.3159
517	S	A	0.0000
518	W	A	-0.0894
519	K	A	-0.6405
520	A	A	0.0000
521	P	A	-0.2297
522	K	A	0.0000
523	T	A	-0.2187
524	Y	A	-0.4798
525	N	A	0.0000
526	S	A	-0.2812
527	I	A	0.0000
528	F	A	0.3713
529	I	A	0.0000
530	T	A	-0.5586
531	H	A	-1.4590
532	P	A	0.0000
533	S	A	-0.4455
534	L	A	0.0000
535	K	A	-1.3324
536	L	A	-0.9606
537	N	A	-2.1444
538	E	A	-2.3308
539	K	A	-2.3651
540	Y	A	0.0000
541	T	A	-0.7395
542	L	A	0.0000
543	V	A	-0.1441
544	S	A	-0.7982
545	G	A	-1.0093
546	T	A	-1.5461
547	E	A	-1.9271
548	S	A	-0.8410
549	I	A	0.3269
550	D	A	0.3908
551	I	A	0.9291
552	T	A	0.6283
553	I	A	0.3947
554	D	A	-1.8344
555	N	A	-1.6358
556	L	A	-0.1932
557	L	A	0.6238
558	T	A	-0.1362
559	T	A	0.0000
560	N	A	-1.2441
561	I	A	-0.1452
562	T	A	-0.4467
563	R	A	-1.2590
564	G	A	-1.3541
565	S	A	-1.3192
566	G	A	-1.6174
567	G	A	-2.3547
568	R	A	-3.0686
569	G	A	-2.6921
570	Q	A	-2.4907
571	R	A	-2.2669
572	P	A	-1.7031
573	P	A	-2.3213
574	R	A	-2.4665
575	S	A	-1.9994
576	E	A	-3.2370
577	E	A	-2.1941
578	F	A	-0.3138
579	Q	A	-1.3389
580	P	A	-1.3275
581	S	A	-0.5812
582	M	A	0.5491
583	E	A	-0.4639
584	P	A	-0.3144
585	T	A	-0.2278
586	N	A	-0.3476
587	V	A	0.6212
588	Q	A	-0.8736