Project name: 730aaccc8c41ad7

Chain sequence(s)	H: EVQLQQSGAEIVRSGASSSVKLSCCAASGFNIKDYYMMHHWVKQRPEQGLEWIGWWIDPENGDIAYAPKFQGKATMMTADTSSNTAYLQLSRLTSEDTAVYFCCNGRGGMITTDFFDYWGQGTTTLTVSSSAKTTPPSVYPLAPGSAAQTNSSMVTLGCCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQQSSDLYTLSSSVTVPSSTWPSETVTCCNVAHPASSTKVDKKIVVPR; L: DVLMTQQTPLSSSLPVSLGDQASISCCRSSQSSIVHSNGNTYLEWYLQKPGQSSPKLLIYKVSNRFSSGVPDRFSGSGSGTDDFTLKISRVEAEDLGVYYCFQGSHVPWWTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCCFLNNFYPKDINNVKWKIDGSEERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERRHNSYTCCEATHKTSTSPIVKSFNRNE
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.064
• Maximal score value: 1.6989
• Average score: -0.7282
• Total score value: -319.6808

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	D	L	-1.3646
2	V	L	0.0000
3	L	L	0.2930
4	M	L	0.0000
5	T	L	-0.5208
6	Q	L	-0.3082
7	T	L	-0.0720
8	P	L	0.5574
9	L	L	1.3525
10	S	L	0.6890
11	L	L	0.2643
12	P	L	-0.5992
13	V	L	0.0000
14	S	L	-0.9230
15	L	L	-0.4767
16	G	L	-1.5529
17	D	L	-2.1039
18	Q	L	-2.4526
19	A	L	0.0000
20	S	L	-0.7585
21	I	L	0.0000
22	S	L	-0.7328
23	C	L	0.0000
24	R	L	-2.3418
25	S	L	0.0000
26	S	L	-1.1575
27	Q	L	-1.5482
28	S	L	-0.9253
29	I	L	0.0000
30	V	L	0.1412
31	H	L	-0.6649
32	S	L	-0.9393
33	N	L	-1.6180
34	G	L	-1.0884
35	N	L	-0.7549
36	T	L	-0.2431
37	Y	L	0.0166
38	L	L	0.0000
39	E	L	0.0000
40	W	L	0.0000
41	Y	L	0.0000
42	L	L	0.0000
43	Q	L	0.0000
44	K	L	-1.6163
45	P	L	-1.3457
46	G	L	-1.5099
47	Q	L	-2.1789
48	S	L	-1.4049
49	P	L	0.0000
50	K	L	-1.3803
51	L	L	0.0000
52	L	L	0.0000
53	I	L	0.0000
54	Y	L	-0.4757
55	K	L	-0.6348
56	V	L	-0.6404
57	S	L	-0.9817
58	N	L	-1.4011
59	R	L	-2.1811
60	F	L	-1.3845
61	S	L	-0.9994
62	G	L	-0.9735
63	V	L	0.0000
64	P	L	-1.4038
65	D	L	-2.3146
66	R	L	-2.2574
67	F	L	0.0000
68	S	L	-1.3558
69	G	L	-0.8706
70	S	L	-0.7346
71	G	L	-1.1018
72	S	L	-0.7953
73	G	L	-0.6925
74	T	L	-1.3892
75	D	L	-1.8116
76	F	L	0.0000
77	T	L	-0.8535
78	L	L	0.0000
79	K	L	-1.3151
80	I	L	0.0000
81	S	L	-2.4223
82	R	L	-2.9852
83	V	L	0.0000
84	E	L	-2.0063
85	A	L	-1.0746
86	E	L	-2.0541
87	D	L	0.0000
88	L	L	-0.4602
89	G	L	-0.5691
90	V	L	0.1274
91	Y	L	0.0000
92	Y	L	0.0000
93	C	L	0.0000
94	F	L	0.0000
95	Q	L	0.0000
96	G	L	0.3272
97	S	L	0.0000
98	H	L	0.0414
99	V	L	1.1307
100	P	L	0.4639
101	W	L	0.3878
102	T	L	-0.0065
103	F	L	-0.0742
104	G	L	0.0000
105	G	L	-0.4633
106	G	L	0.0000
107	T	L	0.0000
108	K	L	0.2537
109	L	L	0.0000
110	E	L	0.0000
111	I	L	-0.6218
112	K	L	-1.9331
113	R	L	-1.8635
114	A	L	-1.3709
115	D	L	-2.3302
116	A	L	-1.2607
117	A	L	-0.6783
118	P	L	0.0000
119	T	L	-0.1133
120	V	L	0.0000
121	S	L	-0.1111
122	I	L	-0.0145
123	F	L	0.0000
124	P	L	-0.2547
125	P	L	0.0000
126	S	L	0.0000
127	S	L	-0.9415
128	E	L	-1.1938
129	Q	L	0.0000
130	L	L	-0.6759
131	T	L	-0.5992
132	S	L	-0.6490
133	G	L	-0.9642
134	G	L	-0.8909
135	A	L	0.0000
136	S	L	0.0000
137	V	L	0.0000
138	V	L	0.0000
139	C	L	0.0000
140	F	L	0.0000
141	L	L	0.0000
142	N	L	0.0000
143	N	L	-0.7825
144	F	L	0.0000
145	Y	L	0.0000
146	P	L	-2.0671
147	K	L	-2.3501
148	D	L	-2.6025
149	I	L	-1.6702
150	N	L	-1.6664
151	V	L	-0.5501
152	K	L	-1.3741
153	W	L	0.0000
154	K	L	-2.2189
155	I	L	0.0000
156	D	L	-2.6933
157	G	L	-2.0319
158	S	L	-2.0061
159	E	L	-3.0726
160	R	L	-2.5824
161	Q	L	-2.4712
162	N	L	-2.1738
163	G	L	-1.2542
164	V	L	-0.5938
165	L	L	-0.2905
166	N	L	-0.0572
167	S	L	0.0000
168	W	L	0.1586
169	T	L	-0.7438
170	D	L	-1.7501
171	Q	L	-1.6165
172	D	L	-1.9773
173	S	L	-1.6900
174	K	L	-2.2661
175	D	L	-1.7149
176	S	L	-1.7342
177	T	L	0.0000
178	Y	L	0.0000
179	S	L	0.0000
180	M	L	0.0000
181	S	L	0.0000
182	S	L	0.0000
183	T	L	0.0000
184	L	L	0.0000
185	T	L	-0.4722
186	L	L	0.0000
187	T	L	-1.4638
188	K	L	-2.3571
189	D	L	-3.3023
190	E	L	-2.7789
191	Y	L	0.0000
192	E	L	-4.0640
193	R	L	-3.7103
194	H	L	-3.2012
195	N	L	-3.2913
196	S	L	-2.1528
197	Y	L	0.0000
198	T	L	-1.0150
199	C	L	0.0000
200	E	L	-0.3528
201	A	L	0.0000
202	T	L	-0.9490
203	H	L	0.0000
204	K	L	-2.4203
205	T	L	-1.2747
206	S	L	-0.6753
207	T	L	-0.5647
208	S	L	-0.3450
209	P	L	-0.3444
210	I	L	0.4631
211	V	L	0.5730
212	K	L	-0.3946
213	S	L	-0.5429
214	F	L	-1.2504
215	N	L	-2.4480
216	R	L	-2.9118
217	N	L	-3.0222
218	E	L	-2.9798
1	E	H	-2.0073
2	V	H	-1.2978
3	Q	H	-1.7374
4	L	H	0.0000
5	Q	H	-1.7985
6	Q	H	0.0000
7	S	H	-0.9885
8	G	H	-0.8026
9	A	H	-0.3006
10	E	H	-0.3614
11	I	H	0.1972
12	V	H	-0.4668
13	R	H	-2.0864
14	S	H	-1.8404
15	G	H	-1.7803
16	A	H	-1.3802
17	S	H	-1.4837
18	V	H	0.0000
19	K	H	-1.9355
20	L	H	0.0000
21	S	H	-0.6563
22	C	H	0.0000
23	A	H	-0.8644
24	A	H	0.0000
25	S	H	-1.2780
26	G	H	-1.2496
27	F	H	-1.3246
28	N	H	-2.1994
29	I	H	0.0000
30	K	H	-3.2623
31	D	H	-2.8109
32	Y	H	-1.2625
33	Y	H	-0.3421
34	M	H	0.0000
35	H	H	0.0000
36	W	H	0.0000
37	V	H	0.0000
38	K	H	0.0000
39	Q	H	-1.3179
40	R	H	-1.8809
41	P	H	-1.6253
42	E	H	-2.6529
43	Q	H	-2.6100
44	G	H	-1.6842
45	L	H	0.0000
46	E	H	-1.8052
47	W	H	0.0000
48	I	H	0.0000
49	G	H	0.0000
50	W	H	0.4522
51	I	H	0.0000
52	D	H	0.0000
53	P	H	0.0000
54	E	H	-3.7562
55	N	H	-3.0404
56	G	H	-2.4816
57	D	H	-2.2875
58	I	H	-0.2535
59	A	H	0.3398
60	Y	H	0.0534
61	A	H	0.0000
62	P	H	-1.3959
63	K	H	-2.2126
64	F	H	0.0000
65	Q	H	-2.0063
66	G	H	-1.7153
67	K	H	-1.6651
68	A	H	0.0000
69	T	H	-0.6121
70	M	H	0.0000
71	T	H	-0.5178
72	A	H	-0.8294
73	D	H	-1.2285
74	T	H	-1.4162
75	S	H	-0.8353
76	S	H	-0.7435
77	N	H	-0.9984
78	T	H	0.0000
79	A	H	0.0000
80	Y	H	-0.3727
81	L	H	0.0000
82	Q	H	-1.1849
83	L	H	0.0000
84	S	H	-1.5923
85	R	H	-2.4422
86	L	H	0.0000
87	T	H	-1.6563
88	S	H	-1.5073
89	E	H	-2.0197
90	D	H	0.0000
91	T	H	-0.6507
92	A	H	0.0000
93	V	H	0.0691
94	Y	H	0.0000
95	F	H	0.0000
96	C	H	0.0000
97	N	H	0.0000
98	G	H	0.0000
99	R	H	0.0000
100	G	H	0.0017
101	G	H	-0.0609
102	M	H	0.5885
103	I	H	1.6989
104	T	H	0.5162
105	T	H	-0.4049
106	D	H	-1.4607
107	F	H	0.0000
108	F	H	-0.0516
109	D	H	0.0000
110	Y	H	0.4529
111	W	H	-0.4751
112	G	H	0.0000
113	Q	H	-1.8408
114	G	H	-1.0258
115	T	H	0.0000
116	T	H	-0.1363
117	L	H	0.0000
118	T	H	0.0000
119	V	H	0.0000
120	S	H	0.0000
121	S	H	-1.2520
122	A	H	-1.1968
123	K	H	-1.7206
124	T	H	-1.0209
125	T	H	-0.5806
126	P	H	-0.7622
127	P	H	0.0000
128	S	H	-0.3818
129	V	H	0.0000
130	Y	H	0.0000
131	P	H	0.0000
132	L	H	0.0000
133	A	H	0.0000
134	P	H	-0.4841
135	G	H	-1.3516
136	S	H	-1.0165
137	A	H	-0.6341
138	A	H	-0.6844
139	Q	H	-1.4108
140	T	H	-1.1898
141	N	H	-1.4900
142	S	H	-0.6197
143	M	H	0.4591
144	V	H	0.0000
145	T	H	0.0000
146	L	H	0.0000
147	G	H	0.0000
148	C	H	0.0000
149	L	H	0.0000
150	V	H	0.0000
151	K	H	-0.1997
152	G	H	-0.3348
153	Y	H	0.0000
154	F	H	0.0000
155	P	H	-0.6504
156	E	H	-0.8755
157	P	H	-0.8087
158	V	H	0.0000
159	T	H	-0.3840
160	V	H	-0.1483
161	T	H	-0.3870
162	W	H	0.0000
163	N	H	-0.9784
164	S	H	-0.7963
165	G	H	-0.7440
166	S	H	-0.5404
167	L	H	-0.2400
168	S	H	-0.4037
169	S	H	-0.3729
170	G	H	-0.3558
171	V	H	0.0848
172	H	H	-0.1365
173	T	H	0.0741
174	F	H	0.0000
175	P	H	-0.0766
176	A	H	-0.0652
177	V	H	0.0602
178	L	H	-0.1728
179	Q	H	-1.0999
180	S	H	-0.8625
181	D	H	-1.2142
182	L	H	-0.4516
183	Y	H	-0.1636
184	T	H	0.0000
185	L	H	0.0000
186	S	H	0.0000
187	S	H	0.0000
188	S	H	0.0000
189	V	H	0.0000
190	T	H	0.1487
191	V	H	0.0000
192	P	H	-0.2114
193	S	H	-0.5637
194	S	H	-0.9441
195	T	H	-0.9361
196	W	H	0.0000
197	P	H	-0.6872
198	S	H	-1.2854
199	E	H	-2.0591
200	T	H	-1.1198
201	V	H	0.0000
202	T	H	-1.2584
203	C	H	0.0000
204	N	H	-1.4028
205	V	H	0.0000
206	A	H	-0.9608
207	H	H	0.0000
208	P	H	-0.7756
209	A	H	-0.3995
210	S	H	-0.5109
211	S	H	-0.7334
212	T	H	-0.9849
213	K	H	-2.0677
214	V	H	-1.5255
215	D	H	-2.3169
216	K	H	-1.8850
217	K	H	-1.6709
218	I	H	0.0000
219	V	H	0.6492
220	P	H	-0.5582
221	R	H	-1.6603